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4419 条记录 (耗时 0.034 秒)

    Chiral cyclen compounds and their uses
    21.
    发明授权
    Chiral cyclen compounds and their uses 有权

    公开(公告)号：US11357873B2

    公开(公告)日：2022-06-14

    申请号：US16334464

    申请日：2017-06-23

    申请人： THE HONG KONG POLYTECHNIC UNIVERSITY

    发明人： Ga-Lai Law ,  Lixiong Dai

    IPC分类号： A61K51/00 ,  A61M36/14 ,  A61K51/04 ,  A61K51/08 ,  C07D257/02 ,  C07F5/00

    摘要： The present invention relates to the preparation of a series of chiral DOTA, DO3A, DO2A, DO1A, cyclen and their metal complexes, which display properties superior to those of previous DOTA-based compounds, and hence are potentially valuable as a platform for diagnostic applications. The chiral DOTAs reveal a high abundance of twisted square antiprism (TSA) geometry favoring them to be used as potential MRI contrast agents, whereas their rapid labelling properties at mild conditions make them excellent candidates for use as radiometal chelators.

    Bioreducible N-oxide-based probes for imaging of hypoxia
    22.
    发明授权
    Bioreducible N-oxide-based probes for imaging of hypoxia 有权

    公开(公告)号：US11292803B2

    公开(公告)日：2022-04-05

    申请号：US16545990

    申请日：2019-08-20

    申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

    发明人： Jefferson Chan ,  Hailey Knox

    IPC分类号： A61K51/00 ,  A61M36/14 ,  C07F5/02 ,  G01N21/64 ,  A61K49/00 ,  A61K49/22

    摘要： Hypoxia occurs when limited oxygen supply impairs physiological functions and is a pathological hallmark of many diseases including cancer and ischemia. Thus, detection of hypoxia can guide treatment planning and serve as a predictor of patient prognosis. Current methods suffer from invasiveness, poor resolution and low specificity. To address these limitations, various hypoxia-responsive probes (HyPs) for photoacoustic imaging are disclosed. The emerging modality converts safe, non-ionizing light to ultrasound waves, enabling acquisition of high-resolution 3D images in deep tissue. The HyPs feature an N-oxide trigger that is reduced in the absence of oxygen by haem proteins such as CYP450 enzymes. Reduction of HyPs produce a spectrally distinct product, facilitating identification via photoacoustic imaging. HyPs exhibit selectivity for hypoxic activation in vitro, in living cells and in multiple disease models in vivo. HyPs are also compatible with NIR fluorescence imaging, establishing its versatility as a multimodal imaging agent.

    Method for preparing tricarbonyl technetium-99m intermediate
    28.
    发明授权
    Method for preparing tricarbonyl technetium-99m intermediate 有权

    公开(公告)号：US10968245B2

    公开(公告)日：2021-04-06

    申请号：US16464919

    申请日：2016-12-28

    申请人： Institute of High Energy Physics, Chinese Academy of Sciences

    发明人： Wenjiang Yang ,  Yu Liu ,  Jingquan Xue ,  Yanhua Zhang

    IPC分类号： A61K51/00 ,  A61M36/14 ,  C07F17/00

    摘要： The invention provides a method for preparing a technetium-99m tricarbonyl intermediate. The method comprises reacting a manganese carbonyl compound used as a carbon monoxide source with pertechnetate and water to obtain the technetium-99m tricarbonyl intermediate. The method for preparing a technetium-99m tricarbonyl intermediate in an embodiment of the invention can complete the preparation of the intermediate at atmospheric pressure and room temperature. The method is easy to operate, uses easily obtained raw materials, has a high labeling yield, and can be used to prepare various types of technetium tricarbonyl labeled probes.

    2,11-diaza-[3.3](2,6)pyridinophane compounds and their application as ligands of essential metal ion based MRI contrast agents and 52MN based PET contrast agents
    29.
    发明授权
    2,11-diaza-[3.3](2,6)pyridinophane compounds and their application as ligands of essential metal ion based MRI contrast agents and 52MN based PET contrast agents 有权

    公开(公告)号：US10968224B2

    公开(公告)日：2021-04-06

    申请号：US15778489

    申请日：2016-11-25

    申请人： DEBRECENI EGYETEM

    发明人： Richárd Botár ,  Zoltán Garda ,  Tamás Fodor ,  Ferenc Krisztián Kálmán ,  Viktória Nagy ,  Gyula Tircsó ,  Imre Tóth

    IPC分类号： A61K51/00 ,  A61M36/14 ,  C07D471/18 ,  A61K51/04

    摘要： The one subject of the invention is the compounds of general formula (I), their isomers, their physiologically acceptable salts and/or Mn(II), Fe(II), Fe(III), Co(II) and Ni(II) complexes. The other subject of the invention is the application of the above compounds. The compounds of general formula (I): wherein —NRR1 group may refer to: a) —NRR1 with N atom in the ring means a ring of 4 to 7, that in certain cases may contain another heteroatom, and in specific cases the ring may be replaced with an aryl group (of 5 to 7 carbon atoms) substituted with —COOH, —OH, —OCH3, —NO2, —NH2, —NCS, —NHS-activated ester, aryl (of 5 to 7 carbon atoms), or nitro-, amino- or isothiocyanate group, or b) in the —NRR1 group R means a H atom, alkyl, aryl, nitroaryl, aminoaryl or isothiocyanate-aryl group (of 1 to 6 carbon atoms) and R4 is a H atom, alkyl (of 1 to 6 carbon atoms) or —(CH2)n—COOH group, whereas n=1 to 10 integer, or c) —NRR1 group is one of the following groups: (formula II) whereas R2 is a H atom, carboxyl- or alkyl-carbonyl group (of 1 to 4 carbon atoms); (formula III) and R2 is a H atom or alkyl or aryl group (of 1 to 6 carbon atoms), and X means independently from one another H atom, —CH3, —COOH, —OH, —OCH3, alkoxy- (of 2 to 6 carbon atoms), —NO2, —NH2, —NCS, —NHS-activated ester, alkyl (of 2 to 12 carbon atoms) or aryl (of 5 to 7 carbon atoms) group, in certain cases the latter may be substituted with hydroxyl, hydroxyalkyl (of 1 to 6 carbon atoms), nitro, amino or isothiocyanate group.