公开(公告)号：US20050164226A1

公开(公告)日：2005-07-28

申请号：US10912556

申请日：2004-08-05

申请人： Zhen Huang

发明人： Zhen Huang

IPC分类号： C12P19/34 ,  C12Q1/68

CPC分类号： C12Q1/6813 ,  C12Q2521/301 ,  C12Q2525/131 ,  C12Q2533/101

摘要： The present invention is directed to a highly sensitive method for direct detection of at least one specific RNA in a sample. The presence of a specific RNA provides a positive indicator of a pathogenic agent, contaminant, and/or normal or abnormal genes in the sample. Applications for which the method of the invention is particularly well suited include point-of-care disease diagnosis, detection of microbial contamination in food and/or water supplies, and pathogen detection in biodefense.

摘要翻译： 本发明涉及用于直接检测样品中至少一种特异性RNA的高度灵敏的方法。 特定RNA的存在提供样品中病原体，污染物和/或正常或异常基因的阳性指标。 本发明的方法特别适合的应用包括护理点疾病诊断，食物和/或水供应中微生物污染的检测以及生物防治中的病原体检测。

公开(公告)号：US06238865B1

公开(公告)日：2001-05-29

申请号：US09173936

申请日：1998-10-16

申请人： Zhen Huang ,  Jack W. Szostak

发明人： Zhen Huang ,  Jack W. Szostak

IPC分类号： C12Q168

CPC分类号： C12P19/34

摘要： A novel 3′-terminus modified nucleic acid and a method of making such product using a synthetic nucleotide template with a defined overhang nucleotide are disclosed. The method allows an efficient incorporation of a single modified nucleotide onto the 3′-terminus of the nucleic acid.

摘要翻译： 公开了一种新的3'-末端修饰的核酸和使用具有限定的突出核苷酸的合成核苷酸模板制备该产物的方法。 该方法允许将单个修饰的核苷酸有效并入核酸的3'末端。

公开(公告)号：US5624010A

公开(公告)日：1997-04-29

申请号：US351501

申请日：1994-12-07

申请人： Zhen Huang ,  Klaus Schmidt ,  Hans Scheerer ,  Andreas Opara

发明人： Zhen Huang ,  Klaus Schmidt ,  Hans Scheerer ,  Andreas Opara

IPC分类号： F16F9/46 ,  B60G17/08

CPC分类号： F16F9/46

摘要： The invention concerns a regulable shock-absorption valve system for the dashpot in a motor vehicle. It has two shock-absorption valves. Each valve consists of an electromagnetic bolt that slides back and forth and operates in conjunction with at least one port and of a pressure-sensitive valve for the suction stage and for the compression stage, mutually coaxially accommodated in an essentially cylindrical housing and capable of communicating by way of hydraulic-fluid channels. The pressure-sensitive valves (7 & 8) in accordance with the present invention rest on a simple or complex component (15) with its ends permanently or temporarily secured in a bore that extends through the center of the pole cores (17 & 18) of the electromagnets (11) that actuate the bolts (5 & 6). The advantages of the present invention are direct transmission of the shock-absorption forces and simpler assembly of the system.

摘要翻译： 本发明涉及用于机动车辆中的缓冲器的可调节减震阀系统。 它有两个减震阀。 每个阀门由电磁螺栓组成，前后滑动并与至少一个端口和用于吸入级和压缩级的压敏阀一起工作，相互同轴地容纳在基本上圆柱形的壳体中并且能够连通 通过液压通道。 根据本发明的压敏阀（7和8）搁置在简单或复杂的部件（15）上，其端部永久地或临时固定在延伸穿过极芯（17和18）的中心的孔中， 的驱动螺栓（5和6）的电磁体（11）。 本发明的优点是直接传递减震力并简化了系统的组装。

公开(公告)号：US5020781A

公开(公告)日：1991-06-04

申请号：US540369

申请日：1990-06-19

申请人： Zhen Huang

发明人： Zhen Huang

IPC分类号： B60G17/015 ,  B60G17/018

CPC分类号： B60G17/018 ,  B60G2400/102 ,  B60G2400/206 ,  B60G2400/512 ,  B60G2500/10 ,  B60G2600/16 ,  B60G2600/184 ,  B60G2600/60

摘要： The invention concerns controls for a semiactive chassis on a motor vehicle that is provided with variable or power-regulated vibration attenuators. The results of various sensor measurements are supplied to a regulator that controls the settings in the vibration attenuators on the sky-hook principle.

摘要翻译： 本发明涉及在机动车辆上设置有可变或功率调节的振动衰减器的半主动底架的控制。 各种传感器测量的结果提供给调节器，该调节器根据天钩原理控制振动衰减器的设置。

公开(公告)号：US11150213B2

公开(公告)日：2021-10-19

申请号：US14126264

申请日：2012-06-14

申请人： Zhen Huang ,  Patrick Kiely ,  Matthew Silver ,  Justin Buck

发明人： Zhen Huang ,  Patrick Kiely ,  Matthew Silver ,  Justin Buck

IPC分类号： G01N27/416 ,  G01N27/327 ,  H01M8/16 ,  G01N33/18

摘要： Bioelectrochemical Systems (BES) for use as Biological Oxygen Demand (BOD) sensors, systems incorporating BES sensors for measuring BOD, and methods of using the sensors and systems for measuring BOD. The disclosed sensors are inexpensive to construct, long-lasting, have a fast response, and a large dynamic range. The invention includes biological oxygen demand (BOD) sensors which incorporate at least three working electrodes, at least one counter electrode, a reservoir for dilution fluid, and a sensor for measuring an electric current or a voltage which flows from the working electrodes to the counter electrode. The BOD sensors will typically also include at least one electrically active microbe disposed in proximity to the working electrode.

公开(公告)号：US20160301044A1

公开(公告)日：2016-10-13

申请号：US15093859

申请日：2016-04-08

申请人： Zhen Huang ,  Grover Knight

发明人： Zhen Huang ,  Grover Knight

IPC分类号： H01M2/10 ,  H01M10/48 ,  H01M10/42

CPC分类号： H01M2/1022 ,  H01M10/425 ,  H01M2010/4271 ,  H01M2010/4278 ,  H01M2220/30

摘要： A battery pack apparatus includes a flexible battery pack with an attachment component for attaching the battery pack to and supporting the battery pack on the arms of goggles or eyeglasses worn by a user, the goggles/eyeglasses supporting an electrical device requiring power from the battery pack. The flexible battery pack counter-balances the weight of at least the electrical device when the goggles/eyeglasses are worn by the user. The battery pack apparatus includes a controller that may be wired or remote and that is operable to control the operation of the battery cells within the battery pack.

摘要翻译： 一种电池组装置包括具有附接部件的柔性电池组件，用于将电池组附接到电池组并将电池组支撑在由用户佩戴的护目镜或眼镜的臂上，护目镜/眼镜支撑需要电池组电力的电气装置 。 当用户佩戴护目镜/眼镜时，柔性电池组可抵消至少电气设备的重量。 电池组装置包括可以是有线或远程的控制器，其可操作以控制电池组内的电池单元的操作。

公开(公告)号：US20130289100A1

公开(公告)日：2013-10-31

申请号：US13810572

申请日：2011-07-15

申请人： Li Niu ,  Zhen Huang ,  Jae Seon Park

发明人： Li Niu ,  Zhen Huang ,  Jae Seon Park

IPC分类号： C12N15/115

CPC分类号： C12N15/115 ,  C12N15/111 ,  C12N15/1138 ,  C12N2310/16 ,  C12N2310/322 ,  C12N2310/3533 ,  C12N2320/13

摘要： Inhibitors of AMPA-type glutamate ion channels are useful as biochemical probes for structure-function studies and as drug candidates for a number of neurological disorders and diseases. Disclosed herein is the identification of an RNA inhibitor or aptamer by an in vitro evolution approach and characterization of its mechanism of inhibition on the sites of interaction by equilibrium binding and on the receptor channel-opening rate by a laser-pulse photolysis technique. The aptamer of the invention is a noncompetitive inhibitor of AMPA-type glutamate ion channels, one that selectively inhibits the GluA2Qflip AMPA receptor subunit without any effect on other AMPA receptor subunits or on kainate or NMDA receptors. Furthermore, the aptamer preferentially inhibits the closed-channel state of GluA2Qflip with a KI=1.5 μM or by ˜15-fold over the open-channel state. The potency and selectivity of this aptamer rival those of small molecule inhibitors. Together, these properties make the aptamers of the present invention promising water-soluble, highly potent, GluA2 subunit-selective drugs.

摘要翻译： AMPA型谷氨酸离子通道的抑制剂可用作结构功能研究的生物化学探针和许多神经障碍和疾病的候选药物。 本文公开了通过体外进化方法鉴定RNA抑制剂或适体，并通过激光脉冲光解技术通过平衡结合和受体通道开放速率表征其抑制作用位点的机制。 本发明的适体是AMPA型谷氨酸离子通道的非竞争性抑制剂，其选择性地抑制GluA2Qflip AMPA受体亚基而对其它AMPA受体亚基或红藻氨酸或NMDA受体没有任何作用。 此外，适体优先抑制GluA2Qflip的闭通道状态，KI =1.5μM或比开放通道状态约15倍。 该适配体的效力和选择性与小分子抑制剂的效力和选择性相当。 这些性质一起使得本发明的适体具有潜在的水溶性，高效的GluA2亚基选择性药物。

公开(公告)号：US20130168068A1

公开(公告)日：2013-07-04

申请号：US13339514

申请日：2011-12-29

申请人： Zhen Huang ,  Vinod Kamath ,  Howard V. Mahaney, JR. ,  Chunjian Ni ,  Mark E. Steinke ,  Jamil A. Wakil

发明人： Zhen Huang ,  Vinod Kamath ,  Howard V. Mahaney, JR. ,  Chunjian Ni ,  Mark E. Steinke ,  Jamil A. Wakil

IPC分类号： F28F3/12

CPC分类号： F28F7/02 ,  F28D15/0233 ,  F28F3/12 ,  F28F2013/001 ,  H01L23/36 ,  H01L23/473 ,  H01L2924/0002 ,  H01L2924/00

摘要： A cold plate comprises a cold plate body having a base for thermally engaging a heat-generating device, a plurality of internal channels extending through the cold plate body for the passage of a liquid coolant, a first region between the base and the plurality of internal channels, and a second region between the plurality of internal channels and a top that is generally opposite the base from the plurality of internal channels. The cold plate body is made from a first thermally conductive material. The cold plate also comprises at least one thermally conductive member extending around the plurality of channels from the first region below the plurality of channels to the second region above the plurality of channels. The at least one thermally conductive member has a greater thermal conductivity than the first thermally conductive material to move heat from the first region to the second region.

摘要翻译： 冷板包括具有用于热接合发热装置的基座的冷板主体，延伸穿过冷板主体以用于液体冷却剂通过的多个内部通道，在基部和多个内部之间的第一区域 通道，以及多个内部通道之间的第二区域和与多个内部通道大致相对的基座的顶部。 冷板体由第一导热材料制成。 冷板还包括至少一个导热构件，其围绕多个通道从多个通道下方的第一区域延伸到多个通道上方的第二区域。 至少一个导热构件具有比第一导热材料更大的热导率，以将热量从第一区域移动到第二区域。

公开(公告)号：US20130158249A1

公开(公告)日：2013-06-20

申请号：US13817820

申请日：2011-08-19

申请人： Zhen Huang

发明人： Zhen Huang

IPC分类号： C07H1/04 ,  C07H19/10 ,  C07H19/20

CPC分类号： C07H1/04 ,  C07H19/10 ,  C07H19/20 ,  C07H21/00

摘要： Disclosed are compounds of nucleoside 5′-triphosphates of formula (I), or derivatives thereof, or pharmaceutically acceptable salts of said nucleoside 5′-triphosphates or said derivatives, wherein the Base of formula (I) is Adenine (A), Cytosine (C), Guanine (G), Thymine (T), Uracil (U), modified nucleobase or unnatural nucleobase; R1 is H or OH, R2 is H or OH, X is independently selected from the group consisting of O, S and Se; and Y is independently selected from the group consisting of O, B (borano, or BH3), S, and Se. Also disclosed are processes of preparing the compounds of formula (I), said process comprising steps according to Scheme A:

摘要翻译： 公开了式（I）的核苷5'-三磷酸的化合物或其衍生物或所述核苷5'-三磷酸或所述衍生物的药学上可接受的盐，其中式（I）的碱是腺嘌呤（A），胞嘧啶 C），鸟嘌呤（G），胸腺嘧啶（T），尿嘧啶（U），修饰的核碱基或非天然核碱基; R1是H或OH，R2是H或OH，X独立地选自O，S和Se; 并且Y独立地选自O，B（硼烷或BH 3），S和Se。 还公开了制备式（I）化合物的方法，所述方法包括根据方案A的步骤：

公开(公告)号：US08450468B2

公开(公告)日：2013-05-28

申请号：US13323161

申请日：2011-12-12

申请人： Li Niu ,  Zhen Huang ,  Hua Shi ,  John T. Lis

发明人： Li Niu ,  Zhen Huang ,  Hua Shi ,  John T. Lis

IPC分类号： A61K48/00 ,  C07H19/00 ,  C07H21/00 ,  C07H21/02

CPC分类号： C12N15/115 ,  C12N2310/16

摘要： The present invention relates to novel nucleic acid ligands or aptamers that bind to and inhibit the activation of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors. Also disclosed is a novel combination of technologies, i.e., SELEX and laser pulse photolysis for the selection and screening of aptamers that inhibit receptor function and are useful therefore, in the treatment of diseases associated with excessive activation of ionotropic glutamate receptors.