公开(公告)号：US10774957B2

公开(公告)日：2020-09-15

申请号：US16049483

申请日：2018-07-30

Applicant: Waters Technologies Corporation

Inventor： Jonathan L. Belanger ,  Sylvain Cormier ,  Steven D. Trudeau ,  Paul Keenan ,  Daniel J. McCormick

IPC: F16L15/04 ,  F16J15/08 ,  G01N30/60 ,  B01D15/10 ,  B01D15/22 ,  B01D15/40 ,  F16L19/02 ,  F16J15/10

Abstract: Described is a mobile phase fitting having reduced corrosion and erosion. The fitting includes a coupling body, compression screw, compression member and gasket. The coupling body has a threaded bore at one end, a tapered cavity, a narrow bore and a fluid channel. The compression screw has an axial bore to receive a tube and a threaded outer surface in engagement with the threaded bore of the coupling body. The compression member is disposed in the tapered cavity and has an axial opening to pass the tube and a tapered surface to engage a surface of the tapered cavity. The gasket is disposed in the narrow bore and has one surface in contact with the first internal surface and has a parallel surface to receive an end face of the tube. Mobile phase flows along a path that includes the tube, an opening in the gasket and the fluid channel.

公开(公告)号：US09823225B2

公开(公告)日：2017-11-21

申请号：US14824431

申请日：2015-08-12

Applicant: Waters Technologies Corporation

Inventor： Sylvain Cormier ,  Mark W. Moeller ,  Peyton C. Beals

IPC: G01N30/20 ,  G01N30/06 ,  G01N30/02 ,  G01N30/24

CPC classification number: G01N30/20 ,  G01N30/06 ,  G01N30/24 ,  G01N2030/027 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/207

Abstract: Described are a method and a system for diluting a sample at a location of injection in a liquid chromatography system. The method includes loading a sample into a first fluid channel, separating a flow of a mobile phase into a first flow in the first fluid channel and a second flow in a second fluid channel, and combining the sample that is displaced from the first fluid channel and the mobile phase exiting the second fluid channel at the location of injection into the system flow to thereby generate a diluted sample in the system flow. The dilution ratio of the diluted sample is responsive to the flow rates of the first and second flows. Advantageously, the flow rates can be changed by changing the flow restriction of one of the fluid channels. Thus providing the proper flow restriction enables a user to obtain a desired dilution ratio.

公开(公告)号：US20160069844A1

公开(公告)日：2016-03-10

申请号：US14824440

申请日：2015-08-12

Applicant: Waters Technologies Corporation

Inventor： Michael R. Jackson ,  Sylvain Cormier

IPC: G01N30/20

CPC classification number: G01N30/20 ,  G01N30/06 ,  G01N30/24 ,  G01N2030/027 ,  G01N2030/201 ,  G01N2030/202

Abstract: Described are a method and a system for injecting a sample into a flow of a liquid chromatography system. The method includes combining a flow of a sample and a flow of a mobile phase to create a diluted sample in the system flow. The volumetric flow rate of the sample is controlled to be at a value that yields a desired dilution ratio for the diluted sample. The particular value at which the volumetric flow rate is maintained can be determined from the desired value of the dilution ratio and the volumetric flow rate of the mobile phase. System embodiments include a syringe that can be used to provide a sample solution at a controllable volumetric flow rate for combination with a high pressure mobile phase.

Abstract translation: 描述了将样品注入液相色谱系统的流程中的方法和系统。 该方法包括组合样品流和流动相流以在系统流中产生稀释样品。 将样品的体积流量控制在为稀释样品产生所需稀释比的值。 维持体积流量的特定值可以根据流动相的稀释比和体积流量的期望值来确定。 系统实施方案包括可用于以可控的体积流速提供样品溶液以与高压流动相组合的注射器。

公开(公告)号：US20150211663A1

公开(公告)日：2015-07-30

申请号：US14414138

申请日：2013-06-25

Applicant: Waters Technologies Corporation

Inventor： Jonathan L. Belanger ,  Sylvain Cormier ,  Steven D. Trudeau ,  Paul Keenan ,  Daniel J. McCormick

IPC: F16L15/04 ,  F16J15/10 ,  F16J15/08 ,  B01D15/22 ,  B01D15/40

CPC classification number: F16L15/04 ,  B01D15/10 ,  B01D15/22 ,  B01D15/40 ,  F16J15/0806 ,  F16J15/102 ,  F16L19/0212 ,  G01N30/60 ,  G01N30/6004 ,  G01N30/6026

Abstract: Described is a mobile phase fitting having reduced corrosion and erosion. The fitting includes a coupling body, compression screw, compression member and gasket. The coupling body has a threaded bore at one end, a tapered cavity, a narrow bore and a fluid channel. The compression screw has an axial bore to receive a tube and a threaded outer surface in engagement with the threaded bore of the coupling body. The compression member is disposed in the tapered cavity and has an axial opening to pass the tube and a tapered surface to engage a surface of the tapered cavity. The gasket is disposed in the narrow bore and has one surface in contact with the first internal surface and has a parallel surface to receive an end face of the tube. Mobile phase flows along a path that includes the tube, an opening in the gasket and the fluid channel.

Abstract translation: 描述了具有减少的腐蚀和侵蚀的流动相配件。 配件包括联接体，压缩螺钉，压缩构件和衬垫。 联接体在一端具有螺纹孔，锥形腔，窄孔和流体通道。 压缩螺杆具有轴向孔以接收管和与联接体的螺纹孔接合的螺纹外表面。 压缩构件设置在锥形空腔中并且具有轴向开口以使管和锥形表面接合以使锥形空腔的表面接合。 垫圈设置在狭窄的孔中并且具有与第一内表面接触的一个表面并且具有平行的表面以容纳管的端面。 流动相沿着包括管，垫圈中的开口和流体通道的路径流动。

公开(公告)号：US20150101419A1

公开(公告)日：2015-04-16

申请号：US14511636

申请日：2014-10-10

Applicant: Waters Technologies Corporation

Inventor： Ryan Hill ,  Joshua A. Shreve ,  Robert Dumas ,  Sylvain Cormier ,  Edwin Denecke ,  Kenneth R. Plant ,  Kurt D. Joudrey

IPC: G01F1/74

CPC classification number: G01F1/74 ,  G01N21/41 ,  G01N30/74

Abstract: The present disclosure relates to phase detection in multi-phase fluids where two fluid phases can be present in the fluid. Phase detection apparatus and methods are disclosed for determining the phase(s) (e.g., supercritical, liquid, and/or gas) of a fluid in a multi-phase fluid system, such as carbon dioxide based separation and chromatography system.

Abstract translation: 本公开涉及在流体中可以存在两个流体相的多相流体中的相位检测。 公开了用于确定多相流体系统中的流体（例如基于二氧化碳的分离和色谱系统）的相（例如超临界，液体和/或气体）的相位检测装置和方法。

公开(公告)号：US20150076068A1

公开(公告)日：2015-03-19

申请号：US14464979

申请日：2014-08-21

Applicant: Waters Technologies Corporation

Inventor： Richard W. Andrews ,  Peyton Beals ,  Sylvain Cormier

IPC: B01D15/16 ,  B01D15/18 ,  B01D15/42

CPC classification number: B01D15/161 ,  B01D15/1871 ,  B01D15/424

Abstract: Described are methods in which the retention times of a chromatographic column are adjusted through the control of the temperature of a mobile phase at the inlet to the chromatographic column. The temperature of the mobile phase at the inlet is different from the temperature of the chromatographic column. Adjustment of the temperature of the mobile phase at the inlet can be used as part of a method to transfer a chromatographic method from one liquid chromatography system to another liquid chromatography system. The method can alternatively be adapted for trapping a sample at the head of a chromatographic column to reduce the amount of band broadening of the sample from the sample injector of a liquid chromatography system. A gradient elution can then be performed to cause the concentrated volume of the analyte in the sample to elute in a tight band, resulting in improved measurement sensitivity.

Abstract translation: 描述了通过控制色谱柱入口处的流动相的温度来调节色谱柱的保留时间的方法。 入口处流动相的温度不同于色谱柱的温度。 入口处流动相温度的调节可用作将色谱法从一个液相色谱系统转移到另一个液相色谱系统的方法的一部分。 该方法可替代地适用于在色谱柱的头部捕获样品以减少来自液相色谱系统的样品注射器的样品的带宽增加量。 然后可以进行梯度洗脱，使得样品中分析物的浓缩体系在紧密带中洗脱，从而提高了测量灵敏度。

公开(公告)号：US11105778B2

公开(公告)日：2021-08-31

申请号：US16098280

申请日：2017-05-04

Applicant: Waters Technologies Corporation

Inventor： Martin Gilar ,  Richard W. Andrews ,  Peyton C. Beals ,  Thomas McDonald ,  Keith Fadgen ,  Jordan Kornfeld ,  Geoff Gerhardt ,  Sylvain Cormier

IPC: G01N30/24 ,  G01N30/06 ,  G01N30/20 ,  G01N30/34 ,  G01N1/38

Abstract: A method for injecting a diluted sample in a chromatography system includes merging a flow of a sample and a flow of a diluent to form a flow of a diluted sample. A dilution ratio of the diluted sample equals a sum of the volumetric flow rates of the sample and the diluent divided by the volumetric flow rate of the sample. The diluted sample is stored in a holding element before injection into a chromatographic system flow. Sample dilution occurs under low pressure relative to the chromatographic flow thereby allowing lower pressure sample and diluent syringes to be used. Other benefits include reduced compressibility and a reduction in leaks due to the lower pressure operation. The method avoids problems associated with manual techniques which can introduce errors due, for example, to loss of sample, sample precipitation and adsorption of sample to vials.

公开(公告)号：US10557834B2

公开(公告)日：2020-02-11

申请号：US16220867

申请日：2018-12-14

Applicant: Waters Technologies Corporation

Inventor： Sylvain Cormier

IPC: G01N30/20 ,  G01N30/24

Abstract: A sampling system comprising an external sampling assembly in fluidic communication with a process sample manager is provided herein. The sampling system can automatically acquire sample from one or more sources of sample to prepare sample for injection into a column or detector. The external sampling assembly has an external sampling valve connected to an external pump and is in fluidic communication with a process sample manager. The external sampling valve has a first configuration and a second configuration useful in three steps of drawing, loading and discharging sample. Two selection valves can be connected to a plurality of external sampling valves for sequential sampling of multiple sources of sample. Sample can also be diluted in the process sample manager and then combined in a solvent composition stream for injection into the column or the detector.

公开(公告)号：US10379088B2

公开(公告)日：2019-08-13

申请号：US15527182

申请日：2015-11-02

Applicant: Waters Technologies Corporation

Inventor： Sylvain Cormier

IPC: G01N30/20

Abstract: A rotary valve used in chromatography includes a stator with a plurality of stator ports arranged on the stator. The stator further includes a stator groove connected at one end to a first stator port and terminating between the first stator port and a second stator port adjacent to the first stator port. A rotor, rotatably fitted to the stator, has a plurality of arcuate channels arranged in an asymmetrical pattern on the rotor. Each rotor channel connects to one or more of the stator ports. Different connections of the rotor channels to the stator ports produce at least three different positions for the injection valve. The three different positions provide a complete chromatography sample injection sequence using only a single valve.

公开(公告)号：US20190170706A1

公开(公告)日：2019-06-06

申请号：US16098280

申请日：2017-05-04

Applicant: Waters Technologies Corporation

Inventor： Martin Gilar ,  Richard W. Andrews ,  Peyton C. Beals ,  Thomas McDonald ,  Keith Fadgen ,  Jordan Kornfeld ,  Geoff Gerhardt ,  Sylvain Cormier

IPC: G01N30/24 ,  G01N30/06

Abstract: A method for injecting a diluted sample in a chromatography system includes merging a flow of a sample and a flow of a diluent to form a flow of a diluted sample. A dilution ratio of the diluted sample equals a sum of the volumetric flow rates of the sample and the diluent divided by the volumetric flow rate of the sample. The diluted sample is stored in a holding element before injection into a chromatographic system flow. Sample dilution occurs under low pressure relative to the chromatographic flow thereby allowing lower pressure sample and diluent syringes to be used. Other benefits include reduced compressibility and a reduction in leaks due to the lower pressure operation. The method avoids problems associated with manual techniques which can introduce errors due, for example, to loss of sample, sample precipitation and adsorption of sample to vials.