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    Multi-through hole testing plate for high throughput screening
    26.
    发明授权
    Multi-through hole testing plate for high throughput screening 有权
    多通孔测试板，用于高通量筛选

    公开(公告)号：US07666360B2

    公开(公告)日：2010-02-23

    申请号：US10223893

    申请日：2002-08-20

    申请人： Volker Schellenberger ,  Amy Deming Liu

    发明人： Volker Schellenberger ,  Amy Deming Liu

    IPC分类号： B01L3/00

    CPC分类号： B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00317 ,  B01J2219/00319 ,  B01J2219/0052 ,  B01J2219/00524 ,  B01J2219/00533 ,  B01J2219/00596 ,  B01J2219/00644 ,  B01J2219/00659 ,  B01J2219/00662 ,  B01J2219/00707 ,  B01L3/5025 ,  B01L3/5085 ,  B01L3/50857 ,  B01L2300/0654 ,  B01L2300/0809 ,  B01L2300/161 ,  C40B60/14 ,  G01N35/1065 ,  G01N2035/00237

    摘要： A method for holding samples for analysis and an apparatus thereof includes a testing plate with a pair of opposing surfaces and a plurality of holes. Each of the holes extends from one of the opposing surfaces to the other one of the opposing surfaces. The holes are arranged in groups, where each group has at least two rows and two columns of holes. The groups are arranged in sets, where each set has at least two rows and two columns of groups. To analyze samples, at least one of the opposing surfaces of the testing plate is immersed in a solution to be analyzed. A portion of the solution enters openings for each of the holes in the immersed opposing surface. Once the holes are filled with solution, the testing plate is removed and is held above a supporting surface. Surface tension holds the solution in each of the holes. The solution in one or more of the holes is then analyzed and the solution in one of these holes is identified for further study. The location of the identified solution is marked based upon its location within a particular set and group of holes.

    摘要翻译： 用于保持用于分析的样品的方法及其装置包括具有一对相对表面和多个孔的测试板。 每个孔从相对表面中的一个延伸到相对表面中的另一个。 孔分组排列，每组具有至少两排和两列孔。 这些组以组合的形式排列，其中每组具有至少两行和两列组。 为了分析样品，将测试板的相对表面中的至少一个浸入待分析的溶液中。 溶液的一部分进入浸入的相对表面中的每个孔的开口。 一旦孔充满了溶液，测试板被移除并被保持在支撑表面上方。 表面张力将溶液保持在每个孔中。 然后分析一个或多个孔中的溶液，并鉴定其中一个孔中的溶液用于进一步研究。 所识别的解决方案的位置基于其在特定组和一组孔内的位置被标记。

    Screening under nutrient limited conditions
    28.
    发明授权
    Screening under nutrient limited conditions 有权
    营养有限条件下筛选

    公开(公告)号：US06248541B1

    公开(公告)日：2001-06-19

    申请号：US09556921

    申请日：2000-04-21

    申请人： Volker Schellenberger

    发明人： Volker Schellenberger

    IPC分类号： C12Q102

    CPC分类号： C12Q1/04

    摘要： Described herein are methods for obtaining from an initial population of cells a plurality of subpopulations of cells having a similar density by growing samples from the initial population in medium having a limiting nutrient. Also provided are methods for using such subpopulation of cells to identify members of an initial population, either spontaneously occurring or induced by mutagenesis, having altered and/or preferred phenotypes.

    摘要翻译： 本文描述的是通过在具有限制性营养物的培养基中培养来自初始群体的样品，从初始种群获得具有相似密度的多个细胞亚群的方法。 还提供了使用这种细胞亚群来鉴定自发发生或通过诱变诱导的具有改变和/或优选表型的初始群体的成员的方法。