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719 条记录 (耗时 0.025 秒)

    DUAL PHASE DRUG RELEASE SYSTEM
    23.
    发明申请
    DUAL PHASE DRUG RELEASE SYSTEM 有权
    双相药物释放系统

    公开(公告)号：US20120289535A1

    公开(公告)日：2012-11-15

    申请号：US13553244

    申请日：2012-07-19

    申请人： Mikhail I. Papisov ,  Alexander Yurkovetskiy

    发明人： Mikhail I. Papisov ,  Alexander Yurkovetskiy

    IPC分类号： A61K31/437 ,  C07D305/14 ,  C07D491/22 ,  C07D207/408 ,  A61K31/4015 ,  A61K31/337

    CPC分类号： A61K31/787 ,  A61K47/61 ,  C08L59/00

    摘要： The present invention relates to conjugate comprising a carrier substituted with one or more occurrences of a moiety having the structure: wherein each occurrence of M is independently a modifier having a molecular weight ≦10 kDa; denotes direct of indirect attachment of M to linker LM; and each occurrence of LM is independently an optionally substituted succinamide-containing linker, whereby the modifier M is directly or indirectly attached to the succinamide linker through an amide bond, and the carrier is linked directly or indirectly to each occurrence of the succinamide linker through an ester bond. In another aspect, the invention provides compositions comprising the conjugates, methods for their preparation, and methods of use thereof in the treatment of various disorder, including, but not limited to cancer.

    摘要翻译： 本发明涉及包含由一个或多个出现的具有以下结构的部分取代的载体的缀合物：其中每次出现的M独立地是具有分子量为nkE的调节剂; 10kDa; 表示M直接连接到接头LM; 并且每次出现的LM独立地是任选取代的含琥珀酰胺的接头，其中改性剂M通过酰胺键直接或间接连接到琥珀酰胺接头上，并且载体通过一个或多个 酯键。 在另一方面，本发明提供包含缀合物的组合物，其制备方法及其在治疗各种病症（包括但不限于癌症）中的用途的方法。

    DUAL PHASE DRUG RELEASE SYSTEM
    24.
    发明申请
    DUAL PHASE DRUG RELEASE SYSTEM 有权

    公开(公告)号：US20120004255A1

    公开(公告)日：2012-01-05

    申请号：US13152790

    申请日：2011-06-03

    申请人： Mikhail I. Papisov ,  Alexander Yurkovetskiy

    发明人： Mikhail I. Papisov ,  Alexander Yurkovetskiy

    IPC分类号： A61K31/4375 ,  C07D405/12 ,  C07D491/22

    CPC分类号： A61K31/787 ,  A61K47/61 ,  C08L59/00

    摘要： The present invention relates to conjugate comprising a carrier substituted with one or more occurrences of a moiety having the structure: wherein each occurrence of M is independently a modifier having a molecular weight ≦10 kDa; denotes direct of indirect attachment of M to linker LM; and each occurrence of LM is independently an optionally substituted succinamide-containing linker, whereby the modifier M is directly or indirectly attached to the succinamide linker through an amide bond, and the carrier is linked directly or indirectly to each occurrence of the succinamide linker through an ester bond. In another aspect, the invention provides compositions comprising the conjugates, methods for their preparation, and methods of use thereof in the treatment of various disorder, including, but not limited to cancer.

    Polyacetal compositions with improved tribological properties
    27.
    发明授权
    Polyacetal compositions with improved tribological properties 有权
    具有改善的摩擦学性能的聚缩醛组合物

    公开(公告)号：US07851585B2

    公开(公告)日：2010-12-14

    申请号：US12288036

    申请日：2008-10-16

    申请人： Anne-Laure Brison ,  Andreas Renken

    发明人： Anne-Laure Brison ,  Andreas Renken

    IPC分类号： C08F6/00 ,  C08G63/00

    CPC分类号： C08L59/00 ,  C08L77/10 ,  C08L83/00 ,  F16C33/201 ,  C08L2666/14 ,  C08L2666/20

    摘要： The invention relates to polyacetal compositions comprising a mixture of (i) a polyacetal resin, (ii) p-aramid particles and (III) a vinyl-terminated dimethyl siloxane polymer. These compositions are useful in preparing molded articles exhibiting a good balance between high self-lubricating properties and wear resistance, and especially useful in articles that are in motion with respect to other parts they are in contact with.

    摘要翻译： 本发明涉及包含（i）聚缩醛树脂，（ii）对芳族聚酰胺颗粒和（III）乙烯基封端的二甲基硅氧烷聚合物的混合物的聚缩醛组合物。 这些组合物可用于制备在高自润滑性和耐磨性之间具有良好平衡的模塑制品，并且特别适用于相对于它们接触的其它部分运动的制品。

    Polyoxymethylene multi-block copolymers, their production and use
    29.
    发明授权
    Polyoxymethylene multi-block copolymers, their production and use 失效
    聚甲醛多嵌段共聚物，其生产和使用

    公开(公告)号：US07795357B2

    公开(公告)日：2010-09-14

    申请号：US10570643

    申请日：2004-09-03

    申请人： Dirk Zierer ,  Klaus Kurz ,  Jens Schiebisch ,  Karl-Friedrich Mück ,  Holger Schmalz

    发明人： Dirk Zierer ,  Klaus Kurz ,  Jens Schiebisch ,  Karl-Friedrich Mück ,  Holger Schmalz

    IPC分类号： C08L59/00 ,  C08L59/04 ,  C08G2/38

    CPC分类号： C08G81/00 ,  C08G2/32 ,  C08L59/00 ,  C08L71/02 ,  C08L2666/16

    摘要： Multiblock copolymers are described and contain the structural unit of formula I -A-O—R1—O—CO—(R2—CO—)m—X-D-X—(CO—R2)m—CO—X—  (I), where A is a radical derived from a homo- or copolyoxymethylene, R1 is an alkylene radical-having at least two carbon atoms or a cycloalkylene radical, R2 is a direct carbon-carbon bond, or an alkylene, cycloalkylene, arylene, or aralkylene radical, X is selected from —O—, —S—, or —NH—, D is a divalent radical B which is a radical of a hydroxy-terminated, mercaptan-terminated, or amino-terminated polymer which derives from polyalkylene glycols, polyvinyl ethers, polyvinyl ether-alkene copolymers, polyvinyl esters, polyvinyl ester-alkene copolymers, polyvinyl alcohols, polyvinyl alcohol-alkene copolymers, polyvinylaromatics, polyacrylates, polymethacrylates, polyacetals, polycarbonates, polyesters, polyamides, polyimines, polyetherester elastomers, polyetheramide elastomers, polyalkadienes, polyurethanes, polyureas, polysiloxanes, or a triblock copolymer radical -PAO-B-PAO-, where B assumes one of the above meanings and PAO is a polyalkylene oxide radical, and m is 0 or 1. The multiblock copolymers may be used to produce moldings.

    摘要翻译： 描述了多嵌段共聚物并含有式I-A-O-R 1 -O-CO-（R 2 -CO-）m -XDX-（CO-R 2）m -CO-X-I（I）的结构单元，其中A为 衍生自均聚或共聚甲醛的基团，R 1是具有至少两个碳原子的亚烷基或亚环烷基，R 2是直接碳 - 碳键或亚烷基，亚环烷基，亚芳基或亚芳基，选择X 由-O - ， - S-或-NH-取代，D是二价基团B，其是由聚亚烷基二醇衍生的羟基封端的，硫醇封端的或氨基封端的聚合物的基团，聚乙烯醚，聚乙烯醚 聚烯烃共聚物，聚乙烯基酯，聚乙烯基酯 - 烯烃共聚物，聚乙烯醇，聚乙烯醇 - 烯烃共聚物，聚乙烯芳烃，聚丙烯酸酯，聚甲基丙烯酸酯，聚缩醛，聚碳酸酯，聚酯，聚酰胺，聚亚胺，聚醚酯弹性体，聚醚酰胺弹性体，聚链烯二烯，聚氨酯，聚脲， 宝 溶解硅氧烷或三嵌段共聚物基团-PAO-B-PAO-，其中B为上述含义之一，而PAO为聚环氧烷基，m为0或1.多嵌段共聚物可用于制备模制品。