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公开(公告)号：US12106954B2
公开(公告)日：2024-10-01
申请号：US17277999
申请日：2019-10-17
Applicant: SHIMADZU CORPORATION
Inventor： Yiming Lin , Wenjian Sun
Abstract: The present invention provides dielectric barrier discharge ionization, including a dielectric barrier discharge tube and an electrode pair consisting of a first electrode and a second electrode. At least a portion of the dielectric barrier discharge tube is provided between the first electrode and the second electrode. The electrode pair can ionize the sample after the power is turned on. The dielectric barrier discharge tube is in communication with a vacuum portion. The pressure range in the dielectric barrier discharge tube is 0.01 to 100 Pa. The dielectric barrier discharge ionization provided by the invention remedies the defects of existing low-pressure ion sources in the pressure range, and provides the low-pressure ion source with high ionization ability, high versatility and simple devices.
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公开(公告)号：US20240213011A1
公开(公告)日：2024-06-27
申请号：US18508669
申请日：2023-11-14
Applicant: SHIMADZU CORPORATION
Inventor： Xiaoqiang ZHANG , Zhi Geng , Wenjian Sun
CPC classification number: H01J49/063 , H01J49/24
Abstract: The technical solution of the present disclosure provides an ion source apparatus and a mass spectrometer. According to the ion source apparatus, the axial ion guide assembly includes the plurality of multipole segments extending axially, the transmission path of axial ions is straight, and the ion transmission efficiency is substantially unaffected when the axial ion source is used alone. Further, since the ion outlet of the lateral ion guide assembly faces a gap between two adjacent segmented multipoles, the lateral ion guide assembly does not affect axial field, thereby integrating the multiple ion sources while ensuring the ion transmission efficiency and ion constraining of the axial ion source.
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公开(公告)号：US11031218B2
公开(公告)日：2021-06-08
申请号：US16645863
申请日：2018-10-29
Applicant: SHIMADZU CORPORATION
Inventor： Xiaoqiang Zhang , Yunqing Huang , Wenjian Sun
Abstract: A data acquisition method in a mass spectrometer includes a. providing an ion source to generate precursor ions; b. feeding the precursor ions into a first mass analyzer that selects one mass window such that the precursor ions located outside the mass window pass through the first mass analyzer and the precursor ions located within the mass window cannot pass through the first mass analyzer; c. feeding the precursor ions passing through the first mass analyzer into a collision cell for collisional dissociation, to generate product ions; d. feeding the product ions into a second mass analyzer for mass analysis and recording a spectrum; and e. repeating Steps b-d. Each time when Step b is repeatedly performed, the selected mass window does not overlap with all the mass windows previously selected. After all the mass windows in a mass range are selected, the repetition is stopped.
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公开(公告)号：US10515790B2
公开(公告)日：2019-12-24
申请号：US15736107
申请日：2016-06-20
Applicant: SHIMADZU CORPORATION
Inventor： Yupeng Cheng , Xiaoqiang Zhang , Wenjian Sun
Abstract: The disclosure relates to an ion guiding device, including two sets of electrodes extending along a certain space axis, a first power supply device and a second power supply device. The electrodes are expandably arranged along a direction perpendicular to the space axis, at least one surface of each electrode in each set of electrodes is substantially on the same space plane, and the space planes for each set of electrodes are not same and not parallel, thereby forming an ion transmission channel having the cross sectional area gradually reduced in a direction perpendicular to the space axis; the first power supply device is used for applying radio-frequency voltages on at least a part of electrodes in the two sets of electrodes; and the second power supply device is used for applying voltage signals on at least a part of electrodes in the two sets of electrodes.
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公开(公告)号：US10020174B2
公开(公告)日：2018-07-10
申请号：US15476149
申请日：2017-03-31
Applicant: SHIMADZU CORPORATION
Inventor： Xiaoqiang Zhang , Yunqing Huang , Wenjian Sun
CPC classification number: H01J49/009 , G01N27/624 , G01N30/72 , G01N30/86 , H01J49/0036 , H01J49/005
Abstract: A method for parallel analysis in mass spectrometry and ion mobility spectrometry includes enabling a sample to be subjected to a chromatography separation; ionizing the chromatography separated sample and then feeding the sample into a succeeding stage device for analysis, comprising: analyzing at least part of the ionized sample through an ion mobility spectrometer to obtain an ion mobility spectrum, and analyzing at least other parts of the sample through a mass spectrometer to obtain a mass spectrum, wherein the period for obtaining each ion mobility spectrum and each mass spectrum being not longer than 5 s; and performing data post-processing, comprising: correlating the peaks in said ion mobility spectrum and the peaks in said mass spectrum with a deconvolution algorithm according to the consistency in retention time or elution profile for the same analyte in said chromatography.
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Patent Agency Ranking
公开(公告)号：US11289318B2
公开(公告)日：2022-03-29
申请号：US17212168
申请日：2021-03-25
Applicant: Shimadzu Corporation
Inventor： Xinfeng Zhou , Ran Qiu , Wenjian Sun
Abstract: The invention provides a mass spectrometry analysis method and a mass spectrometry system. During implementation of the mass spectrometry analysis method, intensity data of the daughter ions, a first parameter of the daughter ions associated with the first physicochemical property, and a second parameter of the daughter ions associated with the second physicochemical property are all recorded to form a spectrogram data set. In a deconvolution step, the spectrogram data set is deconvoluted to categorize the daughter ions from the same parent ion according to two-dimensional features including the first parameter and the second parameter. In the above manner, the mass spectrometry analysis method and the mass spectrometry system provided by the invention can detect ions that partially overlap spectral peaks of other ions significantly, thereby improving the qualitative and quantitative ability of data analysis for data independent acquisition.
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7.发明授权公开(公告)号：US10192728B2
公开(公告)日：2019-01-29
申请号：US15736138
申请日：2016-06-20
Applicant: SHIMADZU CORPORATION
Inventor： Xiaoqiang Zhang , Gongyu Jiang , Yunqing Huang , Jiaqi Shen , Wenjian Sun
Abstract: The disclosure relates to a mass spectrometer and a method applied thereby for reducing ion loss and succeeding stage vacuum load. The mass spectrometer includes an ion source connected via vacuum interfaces, a vacuum chamber and a succeeding stage device; wherein a tubular lens is arranged above a Mach disc formed by a gas flow carrying ions at the vacuum interfaces, so that an ion transfer path is restrained and the ions scattering with the gas flow is reduced. In comparison to a sole reliance on a radio-frequency voltage for focusing ions, the efficiency of ion capture in a jet region is improved by using an aerodynamic lens; and the desolvation efficiency of electrically charged droplets is also improved, thereby further improving the sensitivity of the mass spectrometer. Meanwhile the tubular aerodynamic lens is simple in structure and small in size.
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公开(公告)号：US09502228B2
公开(公告)日：2016-11-22
申请号：US14389516
申请日：2013-03-26
Applicant: SHIMADZU CORPORATION
Inventor： Gongyu Jiang , Wenjian Sun
IPC: H01J49/42
CPC classification number: H01J49/4225 , H01J49/422 , H01J49/423 , H01J49/424 , H01J49/4245 , H01J49/427 , H01J49/4285
Abstract: An ion trap analyzer, an ion trap mass spectrometry analysis method, and an ion fragmentation method are provided. The ion trap analyzer includes an ion trapping space enclosed by multiple electrodes (101, 102, 103, 11, 12, 214), where a high-frequency voltage is applied on at least a part of the electrodes, so as to generate, within the trapping space, a trapping electric field dominated by a quadratic field. The apparatus is provided with an ion ejection outlet (200) in at least one direction away from the center of the trap; an alternating voltage signal used for resonant excitation of ion motions is overlaid on an electrode part that is on a side of the ion ejection outlet and closest to the ejection outlet, while no voltage signal that is identical in range and phase with the alternating voltage is applied on at least one remaining electrode part in said direction. With the method, or by further applying, to the remaining electrode part in said direction, a voltage signal that is inverted to the alternating voltage, the orientation of an alternating electric field induced by the excitation alternating voltage signal can be limited, thereby improving the resonance ejection efficiency of the ion trap, reducing, in ion motions, motion coupling between an ejection direction and a non-ejection direction, and improving the viability of selecting the ion trap as a mass analyzer.
Abstract translation: 提供离子阱分析仪，离子阱质谱分析方法和离子碎片化方法。 离子阱分析仪包括由多个电极（101,102,103,11,12,214）包围的离子捕获空间，其中在至少一部分电极上施加高频电压，从而在 捕获空间，由二次场主导的捕获电场。 该设备在远离捕集器中心的至少一个方向上设置有离子喷射出口（200）; 用于离子运动的共振激发的交流电压信号覆盖在离子喷射出口侧并且最靠近喷射出口的电极部分上，而在交变电压范围和相位上没有相同的电压信号是 施加在所述方向上的至少一个剩余电极部分上。 通过该方法，或者通过进一步向所述方向上的剩余电极部分施加反向交流电压的电压信号，可以限制由激励交流电压信号感应的交变电场的取向，从而改善 离子阱的共振喷射效率，减少离子运动，喷射方向和非喷射方向之间的运动耦合，以及提高作为质量分析器选择离子阱的可行性。
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9.发明授权Ion mobility analyzer, combination device thereof, and ion mobility analysis method 有权离子迁移率分析仪，其组合装置和离子迁移率分析方法公开(公告)号：US09429543B2
公开(公告)日：2016-08-30
申请号：US14735876
申请日：2015-06-10
Applicant: SHIMADZU CORPORATION
Inventor： Gongyu Jiang , Yupeng Cheng , Xiaoqiang Zhang , Wenjian Sun
CPC classification number: G01N27/622 , G01N27/624 , H01J49/004 , H01J49/22
Abstract: An ion mobility analyzer, combination device thereof, and ion mobility analysis method. The ion mobility analyzer comprises an electrode system that surrounds the analytical space and a power device that attaches to the electrode system an ion mobility electric potential field that moves along one space axis. During the process of analyzing mobility of ions to be measured, by always placing the ions to be measured in the moving ion mobility electric potential field, and keeping the movement direction of the ion mobility electric potential field consistent with the direction of the electric field on the ions to be measured within the ion mobility electric potential field, theoretically a mobility path of an infinite length can be formed so as to distinguish ions having mobility or ion cross sections that have very small differences.
Abstract translation: 离子迁移率分析仪，其组合装置和离子迁移率分析方法。 离子迁移率分析仪包括围绕分析空间的电极系统和附接到电极系统的沿着一个空间轴移动的离子迁移电位场的功率器件。 在分析被测离子的迁移率的过程中，通过总是将待测离子置于移动离子迁移电势场，并保持离子迁移率电位场的移动方向与电场方向一致 在离子迁移电势场内要测量的离子理论上可以形成无限长度的迁移率路径，以区分具有极小差异的迁移率的离子或离子横截面。
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公开(公告)号：US12027358B2
公开(公告)日：2024-07-02
申请号：US17216988
申请日：2021-03-30
Applicant: Shimadzu Corporation
Inventor： Wenjian Sun , Ran Qiu , Xiaoqiang Zhang
CPC classification number: H01J49/0072 , G01N30/7206 , G01N30/7233 , H01J49/0036
Abstract: The invention provides a mass spectrometry analysis method and a mass spectrometry system, including: a first sample separation step, separating a sample by a first sample separation device to obtain first isolates; a second sample separation step, introducing ionized first isolates into a second sample separation device for further separation based on a difference in ion mobility to obtain second isolates; and a mass spectrometry analysis step, performing mass spectrometry detection at least on daughter ions obtained from dissociation of the second isolates; in the second sample separation step, the second sample separation device operates in a filter mode, and screens out and releases ions having ion mobility within a specified range from received second isolates. The mass spectrometry analysis method can improve the dynamic range of mass spectrometry analysis.
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