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32 条记录 (耗时 0.021 秒)

    Adsorbent, method for production thereof, and method for use thereof
    1.
    发明授权
    Adsorbent, method for production thereof, and method for use thereof 失效
    吸附剂，其制造方法及其使用方法

    公开(公告)号：US5132402A

    公开(公告)日：1992-07-21

    申请号：US265540

    申请日：1988-11-01

    申请人： Masao Tanihara ,  Kiichiro Oka ,  Hideaki Yamada ,  Akira Kobayashi ,  Toshihide Nakashima ,  Yoshiaki Omura ,  Koichi Takakura

    发明人： Masao Tanihara ,  Kiichiro Oka ,  Hideaki Yamada ,  Akira Kobayashi ,  Toshihide Nakashima ,  Yoshiaki Omura ,  Koichi Takakura

    IPC分类号： A61M1/36 ,  C07K14/705

    CPC分类号： C07K14/705 ,  A61M1/3679

    摘要： There is disclosed an adsorbent, comprising a carrier on which is immobilized a peptide possessing an ability to bind to the human antibody to the nicotinic acetylcholine receptor and represented by the formula:H--X--A--Y--Zwherein A stands for a peptide residue, one of X and Y stands for a single bond, an amino acid residue selected from the class consisting of Asp, Glu, Lys and a divalent group represented by the formula, ##STR1## (wherein n stands for an integer in the range of 1 to 17), or a peptide residue formed by peptide linkage of two to ten amino acid residues of at least one species selected from the class mentioned above and the other of X and Y stands for an amino acid residue selected from the class consisting of Asp, Glu, Lys and a divalent group represented by the formula, ##STR2## (wherein n stands for an integer in the range of 1 to 17), or a peptide residue formed by peptide linkage of two to ten amino acid residues of at least one species selected from the class mentioned above and Z stands for a hydroxyl group or an amino group. A method for the production of the adsorbent and a method for the use of the adsorbent are also disclosed.

    摘要翻译： 公开了一种吸附剂，其包含载体，其上固定有具有与烟碱乙酰胆碱受体的人抗体结合的能力并由下式表示的肽：HXAYZ其中A代表肽残基，X和Y之一 对于单键，选自Asp，Glu，Lys和由下式表示的二价基团的氨基酸残基（其中n表示1至17的整数）或 通过选自上述类别的至少一种的2至10个氨基酸残基和X和Y中的另一个的肽键形成的肽残基代表选自Asp，Glu，Lys和 由下式表示的二价基团（其中n表示1〜17的整数），或由选自所述类别的至少一种的2〜10个氨基酸残基通过肽键形成的肽残基 提到 Z代表羟基或氨基。 还公开了制备吸附剂的方法和吸附剂的使用方法。

    Peptide
    3.
    发明授权
    Peptide 失效
    肽

    公开(公告)号：US4889917A

    公开(公告)日：1989-12-26

    申请号：US265550

    申请日：1988-11-01

    申请人： Masao Tanihara ,  Kiichiro Oka ,  Hideaki Yamada ,  Akira Kobayashi ,  Toshihide Nakashima ,  Yoshiaki Omura ,  Koichi Takakura

    发明人： Masao Tanihara ,  Kiichiro Oka ,  Hideaki Yamada ,  Akira Kobayashi ,  Toshihide Nakashima ,  Yoshiaki Omura ,  Koichi Takakura

    IPC分类号： A61K38/00 ,  A61M1/36 ,  A61P43/00 ,  C07K7/08 ,  C07K14/00 ,  C07K14/435 ,  C07K14/705 ,  G01N33/564 ,  G01N33/566

    CPC分类号： C07K14/705 ,  A61M1/3679 ,  Y02P20/55

    摘要： A peptide is disclosed which is represented by the formula:H-X-Gly-Trp-Lys-His-Trp-Val-Tyr-Tyr-Thr-Cys-Cys-Pro-Asp-Thr-Pro-Tyr-Leu-Asp-Y -Zwherein one of X and Y stands for a single bond, an amino acid residue selected from the class consisting of Asp, Glu, Lys and a divalent group represented by the formula, ##STR1## (wherein n stands for an integer in the range of 1 to 17), or a peptide residue formed by peptide linkage of two to ten amino acid residues of at least one species selected from the class mentioned above, the other of X and Y stands for an amino acid residue selected from the class consisting of Asp, Glu, Lys and a divalent group represented by the formula, ##STR2## (wherein n stands for an integer in the range of 1 to 17), or a peptide residue formed by peptide linkage of two to ten amino acid residues of at least one species selected from the class mentioned above and Z stands for a hydroxyl group or an amino group, and two cysteinyl mercapto groups in the Cys-Cys moiety may be interlinked to each other to form a disulfide bond.

    摘要翻译： 公开了由下式表示的肽：HX-Gly-Trp-Lys-His-Trp-Val-Tyr-Tyr-Thr-Cys-Cys-Pro-Asp-Thr-Pro-Tyr-Le-Asp- Y -Z其中X和Y中的一个代表单键，选自Asp，Glu，Lys和由下式表示的二价基团的氨基酸残基：其中n表示 1至17的范围）或通过选自上述类别的至少一种的2至10个氨基酸残基的肽键形成的肽残基，X和Y中的另一个表示选自以下的氨基酸残基： 由Asp，Glu，Lys和由式表示的二价基团，其中n表示1〜17的整数，或由2〜10个氨基酸的肽键形成的肽残基 选自上述类别中的至少一种的残基和Z表示羟基或氨基，并且Cys-Cys moie中的两个半胱氨酰巯基 ty可以彼此互连以形成二硫键。

    Human IgG.sub.1 monoclonal antibody specific for the nicotinic acetylcholine receptor and hybridoma producing the antibody
    4.
    发明授权
    Human IgG.sub.1 monoclonal antibody specific for the nicotinic acetylcholine receptor and hybridoma producing the antibody 失效
    特异于烟碱乙酰胆碱受体的人IgG1单克隆抗体和产生抗体的杂交瘤

    公开(公告)号：US5192684A

    公开(公告)日：1993-03-09

    申请号：US175304

    申请日：1988-03-30

    申请人： Masao Tanihara ,  Hideaki Yamada ,  Toshihide Nakashima ,  Yoshiaki Omura ,  Koichi Takakura

    发明人： Masao Tanihara ,  Hideaki Yamada ,  Toshihide Nakashima ,  Yoshiaki Omura ,  Koichi Takakura

    IPC分类号： A61B10/00 ,  A61K39/395 ,  A61P21/00 ,  C07K16/28 ,  C12N5/10 ,  C12N5/24 ,  C12N15/02 ,  C12P21/00 ,  C12P21/08 ,  C12R1/91 ,  G01N33/566 ,  G01N33/577

    CPC分类号： C07K16/286

    摘要： A human IgG.sub.1 type monoclonal antibody which possesses a molecular weight in the range of 180,000.+-.20,000 as measured by the method of polyacrylamide gel electrophoresis performed in the presence of sodium dodecyl sulfate and is specific to nicotinic acetylcholine receptor. The human IgG.sub.1 type monoclonal antibody mentioned above is produced by a method which comprises fusing human cells capable of producing an antibody against nicotinic acetylcholine receptor with propagable human cells thereby giving rise to a hybridoma capable of producing the aforementioned human IgG.sub.1 type monoclonal antibody, selecting the hybridoma from the production of the fusion, culturing the hybridoma thereby giving rise to the aforementioned human IgG.sub.1 type monoclonal antibody, and selecting the antibody from the cultured medium. The hybridoma mentioned above is also identified.

    摘要翻译： 通过在十二烷基硫酸钠存在下进行的聚丙烯酰胺凝胶电泳测定，其具有180,000 +/- 20,000范围内的分子量的人IgG1型单克隆抗体，并且对烟碱乙酰胆碱受体是特异性的。 上述人IgG1型单克隆抗体是通过将能够产生抗烟碱型乙酰胆碱受体抗体的人细胞与可扩增人细胞融合从而产生能产生上述人IgG1型单克隆抗体的杂交瘤的方法制备的， 从产生融合物中获得杂交瘤，培养杂交瘤，从而产生上述人IgG1型单克隆抗体，并从培养基中选择抗体。 也鉴定了上述杂交瘤。

    Polymer gel for medical use
    9.
    发明授权
    Polymer gel for medical use 失效
    用于医疗用途的聚合物凝胶

    公开(公告)号：US5980883A

    公开(公告)日：1999-11-09

    申请号：US932096

    申请日：1997-09-17

    申请人： Masao Tanihara ,  Yoshimi Kakimaru

    发明人： Masao Tanihara ,  Yoshimi Kakimaru

    IPC分类号： A61K47/48 ,  A61K31/765 ,  A61K31/785

    CPC分类号： A61K47/48784 ,  A61K47/48238

    摘要： Provided is a medical material useful for wound dressings or a drug delivery system, which material is safe and has high healing effects, more specifically, which is free from cytotoxicity or other side effects caused by a drug and permits the selective healing of the diseased site in a small dosage without damaging the sites other than the diseased site.The medical material so provided is a polymer gel having a sequence represented by the formula: A-Sp1-E-Sp2-G wherein A represents a water-swelling polymer gel, Sp1 represents the first spacer, E represents a cleavable group with the main chain to be cleaved via an enzymatic reaction, Sp2 represents the second spacer and G represents a drug. When the polymer gel is used, the cleavable group (E) is cleaved according to an amount of an enzyme existing at the diseased site to release the drug in accordance with the amount of the enzyme.

    摘要翻译： 提供了一种用于伤口敷料或药物递送系统的医疗材料，该材料是安全的并且具有高愈合效果，更具体地说，其不受药物引起的细胞毒性或其它副作用，并允许病变部位的选择性愈合 在不损害除病变部位之外的部位的小剂量。 如此提供的医疗材料是具有由下式表示的序列的聚合物凝胶：A-Sp1-E-Sp2-G其中A表示水溶胀性聚合物凝胶，Sp1表示第一间隔物，E表示主要的可裂解基团 链通过酶反应裂解，Sp2表示第二间隔物，G表示药物。 当使用聚合物凝胶时，可切割基团（E）根据存在于患病部位的酶的量根据酶的量来释放药物而被切割。

    Medical polymer gel
    10.
    发明授权
    Medical polymer gel 失效
    医用聚合物凝胶

    公开(公告)号：US5770229A

    公开(公告)日：1998-06-23

    申请号：US826097

    申请日：1997-03-24

    申请人： Masao Tanihara ,  Hisao Kinoshita

    发明人： Masao Tanihara ,  Hisao Kinoshita

    IPC分类号： A61K47/48 ,  A61L15/44 ,  A61L15/60 ,  A61L26/00 ,  A61L27/54 ,  A61L31/14 ,  A61L31/16 ,  A61K9/10

    CPC分类号： A61L31/145 ,  A61K47/48784 ,  A61L15/44 ,  A61L15/60 ,  A61L26/0066 ,  A61L26/008 ,  A61L27/54 ,  A61L31/16 ,  A61L2300/00 ,  A61L2300/602 ,  Y10S514/944

    摘要： A medical polymer gel produced by immobilizing a drug onto a water swelling polymer gel through a cleavable group with the main chain to be cleaved via an enzymatic reaction and a spacer, and a water swelling polymer gel produced by covalently crosslinking a polysaccharide having a carboxyl group within the molecule with a diaminoalkane derivative as the crosslinking reagent. Because the medical polymer gel exerts a drug releasing property depending on the level of an enzyme, the gel can release a therapeutically effective dose of a drug only at a focal lesion generating the enzyme. The medical polymer gel is useful as the structural component of wound dressings, adhesives for biological tissues, adhesion preventing agents, bone reinforcing agents, and drug releasing base materials. Wound dressings comprising the structural material of the water swelling polymer gel of the present invention, can be applied to a patient with wound, burn, and decubitus to promote the healing of the wounds of the patient.

    摘要翻译： 一种医用聚合物凝胶，其通过可裂解的基团将药物固定在水溶胀性聚合物凝胶上，通过酶反应和间隔物将待裂解的主链和通过共价交联具有羧基的多糖而产生的水溶性聚合物凝胶 在分子内具有二氨基烷烃衍生物作为交联剂。 由于医用聚合物凝胶根据酶的水平发挥药物释放性质，所以凝胶只能在产生酶的局灶性病变处释放治疗有效剂量的药物。 医用聚合物凝胶可用作伤口敷料的结构组分，用于生物组织的粘合剂，防粘连剂，骨增强剂和药物释放基材。 包含本发明的水溶性聚合物凝胶的结构材料的伤口敷料可以应用于患有伤口，烧伤和褥疮的患者，以促进患者的伤口的愈合。