公开(公告)号：US09205198B2

公开(公告)日：2015-12-08

申请号：US13743661

申请日：2013-01-17

Applicant: Daniel Py

Inventor： Daniel Py

IPC: A61M5/315 ,  A61M5/178 ,  A61J7/00 ,  B05B11/00 ,  B65D83/14 ,  G01F11/02 ,  A61M5/31 ,  A61M5/20

CPC classification number: A61M5/31593 ,  A61J7/0053 ,  A61M5/1782 ,  A61M5/204 ,  A61M2005/3126 ,  A61M2005/3128 ,  B05B9/0426 ,  B05B11/00416 ,  B05B11/007 ,  B05B11/0072 ,  B05B11/3015 ,  B05B11/3028 ,  B05B11/3064 ,  B05B11/3077 ,  B65D83/7535 ,  G01F11/02 ,  G01F11/025 ,  G01F11/027 ,  G01F11/028

Abstract: A multiple dose syringe has a first valve defining a first valve opening pressure and a second valve defining a second valve opening pressure. A storage chamber in fluid communication with the second valve stores multiple doses of a substance therein and includes an outlet for dispensing multiple doses of the stored substance therethrough. A compression surface is movable between first and second positions and defines a compression chamber between the compression surface and the first valve. Movement of the compression surface in a direction from the first position toward the second position dispenses substance in the compression chamber through the first valve and out of the syringe. Movement of the compression surface in a direction from the second position toward the first position causes substance to flow from the storage chamber through the second valve and into the compression chamber.

Abstract translation: 多剂量注射器具有限定第一阀开启压力的第一阀和限定第二阀开启压力的第二阀。 与第二阀流体连通的储存室在其中存储多种剂量的物质，并且包括用于通过其分配多剂量的储存物质的出口。 压缩表面可在第一和第二位置之间移动，并且在压缩表面和第一阀之间限定压缩室。 压缩表面在从第一位置朝向第二位置的方向上的运动通过第一阀和注射器分配压缩室中的物质。 压缩表面在从第二位置朝向第一位置的方向上的移动使得物质从存储室通过第二阀流入压缩室。

公开(公告)号：US09102097B2

公开(公告)日：2015-08-11

申请号：US13396053

申请日：2012-02-14

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65B3/00 ,  B65B7/28 ,  B29C67/00 ,  B29C45/00 ,  B29C45/17 ,  B29C65/00 ,  B65B3/02 ,  B65B55/06 ,  B29L31/56 ,  B29C45/42

CPC classification number: B29C67/004 ,  B29C45/006 ,  B29C45/1701 ,  B29C45/42 ,  B29C65/16 ,  B29C65/1616 ,  B29C66/001 ,  B29C66/0018 ,  B29C66/71 ,  B29C66/91212 ,  B29C66/91216 ,  B29C66/91221 ,  B29C66/91411 ,  B29C66/91431 ,  B29C66/961 ,  B29C2791/005 ,  B29L2031/565 ,  B65B3/003 ,  B65B3/022 ,  B65B55/06 ,  B29C65/00 ,  B29K2023/38

Abstract: A stopper and container body are molded in the same molding machine. An assembly device, such as a pick and place robot, transfers the stopper from one mold cavity into the opening in the container body located within another mold cavity, or vice versa, to assemble the stopper and container body. Then, the assembled container body and stopper are removed from the molding machine and transported to a needle filling and laser resealing station for filling and laser resealing. A laminar flow source directs a substantially laminar flow of air or sterile gas over the mold surfaces, stoppers and container bodies, and assembly device, to prevent contamination during assembly.

Abstract translation: 塞子和容器主体在相同的成型机中成型。 诸如拾放机器人的组装装置将止动器从一个模腔转移到位于另一个模腔内的容器主体中的开口中，反之亦然，以组装止动器和容器主体。 然后，将组装的容器主体和止动件从成型机中取出并输送到针填充和激光重新密封站，用于填充和激光重新密封。 层流源将空气或无菌气体的基本层流引导到模具表面，塞子和容器主体以及组装装置上，以防止组装过程中的污染。

公开(公告)号：US08960242B2

公开(公告)日：2015-02-24

申请号：US13193662

申请日：2011-07-29

Applicant: Daniel Py ,  Norbert M. Assion

Inventor： Daniel Py ,  Norbert M. Assion

IPC: B65B1/20 ,  B65D39/00 ,  B65D51/16 ,  A61B19/00 ,  B65B3/00 ,  A61J1/14 ,  A61J1/18 ,  B65B7/16 ,  B65D51/00 ,  A61J1/20

CPC classification number: B65B3/003 ,  A61J1/1406 ,  A61J1/1412 ,  A61J1/1425 ,  A61J1/1431 ,  A61J1/1468 ,  A61J1/18 ,  A61J1/201 ,  A61J1/2013 ,  A61J1/2055 ,  A61J1/2075 ,  A61J1/2096 ,  A61M2207/00 ,  A61M2209/045 ,  B65B3/027 ,  B65B7/161 ,  B65B51/10 ,  B65B55/08 ,  B65B2039/009 ,  B65D51/002

Abstract: A container and method for filling same. The container includes a penetrable and resealable portion that is resealable, and a container body having a sealed empty chamber in fluid communication with the penetrable and resealable portion for receiving therein a substance. The container also includes a base, a mid-portion, and an upper portion axially spaced from the base on an opposite side of the mid-portion relative to the base. Each of the base and upper portion define a laterally-extending dimension greater than a maximum laterally-extending dimension of the mid-portion. The method of filling the container includes penetrating the penetrable and resealable portion with an injection member and introducing a substance into the chamber, withdrawing the injection member while engaging the base of the body to substantially prevent upward movement of the body, and applying energy to the penetrable and resealable portion to form a gas-tight seal.

Abstract translation: 一种容器及其填充方法。 容器包括可重复密封的可穿透和可重新密封的部分，以及容器主体，其具有与可穿透和可再密封部分流体连通的密封空腔，用于在其中容纳物质。 容器还包括基部，中间部分和与基部相对于基部在中间部分的相对侧上轴向间隔开的上部。 基部和上部中的每一个限定大于中间部分的最大横向延伸尺寸的横向延伸的尺寸。 填充容器的方法包括用注射构件穿透可穿透和可重新密封的部分并将物质引入腔室中，同时接合身体的基部以基本上防止身体的向上运动并且将能量施加到 可渗透和可重新密封的部分以形成气密密封。

公开(公告)号：US08671964B2

公开(公告)日：2014-03-18

申请号：US13080537

申请日：2011-04-05

Applicant: Daniel Py

Inventor： Daniel Py

IPC: F16L37/28

CPC classification number: F16L41/02 ,  A61M39/18 ,  A61M39/26 ,  A61M2039/267 ,  Y10T29/49826 ,  Y10T137/0318 ,  Y10T137/87925 ,  Y10T137/87949 ,  Y10T137/87957

Abstract: An aseptic fluid connector having a first connector including a first fluid passageway for receiving a fluid therein; a first port in fluid communication with the first fluid passageway for passage of the fluid therethrough; and a first deflecting member. The first deflecting member includes a first engaging portion radially spaced relative to the first port, and a first valve movable between a closed position and an open position with movement of the first engaging portion between a non-deflected position and a deflected position, respectively. In the non-deflected position, the first valve is located in the closed position forming a fluid-tight seal between the first valve and first port and preventing the passage of fluid therethrough, and in the deflected position, the first valve is located in the open position allowing the aseptic passage of fluid through the first port.

Abstract translation: 一种无菌流体连接器，其具有包括用于在其中接收流体的第一流体通道的第一连接器; 与第一流体通道流体连通以使流体通过其中的第一端口; 和第一偏转构件。 第一偏转构件包括相对于第一端口径向间隔开的第一接合部分，以及在关闭位置和打开位置之间可移动的第一阀，其中第一接合部分分别在非偏转位置和偏转位置之间移动。 在非偏转位置，第一阀位于关闭位置，在第一阀和第一端口之间形成流体密封并防止流体通过，并且在偏转位置，第一阀位于 打开位置允许流体通过第一端口的无菌通道。

公开(公告)号：US20130298504A1

公开(公告)日：2013-11-14

申请号：US13686863

申请日：2012-11-27

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65B55/02

CPC classification number: B65B31/024 ,  A61L2/04 ,  A61L2/081 ,  A61L2/087 ,  A61L2/26 ,  A61L2202/122 ,  A61L2202/182 ,  B65B5/045 ,  B65B7/02 ,  B65B55/02 ,  B65B55/08 ,  B65B55/16 ,  B65B69/0033 ,  B65B69/0066

Abstract: A sterile enclosure contains a transfer module defining a window. A port covers the window to maintain the inside of the enclosure as a sealed and sterile environment. A sliding, heated cutting element mounted on the port serves to sterilize and sever a portion of a sterile transfer bag assembly attached to the port. Preferably, the excised portion of the sterile transfer bag assembly is affixed to the port when the port opens. The sliding cutting element remains extended and heated to prevent contamination when the port is open. Further, a heating element is mounted about the window in order to sterilize around the opening when the port is open.

公开(公告)号：US08573421B2

公开(公告)日：2013-11-05

申请号：US12259290

申请日：2008-10-27

Applicant: Daniel Py ,  Julian Chan ,  Jeffrey Willey

Inventor： Daniel Py ,  Julian Chan ,  Jeffrey Willey

IPC: A61J9/00 ,  A61J9/08

CPC classification number: B65D47/36 ,  A61J1/202 ,  A61J9/00 ,  A61J9/008 ,  A61J11/04 ,  B65B3/04 ,  B65D47/063 ,  B65D47/265 ,  B65D47/32 ,  B65D51/002

Abstract: A container including a body defining an outflow opening and at least one chamber adapted for storing a product, such as a fat containing liquid product, and a container closure including a primary seal for hermetically sealing the product within the chamber during storage. The container closure includes a sealing member forming a substantially fluid-tight seal between the container closure and the body, and a dispensing member in fluid communication with the chamber. The container closure and body move relative to each other between a first position where the primary seal is seated about the outflow port to hermetically seal the product in the chamber during storage, and a second position where the primary seal is displaced from the outflow port to allow product to pass from the chamber through the outflow port and into dispensing member to dispense the product.

Abstract translation: 一种容器，其包括限定流出开口的主体和适于储存产品（例如含脂肪的液体产品）的至少一个室，以及包含用于在储存期间气密地密封室内的产品的主密封件的容器盖。 容器封闭件包括在容器封闭件和主体之间形成基本上流体密封的密封件和与腔室流体连通的分配构件的密封构件。 容器封闭件和主体在第一位置和第二位置之间移动，第一位置和第二位置之间，第一位置处主要密封件围绕流出端口安置，以便在存储期间将产品气密地密封在腔室中;以及第二位置，其中主密封件从流出端口移位到 允许产品从腔室通过流出口并进入分配构件以分配产品。

公开(公告)号：US08550799B2

公开(公告)日：2013-10-08

申请号：US13311616

申请日：2011-12-06

Applicant: Daniel Py ,  Benoit Adamo ,  John Guthy ,  Nathaniel Houle ,  Giovanni Rodriguez

Inventor： Daniel Py ,  Benoit Adamo ,  John Guthy ,  Nathaniel Houle ,  Giovanni Rodriguez

IPC: B29C45/17 ,  B29C45/44

CPC classification number: B29C45/1701 ,  B29C37/0007 ,  B29C45/006 ,  B29C45/1753 ,  B29C45/40 ,  B29C45/42 ,  B29C2045/1797 ,  B29C2791/005

Abstract: At least one of first and second mold portions defines a mold cavity to receive molten plastic and form therefrom at least one molded part, and is movable relative to the other between (i) a closed position for sealing the mold cavity or cavities and molding at least one part therein, and (ii) an open position defining a fluid passageway between the mold portions and permitting the passage of a fluid sterilant therein. A fluid sterilant source is connectable in fluid communication with the fluid passageway for introducing the sterilant therein in the open position, contacting with the sterilant the surfaces of the first and second mold portions forming the fluid passageway and located adjacent to the at least one mold cavity, but not contacting an interior surface of a molded part within the mold cavity, to sterilize the exposed mold surfaces and thereby prevent contamination of the molded part.

Abstract translation: 第一和第二模具部分中的至少一个限定了模腔以接收熔融塑料并从其形成至少一个模制部件，并且可以在（i）用于密封模腔或空腔的闭合位置和相对于另一模制部件 其中至少一部分，以及（ii）在模具部分之间限定流体通道并允许其中的流体灭菌剂通过的打开位置。 流体灭菌剂源可连接到流体通道，用于将灭菌剂在其中引入打开位置，与杀菌剂接触，形成第一和第二模具部分的形成流体通道的表面并且邻近于至少一个模腔 但是不与模腔内的模制部件的内表面接触，对暴露的模具表面进行消毒，从而防止模制部件的污染。

公开(公告)号：US08448674B2

公开(公告)日：2013-05-28

申请号：US13045655

申请日：2011-03-11

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65B1/20

CPC classification number: B65B3/04 ,  A61L2/08 ,  A61L2/087 ,  A61L2/24 ,  A61L2202/14 ,  B65B3/003 ,  B65B7/16 ,  B65B7/161 ,  B65B55/025 ,  B65B55/08 ,  B65B55/16

Abstract: A sterile filling machine and related method are provided for sterile filling a container with a substance. The container includes a resealable stopper or portion and a chamber for receiving the substance therein. The sealed, empty containers are subjected to radiation capable of penetrating through the resealable portion and chamber for sterilizing the container. The previously sterilized containers are then transported through another sterilizing chamber, such as an e-beam chamber, to sterilize the penetrable surface. A filling member is moved into engagement with the resealable portion to pierce the sterilized penetrable surface of the resealable portion and inject the substance through the filling member and into the chamber of the container. Energy is then transmitted onto the stopper to hermetically re-seal the penetration in the resealable portion.

Abstract translation: 提供了一种无菌灌装机及相关方法，用于无菌填充具有物质的容器。 容器包括可重新密封的塞子或部分和用于在其中接收物质的室。 密封的空容器经受能够穿透可再密封部分和室的辐射以对容器进行灭菌。 先前灭菌的容器然后通过另一个灭菌室，如电子束室输送，以对可穿透表面进行消毒。 填充构件被移动成与可再密封部分接合以刺穿可再密封部分的消毒的可穿透表面，并且将物质通过填充构件注入到容器的室中。 然后将能量传递到塞子上以气密地重新密封可再密封部分中的穿透。

公开(公告)号：US08413854B2

公开(公告)日：2013-04-09

申请号：US13027401

申请日：2011-02-15

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65D88/54

CPC classification number: G01F11/021 ,  B05B11/3001 ,  B05B11/3015 ,  B05B11/3032 ,  B05B11/3047 ,  B05B11/3074 ,  B65D47/2031 ,  B65D83/00 ,  B65D83/0033 ,  B65D83/0072 ,  G01F11/02

Abstract: A dispenser has a housing, and a variable-volume storage chamber formed within the housing and defining a substantially fluid-tight seal between the chamber and exterior of the housing for storing a substance to be dispensed. A piston is mounted within the housing, and a one-way valve is mounted within the housing and coupled in fluid communication with the variable-volume storage chamber. A compression chamber is coupled in fluid communication between the piston and one-way valve, and at least one of the piston and valve is manually depressible relative to the other between (i) a first position in which the piston is located at least partially outside of the compression chamber for permitting substance to flow from the variable-volume storage chamber into the compression chamber, and (ii) a second position in which the piston is located at least partially within the compression chamber for pressurizing substance within the compression chamber above a valve opening pressure and, in turn, dispensing substance through the one-way valve and out of the dispenser.

Abstract translation: 分配器具有壳体和形成在壳体内的可变容积的储存室，并且在壳体的室和外部之间限定基本上流体密封的密封，用于存储待分配的物质。 活塞安装在壳体内，并且单向阀安装在壳体内并且与可变容积存储室流体连通地联接。 压缩室在活塞和单向阀之间流体连通地联接，并且活塞和阀门中的至少一个在第一位置之间相对于另一个手动地相对地被压下，其中活塞位于至少部分外部 的压缩室，用于允许物质从可变容积的储存室流入压缩室，以及（ii）第二位置，其中活塞至少部分地位于压缩室内，用于将压缩室内的物质加压在压缩室的上方 打开阀门的压力，并通过单向阀分配物质并从分配器中分出物质。

公开(公告)号：US08376003B2

公开(公告)日：2013-02-19

申请号：US12861354

申请日：2010-08-23

Applicant: Daniel Py ,  Benoit Adamo ,  John Guthy ,  Nathaniel Houle ,  Brian Tulley ,  Jeffrey Willey

Inventor： Daniel Py ,  Benoit Adamo ,  John Guthy ,  Nathaniel Houle ,  Brian Tulley ,  Jeffrey Willey

IPC: B65B3/04 ,  A61J9/00

CPC classification number: A61J11/0005 ,  A61J1/1406 ,  A61J9/003 ,  A61J11/04 ,  B65D51/002

Abstract: A container is provided for storing a product, such as a fat containing liquid product, and includes a body defining a chamber for receiving the product; and a container closure including a sealing portion for sealing the product within the chamber. The container closure includes a member forming a substantially fluid-tight seal between the container closure and the body; a nipple in fluid communication with the chamber that seals the chamber with respect to the ambient atmosphere during storage of the product in the chamber and that can be opened to dispense product from the chamber therethrough; and a needle penetrable and laser resealable portion that is penetrable by the needle for aseptically filling the chamber with the product, and that is thermally resealable by the application of laser radiation thereto to seal the product within the chamber.

Abstract translation: 提供容器用于储存诸如含脂肪的液体产品的产品，并且包括限定用于容纳产品的室的主体; 以及容器封闭件，其包括用于密封腔室内的产品的密封部分。 容器封闭件包括在容器封闭件和主体之间形成基本上流体密封的密封件; 与腔室流体连通的乳头，其在产品在腔室中储存期间相对于环境大气密封腔室，并且可以打开以从腔室通过其分配产品; 以及针可穿透和可激光重新密封的部分，其可由针穿透，用于用产品无菌填充腔室，并且通过施加激光辐射可热再密封以密封腔室内的产品。