公开(公告)号：US09620347B2

公开(公告)日：2017-04-11

申请号：US14410202

申请日：2013-05-28

申请人： SHIMADZU CORPORATION

发明人： Xiaoqiang Zhang ,  Wenjian Sun

IPC分类号： H01J3/14 ,  H01J49/06 ,  G01N27/62 ,  H01J49/00 ,  H01J49/26

CPC分类号： H01J49/066 ,  G01N27/622 ,  H01J49/005 ,  H01J49/065 ,  H01J49/26

摘要： The present invention relates to an ion guide device and an ion guiding method. The ion guide device comprises: a plurality of electrode sets distributed along a central axis longitudinally, wherein each electrode set has a ring shape and consists of at least 2 segmented electrodes (for example, 1, 2 and 3, 4 for 2 sets respectively); the power supply system which provides radio-frequency with different phases applied to the adjacent electrode sets (for example, between 1,3 and 2,4) along the central axis, and provides DC Voltages on each segmented electrode (1,2,3,4), wherein, distribution of DC potential drives ions to move in the radial direction while driving said ions to move along the central axis. The ion guide can be used to guide and focus ions under relatively high gas pressure; especially it can be used for off-axis transmission of ions with the purpose to reduce the neutral noise.

公开(公告)号：US20160035556A1

公开(公告)日：2016-02-04

申请号：US14445595

申请日：2014-07-29

申请人： Smiths Detection Inc.

发明人： Vadym Berkout ,  Jan Hendrikse

IPC分类号： H01J49/06

CPC分类号： H01J49/066

摘要： A sample inlet device and methods for use of the sample inlet device are described that include an ion funnel having a plurality of electrodes with apertures arranged about an axis extending from an inlet of the ion funnel to an outlet of the ion funnel, the ion funnel including a plurality of spacer elements disposed coaxially with the plurality of electrodes, each of the plurality of spacer elements being positioned between one or two adjacent electrodes, each of the plurality of spacer elements having an aperture with a diameter that is greater than a diameter of each adjacent electrode. The ion funnel is configured to pass an ion sample through the apertures of the electrodes and the spacer elements to additional portions of a detection system, such as to a mass analyzer system and detector.

摘要翻译： 描述了样品入口装置和使用样品入口装置的方法，其包括具有多个电极的离子漏斗，所述多个电极具有围绕从离子漏斗的入口延伸到离子漏斗的出口的轴线排列的离子漏斗 包括与所述多个电极同轴设置的多个间隔元件，所述多个间隔元件中的每一个位于一个或两个相邻的电极之间，所述多个间隔元件中的每一个具有直径大于 每个相邻电极。 离子漏斗被配置为使离子样品通过电极和间隔元件的孔通过检测系统的附加部分，例如质量分析器系统和检测器。

公开(公告)号：US08907272B1

公开(公告)日：2014-12-09

申请号：US14046020

申请日：2013-10-04

申请人： Thermo Finnigan LLC

发明人： Eloy R. Wouters ,  R. Paul Atherton ,  Satendra Prasad ,  Jean-Jacques Dunyach

IPC分类号： H01J49/26 ,  H01J49/36 ,  H01J49/00

CPC分类号： H01J49/066

摘要： A method for transporting ions within a mass spectrometer comprises: inputting the ions and neutral molecules to a first end of an ion transport apparatus comprising a plurality of non co-planar ring-shaped electrode portions having respective central apertures having centers that lie along a common axis and that define an ion channel, the radii of the central apertures decreasing in a direction from the first end to a second end of the ion transport apparatus; applying a set of Radio Frequency voltages to the plurality of electrode portions such that the ions remain substantially confined to the ion channel while passing from the first to the second end; and exhausting the neutral molecules from the ion transport apparatus though a plurality of channels or apertures other than the apertures that define the ion channel, the exhausting performed in one or more directions that are non-perpendicular to the axis.

摘要翻译： 用于在质谱仪内输送离子的方法包括：将离子和中性分子输入到离子传输设备的第一端，离子传输设备的第一端包括多个非共面的环状电极部分，其具有各自的中心孔，所述中心孔具有沿着共同的中心 并且限定离子通道，中心孔的半径在离子传输装置的第一端至第二端的方向上减小; 将一组射频电压施加到所述多个电极部分，使得所述离子在从所述第一至第二端通过时基本上保持在所述离子通道上; 以及通过除了限定离子通道的孔之外的多个通道或孔而从离子传输装置排出中性分子，在与轴不垂直的一个或多个方向上进行排气。

公开(公告)号：US20140158878A1

公开(公告)日：2014-06-12

申请号：US14080301

申请日：2013-11-14

申请人： Micromass UK Limited

发明人： Martin Raymond Green ,  Jason Lee Wildgoose

IPC分类号： H01J49/06 ,  H01J49/40

CPC分类号： H01J49/40 ,  H01J49/004 ,  H01J49/005 ,  H01J49/062 ,  H01J49/063 ,  H01J49/065 ,  H01J49/066

摘要： A mass spectrometer is disclosed comprising a time of flight mass analyser. The time of flight mass analyser comprises an ion guide comprising a plurality of electrodes which are interconnected by a series of resistors forming a potential divider. Ions are confined radially within the ion guide by the application of a two-phase RF voltage to the electrodes. A single phase additional RF voltage is applied across the potential divider so that an inhomogeneous pseudo-potential force is maintained along the length of the ion guide.

摘要翻译： 公开了一种质谱仪，其包括飞行时间质量分析器。 飞行时间质量分析器包括离子导向器，其包括由形成分压器的一系列电阻器互连的多个电极。 离子通过向电极施加两相RF电压而在离子导向器内径向限制。 在分压器上施加单相附加RF电压，使得沿着离子导向器的长度保持不均匀的伪势力。

公开(公告)号：US08704170B2

公开(公告)日：2014-04-22

申请号：US13634190

申请日：2011-04-22

申请人： Sumio Kumashiro ,  Wenjian Sun ,  Li Ding

发明人： Sumio Kumashiro ,  Wenjian Sun ,  Li Ding

IPC分类号： H01J49/00 ,  H01J49/10 ,  H01J49/24 ,  H01J49/16

CPC分类号： H01J49/10 ,  G01N27/622 ,  H01J49/066 ,  H01J49/161 ,  H01J49/164 ,  H01J49/165 ,  H01J49/24

摘要： The current invention involves a method and a device for generating and analyzing ions in order to analyze samples directly without sample preparation. The gaseous neutral molecules are desorbed under atmospheric pressure by a desorption method. The desorbed neutral molecules are then transferred into a low pressure region where they are post-ionized by a mist from an electrospray probe tip or by photons from a vacuum UV source. The generated ions are then focused in a time varying electric field in the low pressure chamber before they are transferred into a mass spectrometer or ion mobility spectrometer for further analysis.

摘要翻译： 本发明涉及用于生成和分析离子的方法和装置，以便在不进行样品制备的情况下直接分析样品。 气态中性分子通过解吸法在大气压下解吸。 然后将解吸的中性分子转移到低压区域，在那里它们被来自电喷雾探针尖端的雾或者来自真空UV源的光子后离子化。 然后将所产生的离子聚焦在低压室中的时变电场中，然后将其转移到用于进一步分析的质谱仪或离子迁移谱仪中。

公开(公告)号：US08569687B2

公开(公告)日：2013-10-29

申请号：US13663191

申请日：2012-10-29

申请人： Micromass UK Limited

发明人： Robert Harold Bateman ,  Kevin Giles ,  Steven Derek Pringle ,  Jason Lee Woldgoose

IPC分类号： H01J49/40 ,  H01J49/42 ,  H01J49/00 ,  H01J49/06

CPC分类号： G01N27/622 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/0045 ,  H01J49/02 ,  H01J49/062 ,  H01J49/065 ,  H01J49/066 ,  H01J49/40 ,  H01J49/401 ,  H01J49/42

摘要： A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator and an ion guide arranged downstream of the ion mobility spectrometer or separator. A plurality of axial potential wells are created in the ion guide so that ions received from the ion mobility spectrometer or separator become confined in separate axial potential wells. The potential wells maintain the fidelity and/or composition of ions received from the ion mobility spectrometer or separator. The potential wells are translated along the length of the ion guide.

公开(公告)号：US20130187044A1

公开(公告)日：2013-07-25

申请号：US13357470

申请日：2012-01-24

申请人： LI DING ,  GONGYU JIANG ,  WENJIAN SUN

发明人： LI DING ,  GONGYU JIANG ,  WENJIAN SUN

IPC分类号： H01J49/22

CPC分类号： H01J49/065 ,  H01J49/066

摘要： This invention presents a kind of ion guide device comprising multiple layers of stretched wire electrodes crossing in space. These wire electrodes are distributed along a defined ion guiding axis in the ion guide device. Each layer of wire electrodes contains at least two wire electrodes with some distance away from the guiding axis, and rotates with an angle relative to wire electrodes on neighboring layer. The ion guide contains multiple layers of wire electrodes to form a cage-like ion guide tunnel and keeps the mounting framework of those wire electrodes outside of the ion guide tunnel, thus reducing the interference of the gas flows from the ion guide device. A power supply provides voltage to each layer of wire electrodes, creates an electric field which focuses the ions towards the guiding axis.

摘要翻译： 本发明提供了一种离子导向装置，其包括在空间上交叉的多层拉伸线电极。 这些线电极沿离子导向装置中限定的离子引导轴分布。 每层线电极包含至少两根与引导轴距离一定距离的线电极，并相对于相邻层上的线电极以一定角度旋转。 离子导向器包含多层线电极以形成笼状离子导向通道，并将这些线电极的安装框架保持在离子引导通道外部，从而减少离子导向装置的气流的干扰。 电源为每层线电极提供电压，产生将离子聚焦到引导轴的电场。

公开(公告)号：US20110147575A1

公开(公告)日：2011-06-23

申请号：US12640089

申请日：2009-12-17

申请人： Alexander Mordehai ,  Mark H. Werlich

发明人： Alexander Mordehai ,  Mark H. Werlich

IPC分类号： H01J49/26

CPC分类号： H01J49/066

摘要： An interface for use in a mass spectrometer is disclosed. The interface comprises a first ion funnel comprising a first inlet and a first outlet, and a first axis between the first inlet and the first outlet. The interface further comprises a second ion funnel in tandem with the first ion funnel, the second ion funnel comprising a second inlet and a second outlet, and a second axis between the second inlet and the second outlet. The first axis and the second axis are offset relative to one another. A mass spectrometer comprising the interface and a method are disclosed.

摘要翻译： 公开了一种用于质谱仪的界面。 界面包括第一离子漏斗，其包括第一入口和第一出口，以及在第一入口和第一出口之间的第一轴线。 界面还包括与第一离子漏斗串联的第二离子漏斗，第二离子漏斗包括第二入口和第二出口，以及在第二入口和第二出口之间的第二轴。 第一轴和第二轴相对于彼此偏移。 公开了包括界面和方法的质谱仪。

公开(公告)号：US07915580B2

公开(公告)日：2011-03-29

申请号：US12252013

申请日：2008-10-15

申请人： Maurizio A. Splendore ,  Eloy R. Wouters ,  Michael W. Senko ,  Paul R. Atherton ,  Jean Jacques Dunyach ,  Christopher Mullen

发明人： Maurizio A. Splendore ,  Eloy R. Wouters ,  Michael W. Senko ,  Paul R. Atherton ,  Jean Jacques Dunyach ,  Christopher Mullen

IPC分类号： H01J49/06

CPC分类号： H01J49/0404 ,  H01J49/066

摘要： A device for improved transportation and focusing of ions in a low vacuum or atmospheric-pressure region of a mass spectrometer is constructed from one or more electro-dynamic or electrostatic focusing lenses that is/are coupled to the first electrode of a stacked ring ion guide (SRIG) to which oscillatory (e.g., radio-frequency) voltages are applied. Such configurations as disclosed herein, minimizes deleterious field effects and/or repositioning problems of desired ion transfer instruments that utilize such stacked ring ion guides by generally configuring the outlet end of the ion transfer device to a desired position within the electro-dynamic or electro-static focusing lens(es).

摘要翻译： 用于改善离子在质谱仪的低真空或大气压力区域中的运输和聚焦的装置由一个或多个电动或静电聚焦透镜构成，所述电动或静电聚焦透镜被耦合到堆叠环离子导向件的第一电极 （SRIG），施加振荡（例如，射频）电压。 通过将离子转移装置的出口端大致配置到电动态或电动式离子转移装置中的期望位置，使这种堆叠的环形离子引导件的所需离子传递装置的有害场效应和/或重新定位问题最小化， 静态聚焦透镜。

公开(公告)号：US20100090104A1

公开(公告)日：2010-04-15

申请号：US12252013

申请日：2008-10-15

申请人： Maurizio A. Splendore ,  Eloy R. Wouters ,  Michael W. Senko ,  Paul R. Atherton ,  Jean Jacques Dunyach ,  Christopher Mullen

发明人： Maurizio A. Splendore ,  Eloy R. Wouters ,  Michael W. Senko ,  Paul R. Atherton ,  Jean Jacques Dunyach ,  Christopher Mullen

IPC分类号： B01D59/46

CPC分类号： H01J49/0404 ,  H01J49/066

摘要： A device for improved transportation and focusing of ions in a low vacuum or atmospheric-pressure region of a mass spectrometer is constructed from one or more electro-dynamic or electrostatic focusing lenses that is/are coupled to the first electrode of a stacked ring ion guide (SRIG) to which oscillatory (e.g., radio-frequency) voltages are applied. Such configurations as disclosed herein, minimizes deleterious field effects and/or repositioning problems of desired ion transfer instruments that utilize such stacked ring ion guides by generally configuring the outlet end of the ion transfer device to a desired position within the electro-dynamic or electro-static focusing lens(es).

摘要翻译： 用于改善离子在质谱仪的低真空或大气压力区域中的运输和聚焦的装置由一个或多个电动或静电聚焦透镜构成，所述电动或静电聚焦透镜被耦合到堆叠环离子导向件的第一电极 （SRIG），施加振荡（例如，射频）电压。 通过将离子转移装置的出口端大致配置到电动态或电动式离子转移装置中的期望位置，使这种堆叠的环形离子引导件的所需离子传递装置的有害场效应和/或重新定位问题最小化， 静态聚焦透镜。