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公开(公告)号：US10765128B2
公开(公告)日：2020-09-08
申请号：US15752776
申请日：2016-08-19
Inventor： Tae Sook Jeong , Ho Yong Park , Dong-Ha Shin , Myung-Sook Choi , Hua Li , Han-Young Cho , Hyeon-Seon Ji
IPC: A61K36/48 , A23K10/30 , A61K31/7048 , A23K20/121 , A23K20/10 , A23L33/105
Abstract: A composition for prevention or treatment of metabolic syndrome or for antioxidation includes black soybean leaf extracts and flavonol glycoside compounds isolated thereof as active ingredients. It has been confirmed that the black soybean leaf extracts and the flavonol glycoside compounds isolated thereof effectively inhibit α-glucosidase activity; LDL oxidation and DDP-4; have excellent DPPH radical scavenging activity; inhibitory activity of reactive oxygen species (ROS) accumulation; effectively promote insulin secretion; regulate the expression of major genes; have an excellent ability to reduce a waist/hip circumference ratio; decrease the concentrations of plasma free fatty acid and plasma triglyceride; increase the concentration of plasma HDL-cholesterol; decrease an atherogenic index; increase erythrocyte catalase, SOD and GR activities; decrease erythrocyte lipid peroxide TBARS; decrease the concentrations of inflammatory cytokines MCP-1 and PAI-1, and resistin; and increase the concentration of plasma adiponectin.
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公开(公告)号：US10695390B2
公开(公告)日：2020-06-30
申请号：US16060780
申请日：2016-12-09
Inventor： Chul Ho Lee , Yong-Hoon Kim , Jung Ran Noh , Dong Hui Choi , Jung Hwan Hwang , Kyoung Shim Kim , Yun-Jung Seo , In-Bok Lee , Jung-Hyeon Choi
IPC: A61K36/428 , A61K36/42 , A23K10/30 , A23L33/105 , A61P1/16
Abstract: The present invention relates to: a composition comprising a Sicyos angulatus extract or a fraction thereof as an effective ingredient for preventing, alleviating, or treating liver diseases; and a method for preventing or treating liver diseases, comprising a step of administering the composition to a subject suspected of having a liver disease.
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公开(公告)号：US20200046728A1
公开(公告)日：2020-02-13
申请号：US16339130
申请日：2017-09-29
Inventor： Mun Chual RHO , Seung Woong LEE , Soyoung LEE , Sang-Hyun KIM , Kwon Moo PARK , Woo Song LEE , Kyungsook JUNG , Chan Sun PARK
Abstract: The present invention relates to a composition for preventing, improving or treating drug-induced nephrotoxicity, the composition comprising oleanolic acid acetate as an active ingredient. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating drug-induced nephrotoxicity comprising oleanolic acid acetate or a pharmaceutically acceptable salt thereof as an active ingredient, a health functional food for preventing or improving drug-induced nephrotoxicity comprising the active ingredients, and an anticancer adjuvant comprising the active ingredients. The oleanolic acid acetate of the present invention is derived from a natural product and has no side effects and no cytotoxicity and has excellent effects of preventing, improving and treating nephrotoxicity caused by a drug, particularly a platinum-based anticancer drug, so that it can be utilized as a pharmaceutical composition, a health functional food, and a cancer adjuvant thereof.
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公开(公告)号：US10413579B2
公开(公告)日：2019-09-17
申请号：US14902439
申请日：2014-07-01
Inventor： Kyung Seop Ahn , Sei Ryang Oh , Ok Kyoung Kwon , In Sik Shin , Hyung Won Ryu , Sang Woo Lee , Joong Ku Lee , Hyeong Kyu Lee , Sang Ho Choi , Doo Young Kim , Jung Hee Kim , Li Wan Yi , Jin Hang
IPC: A61K36/22 , A23L33/105
Abstract: The present invention relates to a composition for preventing or treating asthma comprising a Pistacia weinmannifolia J. Poiss. ex Franch extract or a fraction thereof. The Pistacia weinmannifolia J. Poiss. ex Franch extract or the fraction thereof according to the present invention does not exhibit toxicity, inhibits the generation of NO, IL-4, IL-5, and IL-13 and the generation of reactive oxygen species in the bronchial tubes, and has significantly induced the alleviation of airway hyperresponsiveness, inhibition of the infiltration of inflammatory cells into the bronchial tubes, and reduction of inflammatory cells in bronchoalveolar lavage fluid in an ovalbumin-induced asthma mouse model. In addition, the Pistacia weinmannifolia J. Poiss. ex Franch extract or the fraction thereof according to the present invention effectively inhibits the secretion of immunoglobulins in serum, secretion of mucus in the bronchial tubes, and infiltration of inflammatory cells into lung tissue and thus can be usefully used as a safe preparation for preventing and treating asthma.
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公开(公告)号：US10392596B2
公开(公告)日：2019-08-27
申请号：US15694140
申请日：2017-09-01
Inventor： Shin Hwa Chung , Hee Sik Kim , Dae Hyun Cho , Hee Mock Oh , Jin A Heo
Abstract: Provided is a high throughput photobioreactor. The high throughput photobioreactor includes: a chamber; a plate installed in the chamber and mounted with a plurality of wells; a plurality of light sources installed in the chamber and irradiating light toward the plate; a light quantity controller positioned on an upper part of the plate to make quantities of light irradiated to the plurality of wells different; and a temperature controller controlling a temperature of the plate.
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Patent Agency Ranking
公开(公告)号：US10281460B2
公开(公告)日：2019-05-07
申请号：US15037637
申请日：2014-11-14
Inventor： Seonghun Kim
IPC: C07K14/375 , G01N33/53 , G01N33/569
Abstract: The present invention relates to a method for producing a Polyporus squamosus-derived PSL1b recombinant lectin, which binds specifically to sialic acid containing glycoconjugates, from an Escherichia coli PSL1b strain (deposit number: KCTC12507BP) or a Pichia pastoris PSL1b strain (deposit number: KCTC12500BP) and a lectin produced thereby. The recombinant lectin of the present invention can be useful as an active ingredient of a composition or a kit for measuring or detecting glycoproteins, glycopeptides, glycolipids, sugar precursors, or oligosaccharides having sialic acid moieties.
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27.发明授权公开(公告)号：US10267737B2
公开(公告)日：2019-04-23
申请号：US15824157
申请日：2017-11-28
Inventor： Chang-Soo Lee , Chul Soon Park , Oh Seok Kwon , Tai Hwan Ha
IPC: C07F9/06 , G01N21/64 , C12N9/18 , C07D209/10 , C07D311/80 , C09K11/06
Abstract: A near-infrared fluorescent probe for detecting ALP is represented by Chemical 1. The fluorescent probe capable of detecting ALP can selectively detect ALP only quickly and accurately. In addition, the fluorescent probe allows monitoring of a biological phenomenon occurring in cells and tissues through noninvasive in-vivo imaging and during the early osteogenic differentiation in real time.
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公开(公告)号：US10231999B2
公开(公告)日：2019-03-19
申请号：US15506216
申请日：2015-08-13
Inventor： Sang Chul Lee , Baek Soo Han , Kwang-Hee Bae , Hyejin Kim , Won Kon Kim , Kyoung Jin Oh
Abstract: The present invention relates to a method for producing cholinergic neurons comprising obtaining neural progenitor cells from stem cells so as to continuously produce cholinergic neural cells with high purity and the same traits, followed by differentiating the neural progenitor cells into the cholinergic neurons, and cholinergic neurons produced therefrom. Since the method of preparing the cholinergic neurons provided in the present invention enables not only production of the cholinergic neurons with high purity, but also rapid production of the cholinergic neurons with the same traits, it can be widely used for effectively treating degenerative cranial nerve diseases such as Alzheimer's disease.
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公开(公告)号：US10188594B2
公开(公告)日：2019-01-29
申请号：US15148166
申请日：2016-05-06
Inventor： Kwang-Nyeon Kim , Ju-Hyun Son , Hee-Sik Kim , Jong-Seok Yun
Abstract: The present invention relates to a fermented vegetable oil, to a method for preparing the oil, and to a composition including the oil. More particularly, the present invention relates to a technique for providing a fermented vegetable oil having the effects of enhancing emulsion stability due to water retention ability, improving texture and flavor, and enhancing moisturization.
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公开(公告)号：US20180340195A1
公开(公告)日：2018-11-29
申请号：US15771799
申请日：2016-10-27
Inventor： Jung Oh AHN , Hong Weon LEE , Min Jeong JANG , Chun Sug KIM , Gyu Yeon PARK
Abstract: The present invention relates to a method for producing medium chain diol and, more particularly to recombinant microorganisms in which fatty alcohol dehydrogenase and/or fatty alcohol oxidase genes on a ω-oxidative metabolism pathway are deleted, the fatty aldehyde dehydrogenase genes are optionally deleted, and β-oxidative metabolism pathway-related genes are deleted, and to a method for producing medium chain diol from fatty acid-derived alcohol or alkane by culturing the recombinant microorganisms. The recombinant microorganisms of the present invention can produce a high yield of medium chain diol by preventing further oxidation and β-oxidative metabolism of fatty alcohols.
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