公开(公告)号：US20220310373A1

公开(公告)日：2022-09-29

申请号：US17620049

申请日：2020-06-17

申请人： Fluidigm Canada Inc.

发明人： Paul Corkum ,  Alexander Loboda ,  David M. Rayner

IPC分类号： H01J49/00 ,  H01J49/16 ,  H01J49/04 ,  G01N15/14

摘要： Embodiments of the present invention relate to replacement of the previous ICP-based ionisation system with a new laser ionisation system, providing improved mass spectrometer-based apparatus and methods for using them to analyse samples, in particular the use of mass spectrometry mass cytometry, imaging mass spectrometry and imaging mass cytometry, for the analysis of biological samples. Accordingly, embodiments of the present invention provide an apparatus, for example a mass cytometer, comprising: 1) a sampler; 2) a laser ionisation system to receive material removed from the sample by the sampler, wherein the laser ionisation system comprises an ionisation system conduit and a pulsed laser adapted to ionise sample material passing through or exiting the ionisation system conduit; and 3) a mass spectrometer to receive elemental ions from said ionisation system and to analyse said elemental ions.

公开(公告)号：US20220285142A1

公开(公告)日：2022-09-08

申请号：US17684056

申请日：2022-03-01

申请人： Bruker Daltonics GmbH & Co. KG

发明人： Andreas HAASE ,  Jens HÖHNDORF ,  Jens BOßMEYER

IPC分类号： H01J49/16 ,  H01J49/24

摘要： An apparatus to generate ions from sample material deposited on a substrate which is at least partially transparent to electromagnetic waves, comprises: —a support device having a holder for the substrate, —a desorption/ionization unit including a desorption device and an ionization device, said desorption device being configured to desorb deposited sample material from a desorption site on the substrate using at least one energy burst, and said ionization device being configured to irradiate the desorbed sample material above the substrate with electromagnetic waves after the at least one energy burst, wherein the electromagnetic waves pass through the substrate before encountering the desorbed sample material at a location which corresponds to the desorption site, and —an extraction device which is arranged and designed to extract ions from the desorbed sample material and transfer them into an analyzer. The invention also relates to a correspondingly arranged method.

公开(公告)号：US11430646B2

公开(公告)日：2022-08-30

申请号：US17089424

申请日：2020-11-04

申请人： Thermo Fisher Scientific (Bremen) GmbH

发明人： Aivaras Venckus ,  Hamish Stewart ,  Christian Albrecht Hock ,  Jan-Peter Hauschild

IPC分类号： H01J49/00 ,  H01J49/04 ,  G01N27/622 ,  H01J49/14 ,  H01J49/16 ,  H01J49/24 ,  H01J49/40 ,  H01J49/42

摘要： An interface for receiving ions in a carrier gas from an atmospheric pressure ion source at a spectrometer that is configured to analyse the received ions at a lower pressure includes an interface vacuum chamber having a downstream aperture; a support assembly defining an axial bore arranged to allow a removable capillary tube to extend therethrough; ions being received from the atmospheric pressure ion source through the capillary tube and directed towards the downstream aperture; and a jet disruptor, positioned downstream from the axial bore and configured to disrupt gas flow between the axial bore and the downstream aperture only when the capillary tube is not fully inserted through the axial bore.

公开(公告)号：US20220265172A1

公开(公告)日：2022-08-25

申请号：US17692613

申请日：2022-03-11

申请人： Purdue Research Foundation

发明人： Robert Graham Cooks ,  Zheng Ouyang ,  Chien-hsun Chen ,  Ziqing Lin ,  Livia Schiavinato Eberlin

IPC分类号： A61B5/1477 ,  A61B10/00 ,  H01J49/04 ,  A61M11/00 ,  A61M25/00 ,  H01J49/00 ,  H01J49/16 ,  H01J49/34 ,  G01N33/483

摘要： The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.

公开(公告)号：US11424116B2

公开(公告)日：2022-08-23

申请号：US17266246

申请日：2020-10-26

申请人： IonSense Inc.

发明人： Scott Oro ,  Brian D Musselman

IPC分类号： H01J49/16 ,  H01J49/14 ,  H01J49/42

摘要： In an embodiment of the present ambient ionization experiment, the abundance of background chemicals relative to ions of interest is decreased by pulsing the carrier gas used to generate the excited species directed at the sample. The excited species are stepwise directed at the sample reducing the overall abundance of background chemicals introduced into the ionizing region. In an embodiment of the present ambient ionization experiment, the combination of stepping the sample in front of the excited species and pulsing the carrier gas used to generate the excited species increases the sensitivity of detection.

公开(公告)号：US11420205B2

公开(公告)日：2022-08-23

申请号：US16772394

申请日：2018-12-05

申请人： INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION ,  THE TEXAS A&M UNIVERSITY SYSTEM

发明人： David E. Clemmer ,  Tarik J. El-Baba ,  Daniel R. Fuller ,  Daniel W. Woodall ,  David H. Russell ,  Evan R. Williams

IPC分类号： B01L3/00 ,  G01N33/68 ,  H01J49/16

摘要： An instrument for energizing molecules contained in a sample solution may include a droplet generator configured to generate droplets of the sample solution. The droplet generator illustratively has an elongated nozzle defining an orifice at one end thereof from which the droplets exit the droplet generator, and the orifice illustratively defines a first longitudinal axis centrally therethrough. A molecule energizing source is configured to produce a molecule energizing field, and is positioned relative to the nozzle orifice such that the molecule energizing field extends into at least some of the generated droplets along a direction non-parallel with the first longitudinal axis. The molecule energizing field illustratively carries energy which heats at least one of the generated droplets sufficiently to induce structural changes in at least one molecule contained in the at least one of the generated droplets.

公开(公告)号：US20220223399A1

公开(公告)日：2022-07-14

申请号：US17403033

申请日：2021-08-16

申请人： Frenny Kaushal ,  Gholamreza Javahery ,  Lisa Cousins ,  Charles Jolliffe

发明人： Frenny Kaushal ,  Gholamreza Javahery ,  Lisa Cousins ,  Charles Jolliffe

IPC分类号： H01J49/16 ,  H01J49/42 ,  H01J49/06

摘要： An ionizer includes a probe having multiple coaxially aligned conduits. The conduits may carry liquids, and nebulizing and heating gases at various flow rates and temperatures, for generation of ions from a liquid source. An outermost conduit defines an entrainment region that transports and entrains ions in a gas for a defined distance along the length of the conduits. In embodiments, various voltages may be applied to the multiple conduits to aid in ionization and to guide ions. Depending on the voltages applied to the multiple conduits and electrodes, the ionizer can act as an electrospray, APCI, or APPI source. Further, the ionizer may include a source of photons or a source of corona ionization. Formed ions may be provided to a downstream mass analyser.

公开(公告)号：US20220214307A1

公开(公告)日：2022-07-07

申请号：US17600489

申请日：2019-05-15

申请人： SHIMADZU CORPORATION

发明人： Shosei YAMAUCHI ,  Masaji FURUTA ,  Kosuke HOSOI

IPC分类号： G01N27/64 ,  H01J49/16 ,  H01J49/24

摘要： An ion analyzer 1 includes: an ionization chamber 10; an ionization unit 3 configured to generate ions from a sample 11 in the ionization chamber 10; an analysis chamber 20 separated from the ionization chamber 10 by a partition wall 21 in which an opening 211 is formed; an ion transport unit 22, 23, and 24 provided in the analysis chamber 20 and configured to transport the ions generated in the ionization unit; an ion trapping unit 25 provided in the analysis chamber 20 and configured to trap the ions transported by the ion transport unit 22, 23, and 24; an ion detection unit 26 provided in the analysis chamber 20 and configured to detect the ions released from the ion trapping unit 25; and a single evacuation mechanism 28 connected only to the analysis chamber 20 and configured to evacuate the analysis chamber 20 to a pressure of 103 Pa or less.

公开(公告)号：US11361954B2

公开(公告)日：2022-06-14

申请号：US16494973

申请日：2018-03-22

申请人： Purdue Research Foundation

发明人： Robert Graham Cooks

IPC分类号： H01J49/00 ,  H01J49/16

摘要： The invention generally relates to systems and methods for conducting reactions and screening for reaction products.

公开(公告)号：US11348776B2

公开(公告)日：2022-05-31

申请号：US17134571

申请日：2020-12-28

申请人： ASTA, CO. LTD.

发明人： Eung Joon Jo

IPC分类号： H01J49/40 ,  H01J49/00 ,  H01J49/16 ,  G01N33/49 ,  G01N33/483

摘要： A disease diagnostic system where a sample preparation unit and/or a matrix-assisted laser desorption/ionization time-of-flight mass spectrometer (MALDI-TOF MS) data generation unit may be integrated in one system or a set of a system to improve the user-friendliness of the system. The system may include a sample preparation unit with processing modules and/or a handler to move samples in an autonomous manner to enhance reproducibility of measurement data and/or user-friendliness. A different set of processing modules may be selected for a particular disease type (e.g. such as cancer) to be diagnosed. The system may be used to identify biomaterials such as bacteria, virus, and fungi from body fluids like blood, urine, and saliva and other cells.