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21.发明申请公开(公告)号：US20180094279A1
公开(公告)日：2018-04-05
申请号：US15559272
申请日：2016-03-30
申请人： Glycotope GmbH
发明人： Steffen GOLETZ , Doreen JAHN , Antje DANIELCZYK
CPC分类号： C12N15/85 , C07K14/473 , C07K14/59 , C07K14/7151 , C12N15/66 , G01N33/5047
摘要： The present invention pertains to the field of recombinant protein production. Novel expression cassettes comprising elements of the human globin gene clusters are provided which show enhanced expression rates of proteins or polypeptides of interest.
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公开(公告)号：US09845361B2
公开(公告)日：2017-12-19
申请号：US14316389
申请日：2014-06-26
申请人： Glycotope GmbH
发明人： Steffen Goletz , Antje Danielczyk , Renate Stahn , Uwe Karsten
CPC分类号： C07K16/3092 , A61K51/08 , A61K51/088 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2319/00
摘要： The invention relates to recognition molecules directed towards tumors, and it also relates to pharmaceutical compositions comprising said recognition molecules, methods for the production of said recognition molecules, and to the use of said recognition molecules in the diagnosis and therapy of tumor diseases.
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公开(公告)号：US09527899B2
公开(公告)日：2016-12-27
申请号：US13814059
申请日：2011-08-04
申请人： Steffen Goletz , Lars Stöckl
发明人： Steffen Goletz , Lars Stöckl
摘要： The present invention pertains to improved FSH preparations which are capable of stimulating sex steroid release at much lower concentration than the commonly used urinary FSH or recombinant FSH obtained from CHO cells and which act independent of cAMP signaling These improved FSH preparations can be used in infertility treatment.
摘要翻译： 本发明涉及改进的FSH制剂，其能够以比常规使用的尿FSH或从CHO细胞获得的重组FSH更低的浓度刺激性类固醇释放，并且其独立于cAMP信号。这些改进的FSH制剂可用于不孕症治疗 。
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公开(公告)号：US20150118354A1
公开(公告)日：2015-04-30
申请号：US14239934
申请日：2012-08-22
CPC分类号： A23L29/065 , A23C9/1203 , A23L33/135 , A23V2002/00 , C12N1/20 , C12R1/01 , A23V2200/30 , A23V2200/3204
摘要： The present invention pertains to food products comprising microorganisms of the species Bacteroides xylanisolvens, in particular fermented food and probiotic food. These microorganisms are particularly characterized as having a very low pathogenicity and a high safety for human consumption. Furthermore, methods for producing said food products, in particular by fermentation, as well as suitable bacterial strains Bacteroides xylanisolvens of are provided.
摘要翻译： 本发明涉及包含拟杆菌木聚糖异构酶的微生物，特别是发酵食品和益生菌食品的食品。 这些微生物的特征在于具有非常低的致病性和对人类消费的高安全性。 此外，提供了特别是通过发酵生产所述食品的方法以及合适的细菌菌株木霉菌木聚糖溶酶。
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公开(公告)号：US08779102B2
公开(公告)日：2014-07-15
申请号：US10540479
申请日：2004-01-23
申请人： Steffen Goletz , Antje Danielczyk , Renate Stahn , Uwe Karsten
发明人： Steffen Goletz , Antje Danielczyk , Renate Stahn , Uwe Karsten
IPC分类号： C12P21/08
CPC分类号： C07K16/3092 , A61K51/08 , A61K51/088 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2319/00
摘要： The invention relates to recognition molecules directed towards tumors, and it also relates to pharmaceutical compositions comprising such recognition molecules, methods for the production of such recognition molecules, and to the use of such recognition molecules in the diagnosis and therapy of tumor diseases.
摘要翻译： 本发明涉及针对肿瘤的识别分子，并且还涉及包含这种识别分子的药物组合物，用于产生这种识别分子的方法，以及这些识别分子在肿瘤疾病的诊断和治疗中的应用。
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公开(公告)号：US08617846B2
公开(公告)日：2013-12-31
申请号：US13302698
申请日：2011-11-22
申请人： Steffen Goletz , Antje Danielczyk , Uwe Karsten , Peter Ravn , Renate Stahn , Peter Astrup Christensen
发明人： Steffen Goletz , Antje Danielczyk , Uwe Karsten , Peter Ravn , Renate Stahn , Peter Astrup Christensen
IPC分类号： C12P21/08 , C07K16/30 , A61K39/395
CPC分类号： A61K51/1045 , A61K47/6851 , A61K47/6903 , A61K2039/505 , C07K16/3076 , C07K2317/24 , C07K2317/622 , C07K2317/626 , C07K2319/00
摘要： The invention relates to recognition molecules which are directed towards tumors and can be used in the diagnosis and therapy of tumor diseases.
摘要翻译： 本发明涉及指向肿瘤并可用于诊断和治疗肿瘤疾病的识别分子。
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27.发明申请METHODS FOR CULTURING HUMAN MYELOID LEUKAEMIA CELLS AND CELLS DERIVED THEREFROM 有权培养人髓磷酸杆菌细胞的方法及其衍生的细胞公开(公告)号：US20130330768A1
公开(公告)日：2013-12-12
申请号：US13995730
申请日：2011-12-21
申请人： Rainer Stahn
发明人： Rainer Stahn
IPC分类号： C07K16/00
CPC分类号： C07K16/00 , C12N5/0694 , C12N2511/00 , C12N2521/00
摘要： The present invention pertains to a method for culturing a suspension of immortalized human blood cells, preferably cells of myeloid leukaemia origin or cells derived therefrom, wherein said method provides a high productivity, a high cell viability and growth rate and a high batch-to-batch consistency, and can be scaled up without altering these parameters.
摘要翻译： 本发明涉及培养永生化人血细胞悬液的方法，优选骨髓性白血病来源的细胞或由其衍生的细胞，其中所述方法提供高生产率，高细胞活力和生长速率以及高批次 - 批量一致性，并且可以扩大而不改变这些参数。
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28.发明授权Carbohydrate specific cellular immunity inducing microorganisms and fractions thereof 有权碳水化合物特异性细胞免疫诱导微生物及其级分公开(公告)号：US08592165B2
公开(公告)日：2013-11-26
申请号：US12514200
申请日：2007-11-12
申请人： Steffen Goletz , Philippe Ulsemer , Anja Löffler
发明人： Steffen Goletz , Philippe Ulsemer , Anja Löffler
IPC分类号： G01N33/50
CPC分类号： G01N33/56972 , A23L33/135 , A61K39/0011 , A61K39/02 , A61K2039/5152 , A61K2039/5154 , A61K2039/5158 , A61K2039/52 , A61K2039/521 , A61K2039/522 , A61K2039/54 , A61K2039/542 , A61K2039/57 , C07K16/3092 , C07K2317/73 , C12N1/20 , C12R1/01 , C12R1/19 , G01N33/5058 , G01N33/56911 , G01N2400/00 , G01N2469/20
摘要： The present invention relates to the field of prevention and treatment of disorders associated with the occurrence of certain carbohydrate epitopes. The present invention relates to the prevention and treatment of carbohydrate epitope positive tumors. The invention relates to formulations and methods for the induction of an effective carbohydrate specific cellular immune response.
摘要翻译： 本发明涉及预防和治疗与某些碳水化合物表位发生相关的病症的领域。 本发明涉及预防和治疗碳水化合物表位阳性肿瘤。 本发明涉及用于诱导有效的碳水化合物特异性细胞免疫应答的制剂和方法。
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29.发明授权公开(公告)号：US08455253B2
公开(公告)日：2013-06-04
申请号：US10486966
申请日：2002-08-19
IPC分类号： C12N5/078 , C12N5/0784 , C12N5/10 , C12N5/12 , C12N5/22
CPC分类号： C12N5/0694 , A61K39/0011 , A61K2039/5152 , A61K2039/5154 , A61K2039/5156 , C12N5/0639 , C12N2501/15 , C12N2501/22 , C12N2501/24 , C12N2501/25 , C12N2501/39 , C12N2510/00
摘要： Disclosed is a method for the production and use of CD124+ and CD116+ cell lines in the production of effective dendritic cells (DC) with the aid of stimulatory molecules.
摘要翻译： 公开了一种在刺激分子的帮助下生产和使用CD124 +和CD116 +细胞系以生产有效树突状细胞（DC）的方法。
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公开(公告)号：US20130137636A1
公开(公告)日：2013-05-30
申请号：US13814059
申请日：2011-08-04
申请人： Steffen Goletz , Lars Stockl
发明人： Steffen Goletz , Lars Stockl
IPC分类号： C07K14/59
摘要： The present invention pertains to improved FSH preparations which are capable of stimulating sex steroid release at much lower concentration than the commonly used urinary FSH or recombinant FSH obtained from CHO cells and which act independent of cAMP signaling These improved FSH preparations can be used in infertility treatment.
摘要翻译： 本发明涉及改进的FSH制剂，其能够以比常规使用的尿FSH或从CHO细胞获得的重组FSH更低的浓度刺激性类固醇释放，并且其独立于cAMP信号。这些改进的FSH制剂可用于不孕症治疗 。
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