公开(公告)号：US06724930B1

公开(公告)日：2004-04-20

申请号：US09498963

申请日：2000-02-04

申请人： Akio Kosaka ,  Akito Saito ,  Takao Shibasaki ,  Takeo Asano ,  Hiroshi Matsuzaki ,  Yukihito Furuhashi

发明人： Akio Kosaka ,  Akito Saito ,  Takao Shibasaki ,  Takeo Asano ,  Hiroshi Matsuzaki ,  Yukihito Furuhashi

IPC分类号： G06K900

CPC分类号： G06K9/6211 ,  G01B11/002 ,  G06K9/3208 ,  G06T7/73

摘要： A three-dimensional position and orientation sensing apparatus including: an image input section which inputs an image acquired by an image acquisition apparatus and showing at least three markers having color or geometric characteristics as one image, three-dimensional positional information of the markers with respect to an object to be measured being known in advance; a region extracting section which extracts a region corresponding to each marker in the image; a marker identifying section which identifies the individual markers based on the color or geometric characteristics of the markers in the extracted regions; and a position and orientation calculating section which calculates the three-dimensional position and orientation of the object to be measured with respect to the image acquisition apparatus, by using positions of the identified markers in the image input to the image input section, and the positional information of the markers with respect to the object to be measured.

摘要翻译： 一种三维位置和方向检测装置，包括：图像输入部，其输入由图像获取装置获取的图像，并且将至少三个具有颜色或几何特征的标记显示为一个图像，所述标记的三维位置信息相对于 预先知道要被测量的物体; 区域提取部，其提取与图像中的每个标记对应的区域; 基于提取区域中的标记的颜色或几何特征来识别各个标记的标记识别部分; 以及位置和姿势计算部分，通过使用输入到图像输入部分的图像中识别的标记的位置来计算相对于图像获取装置的待测量对象的三维位置和取向，以及位置 关于待测量对象的标记的信息。

公开(公告)号：US06466815B1

公开(公告)日：2002-10-15

申请号：US09533651

申请日：2000-03-22

申请人： Akito Saito ,  Takao Shibasaki ,  Takeo Asano ,  Hiroshi Matsuzaki ,  Yukihito Furuhashi ,  Akio Kosaka

发明人： Akito Saito ,  Takao Shibasaki ,  Takeo Asano ,  Hiroshi Matsuzaki ,  Yukihito Furuhashi ,  Akio Kosaka

IPC分类号： A61B505

CPC分类号： A61B5/064 ,  A61B1/0005 ,  A61B34/20 ,  A61B90/20 ,  A61B90/36 ,  A61B90/361 ,  A61B2034/2055 ,  A61B2034/2072 ,  A61B2090/3983 ,  G06F19/00

摘要： A navigation apparatus comprises a navigation-related information generating section and a display section. The navigation-related information generating section measures the position and orientation of an object and a target in a three-dimensional space and generate navigation-related information to be used for navigating the object toward the target. The display section displays the navigation-related information generated by the navigation-related information generating section in any of different modes depending on the relationship of the position and orientation of the object and that of the target. A surgical operation image acquisition/display apparatus comprises an observation section, an image display section and a specifying section. The observation section includes a plurality of observation sections whose position and orientation is modifiable. The image display section is adapted to alternatively display any of the images obtained by the observation sections or synthetically combine and display the combined images. The specifying section specifies the image to be displayed to the image display section according to the position and orientation of the observation section.

公开(公告)号：US06283763B1

公开(公告)日：2001-09-04

申请号：US09192902

申请日：1998-11-16

申请人： Hiroshi Matsuzaki ,  Takao Shibasaki ,  Akito Saito ,  Takeo Asano

发明人： Hiroshi Matsuzaki ,  Takao Shibasaki ,  Akito Saito ,  Takeo Asano

IPC分类号： G09B2328

CPC分类号： G09B23/286 ,  G06F19/00

摘要： A medical operation simulator includes a three-dimensional image reconstruction section, an instrument-image forming section, and an approach data presenting section. The three-dimensional image reconstructing section processes data representing slice images, thereby generating three-dimensional image data. The three-dimensional image data is supplied to a display device. The instrument-image forming section forms an image of a medical instrument. The image moves in the same way that a medical instrument provided on an operation input device is manipulated by an operator. The instrument-image forming section supplies data representing the image of the instrument to the display device. The display device displays the image of the instrument together with a three-dimensional image represented by the three-dimensional image data generated by the three-dimensional image reconstructing means. The approach data presenting section converts data showing an approach of the medical instrument toward a region of interest into at least one of an aural sensation, visual sensation, pressure sensation and touch sensation, by performing approach data presentation processing, and then presents at least one of the aural sensation, visual sensation, pressure sensation and touch sensation.

摘要翻译： 医疗操作模拟器包括三维图像重建部分，仪器图像形成部分和方法数据呈现部分。 三维图像重建部分处理表示切片图像的数据，从而生成三维图像数据。 三维图像数据被提供给显示装置。 仪器图像形成部分形成医疗器械的图像。 图像的移动方式与操作输入装置上提供的医疗器械由操作者操纵相同。 仪器图像形成部将表示仪器的图像的数据提供给显示装置。 显示装置与由三维图像重建装置生成的三维图像数据所表示的三维图像一起显示仪器的图像。 方法数据呈现部分通过执行方法数据呈现处理将表示医疗器械朝向感兴趣区域的方法的数据转换为听觉，视觉，压力感觉和触觉中的至少一种，然后呈现至少一个 的听觉，视觉感受，压力感和触感。

公开(公告)号：US06640127B1

公开(公告)日：2003-10-28

申请号：US09590466

申请日：2000-06-09

申请人： Akio Kosaka ,  Takao Shibasaki ,  Akito Saito ,  Takeo Asano ,  Hiroshi Matsuzaki ,  Yukihito Furuhashi

发明人： Akio Kosaka ,  Takao Shibasaki ,  Akito Saito ,  Takeo Asano ,  Hiroshi Matsuzaki ,  Yukihito Furuhashi

IPC分类号： A61B505

CPC分类号： A61B90/36 ,  A61B34/20 ,  A61B90/14 ,  A61B90/39 ,  A61B2034/2055 ,  A61B2034/2072 ,  A61B2090/364 ,  A61B2090/3945 ,  A61B2090/3979 ,  A61B2090/3983 ,  A61B2090/3995

摘要： A reference frame adapted to be fitted to a subject of medical treatment and provided with markers for determining the position or the orientation of the subject comprises fitting section for fitting the reference frame with the subject at least three spots (tops of the left and right ears and the nasal projection) along the undulations of the surface thereof and three or more than three markers detectable at least ether in an X-ray image or in an MRI image of the reference frame, the markers being to be arranged at predetermined positions not connectable by a straight line. A surgical operation navigating system determines the coordinates of the markers in a coordinate system defined for the image taken for the purpose of medical examination of the subject who is carrying the reference frame on the basis of the obtained image. Then the corresponding relationship is established between the coordinate system for the image for examination and the coordinate system for the real space containing the markers on the basis of the result of the operation of determining the coordinates of the markers in the coordinate system for the image for examination and the coordinates of the markers in the coordinate system for the real space.

摘要翻译： 适于装配到医疗对象并具有用于确定受试者的位置或取向的标记的参考框架包括用于将参考框架与受试者相配合的装配部分至少三个点（左耳和右耳的顶部 和鼻突起），以及在X射线图像或参考框架的MRI图像中可检测至少为乙醚的三个或三个以上三个标记，标记将被布置在不可连接的预定位置 用直线。 外科手术导航系统基于所获得的图像确定为为进行参考框架的对象的医学检查而拍摄的图像所定义的坐标系中的标记的坐标。 然后，基于确定图像坐标系中的标记坐标的操作结果，在用于检查的图像的坐标系和包含标记的实际空间的坐标系之间建立对应的关系， 检查和坐标系坐标系中的实际空间。

公开(公告)号：US07088389B2

公开(公告)日：2006-08-08

申请号：US09951872

申请日：2001-09-13

申请人： Takao Shibasaki ,  Yulchiro Akatsuka ,  Akito Salto

发明人： Takao Shibasaki ,  Yulchiro Akatsuka ,  Akito Salto

IPC分类号： H04N5/262

CPC分类号： H04N1/00323 ,  G01C21/20 ,  H04N1/00127 ,  H04N1/00204 ,  H04N1/0044 ,  H04N2101/00 ,  H04N2201/3225 ,  H04N2201/3253 ,  H04N2201/3273

摘要： According to an embodiment of the present invention, a system for displaying information in a specific region includes a capturing unit for capturing a desired subject, an image capturing unit for capturing an image of the subject, a position and attitude calculating unit for calculating at least the position and the facing direction of the capturing unit on the basis of the captured image, a determining unit for determining the subject in the image captured by the image capturing unit on the basis of an output of the position and attitude calculating unit, a related information obtaining unit for obtaining at least information related to the determined subject, and a related information superimposition display unit for displaying the obtained information together with the image related to the subject on a display unit.

公开(公告)号：US20100041916A1

公开(公告)日：2010-02-18

申请号：US12441004

申请日：2007-04-20

申请人： Kuniaki Okamoto ,  Tsutomu Watahiki ,  Motoshige Sumino ,  Takao Shibasaki

发明人： Kuniaki Okamoto ,  Tsutomu Watahiki ,  Motoshige Sumino ,  Takao Shibasaki

IPC分类号： C07C309/30 ,  C07C309/01 ,  C07C309/28

CPC分类号： C07C303/26 ,  C07D327/00 ,  C07C309/65 ,  C07C309/66 ,  C07C309/73 ,  C07C309/76 ,  C07C309/67

摘要： The present invention provides a method for producing a sulfonate ester efficiently and in high yield.The present invention is an invention of a method for producing a sulfonate ester compound, which comprising reacting: (a) a compound having a sulfo group (—SO3H); and (b) a compound having a group represented by the general formula [1]: —OR1  [1] [wherein, R1 represents a sulfonyl group represented by the general formula [2]: —SO2—R2  [2] (wherein, R2 represents a halogen atom, a haloalkyl group, an alkoxy group, or an optionally substituted alkyl group or an optionally substituted aryl group) or an acyl group represented by the general formula [3]: (wherein, R3 represents an optionally substituted alkyl group or an optionally substituted aryl group)]; in the presence of an organic base which is capable of forming a salt with said sulfo group.

摘要翻译： 本发明提供了一种有效且高收率地生产磺酸酯的方法。 本发明是一种磺酸酯化合物的制造方法的发明，其包括：（a）具有磺基（-SO 3 H）的化合物; 和（b）具有由通式[1]表示的基团的化合物：-OR1 [1] [其中，R1表示由通式[2]表示的磺酰基：-SO 2 -R 2 [2]（其中， R2表示卤素原子，卤代烷基，烷氧基或任选取代的烷基或任选取代的芳基）或由通式[3]表示的酰基：（其中，R 3表示任选取代的烷基 或任选取代的芳基）]; 在能够与所述磺基形成盐的有机碱存在下进行。

公开(公告)号：US06804683B1

公开(公告)日：2004-10-12

申请号：US09716692

申请日：2000-11-20

申请人： Hiroshi Matsuzaki ,  Akio Kosaka ,  Takao Shibasaki

发明人： Hiroshi Matsuzaki ,  Akio Kosaka ,  Takao Shibasaki

IPC分类号： G06F1730

CPC分类号： G06F17/30256 ,  Y10S707/99931 ,  Y10S707/99945 ,  Y10S707/99948

摘要： A similar image retrieving means has a region of interest setting portion, a feature quantity calculation portion, a similarity calculation portion and an image selection portion. A part of the three-dimensional image of the retrieval object is set as a region of interest. The feature quantity calculation portion calculates the quantity of the region of interest. The similarity calculation portion calculates the similarity between the retrieval object and the three-dimensional image data stored in advance by comparing the feature quantity of the region of interest of the retrieval object which quantity is calculated with the feature quantity calculation means with the three-dimensional image data where the region of interest is set which is stored in advance in the image database, and the feature quantity of this region of interest is calculated. The image selection portion selects similar images in an order of decreasing similarity from the image database.

摘要翻译： 类似的图像检索装置具有感兴趣区域设置部分，特征量计算部分，相似度计算部分和图像选择部分。 将检索对象的三维图像的一部分设置为感兴趣的区域。 特征量计算部分计算感兴趣区域的数量。 相似度计算部分通过将检索对象的感兴趣区域的特征量与计算特征量计算装置的特征量进行比较，来计算检索对象与预先存储的三维图像数据之间的相似度， 设置预先存储在图像数据库中的感兴趣区域的图像数据，并且计算该感兴趣区域的特征量。 图像选择部分以与图像数据库相似度降低的顺序选择相似的图像。

公开(公告)号：US06681129B2

公开(公告)日：2004-01-20

申请号：US09966972

申请日：2001-09-28

申请人： Hiroshi Matsuzaki ,  Akito Saito ,  Yukihito Furuhashi ,  Takao Shibasaki

发明人： Hiroshi Matsuzaki ,  Akito Saito ,  Yukihito Furuhashi ,  Takao Shibasaki

IPC分类号： A61B505

CPC分类号： A61B5/055 ,  A61B1/0005 ,  A61B1/04 ,  A61B5/743

摘要： A surgical operation navigation apparatus comprises a medical image storage section that stores three-dimensional information of a subject measured by a medical image diagnosis unit. A modification information storage section modifies and stores the three-dimensional information of the subject based on predicted modification of the subject. A morphological shape measuring instrument measures a three-dimensional morphological shape of the subject. A morphological shape information storage section compares a three-dimensional morphological shape of a subject with three-dimensional information, and selects and outputs three-dimensional information of the subject that is the most analogous to the morphological shape of the subject. A data image generating section generates data image from the selected, outputted three-dimensional information of the subject. An image superimposing section superimposes a data image from the data image generation section and an image of the subject from the surgical operation utensil, and outputs the superimposed image to an image display device.

摘要翻译： 外科手术导航装置包括医疗图像存储部，其存储由医学图像诊断部测量的被检体的三维信息。 修改信息存储部根据被检体的预测修正来修正并存储被检体的三维信息。 形态测量仪器测量受试者的三维形态。 形态形状信息存储部将被检体的三维形状形状与三维信息进行比较，并且选择并输出与被检体的形态形状最相似的被检体的三维信息。 数据图像生成部从所选择的输出的被检体的三维信息生成数据图像。 图像叠加部将来自数据图像生成部的数据图像和来自外科手术器具的被检体的图像重叠，并将叠加后的图像输出到图像显示装置。

公开(公告)号：US08269038B2

公开(公告)日：2012-09-18

申请号：US12441004

申请日：2007-04-20

申请人： Kuniaki Okamoto ,  Tsutomu Watahiki ,  Motoshige Sumino ,  Takao Shibasaki

发明人： Kuniaki Okamoto ,  Tsutomu Watahiki ,  Motoshige Sumino ,  Takao Shibasaki

IPC分类号： C07D487/00 ,  C07C309/00

CPC分类号： C07C303/26 ,  C07D327/00 ,  C07C309/65 ,  C07C309/66 ,  C07C309/73 ,  C07C309/76 ,  C07C309/67

摘要： The present invention provides a method for producing a sulfonate ester efficiently and in high yield.The present invention is an invention of a method for producing a sulfonate ester compound, which comprising reacting: (a) a compound having a sulfo group (—SO3H); and (b) a compound having a group represented by the general formula [1]: —OR1  [1] [wherein, R1 represents a sulfonyl group represented by the general formula [2]: —SO2—R2  [2] (wherein, R2 represents a halogen atom, a haloalkyl group, an alkoxy group, or an optionally substituted alkyl group or an optionally substituted aryl group) or an acyl group represented by the general formula [3]: (wherein, R3 represents an optionally substituted alkyl group or an optionally substituted aryl group)]; in the presence of an organic base which is capable of forming a salt with said sulfo group.

摘要翻译： 本发明提供了一种有效且高收率地生产磺酸酯的方法。 本发明是一种磺酸酯化合物的制造方法的发明，其包括：（a）具有磺基（-SO 3 H）的化合物; 和（b）具有由通式[1]表示的基团的化合物：-OR1 [1] [其中，R1表示由通式[2]表示的磺酰基：-SO 2 -R 2 [2]（其中， R2表示卤素原子，卤代烷基，烷氧基或任选取代的烷基或任选取代的芳基）或由通式[3]表示的酰基：（其中，R 3表示任选取代的烷基 或任选取代的芳基）]; 在能够与所述磺基形成盐的有机碱存在下进行。

公开(公告)号：US07433510B2

公开(公告)日：2008-10-07

申请号：US11327776

申请日：2006-01-06

申请人： Akito Saito ,  Takao Shibasaki ,  Kazuhiko Takahashi ,  Takemasa Sugita

发明人： Akito Saito ,  Takao Shibasaki ,  Kazuhiko Takahashi ,  Takemasa Sugita

IPC分类号： G06K9/00

CPC分类号： G06T7/73

摘要： A three-dimensional position posture relation detection unit detects a relation of relative three-dimensional position and posture between an image input unit and a target object using the image of the target object in a real space input from the image input unit. A difference comparison detection unit compares the detected position and posture of the target object and a value stored in a figuration information storage unit corresponding to a part of the target object so as to detect a difference between an actual position and posture of the input target object and stored figuration information of the target object. A figuration information management unit reflects a value of the detected difference on figuration information stored in the figuration information storage unit. A superposed image generation unit generates an image which is obtained by superposing the image of the input target object and stored figuration information of the target object.

摘要翻译： 三维位置姿势关系检测单元使用从图像输入单元输入的实际空间中的目标对象的图像来检测图像输入单元和目标对象之间的相对三维位置和姿势的关系。 差分比较检测单元将检测到的目标对象的位置和姿势与存储在与目标对象的一部分对应的图形信息存储单元中的值进行比较，以检测输入目标对象的实际位置和姿势之间的差异 并存储目标对象的形状信息。 形状信息管理单元反映检测到的差异值存储在形状信息存储单元中的形状信息。 叠加图像生成单元生成通过叠加输入目标对象的图像和存储的目标对象的形状信息而获得的图像。