摘要:
The present invention provides compounds represented by general formula (I): a prodrug thereof, or pharmaceutical acceptable salts thereof, wherein R1 is hydrogen or lower alkyl; each of R2 and R3 is independently hydrogen or lower alkyl; each of R4, R5 and R6 is independently hydrogen, halogen, lower alkyl or lower alkoxy; R7 is hydrogen or lower alkyl; R8 is hydrogen, halogen, lower alkyl, lower alkoxy, etc; R9 is —COR10, -A1-COR10, —O-A2-COR10, etc; Ar is optionally substituted phenyl or heteroaryl; and A is a bond, —OCH2—, etc, which exhibit potent and selective β3-adrenoceptor stimulating activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.
摘要翻译:本发明提供由通式(I)表示的化合物:其前药或其药学上可接受的盐,其中R 1是氢或低级烷基; R2和R3各自独立地为氢或低级烷基; R 4,R 5和R 6各自独立地是氢,卤素,低级烷基或低级烷氧基; R 7是氢或低级烷基; R 8是氢,卤素,低级烷基,低级烷氧基等; R 9是-COR 10,-A 1 -OR 10,-OA 2, SUP> -COR 10等; Ar是任选取代的苯基或杂芳基; 并且A是表现出有效和选择性的β3肾上腺素受体刺激活性的键-OCH 2 - 2等。 本发明还提供含有所述化合物的药物组合物及其用途。
摘要:
A -Zener diode includes a first conductivity type semiconductor region and a second conductivity type semiconductor region which form pn junction, an insulating film for covering the junction part of the semiconductor regions, a first electrode electrically connected with the first conductivity type semiconductor region, and a second electrode electrically connected with the second conductivity type semiconductor region. The second conductivity type semiconductor region has an impurity concentration distribution which is a combination of a first impurity concentration distribution having first diffusion depth and first peak concentration and a second impurity concentration distribution having second diffusion depth shallower than the first diffusion depth and second peak concentration higher than the first peak concentration. The first impurity concentration distribution is higher than the second impurity concentration distribution in concentration at the junction part.
摘要:
A gate line driving circuit includes a shift register section that selects gate lines for gradation display in units of one gate line, and selects the gate lines for black insertion in units of a group including at least two adjacent gate lines, and an output circuit that outputs driving signals to the gate lines selected by the shift register section. In particular, the output circuit is configured such that an output period of a driving signal to an odd-numbered gate line, which is included in the group selected for black insertion by the shift register section and extends along a row of liquid crystal pixels that are capacitive-coupled to a non-selected gate line other than the gate lines of the group, is set to be shorter than an output period of a driving signal to an even-numbered gate line of the group.
摘要:
The coupling apparatus for structural members includes a paired couplers for coupling structural members with each other, and each coupler includes a cylindrical main body, engaging projections spaced apart from each other at predetermined intervals in a circumferential direction at an end of the body and projecting along the center line of the body, and engaging hooks projecting in one circumferential direction at the projecting end portions of the projections. At least one coupler further includes a coupling direction changing mechanism which couples the at least one coupler with a predetermined position of a structural member corresponding thereto so that the center line of the body of the at least one coupler can be orientated in a desired direction.
摘要:
In a method of manufacturing a fibrous formed product, a mixture of fibers, including thick fibers and thin fibers, is prepared in order to form fibrous mats. The mixed fibers are supplied onto an outer peripheral surface of a roller. As the roller rotates, the mixed fibers are released from the roller and are thrown toward a fiber receiving surface. A fibrous mat is formed on the fiber receiving surface with a low-density layer next to the fiber receiving surface and a high-density layer on top of the low-density layer. Thick fibers mainly form the low-density layer and thin fibers mainly form the high-density layer. First and second fibrous mats are overlaid with one another such that their low-density layers oppose each other.
摘要:
An objective lens is substantially telecentric toward the image side, and provided with an ultraviolet cut coating on its rearmost surface. An imaging plane of a CCD is arranged near a position where an image of an object is formed through the objective lens. An ultraviolet and infrared cut filter is interposed between the objective lens and the CCD. The cut coating and the cut filter have a total transmittance of 0.1% or lower for ultraviolet light.
摘要:
An apparatus for monitoring an area adjacent to a subject vehicle includes an image taking device for taking an image of an area at and around a place to which the subject vehicle is directed. A predicting device operates for predicting a region to which the subject vehicle will travel. The predicted region has a left-hand boundary and a right-hand boundary. A setting device operates for setting a detection area near at least one of the left-hand boundary and the right-hand boundary of the predicted region. The detection area extends along a direction of travel of the subject vehicle. A deciding device operates for deciding whether or not a three-dimensional object exists in the detection area in response to the image taken by the image taking device. The three-dimensional object is, for example, a cut-in vehicle with respect to the subject vehicle.
摘要:
A remote control signal transmission device includes a plurality of operation keys; a detector for detecting which operation keys have been operated; a memory for storing correspondence tables between the operation keys and remote control signals, with each of the correspondence tables differing depending on an electronic apparatus taken as a remote control target; a setter that receives a detection output of the detector and, when consecutive operation of a pre-defined plurality of said operation keys is detected as the detection output, selects a correspondence table for an electronic apparatus corresponding to the consecutive operation from within a plurality of the correspondence tables stored in the memory; a remote control signal generator, the signal from which corresponds to an operated key according to a correspondence table set by the setter and transmitting the remote control signal to electronic apparatus taken as the control target; and a setting protector for protecting settings of the setting means.
摘要:
A propylene resin composition containing a phenolic antioxidant, and a phosphorus-containing antioxidant which has a differential melt index (.DELTA.MI) calculated from a melt index (MIi) as measured at a propylene temperature of 230.degree. C. and under a load of 2,160 g and a melt index (MIe) as measured at a propylene temperature of 230.degree. C. and under a load of 2,160 g after five repetitions of a 100% recycle test is not greater than 0.5 g/10 min, and MIe is not greater than 1.2 g/10 min. This propylene resin composition enables manufacture of large-sized blow-molded articles featuring light weight, excellent rigidity, dimensional stability, heat resistance and showing good drawdown resistance, suitable for continuous blow molding. Blow moldings are advantageously used as automobile bumpers, bumper beams, or like parts.
摘要:
A plastic optical-fiber is provided having a desired length and a desired graded refractive index. To this end, a base polymer is mixed with a non-polymerizable compound having a higher refractive index to obtain a fiber material. This material is then transformed continuously into a fiber in a fiber-preparing unit. A plurality of diffusion tanks are each provided with a solution, each solution having a level of viscosity different from one another. The fiber is then dipped successively into the solutions in the order from a lowest viscosity level to a higher viscosity level. During this process, the non-polymerizable compound and polymerizable compound diffuse inside the fiber and form a graded refractive index distribution. The polymerizable compound is then polymerized and hardened in a drying-and-heating unit. The fiber thus obtained is drawn and coated with a cladding.