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40 条记录 (耗时 0.028 秒)

    Farnesylacetic acid ester derivatives
    21.
    发明授权
    Farnesylacetic acid ester derivatives 失效
    法呢基乙酸酯衍生物

    公开(公告)号：US4289786A

    公开(公告)日：1981-09-15

    申请号：US96570

    申请日：1979-11-21

    申请人： Susumu Okabe ,  Yoshiaki Omura ,  Yoichi Ninagawa ,  Yoshiji Fujita

    发明人： Susumu Okabe ,  Yoshiaki Omura ,  Yoichi Ninagawa ,  Yoshiji Fujita

    IPC分类号： A61K31/215 ,  A61K31/22 ,  A61K31/445 ,  A61P1/04 ,  C07C67/00 ,  C07C213/00 ,  C07C219/08 ,  C07C219/10 ,  C07D211/22 ,  C07D211/42 ,  C07D211/46 ,  C07D295/088 ,  A61K31/23 ,  C09F5/08

    CPC分类号： C07D295/088 ,  C07D211/22 ,  C07D211/42 ,  C07D211/46 ,  Y10S514/925

    摘要： Novel farnesylacetic acid ester derivatives containing an amine nitrogen in the alcohol residue thereof and represented by the following general formula exhibit high levels of antiulcerogenic activity and very low levels of toxicity: ##STR1## wherein A is an alkylene radical containing at least 2 carbon atoms; R.sup.1 is H, alkyl, cycloalkyl, aryl, aralkyl or alkenyl; R.sup.2 and R.sup.3 are independently H, alkyl, aryl, aralkyl or alkenyl or one of R.sup.2 and R.sup.3 forms, together with A, a piperidine, pyrrolidine, tetrahydropyrimidine or piperazine ring which contains the nitrogen atom lying therebetween or R.sup.2 and R.sup.3 combine to form, together with the adjacent nitrogen atom, a piperazine ring; provided that the total number of carbon atoms contained in A, R.sup.1, R.sup.2 and R.sup.3 is at least 5.

    摘要翻译： 在其醇残基中含有胺氮并由下列通式表示的新型法呢基乙酸酯衍生物具有高水平的抗致癌活性和非常低的毒性水平：其中A是含有至少2个碳原子的亚烷基; R1是H，烷基，环烷基，芳基，芳烷基或烯基; R2和R3独立地是H，烷基，芳基，芳烷基或烯基或R2和R3中的一个与A，哌啶，吡咯烷，四氢嘧啶或哌嗪环一起形成，其中氮原子位于其间或R2和R3结合形成， 与相邻的氮原子一起形成哌嗪环; 条件是A，R1，R2和R3中含有的碳原子总数至少为5。

    Allenic esters, process for preparation thereof and process for rearrangement thereof
    22.
    发明授权
    Allenic esters, process for preparation thereof and process for rearrangement thereof 失效
    烯酸酯，其制备方法及其重排方法

    公开(公告)号：US3978100A

    公开(公告)日：1976-08-31

    申请号：US461977

    申请日：1974-04-18

    申请人： Yoshiji Fujita ,  Yoshiaki Omura ,  Takashi Hishida ,  Kazuo Itoi

    发明人： Yoshiji Fujita ,  Yoshiaki Omura ,  Takashi Hishida ,  Kazuo Itoi

    IPC分类号： C07C69/587 ,  C11C3/02

    CPC分类号： C07C69/587 ,  C07C403/20 ,  C07C2101/16

    摘要： Allenic esters of the formula: ##EQU1## (specific examples of R, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are given) and a process for the preparation thereof which comprises reacting propargyl alcohol derivatives with 2-substituted ortho-acetic acid esters in the presence of an acidic catalyst. These allenic esters are rearranged in the presence of an alkali catalyst to form .alpha., .beta., .gamma., .delta.-unsaturated carboxylic acid esters and are useful as intermediates in the synthesis of various perfumes, medicines, agricultural chemicals and the like.

    摘要翻译： 式R 2 R 1 R 4的酰亚胺酯R 3 -C = C = C-CH-COOR（R，R 1，R 2，R 3和R 4的具体实例）及其制备方法，其包括使炔丙醇衍生物 与2-取代的原乙酸酯在酸性催化剂存在下反应。 这些烯酸酯在碱催化剂存在下重排，形成α，β，γ，δ-不饱和羧酸酯，可用作合成各种香料，药物，农药等的中间体。

    Substituted cyclopropanecarboxylic acid esters and pesticidal compositions containing the same as active ingredient
    24.
    发明授权
    Substituted cyclopropanecarboxylic acid esters and pesticidal compositions containing the same as active ingredient 失效
    取代的环丙烷羧酸酯和含有与活性成分相同的杀虫组合物

    公开(公告)号：US4389412A

    公开(公告)日：1983-06-21

    申请号：US134589

    申请日：1980-03-27

    申请人： Fumio Mori ,  Manzo Shiono ,  Yoshiaki Omura

    发明人： Fumio Mori ,  Manzo Shiono ,  Yoshiaki Omura

    IPC分类号： A01N53/00 ,  A01N53/08

    CPC分类号： A01N53/00

    摘要： A new pyrethroid compound which is low in toxicity to fish and a pesticidal composition containing the same as an active ingredient are provided. The above pyrethroid compound is a substituted cyclopropanecarboxylic acid ester of the general formula: ##STR1## (wherein A is a hydrogen atom or an ethynyl group) Despite its broad pesticidal spectrum and high pesticidal activity, this ester is very low in toxicity to man and domestic animals and especially low in toxicity to fish as compared with the conventional pyrethroid compounds.

    摘要翻译： 提供了一种对鱼类毒性低的新型拟除虫菊酯化合物，含有与活性成分相同的农药组合物。 上述拟除虫菊酯化合物是以下通式的取代环丙烷羧酸酯：其中A为氢原子或乙炔基。尽管其广泛的杀虫谱和高杀虫活性，但该酯对人类的毒性非常低， 与常规的拟除虫菊酯化合物相比，对鱼类的毒性特别低。

    Oscilloscopic hand-dynamographic transducer
    26.
    发明授权
    Oscilloscopic hand-dynamographic transducer 失效
    示波手动换能器

    公开(公告)号：US4757711A

    公开(公告)日：1988-07-19

    申请号：US890808

    申请日：1986-07-24

    申请人： Yoshiaki Omura

    发明人： Yoshiaki Omura

    IPC分类号： A61B5/22 ,  G01L1/00 ,  H01C10/10

    CPC分类号： A61B5/225 ,  G01L1/00

    摘要： A dynamometer comprising a first member, a second member which is movable relative to the first member along a predetermined path, a piston and cylinder arrangement for resisting movement of the second member with respect to the first member in one direction along the predetermined path with a force which increases from zero with the distance moved from a rest position, and a potentiometer having a first elongate resistor element having two ends and a second wiper element which is in electrical contact with the resistor element and is movable with respect thereto to establish an electrical resistance between the wiper element and one end of the resistor element which increases with relative movement of the elements in one direction. One of the elements of the potentiometer is fixedly mounted on the first member, and the other element is coupled to the second member so that movement of the second member along the predetermined path away from the rest position is accompanied by relative movement of the elements in the direction to increase the electrical resistance between the wiper element and the end of the resistor element.

    摘要翻译： 一种测力计，包括第一构件，可沿着预定路径相对于第一构件移动的第二构件;活塞和气缸装置，用于沿着预定路径阻止第二构件相对于第一构件在一个方向上的运动， 力从静止位置移动的距离从零增加;以及电位器，其具有具有两端的第一细长电阻元件和与电阻元件电接触并可相对于其移动的第二擦拭元件，以形成电 擦拭器元件和电阻元件的一端之间的阻力随元件沿一个方向的相对移动而增加。 电位器的一个元件固定地安装在第一构件上，另一个元件联接到第二构件，使得第二构件沿着预定路径远离静止位置的移动伴随着元件的相对运动 增加擦拭器元件和电阻元件端部之间的电阻的方向。

    ISLETS OF LANGERHANS TRANSPLANT USING ISLETS OF LANGERHANS AND ADIPOSE TISSUE DERIVED STEM CELLS
    28.
    发明申请
    ISLETS OF LANGERHANS TRANSPLANT USING ISLETS OF LANGERHANS AND ADIPOSE TISSUE DERIVED STEM CELLS 有权
    使用兰格兰和ADIPOSE组织衍生的干细胞分离的兰格兰运输途径

    公开(公告)号：US20130171114A1

    公开(公告)日：2013-07-04

    申请号：US13814489

    申请日：2011-08-05

    申请人： Masahiro Tanemura ,  Yoshiaki Omura ,  Hiroaki Nagano ,  Masaki Mori ,  Yuichiro Doki ,  Toshinori Ito

    发明人： Masahiro Tanemura ,  Yoshiaki Omura ,  Hiroaki Nagano ,  Masaki Mori ,  Yuichiro Doki ,  Toshinori Ito

    IPC分类号： A61K35/39

    CPC分类号： A61K35/39 ,  A61K35/28 ,  C12N5/0676 ,  C12N2502/1382 ,  A61K2300/00

    摘要： An object of the present invention is to provide a pancreatic islet transplantation technique that enables increase of graft survival rate of pancreatic islets after pancreatic islet transplantation, to maintain survival of pancreatic islets, and to reduce the number of transplanted pancreatic islets required for normalizing blood glucose level. When performing pancreatic islet transplantation, by transplanting pancreatic islets and adipose tissue-derived stem cells together, it is possible to significantly improve graft survival rate of transplanted pancreatic islets, and reduce by half the number of transplanted pancreatic islets required for normalizing blood glucose level.

    摘要翻译： 本发明的目的是提供胰岛移植技术，其能够增加胰岛移植后胰岛的移植物存活率，保持胰岛的存活，并减少使血糖正常化所需的移植胰岛数量 水平。 当进行胰岛移植时，通过将胰岛和脂肪组织衍生的干细胞移植到一起，可以显着提高移植胰岛的移植物存活率，并减少标准化血糖水平所需的移植胰岛数量的一半。

    Human IgG.sub.1 monoclonal antibody specific for the nicotinic acetylcholine receptor and hybridoma producing the antibody
    29.
    发明授权
    Human IgG.sub.1 monoclonal antibody specific for the nicotinic acetylcholine receptor and hybridoma producing the antibody 失效
    特异于烟碱乙酰胆碱受体的人IgG1单克隆抗体和产生抗体的杂交瘤

    公开(公告)号：US5192684A

    公开(公告)日：1993-03-09

    申请号：US175304

    申请日：1988-03-30

    申请人： Masao Tanihara ,  Hideaki Yamada ,  Toshihide Nakashima ,  Yoshiaki Omura ,  Koichi Takakura

    发明人： Masao Tanihara ,  Hideaki Yamada ,  Toshihide Nakashima ,  Yoshiaki Omura ,  Koichi Takakura

    IPC分类号： A61B10/00 ,  A61K39/395 ,  A61P21/00 ,  C07K16/28 ,  C12N5/10 ,  C12N5/24 ,  C12N15/02 ,  C12P21/00 ,  C12P21/08 ,  C12R1/91 ,  G01N33/566 ,  G01N33/577

    CPC分类号： C07K16/286

    摘要： A human IgG.sub.1 type monoclonal antibody which possesses a molecular weight in the range of 180,000.+-.20,000 as measured by the method of polyacrylamide gel electrophoresis performed in the presence of sodium dodecyl sulfate and is specific to nicotinic acetylcholine receptor. The human IgG.sub.1 type monoclonal antibody mentioned above is produced by a method which comprises fusing human cells capable of producing an antibody against nicotinic acetylcholine receptor with propagable human cells thereby giving rise to a hybridoma capable of producing the aforementioned human IgG.sub.1 type monoclonal antibody, selecting the hybridoma from the production of the fusion, culturing the hybridoma thereby giving rise to the aforementioned human IgG.sub.1 type monoclonal antibody, and selecting the antibody from the cultured medium. The hybridoma mentioned above is also identified.

    摘要翻译： 通过在十二烷基硫酸钠存在下进行的聚丙烯酰胺凝胶电泳测定，其具有180,000 +/- 20,000范围内的分子量的人IgG1型单克隆抗体，并且对烟碱乙酰胆碱受体是特异性的。 上述人IgG1型单克隆抗体是通过将能够产生抗烟碱型乙酰胆碱受体抗体的人细胞与可扩增人细胞融合从而产生能产生上述人IgG1型单克隆抗体的杂交瘤的方法制备的， 从产生融合物中获得杂交瘤，培养杂交瘤，从而产生上述人IgG1型单克隆抗体，并从培养基中选择抗体。 也鉴定了上述杂交瘤。

    Bi-digital O-ring test for imaging and diagnosis of internal organs of a patient
    30.
    发明授权
    Bi-digital O-ring test for imaging and diagnosis of internal organs of a patient 失效
    双数字O形圈测试，用于成像和诊断患者的内脏

    公开(公告)号：US5188107A

    公开(公告)日：1993-02-23

    申请号：US479195

    申请日：1990-02-13

    申请人： Yoshiaki Omura

    发明人： Yoshiaki Omura

    IPC分类号： A61B5/00 ,  A61B10/00

    CPC分类号： A61B5/411 ,  A61B10/00 ,  A61B5/00 ,  A61B5/415

    摘要： A method of imaging an internal organ of a patient for purposes of medical diagnosis, where a patient forms an O-ring shape with one of hands by placing the fingertips of his thumb and one of his remaining fingers together and a sample of tissue of an internal organ is placed on the patient's other hand, and the patient's internal organ is non-invasively externally probed with a probing instrument. The internal organ is the same type of organ as that of the sample. Simultaneously a tester attempts to pull apart the O-ring shape by means of the tester placing his thumb and one of the remaining fingers of each of his hands within the O-ring shape of the patient to form interlocking O-rings and pulling the thumb and the finger of the patient apart due to an electromagnetic field of the tissue of the sample interacting with an electromagnetic field of the internal organ being probed and this interaction is detected by the ability to pull apart the O-ring shape thereby permitting imaging of the boundaries of the internal organ being probed.

    摘要翻译： 一种用于医疗诊断的患者的内部器官成像的方法，其中患者通过将他的拇指的指尖和他的剩余手指中的一个放在一起而使用手之一形成O形圈形状，并且将一个手指的组织样品 内部器官置于患者的另一只手上，病人的内脏器官用探测器非侵入式外部探测。 内脏器官与样品相同类型的器官。 同时，测试者试图通过测试仪将他的拇指和每只手的剩余手指中的一只手放在患者的O形环之间来分开O形环，以形成互锁的O形环并拉动拇指 并且患者的手指由于样本组织的电磁场与被探测的内部器官的电磁场相互作用而分开，并且这种相互作用通过拉伸O形环的能力来检测，从而允许 内部器官的边界被探测。