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42 条记录 (耗时 0.021 秒)

    BIOSIGNAL MEASUREMENT DEVICE
    21.
    发明申请
    BIOSIGNAL MEASUREMENT DEVICE 有权
    BIOSIGNAL测量设备

    公开(公告)号：US20120190959A1

    公开(公告)日：2012-07-26

    申请号：US13380424

    申请日：2010-06-28

    申请人： Tomohiro Hayakawa ,  Haruhiko Soma ,  Seiji Wada ,  Fan Wang ,  Natsuki Kimura ,  Mitsuhiro Nakamura ,  Shiko Yamashita ,  Yusaku Nakashima ,  Takuro Yamamoto

    发明人： Tomohiro Hayakawa ,  Haruhiko Soma ,  Seiji Wada ,  Fan Wang ,  Natsuki Kimura ,  Mitsuhiro Nakamura ,  Shiko Yamashita ,  Yusaku Nakashima ,  Takuro Yamamoto

    IPC分类号： A61B5/04

    CPC分类号： A61B5/0478 ,  A61B5/0496 ,  A61B5/4815 ,  A61B5/6814 ,  A61B5/6887

    摘要： A biosignal measurement device is proposed which can improve measurement accuracy without forcing an excessive burden on subjects.A biosignal measurement device used for measurement of a biosignal in a head includes a support that can support the head, and an electrode provided to the support. The electrode has a plurality of teeth each including an annular portion in which a pair of linear members having conductivity are formed in an annular shape, and a rod-like portion in which the pair of linear members are wound in opposite directions and formed in a rod-like shape. The rod-like portion in each of the plurality of teeth is directly or indirectly fixed at one end to the support.

    摘要翻译： 提出了一种生物信号测量装置，可以提高测量精度，而不会对主体造成过大的负担。 用于测量头部中的生物信号的生物信号测量装置包括可支撑头部的支撑体和设置在支撑体上的电极。 电极具有多个齿，每个齿包括环形部分，其中一对具有导电性的线性部件形成为环形，并且一个线状部件沿其相反方向缠绕并形成在其中的杆状部分 棒状形状。 多个齿中的每一个中的杆状部分一端直接或间接地固定到支撑件上。

    Method and apparatus for determining base sequence of nucleic acid molecule
    23.
    发明申请
    Method and apparatus for determining base sequence of nucleic acid molecule 有权
    确定核酸分子碱基序列的方法和装置

    公开(公告)号：US20060115833A1

    公开(公告)日：2006-06-01

    申请号：US11231998

    申请日：2005-09-22

    申请人： Takayoshi Mamine ,  Atsumi Tsujimoto ,  Takuro Yamamoto

    发明人： Takayoshi Mamine ,  Atsumi Tsujimoto ,  Takuro Yamamoto

    IPC分类号： C12Q1/68 ,  C12P19/34

    CPC分类号： C12Q1/6872 ,  C12Q2565/607 ,  C12Q2537/149 ,  C12Q2521/319

    摘要： Disclosed herein is a method and apparatus for determining the base sequence of a nucleic acid molecule by cleaving a nucleic acid molecule of interest while controlling the cleavage site, measuring the change in mass which occurs in the nucleic acid molecule after the cleavage step, and acquiring the base information of the cleaved nucleic acid molecule from the data about the change in mass. The method and apparatus are based on the principle which is entirely different from that used for the conventional technique.

    摘要翻译： 本文公开了一种方法和装置，用于通过在控制切割位点的同时切割感兴趣的核酸分子来测定核酸分子的碱基序列，测量在切割步骤后在核酸分子中发生的质量变化，并获取 从关于质量变化的数据的切割的核酸分子的基础信息。 该方法和装置基于与用于常规技术的原理完全不同的原理。

    Driving an image apparatus by simultaneous application of two reset voltages
    24.
    发明授权
    Driving an image apparatus by simultaneous application of two reset voltages 有权
    通过同时施加两个复位电压来驱动图像设备

    公开(公告)号：US09018574B2

    公开(公告)日：2015-04-28

    申请号：US13540505

    申请日：2012-07-02

    申请人： Koichiro Iwata ,  Tomoyuki Noda ,  Takeshi Akiyama ,  Kazumichi Morita ,  Kazuhiro Sonoda ,  Takuro Yamamoto

    发明人： Koichiro Iwata ,  Tomoyuki Noda ,  Takeshi Akiyama ,  Kazumichi Morita ,  Kazuhiro Sonoda ,  Takuro Yamamoto

    IPC分类号： H01L27/146 ,  H04N5/365 ,  H04N5/378 ,  H04N5/3745

    CPC分类号： H01L27/14643 ,  H04N5/3658 ,  H04N5/37457 ,  H04N5/378

    摘要： A driving method of an imaging apparatus comprises: horizontally transferring, by a horizontal scanning circuit, a signal based on a photoelectric conversion portion of a first pixel unit held in a signal holding capacitor to a common line; before ending of the horizontal transfer; applying, by a reset switch of a second pixel unit, a selection reset voltage to a floating diffusion region of the second pixel unit; and after the horizontal transfer, transferring, by a transfer switch of the second pixel unit, a signal of a photoelectric conversion portion of the second pixel unit to the floating diffusion region of the second pixel unit and amplifying, by an amplification transistor of the second pixel unit, a signal of the floating diffusion region of the second pixel unit to output the signal to an output line.

    摘要翻译： 一种成像装置的驱动方法包括：通过水平扫描电路将保持在信号保持电容器中的第一像素单元的光电转换部分的信号水平地传送到公共线; 在结束水平转移之前; 通过第二像素单元的复位开关将选择复位电压施加到第二像素单元的浮动扩散区; 并且在水平传送之后，通过第二像素单元的转移开关将第二像素单元的光电转换部分的信号传送到第二像素单元的浮动扩散区域，并通过第二像素单元的放大晶体管进行放大 像素单元，是第二像素单元的浮动扩散区域的信号，以将信号输出到输出线。

    Wake-up assisting apparatus and wake-up assisting method
    25.
    发明授权
    Wake-up assisting apparatus and wake-up assisting method 失效
    唤醒辅助装置和唤醒辅助方法

    公开(公告)号：US08692677B2

    公开(公告)日：2014-04-08

    申请号：US13289344

    申请日：2011-11-04

    申请人： Seiji Wada ,  Takuro Yamamoto

    发明人： Seiji Wada ,  Takuro Yamamoto

    IPC分类号： G08B23/00

    CPC分类号： G04G13/00

    摘要： Disclosed herein is a wake-up assisting apparatus including: an electrode which comes into contact with the parietal of the human body; a signal processing part which detects brain waves through the electrode, determines the sleep stage from the thus detected brain waves, and decides the wake-up time according to the sleep stage; and a stimulating part which gives stimuli to the human body at the wake-up time.

    摘要翻译： 本文公开了一种唤醒辅助装置，包括：与人体顶层接触的电极; 通过电极检测脑电波的信号处理部，根据该检测出的脑电波判定睡眠阶段，根据睡眠阶段决定唤醒时间; 以及刺激部分，在唤醒时间给人体带来刺激。

    ROR ALPHA PROMOTING THE INDUCTION OF BMALL
    27.
    发明申请
    ROR ALPHA PROMOTING THE INDUCTION OF BMALL 审中-公开
    ROR ALPHA促进BMALL的诱导

    公开(公告)号：US20120093807A1

    公开(公告)日：2012-04-19

    申请号：US13234273

    申请日：2011-09-16

    申请人： Takuro Yamamoto ,  Takayoshi Mamine ,  Toru Takumi ,  Makoto Akashi

    发明人： Takuro Yamamoto ,  Takayoshi Mamine ,  Toru Takumi ,  Makoto Akashi

    IPC分类号： A61K39/395 ,  A61P25/24 ,  A61P25/20 ,  A61P35/00 ,  A61P25/00

    CPC分类号： A61K31/7105 ,  A61K31/7088 ,  C07K14/4702 ,  C07K14/70567 ,  G01N33/743 ,  G01N2333/70567 ,  G01N2500/00

    摘要： An object of the present invention is to clarify unelucidated aspects in the control mechanism of circadian rhythms. The present inventors have newly found that RORα (retinoic acid binding-receptor alpha; the same shall apply hereinafter) stimulates an induction of Bmal1 expression and also that the induction of Bmal1 expression is promoted under hypoxia. These findings strongly suggest the existence of a control mechanism of circadian rhythms that, when RORα expression is promoted under hypoxia or the like, an induction of Bmal1 expression is stimulated and, when the induction of Bmal1 expression is stimulated, binding between BMAL1 and CLOCK is stimulated and an induction of Per gene or Cry gene expression is stimulated. The present invention, therefore, has applicability as jet-lag regulating agents and anticancer agents.

    摘要翻译： 本发明的目的是澄清昼夜节律控制机制中的未消化方面。 本发明人新发现RORα（视黄酸结合受体α，以下同样适用）刺激Bmal1表达的诱导，并且在缺氧下促进Bmal1表达的诱导。 这些发现强烈地表明存在昼夜节律的控制机制，当在缺氧等下促进RORα表达时，刺激Bmal1表达的诱导，并且当刺激Bmal1表达的诱导时，BMAL1和CLOCK之间的结合是 刺激并诱导Per基因或Cry基因表达。 因此，本发明具有作为喷射滞后调节剂和抗癌剂的适用性。

    METHOD FOR PREDICTING BIOLOGICAL RHYTHM
    28.
    发明申请
    METHOD FOR PREDICTING BIOLOGICAL RHYTHM 审中-公开
    预测生物RHYTHM的方法

    公开(公告)号：US20110196619A1

    公开(公告)日：2011-08-11

    申请号：US13123847

    申请日：2009-10-13

    申请人： Haruhiko Soma ,  Takuro Yamamoto ,  Makoto Akashi ,  Koichi Node ,  Noriyuki Kishii ,  Kazuhiro Nakagawa ,  Shiko Yamashita ,  Tomohiro Hayakawa

    发明人： Haruhiko Soma ,  Takuro Yamamoto ,  Makoto Akashi ,  Koichi Node ,  Noriyuki Kishii ,  Kazuhiro Nakagawa ,  Shiko Yamashita ,  Tomohiro Hayakawa

    IPC分类号： G06F19/00

    CPC分类号： C12Q1/6876 ,  A61B10/02 ,  C12Q1/6809 ,  C12Q2600/158 ,  G16B25/00 ,  G16B40/00 ,  C12Q2537/165

    摘要： There is provided a method that achieves the prediction of a biological rhythm with high precision while minimizing the number of times a biological specimen is collected from a subject. There is also provided a method for predicting a biological rhythm of a subject on the basis of time series expression level data obtained by measuring expression levels of two clock genes in biological specimens collected from the subject three times within 24 hours, the clock genes having different phases of circadian cycles of a change in expression levels. In this method for predicting a biological rhythm, a biological rhythm can be predicted with particularly high precision by collecting a biological specimen from a subject three times within 24 hours at eight-hour intervals.

    摘要翻译： 提供了一种以最小化从受试者收集生物标本的次数来实现高精度的生物节律预测的方法。 还提供了一种基于通过在24小时内测量从受试者收集的生物标本中的两个时钟基因的表达水平获得的时间序列表达水平数据，时钟基因具有不同的方式来预测受试者的生物节律的方法 表达水平发生变化的昼夜循环阶段。 在这种用于预测生物节律的方法中，通过以8小时的间隔在24小时内收集受试者三次生物样本，可以以特别高的精度预测生物节律。

    Method for stress evaluation
    30.
    发明申请
    Method for stress evaluation 审中-公开
    压力评估方法

    公开(公告)号：US20070099217A1

    公开(公告)日：2007-05-03

    申请号：US11543774

    申请日：2006-10-06

    申请人： Takuro Yamamoto ,  Haruhiko Soma ,  Toru Takumi ,  Yasukazu Nakahata

    发明人： Takuro Yamamoto ,  Haruhiko Soma ,  Toru Takumi ,  Yasukazu Nakahata

    IPC分类号： C12Q1/68 ,  G01N33/567 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705 ,  C07K16/28

    CPC分类号： C12Q1/6883 ,  C12Q2600/158

    摘要： The molecular reaction mechanism that associates the clock gene with stress is elucidated based on the finding that stress is accompanied by an increase in the expression level of Per1 gene in peripheral tissues, stress response does not change the circadian rhythm in peripheral tissues, and Per1 gene increases in its expression level dependently on the responsive element of glucocorticoid existing in its promoter region. This finding is used for stress evaluation. That is, stress can be evaluated for its presence or absence or degree by detection and determination of an increase in the transcript (mRNA) of Per1 gene in peripheral tissues (an increase in the protein coded by Per1 gene).

    摘要翻译： 基于应激伴随着外周组织中每1基因表达水平的增加，应激反应不改变周围组织中的昼夜节律，并且Per 1基因的表达水平依赖于存在于其启动子区域的糖皮质激素的反应元件。 这个发现用于压力评估。 也就是说，可以通过检测和测定外周组织中每1基因的转录物（mRNA）的增加（通过Per 1基因编码的蛋白质的增加）来评估其存在或不存在或程度的压力。