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公开(公告)号:US10351876B2
公开(公告)日:2019-07-16
申请号:US15253781
申请日:2016-08-31
发明人: Dietrich M. Egli
IPC分类号: C12N15/00 , C12N15/873 , C12N5/075 , C12N5/16 , C12N15/877 , A61K35/54 , C12N7/00
摘要: The present invention provides modified oocytes having a nuclear genome derived from a first oocyte and cytoplasm derived from a second oocyte from a different subject, and methods for making and using such modified oocytes. The methods and compositions of the present invention can be useful in a variety of settings including, but not limited to, in in vitro fertilization (“IVF”) procedures.
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公开(公告)号:US11471285B2
公开(公告)日:2022-10-18
申请号:US15108996
申请日:2014-12-29
IPC分类号: A61F2/30 , C12N5/00 , A61K35/12 , C12M3/00 , C12M1/12 , C12M1/00 , A61F2/28 , A61L27/38 , C12N5/074 , A61F2/46
摘要: In some embodiments, the present invention provides tissue grafts, such as vascularized bone grafts, and methods for preparing and using such tissue grafts. In some embodiments the tissue grafts are made using pluripotent stem cells, such as autologous pluripotent stem cells. In some embodiments, the tissue grafts are made by creating a digital model of a tissue portion to be replaced or repaired, such as a bone defect, partitioning the model into two or more model segments, and then producing tissue graft segments having a size and shape corresponding to that of the model segments. Such tissue graft segments may be assembled to form a tissue graft having a size and shape corresponding to that of the tissue portion to be replaced or repaired.
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公开(公告)号:US20220249740A1
公开(公告)日:2022-08-11
申请号:US17592169
申请日:2022-02-03
摘要: Described herein are methods for using localized source of heat, such as thermal scanning probe lithography (tSPL), for the low-cost and high-throughput fabrication of biological tissue replicas.
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24.
公开(公告)号:US10961503B2
公开(公告)日:2021-03-30
申请号:US15747103
申请日:2016-07-28
申请人: New York Stem Cell Foundation, Inc. , Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
发明人: Dietrich M. Egli , Nissim Benvenisty , Ido Sagi
IPC分类号: C12N5/0735 , C12N5/075 , C12N5/071
摘要: Haploid human embryonic stem cells and cell lines, haploid multipotent human cells, and haploid differentiated human cells are provided. In addition, methods of making and using the haploid human cells are provided.
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公开(公告)号:US10214714B2
公开(公告)日:2019-02-26
申请号:US14959950
申请日:2015-12-04
摘要: In some embodiments the present invention provides perfusion bioreactors and cell culture scaffolds suitable for the preparation of tissue grafts, such as bone tissue grafts. In some embodiments, the perfusion bioreactors comprise a graft chamber and/or a graft chamber insert configured to hold a tissue graft having a certain shape and/or certain dimensions, and/or to allow culture of such tissue grafts under press-fit direct perfusion conditions. In some embodiments, the perfusion bioreactors comprise an equilibration chamber.
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公开(公告)号:US20230377355A1
公开(公告)日:2023-11-23
申请号:US18320694
申请日:2023-05-19
发明人: Daniel John Paull , Bianca Migliori
CPC分类号: G06V20/698 , G06V10/82 , G06V10/774 , G06V10/7715 , G06T7/0012 , G16H50/20 , G06N5/022 , G06T2207/30036 , G06T2207/20084 , G06T2207/20081 , G06T2207/10064
摘要: The present disclosure provides automated methods and systems for implementing a pipeline involving the training and deployment of a predictive model for predicting cellular diseased state (e.g., neurodegenerative disease state such as presence or absence of Parkinson's Disease) and for identifying features specific to a disease. Such a predictive model is trained by using training data generated from at least one cohort of synthetically pooled cells of a known disease state.
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公开(公告)号:US11732242B2
公开(公告)日:2023-08-22
申请号:US17194047
申请日:2021-03-05
发明人: Scott Noggle , Kevin C. Eggan , Stephen Chang , Susan L. Solomon
CPC分类号: C12N5/0696 , C12M23/04 , C12M35/02 , C12M35/08 , C12M47/04
摘要: The invention provides an automated system for producing induced pluripotent stem cells (iPSCs) from adult somatic cells. Further, the system is used for producing differentiated adult cells from stem cells.
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公开(公告)号:US11149250B2
公开(公告)日:2021-10-19
申请号:US15449519
申请日:2017-03-03
IPC分类号: C12N5/079 , C12N5/0735 , A61K35/30 , G01N33/50
摘要: The present invention provides methods and compositions for the generation of microglial progenitor cells and microglial cells from pluripotent stem cells, such as embryonic stem cells and induced pluripotent stem cells. The present invention also provides cells produced using such methods, and both methods of treatment and methods of drug screening that use such cells. Also provided are various tissue culture media, tissue culture media supplements, and kits useful for the generation of human microglial progenitor cells and human microglial cells.
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公开(公告)号:US11136556B2
公开(公告)日:2021-10-05
申请号:US16587801
申请日:2019-09-30
发明人: Scott Noggle , Kevin Eggan , Stephen Chang , Susan Solomon
摘要: The present invention provides various improved systems and methods for obtaining, generating, culturing, and handling cells, such as stem cells (including induced pluripotent stem cells or iPSCs) and differentiated cells, as well as cells and cell panels produced using such systems and methods, and uses of such cells and cell panels.
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