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21.发明授权公开(公告)号：US09359624B2
公开(公告)日：2016-06-07
申请号：US13944239
申请日：2013-07-17
摘要： The invention relates to recombinant expression of a taxadiene synthase enzyme and a geranylgeranyl diphosphate synthase (GGPPS) enzyme in cells and the production of terpenoids.
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公开(公告)号：US20160076061A1
公开(公告)日：2016-03-17
申请号：US14864493
申请日：2015-09-24
CPC分类号： C12P7/24 , C12N9/0006 , C12N9/0008 , C12N9/0022 , C12N9/1096 , C12N9/1205 , C12N9/1229 , C12N9/16 , C12N9/88 , C12N9/90 , C12N15/52 , C12N15/70 , C12P7/18 , C12P2203/00 , C12Y101/01071 , C12Y102/01021 , C12Y102/01052 , C12Y207/01016 , C12Y207/01017 , C12Y207/01047 , C12Y401/02017 , C12Y501/03
摘要： The invention relates to recombinant cells and their use in the production of ethylene glycol.
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23.发明申请ENGINEERED MICROBES AND METHODS FOR MICROBIAL OIL OVERPRODUCTION FROM CELLULOSIC MATERIALS 有权用于微生物油的工程微生物和方法从细胞材料过度引入公开(公告)号：US20130344548A1
公开(公告)日：2013-12-26
申请号：US13923607
申请日：2013-06-21
IPC分类号： C12P7/64
CPC分类号： C12N9/92 , C12N9/0006 , C12P7/6463 , C12P7/649 , C12P2203/00 , C12Y101/01009 , C12Y101/0101 , C12Y101/01307 , C12Y503/01005 , Y02E50/13 , Y02E50/17
摘要： The invention relates to engineering microbial cells for utilization of cellulosic materials as a carbon source, including xylose.
摘要翻译： 本发明涉及用于利用纤维素材料作为碳源（包括木糖）的工程微生物细胞。
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公开(公告)号：US11649472B2
公开(公告)日：2023-05-16
申请号：US16023336
申请日：2018-06-29
发明人： Junyoung Park , Nian Liu , Gregory Stephanopoulos
IPC分类号： C12P7/54 , C12P7/6409 , C12P7/6463 , C12N1/20 , C12N1/16 , C12N1/32 , C12N9/22 , C12N9/42 , C12N9/26 , C12P7/64 , C12R1/02 , C12R1/145
CPC分类号： C12P7/54 , C12N1/16 , C12N1/205 , C12N1/32 , C12N9/22 , C12N9/2437 , C12N9/2474 , C12P7/64 , C12P7/6409 , C12P7/6463 , C12R2001/02 , C12R2001/145 , C12Y302/01004 , C12Y302/01035
摘要： The disclosure provides methods using mixed substrate cofeeding for bioproduct synthesis, which enables faster, more efficient, and higher yield carbon conversion in various organisms.
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25.发明授权公开(公告)号：US11028413B2
公开(公告)日：2021-06-08
申请号：US16809838
申请日：2020-03-05
IPC分类号： C12P5/00 , C12P17/02 , C12P23/00 , C12P15/00 , C12P7/42 , C12P19/56 , C12N15/70 , C12P9/00 , C12Q1/689
摘要： The invention relates to the production of one or more terpenoids through microbial engineering, and relates to the manufacture of products comprising terpenoids.
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26.发明授权公开(公告)号：US10227597B2
公开(公告)日：2019-03-12
申请号：US15718748
申请日：2017-09-28
摘要： The invention relates to recombinant expression of a taxadiene synthase enzyme and a geranylgeranyl diphosphate synthase (GGPPS) enzyme in cells and the production of terpenoids.
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公开(公告)号：US20190032003A1
公开(公告)日：2019-01-31
申请号：US16023336
申请日：2018-06-29
发明人： Junyoung Park , Nian Liu , Gregory Stephanopoulos
摘要： The disclosure provides methods using mixed substrate cofeeding for bioproduct synthesis, which enables faster, more efficient, and higher yield carbon conversion in various organisms.
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28.发明授权公开(公告)号：US09879248B2
公开(公告)日：2018-01-30
申请号：US14817489
申请日：2015-08-04
CPC分类号： C12N9/92 , C12N9/0006 , C12P7/6463 , C12P7/649 , C12P2203/00 , C12Y101/01009 , C12Y101/0101 , C12Y101/01307 , C12Y503/01005 , Y02E50/13 , Y02E50/17
摘要： The invention relates to engineering microbial cells for utilization of cellulosic materials as a carbon source, including xylose.
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公开(公告)号：US09862977B2
公开(公告)日：2018-01-09
申请号：US14547304
申请日：2014-11-19
IPC分类号： C12P7/64 , C12N1/00 , C12P1/00 , C12P21/06 , C12P19/34 , C12N15/00 , C07H21/04 , C07K1/00 , C12N15/81 , C12N9/02 , C12N9/10 , C12N9/88 , C12N9/00 , C12N1/16
CPC分类号： C12P7/649 , C12N1/16 , C12N9/0083 , C12N9/0097 , C12N9/1025 , C12N9/1029 , C12N9/88 , C12N9/93 , C12N15/815 , C12P7/64 , C12P7/6463 , C12Y114/19001 , C12Y203/03008 , C12Y604/01002
摘要： Some aspects of this invention provide engineered microbes for oil production. Methods for microbe engineering and for use of engineered microbes are also provided herein. In some embodiments, microbes are provided that are engineered to modulate a combination of rate-controlling steps of lipid synthesis, for example, a combination of a step generating metabolites, acetyl-CoA, ATP or NADPH for lipid synthesis (a push step), and a step sequestering a product or an intermediate of a lipid synthesis pathway that mediates feedback inhibition of lipid synthesis (a pull step). Such push-and-pull engineered microbes exhibit greatly enhanced conversion yields and TAG synthesis and storage properties.
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公开(公告)号：US11891646B2
公开(公告)日：2024-02-06
申请号：US17074682
申请日：2020-10-20
CPC分类号： C12P7/649 , C12M23/58 , C12M43/00 , C12P7/10 , C12P7/16 , C12P7/54 , C12P7/6463 , Y02E50/10 , Y02E50/30
摘要： Some aspects of this invention provide methods and bioreactors for converting a carbon source into a lipid. In some embodiments, lipid production is carried out in an aerobic fermentor and carbon dioxide generated during lipid production is converted into a carbon substrate by CO2 fixation in an anaerobic fermentor. In some embodiments, the carbon substrate generated by CO2 fixation is used as the carbon source for lipid production, thus achieving total carbon utilization in lipid production.
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