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公开(公告)号：US20240125800A1
公开(公告)日：2024-04-18
申请号：US18270194
申请日：2021-12-29
Applicant: KANSAS STATE UNIVERSITY RESEARCH FOUNDATION , THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
Inventor： Stefan H. BOSSMANN , Obdulia COVARRUBIAS-ZAMBRANO , Sumia EHSAN , Kayla ESCHLIMAN , Massoud MOTAMEDI , Raul NERI , Jose COVARRUBIAS
IPC: G01N33/68 , G01N33/542 , G01N33/543
CPC classification number: G01N33/6893 , G01N33/542 , G01N33/5434 , G01N2333/96425 , G01N2333/966 , G01N2800/122
Abstract: Nanoparticle-based nanosensors comprising supramolecular recognition sequences, protease consensus sequences, post-translationally modifiable sequences, or sterically hindered benzylether bonds for specific interaction with a biological marker, and methods for rapid diagnosis of lung conditions using specified panels of target biomarkers.
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302.发明公开公开(公告)号：US20240122534A1
公开(公告)日：2024-04-18
申请号：US18393984
申请日：2023-12-22
Inventor： Rajiv CHOPRA , David GREENBERG , Yonatan CHATZINOFF
CPC classification number: A61B5/4851 , A61B5/0071 , A61B5/01 , A61B5/412 , A61B5/4528 , A61B5/4836 , A61B8/0841 , A61F2/30 , A61N1/025 , A61N1/378 , A61N1/40 , A61N1/403 , A61N1/406 , A61N2/02
Abstract: Methods, apparatuses, systems, and implementations for inductive heating of a foreign metallic implant are disclosed. A foreign metallic implant may be heated via AMF pulses to ensure that the surface of the foreign metallic implant heats in a uniform manner. As the surface temperature of the foreign metallic implant rises, acoustic signatures may be detected by acoustic sensors that may indicate that tissue may be heating to an undesirable level approaching a boiling point. Once these acoustic signatures are detected, the AMF pulses may be shut off for a time period to allow the surface temperature of the implant to cool before applying additional AMF pulses. In this manner, the surface temperature of a foreign metallic implant may be uniformly heated to a temperature adequate to treat bacterial biofilm buildup on the surface of the foreign metallic implant without damaging surrounding tissue. The AMF pulse treatment can be combined with an antibacterial/antimicrobial treatment regimen to reduce the time and/or antibacterial dosage amount needed to remove the biofilm from the metallic implant.
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公开(公告)号：US20240116859A1
公开(公告)日：2024-04-11
申请号：US18508192
申请日：2023-11-13
Inventor： Daniel J. SIEGWART , Kejin ZHOU
IPC: C07C321/14 , A61K9/51 , A61K31/7105 , A61K31/7125 , A61K47/20 , A61K47/22 , A61K47/59 , A61K47/60 , A61K47/69 , A61K48/00 , C07C323/52 , C07D295/15
CPC classification number: C07C321/14 , A61K9/513 , A61K9/5146 , A61K31/7105 , A61K31/7125 , A61K47/20 , A61K47/22 , A61K47/59 , A61K47/60 , A61K47/6931 , A61K48/0041 , C07C323/52 , C07D295/15
Abstract: Modular dendrimers with cationic groups and lipophilic groups are provided herein. In some aspects, the dendrimers provided herein may be formulated in compositions which contain a nucleic acid and one or more helper excipients. In some aspects, these compositions may also be used to treat diseases or disorders with a therapeutic nucleic acid.
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304.发明公开公开(公告)号：US20240087671A1
公开(公告)日：2024-03-14
申请号：US18505757
申请日：2023-11-09
Applicant: University of Central Florida Research Foundation, Inc. , The Board of Regents of the University of Texas System
Inventor： Degui Zhi , Shaojie Zhang , Ardalan Naseri , Ahsan Sanaullah , Erwin Holzhauser
Abstract: A system for indexing, updating, and search haplotypes for genetic genealogical discovery in genotype databases. The system includes a pool of genetic indexes, a haplotype ingestion engine, and a haplotype query engine. The haplotypes of a number of individuals in a genotype database are indexed by a pool of multiple panels, and each panel pool can be dynamically updated by the insertion or deletion of individual haplotypes. A genetic genealogical search of a query haplotype against the database is achieved by first projecting the query onto a subset of panels in the pool, then conducting long match queries over each panel, and finally aggregating the identified long matches into Identical-by-Descent segments, i.e., DNA matches, between the query and the haplotypes in the database.
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公开(公告)号：US20240058470A1
公开(公告)日：2024-02-22
申请号：US18248862
申请日：2021-10-13
Inventor： JACQUES LUX , SINA KHORSANDI , CAROLINE DE GRACIA LUX , ROBERT F. MATTREY
CPC classification number: A61K47/6925 , A61K41/0028
Abstract: Spermine-decorated microbubbles and methods of making the same as well as methods for using spermine-decorated microbubbles for drug delivery are described.
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Patent Agency Ranking
公开(公告)号：US20240050047A1
公开(公告)日：2024-02-15
申请号：US18269859
申请日：2020-12-31
Inventor： Yiping SHAO , Yuncheng ZHONG , Xinyi CHENG
CPC classification number: A61B6/037 , A61B6/12 , A61B6/542 , A61B6/4208
Abstract: Disclosed embodiments include devices, systems, and methods for real time marker less tumor tracking (RMTT). In various embodiments, the RMTT embodiments use positron emission tomography (PET) and time of flight data to determine a 3D position of the tumor. The 3D position of the tumor may be continuously determined multiple times per section during a radiation therapy session to track the position of a moving tumor in real time. The real time tumor tracking data may be used to position a radiation source to deliver radiation directly to the tumor at all times during radiation therapy to improve the effectiveness of radiation treatments.
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公开(公告)号：US20240043838A1
公开(公告)日：2024-02-08
申请号：US18265226
申请日：2021-12-02
Inventor： Bruce Beutler , Evan D. Nair-Gill
IPC: C12N15/113 , A61K45/06 , A61P37/06
CPC classification number: C12N15/113 , A61K45/06 , A61P37/06
Abstract: Compositions and methods for attenuating or preventing lymphoproliferation in a subject are provided. The subject may have, be suspected of having, or at risk of having a lymphoproliferative disease. The methods herein include administering to the subject a composition effective for decreasing WD repeat domain protein 37 (Wdr37) expression and/or activity.
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公开(公告)号：US20240035091A1
公开(公告)日：2024-02-01
申请号：US18265571
申请日：2021-12-08
Inventor： Yang XIE , Guanghua XIAO
IPC: C12Q1/6886 , G16B25/10 , G16H20/10 , G16H50/30
CPC classification number: C12Q1/6886 , G16B25/10 , G16H20/10 , G16H50/30 , C12Q2600/118 , C12Q2600/158 , C12Q2600/106
Abstract: Provided herein is a 7-genes signature, an algorithm to evaluate a patient's risk score, and methods of use thereof. The methods provided herein include methods of use of a risk score to predict lung cancer patient survival and lung cancer patient likelihood to respond to adjuvant chemotherapy.
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公开(公告)号：US11865157B2
公开(公告)日：2024-01-09
申请号：US18157648
申请日：2023-01-20
Inventor： Damith Gomika Udugamasooriya , Aaron Raymond , John Minna
Abstract: Described herein are pharmaceutical compositions containing peptoids of general formula (I), (II), or (III) capable of reducing proliferation of cancer stem cells in a subject and methods of treatment or prophylactic administration of these pharmaceutical compositions to treat cancer. Also provided herein are method of detecting and treating cancerous cell masses by use of peptoids of general formula (I), (II), or (III).
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公开(公告)号：US11864911B2
公开(公告)日：2024-01-09
申请号：US17992050
申请日：2022-11-22
Inventor： Rajiv Chopra , David Greenberg , Yonatan Chatzinoff
CPC classification number: A61B5/4851 , A61B5/0071 , A61B5/01 , A61B5/412 , A61B5/4528 , A61B5/4836 , A61B8/0841 , A61F2/30 , A61N1/025 , A61N1/378 , A61N1/40 , A61N1/403 , A61N1/406 , A61F2002/30668 , A61F2002/30719 , A61F2002/30932 , A61N2/02
Abstract: Methods, apparatuses, systems, and implementations for inductive heating of a foreign metallic implant are disclosed. A foreign metallic implant may be heated via AMF pulses to ensure that the surface of the foreign metallic implant heats in a uniform manner. As the surface temperature of the foreign metallic implant rises, acoustic signatures may be detected by acoustic sensors that may indicate that tissue may be heating to an undesirable level approaching a boiling point. Once these acoustic signatures are detected, the AMF pulses may be shut off for a time period to allow the surface temperature of the implant to cool before applying additional AMF pulses. In this manner, the surface temperature of a foreign metallic implant may be uniformly heated to a temperature adequate to treat bacterial biofilm buildup on the surface of the foreign metallic implant without damaging surrounding tissue. The AMF pulse treatment can be combined with an antibacterial/antimicrobial treatment regimen to reduce the time and/or antibacterial dosage amount needed to remove the biofilm from the metallic implant.
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