公开(公告)号：US20150057499A1

公开(公告)日：2015-02-26

申请号：US14394241

申请日：2013-04-08

Applicant: Mustafa Suphi Erden ,  Benoit Rosa ,  Jérôme Szewczyk ,  Guillaume Morel ,  Clément Vidal ,  Patrick Henri ,  Nicolas Boularot

Inventor： Mustafa Suphi Erden ,  Benoit Rosa ,  Jérôme Szewczyk ,  Guillaume Morel ,  Clément Vidal ,  Patrick Henri ,  Nicolas Boularot

IPC: A61B1/005 ,  A61B1/00

CPC classification number: A61B1/0057 ,  A61B1/00133 ,  A61B1/00165 ,  A61B1/00172 ,  A61B5/0062 ,  A61B5/0068 ,  A61B5/0084 ,  G02B6/0008 ,  G02B6/04 ,  G02B2006/0098

Abstract: A miniaturized scanning system to generate movement of a flexible device positioned at a distal part of a medical tool. The miniaturized scanning system includes an inner shaft with a longitudinal axis, adapted to guide said flexible device along the longitudinal axis, an abutment comprising an external surface and adapted to maintain said device, and a pusher mechanism adapted to engage with said abutment. The miniaturized scanning system includes at least one end portion adapted to contact said external surface of the abutment at a contact point, wherein said end portion is configured to translate along said longitudinal axis of the inner shaft and wherein the translation of said end portion results in a bending of the device in a bending plane defined by the longitudinal axis of the inner shaft and said contact point.

Abstract translation: 一种微型扫描系统，用于产生位于医疗工具的远端部分的柔性装置的运动。 小型化扫描系统包括具有纵向轴线的内轴，其适于沿着纵向轴线引导所述柔性装置，包括外表面并适于维持所述装置的支座以及适于与所述支座接合的推动器机构。 小型化扫描系统包括适于在接触点处接触邻接件的所述外表面的至少一个端部部分，其中所述端部部分构造成沿着所述内轴的所述纵向轴线平移，并且其中所述端部部分的平移导致 该装置在由内轴和所述接触点的纵向轴线限定的弯曲平面中的弯曲。

公开(公告)号：US08644663B2

公开(公告)日：2014-02-04

申请号：US12987736

申请日：2011-01-10

Applicant: Bertrand Viellerobe ,  Francois Lacombe ,  Nicolas Boularot ,  Francois Doussoux ,  Nicolas Lavillonniere

Inventor： Bertrand Viellerobe ,  Francois Lacombe ,  Nicolas Boularot ,  Francois Doussoux ,  Nicolas Lavillonniere

IPC: G02B6/06

CPC classification number: G01N21/6458 ,  A61B1/00117 ,  A61B1/00165 ,  A61B1/00172 ,  A61B1/043 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/07 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0084 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2201/024 ,  G01N2201/0846 ,  G01N2201/086 ,  G02B6/29362 ,  G02B21/16

Abstract: An imaging device including an illumination module including at least one emitter for emitting at least one excitation beam, a scanning and injection module including an image guide, a proximal end and a distal end of which are linked by a plurality of optical fibers, and a scanning and injection optical system configured to alternately inject the at least one excitation beam into an optical fiber of the image guide from the proximal end of the image guide, and a detection module including at least one detector for detecting at least one luminous flux collected at the distal end of the image guide. At least one of the illumination module and the detection module is optically conjugated with the scanning and injection module by a conjugating optical fiber.

Abstract translation: 一种成像装置，包括包括至少一个用于发射至少一个激发光束的发射器的照明模块，包括图像引导件的扫描和注射模块，其近端和远端由多根光纤连接， 扫描和注射光学系统，被配置为将至少一个激发光束从图像引导件的近端交替地注入到图像引导件的光纤中，以及检测模块，包括至少一个检测器，用于检测在 图像引导件的远端。 照明模块和检测模块中的至少一个通过共轭光纤与扫描和注入模块光学共轭。

公开(公告)号：US08300326B2

公开(公告)日：2012-10-30

申请号：US12299158

申请日：2007-04-27

Applicant: Magalie Genet ,  Gilles Mathieu ,  Bertrand Viellerobe ,  François Doussoux ,  Nicolas Boularot ,  Nicolas Lavillonniere

Inventor： Magalie Genet ,  Gilles Mathieu ,  Bertrand Viellerobe ,  François Doussoux ,  Nicolas Boularot ,  Nicolas Lavillonniere

IPC: G02B9/34

CPC classification number: A61B1/00188 ,  G02B21/0028 ,  G02B21/0072 ,  G02B23/243 ,  G02B27/0025

Abstract: A miniaturized optical head provided to equip the distal end of a beam of flexible optical fibers scanned by a laser beam, is designed to come in contact with a sample and to excite the sample confocally. This optical head includes elements for correcting spherical aberrations and focusing members. The focusing members include: at least a first lens (L4) of high convergence associated with a spherical or hemispherical lens (L5) arranged at the distal end of the optical head, and elements for correcting the axial and lateral chromatic aberration provided with a single divergent lens (3b) whose curvature is substantially centered on the pupil of the optical fiber beam and arranged at the exact distance for this pupil for which the conditions of lateral achromatization coincide with the conditions of axial achromatization; this divergent lens being associated with a second convergent lens (L3a) in the form of a doublet (L3).

Abstract translation: 设置用于装备由激光束扫描的柔性光纤束的远端的小型化光学头设计成与样品接触并共同激发样品。 该光学头包括用于校正球面像差和聚焦构件的元件。 聚焦构件包括：至少与布置在光学头的远端处的球形或半球形透镜（L5）相关联的高会聚的第一透镜（L4），以及用于校正轴向和横向色像差的元件，其具有单个 发散透镜（3b），其曲率基本上位于光纤束的光瞳上，并且被布置在该瞳孔的准确距离处，其侧向消色差条件与轴向消色差条件一致; 该发散透镜与双峰（L3）形式的第二会聚透镜（L3a）相关联。

公开(公告)号：US20110317963A1

公开(公告)日：2011-12-29

申请号：US13255249

申请日：2010-03-12

Applicant: Alexandra Rocher ,  Francois Doussoux ,  Sophie Clade ,  Sylvain Petit ,  Nicolas Boularot

Inventor： Alexandra Rocher ,  Francois Doussoux ,  Sophie Clade ,  Sylvain Petit ,  Nicolas Boularot

IPC: G02B6/40

CPC classification number: G02B6/4292 ,  G02B6/3821 ,  G02B6/3853 ,  G02B6/389 ,  G02B6/3893 ,  G02B6/40 ,  G02B6/4204 ,  G02B6/4226

Abstract: A connector to connect a fiber bundle probe to a light injection module including a tightening cam having an opening of a specified shape adapted to receive the fiber bundle probe, a cam driving coupled to the tightening cam, wherein the tightening cam is configured to translate in response to rotation of the cam driving until the tightening cam is blocked, at least one spring extending between the tightening cam and the cam driving, wherein the at least one spring is configured to resist when the cam driving is actuated by rotation and the tightening cam is blocked, and a locking mechanism to lock the cam driving into a selected position.

Abstract translation: 一种用于将光纤束探针连接到光注射模块的连接器，所述光注射模块包括紧固凸轮，所述紧固凸轮具有适于容纳所述纤维束探针的特定形状的开口，联接到所述紧固凸轮的凸轮驱动器，其中所述紧固凸轮被配置成在 响应于所述凸轮驱动的旋转直到所述紧固凸轮被阻挡，至少一个弹簧在所述紧固凸轮和所述凸轮驱动之间延伸，其中所述至少一个弹簧构造成当所述凸轮驱动通过旋转而被致动时，所述紧固凸轮 被锁定，并且锁定机构将凸轮驱动锁定到选定位置。

公开(公告)号：US07513619B2

公开(公告)日：2009-04-07

申请号：US10586716

申请日：2005-01-21

Applicant: François Lacombe ,  David Lafaille ,  Marie Glanc ,  Eric Gendron

Inventor： François Lacombe ,  David Lafaille ,  Marie Glanc ,  Eric Gendron

IPC: A61B3/10 ,  G01B11/02

CPC classification number: A61B3/102

Abstract: An in-vivo high resolution lateral and axial tomography system of the retina, is provided, including a Michelson interferometer, generating a tomographical image by full field OCT interference with Z sweeping, adaptive optical correction apparatus, correcting the wave fronts coming from and going to the eye, including a reference source, a deformable mirror and wave surface analysis apparatus, detection apparatus producing an image from an interferometric measurement using the OCT principle and apparatus for focussing the wave surface analyser. The apparatus for focussing are embodied and controlled, synchronously with the Z sweeping to force the deformable mirror to adopt an additional curvature, such as to combine the input light source and detection apparatus at a given depth in the retina.

Abstract translation: 提供视网膜的体内高分辨率横向和轴向断层摄影系统，包括迈克尔逊干涉仪，通过全场OCT干涉Z扫描产生断层图像，自适应光学校正装置，校正来自和进入的波前 眼睛，包括参考源，可变形反射镜和波面分析装置，使用OCT原理从干涉测量产生图像的检测装置和用于聚焦波面分析仪的装置。 用于聚焦的装置被实施和控制，与Z扫描同步，以迫使可变形反射镜采用额外的曲率，例如将输入光源和检测装置组合在视网膜中给定的深度处。

公开(公告)号：US20090023999A1

公开(公告)日：2009-01-22

申请号：US10584854

申请日：2004-12-29

Applicant: Gilles Mathieu ,  Magalie Genet ,  Bertrand Viellerobe ,  Frederic Berier

Inventor： Gilles Mathieu ,  Magalie Genet ,  Bertrand Viellerobe ,  Frederic Berier

IPC: A61B1/06

CPC classification number: G02B21/0036 ,  A61B1/00188 ,  A61B1/05 ,  G02B7/027 ,  G02B21/0032

Abstract: A miniature confocal optical head (4) for a confocal imaging system, in particular endoscopic, includes a point source (2a) for producing a light beam (13); a ball lens (12) arranged at the tip of the optical head, partly outside, to cause the light beam to converge in an excitation point (19) located in a subsurface field under observation (14) of a sample (15), the digital aperture of the lens and the dimension of the point source being adapted to ensure confocality of the assembly; and a scanner (10, 211, 22) for rotating the point source so that the excitation point (19) scans the field under observation. The system produces a real-time confocal image (about 10 images/sec.) of very high quality and homogeneous in the entire field (the optical aberrations are constant in the entire field due to the spherical symmetry of the ball lens), achieved through a miniature head.

Abstract translation: 用于共焦成像系统，特别是内窥镜的微型共焦光学头（4）包括用于产生光束（13）的点光源（2a）; 布置在所述光学头部的前端的球状透镜（12），其部分地在外部，以使所述光束会聚在位于样品（15）的观察（14）的地下场的激发点（19）中，所述激光点 透镜的数字孔径和点源的尺寸适于确保组件的共焦; 以及用于旋转点源的扫描器（10,211,22），使得激发点（19）扫描观察的场。 该系统在整个场中产生非常高质量和均匀的实时共焦图像（约10个图像/秒）（由于球透镜的球形对称性，光学像差在整个场中是恒定的），通过 一个微型头。

公开(公告)号：US07438415B2

公开(公告)日：2008-10-21

申请号：US10586839

申请日：2005-01-21

Applicant: François Lacombe ,  David Lafaille ,  Marie Glanc ,  Eric Gendron ,  Douchane Stefanovitch

Inventor： François Lacombe ,  David Lafaille ,  Marie Glanc ,  Eric Gendron ,  Douchane Stefanovitch

IPC: A61B3/10 ,  A61B3/14 ,  A61B3/00

CPC classification number: A61B3/0091

Abstract: A sighting device is provided for an examination of the eye, including at least one moving target with a programmable form and trajectory, the target being displayed on a visualisation unit, such as an appropriate screen and visible from both eyes during the examination. An in-vivo tomographical eye examination system is also provided, including: a Michelson interferometer, generating a full-field OCT image, adaptable optical apparatus, arranged between the interferometer and an eye for examination, achieving the correction of the wavefronts coming from the eye and also the wavefronts going to the eye, detection apparatus, arranged after the interferometer, permitting the interferometric measurement by the OCT principle without modulation nor synchronized detection and a sighting device, with at least one mobile target with a programmable form and trajectory, the target being displayed on an appropriate screen and visible from at least one of the eyes during the examination.

Abstract translation: 提供了一种用于检查眼睛的瞄准装置，包括至少一个具有可编程形式和轨迹的移动目标，目标被显示在可视化单元（例如适当的屏幕上）并且在检查期间从双眼可见。 还提供了一种体内断层扫描检查系统，包括：迈克尔逊干涉仪，生成全场OCT图像，适应光学装置，布置在干涉仪和眼睛之间进行检查，实现来自眼睛的波前的校正 以及布置在干涉仪之后的波前，检测装置，允许通过OCT原理进行干涉测量而不进行调制或同步检测，以及具有可编程形式和轨迹的至少一个移动目标的瞄准装置，目标 在检查期间显示在适当的屏幕上并且从至少一个眼睛可见。

公开(公告)号：US20060056017A1

公开(公告)日：2006-03-16

申请号：US10539519

申请日：2003-12-12

Applicant: Frederic Berier ,  Bertrand Viellerobe ,  Magalie Genet ,  Francois Lacombe ,  Pedro Santos

Inventor： Frederic Berier ,  Bertrand Viellerobe ,  Magalie Genet ,  Francois Lacombe ,  Pedro Santos

IPC: G02B21/00

CPC classification number: G02B21/0072 ,  A61B1/0008 ,  A61B1/00172 ,  G02B21/0028 ,  G02B23/2407 ,  G02B26/0875 ,  G02B26/101

Abstract: An optical head includes: a point source producing an excitation beam, optical elements adapted to converge the optical beam into an excitation point located in a subsurface plane relative to the surface of a sample, the plane being perpendicular to the optical axis of the optical head; and elements for scanning the excitation point so as to define an observation field in the subsurface plane along two perpendicular scanning directions, a rapid online scanning and a slow columnar scanning. The invention includes micro-electrical mechanical systems designed to move in translation along a selected displacement at least one of the optical elements, which is mobile along a direction perpendicular to the optical axis so as to obtain at least one of the scanning directions. The invention provides the advantages of maintaining an axial illumination of the sample and of using a miniature head.

公开(公告)号：US20050242298A1

公开(公告)日：2005-11-03

申请号：US10521607

申请日：2003-07-11

Applicant: Magalie Genet ,  Bertrand Viellerobe ,  Frederic Berier ,  Sophie Clade

Inventor： Magalie Genet ,  Bertrand Viellerobe ,  Frederic Berier ,  Sophie Clade

IPC: G01N21/64 ,  A61B1/00 ,  A61B1/04 ,  A61B5/00 ,  G02B21/00 ,  G02B23/24 ,  G02B23/26 ,  G02B26/10 ,  H04N1/028

CPC classification number: H04N1/0281 ,  A61B5/0062 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0073 ,  A61B5/0084 ,  G02B21/0028 ,  G02B21/0032 ,  G02B21/0048 ,  G02B21/0072 ,  G02B21/0076 ,  G02B21/0084 ,  G02B23/26 ,  G02B26/101

Abstract: A method using an image guide having several thousands of optical fibers, an excitation signal emitted by a source, deflected and injected by turns into the optical fibers, each excitation point of the tissue in the fiber output emitting in return a fluorescence signal collected by the fiber, then detected and digitized to form an image element. The method provides for the focussing of the beam in the fiber output to excite a subsurface plane to produce a confocal image, and the production of a divergent beam in the fiber output capable of exciting a micro-volume of the tissue from the surface. The method consists in deflecting the excitation signal at a speed corresponding to acquisition of a number of images per second sufficient for real time use and in detecting the fluorescence signal at a detecting frequency corresponding to a minimum frequency for sampling the fibers one by one.

Abstract translation: 使用具有数千光纤的图像引导器的方法，由源发射的激发信号，被偏转并被轮流注入光纤中，光纤输出中的组织的每个激发点发射，以返回由 光纤，然后检测并数字化以形成图像元素。 该方法提供了光束在光纤输出中的聚焦以激发地下平面以产生共聚焦图像，并且在光纤输出中产生能够从表面激发组织的微量的发散光束。 该方法包括使激发信号以对应于获得足够实时使用的每秒数量的图像的速度偏转，以及在对应于最小频率的检测频率检测荧光信号，逐个采样光纤。

公开(公告)号：US10765412B2

公开(公告)日：2020-09-08

申请号：US14123659

申请日：2012-06-25

Applicant: Benoît Rosa ,  Benoît Herman ,  Jérôme Szewczyk ,  Guillaume Morel ,  Clément Vidal ,  Patrick Henri ,  François Lacombe ,  Jérôme Lopez

Inventor： Benoît Rosa ,  Benoît Herman ,  Jérôme Szewczyk ,  Guillaume Morel ,  Clément Vidal ,  Patrick Henri ,  François Lacombe ,  Jérôme Lopez

IPC: A61B1/00 ,  A61B17/00 ,  A61B34/00

Abstract: The invention relates to an endoscopic instrument (1) having an elongate body with a distal end (4) designed to be introduced into the body of the patient so as to come into proximity with an internal organ, the distal end carrying a tool (7) for intervention on the internal organ. The endoscopic instrument has a fool (10) rigidly connected to the distal end and designed to bear on the internal organ, and also controllable means (13) for conferring movements on the tool, at least in directions transverse to a longitudinal axis (X) of the distal end of the endoscopic instrument, when the foot is bearing against the internal organ.