公开(公告)号：US20100036795A1

公开(公告)日：2010-02-11

申请号：US12083282

申请日：2006-10-11

Applicant: Kenneth W. Busch ,  Christopher B. Davis ,  Marianna Busch

Inventor： Kenneth W. Busch ,  Christopher B. Davis ,  Marianna Busch

IPC: G06F17/10

CPC classification number: G01N21/359 ,  G01N21/3563 ,  G01N2201/129

Abstract: A method for classifying textile samples and unknown fabrics into known categories using spectroscopy, chemometric modeling, and soft independent modeling of class analogies (“SIMCA”). The method involves collecting spectral data, preferably diffuse near infrared reflectance data, for a library of known fabric samples, creating a database of principal component analyses for each type of fabric, and using SIMCA to classify an unknown fabric sample according to the database.

Abstract translation: 使用光谱学，化学计量建模和类别类软件（“SIMCA”）的软独立建模将纺织品样品和未知织物分类成已知类别的方法。 该方法包括收集已知织物样品库的光谱数据，优选扩散近红外反射率数据，为每种类型的织物创建主成分分析数据库，并使用SIMCA根据数据库对未知织物样品进行分类。

公开(公告)号：US20100033717A1

公开(公告)日：2010-02-11

申请号：US12537671

申请日：2009-08-07

Applicant: Janice Panza ,  John Maier

Inventor： Janice Panza ,  John Maier

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01N21/65 ,  G01N2201/129

Abstract: A system and method of determining an attribute of a biological tissue sample or a drug delivery device. A sample is illuminated with substantially monochromatic light to thereby generate Raman scattered photons. The Raman scattered photons are assessed to thereby generate a spectroscopic data set wherein said spectroscopic data set comprises at least one of: a Raman spectra and a spatially accurate wavelength resolved image. Tile spectroscopic data set is evaluated to determine at least one of: an attribute of a biological tissue sample and a drug delivery device. In one embodiment, the biological tissue comprises arterial tissue. In another embodiment, the drug delivery device is a drug-eluting stent. In another embodiment, Raman chemical imaging can be used to evaluate a sample and identify at least one of: the tissue, a drug, a drug delivery device, and a matrix associated with a drug delivery device.

Abstract translation: 一种确定生物组织样品或药物递送装置的属性的系统和方法。 用基本单色光照射样品，从而产生拉曼散射光子。 评估拉曼散射光子，从而产生光谱数据集，其中所述光谱数据集包括拉曼光谱和空间上准确的波长分辨图像中的至少一个。 评估平铺光谱数据集以确定生物组织样品和药物递送装置的属性中的至少一个。 在一个实施方案中，生物组织包含动脉组织。 在另一个实施方案中，药物递送装置是药物洗脱支架。 在另一个实施方案中，拉曼化学成像可用于评估样品并鉴定组织，药物，药物递送装置和与药物递送装置相关联的基质中的至少一种。

公开(公告)号：US20100014069A1

公开(公告)日：2010-01-21

申请号：US12443849

申请日：2007-10-04

Applicant: Yoshimasa Miura ,  Masayuki Shirao ,  Takuya Saiwaki ,  Takashi Ohmori

Inventor： Yoshimasa Miura ,  Masayuki Shirao ,  Takuya Saiwaki ,  Takashi Ohmori

IPC: G01J3/00

CPC classification number: G01N21/33 ,  G01N2201/129

Abstract: A first step of measuring a change over time in the spectral transmission spectrum of a measurement sample by its exposure to the light of a light source including an ultraviolet radiation for a preset light exposure time, a second step of performing a correction according to the change over time in the spectral transmission spectrum of the measurement sample based on the result of the measurement obtained by the first step, and a third step of calculating the final in vitro predicted SPF of the measurement sample using the result of the correction obtained by the second step are included.

Abstract translation: 第一步骤，通过对包含紫外线的光源的光的曝光来测量测量样本的光谱透射光谱随时间的变化，以达到预设的曝光时间;第二步骤，根据变化执行校正 基于由第一步骤获得的测量结果在测量样本的光谱透射光谱中随时间推移的第三步骤，以及使用由第二步获得的校正结果计算测量样品的最终体外预测SPF的第三步骤 包括步骤。

公开(公告)号：US20100010325A1

公开(公告)日：2010-01-14

申请号：US12562050

申请日：2009-09-17

Applicant: Trent Ridder ,  Ben ver Steeg ,  James McNally ,  John Maynard ,  Russell Abbink ,  Mike Mills ,  Bentley Laaksonen

Inventor： Trent Ridder ,  Ben ver Steeg ,  James McNally ,  John Maynard ,  Russell Abbink ,  Mike Mills ,  Bentley Laaksonen

IPC: A61B5/1455 ,  A61B5/117 ,  G06F7/04

CPC classification number: A61B5/4845 ,  A61B5/0075 ,  A61B5/0088 ,  A61B5/117 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/6826 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/0229 ,  G01J3/0291 ,  G01J3/14 ,  G01J2003/1286 ,  G01N21/274 ,  G01N21/359 ,  G01N21/474 ,  G01N2201/129

Abstract: An apparatus and method for noninvasive determination of analyte properties of human tissue by quantitative infrared spectroscopy to clinically relevant levels of precision and accuracy. The system includes subsystems optimized to contend with the complexities of the tissue spectrum, high signal-to-noise ratio and photometric accuracy requirements, tissue sampling errors, calibration maintenance problems, and calibration transfer problems. The subsystems can include an illumination/modulation subsystem, a tissue sampling subsystem, a data acquisition subsystem, a computing subsystem, and a calibration subsystem. The invention can provide analyte property determination and identity determination or verification from the same spectroscopic information, making unauthorized use or misleading results less likely than in systems that use separate analyte and identity determinations. The invention can be used to control and monitor individuals accessing controlled environments.

Abstract translation: 一种用于通过定量红外光谱法非临床确定人体组织的分析物质的临床相关水平的精确度和准确度的装置和方法。 该系统包括优化的子系统，以应对组织光谱的复杂性，高信噪比和光度精度要求，组织采样误差，校准维护问题和校准转移问题。 子系统可以包括照明/调制子系统，组织采样子系统，数据采集子系统，计算子系统和校准子系统。 本发明可以提供来自相同光谱信息的分析物质性质确定和鉴别确定或验证，使得未经授权的使用或误导结果比使用单独的分析物和身份确定的系统更不可能。 本发明可用于控制和监视访问受控环境的个人。

公开(公告)号：US20090321648A1

公开(公告)日：2009-12-31

申请号：US12164025

申请日：2008-06-28

Applicant: Paul Shelley ,  Greg Werner

Inventor： Paul Shelley ,  Greg Werner

IPC: G01N21/35

CPC classification number: G01N21/3563 ,  G01N21/278 ,  G01N2021/8472 ,  G01N2201/0221 ,  G01N2201/129

Abstract: A method of non-destructively determining the physical property of a material surface, the method including irradiating a surface with infrared energy over a spectrum of wavelengths; detecting said infrared energy reflected from said surface over said spectrum of wavelengths; performing multivariate calibration of said reflected infrared energy at a plurality of selected wavelengths including said spectrum of wavelengths; using results of said multivariate calibration to predict one or more physical properties of said model material; and, determining said one or more physical properties of said surface. Details are included for the case where uni-directional fiber CFRP materials are to be calibrated and predicted because special care must be taken for that material to insure the incident light from the spectrometer is at the proper orientation for calibration and for prediction of samples in question.

Abstract translation: 一种非破坏性地确定材料表面的物理性质的方法，所述方法包括在波长范围上用红外能量照射表面; 检测在所述波长波长上从所述表面反射的所述红外能量; 在包括所述波长光谱的多个选定波长下执行所述反射的红外能量的多变量校准; 使用所述多变量校准的结果来预测所述模型材料的一种或多种物理性质; 以及确定所述表面的所述一种或多种物理性质。 包括对于单向纤维CFRP材料进行校准和预测的情况的细节，因为必须特别注意该材料以确保来自光谱仪的入射光处于正确的校准方向并用于预测样品的问题 。

公开(公告)号：US20090321647A1

公开(公告)日：2009-12-31

申请号：US12164026

申请日：2008-06-28

Applicant: Paul H. Shelley ,  Greg J. Werner ,  Diane R. LaRiviere ,  Gwen M. Gross

Inventor： Paul H. Shelley ,  Greg J. Werner ,  Diane R. LaRiviere ,  Gwen M. Gross

IPC: G01J5/02

CPC classification number: G01N21/3563 ,  G01N21/55 ,  G01N21/84 ,  G01N2021/8472 ,  G01N2201/0221 ,  G01N2201/129 ,  G01N2201/1293

Abstract: A method of non-destructively determining the amount of ultraviolet degradation of a surface and/or paint adhesion characteristics of the surface corresponding with UV damage including determining a physical property of a composite material/surfacing film by providing a series of composite materials/surfacing films which are subjected to increasing UV light experience to create a set of UV damage standards, collecting mid-IR spectra on those standards, performing data pre-processing and then multivariate calibration on the spectra of the composite materials/surfacing films, and using that calibration to predict the UV damage for samples in question.

Abstract translation: 一种非破坏性地确定表面的紫外线降解量和/或与UV损伤相对应的表面的涂料粘附特性的方法，包括通过提供一系列复合材料/表面膜来确定复合材料/表面膜的物理性能 它们经受增加的紫外线经验以产生一组UV损伤标准，在这些标准上收集中红外光谱，对复合材料/表面膜的光谱进行数据预处理，然后对多光谱进行多变量校准，并使用该校准 以预测有问题的样品的紫外线损伤。

公开(公告)号：US20090101843A1

公开(公告)日：2009-04-23

申请号：US11541935

申请日：2006-10-02

Applicant: Philip D. Henshaw ,  Pierre C. Trepagnier

Inventor： Philip D. Henshaw ,  Pierre C. Trepagnier

IPC: H05B33/00 ,  G01J3/00

CPC classification number: G01J3/28 ,  G01J3/44 ,  G01N21/6408 ,  G01N2021/6417 ,  G01N2021/6421 ,  G01N2201/129

Abstract: The present invention generally provides systems and methods for detection of agents of interest in a bulk quantity of matter, which also contains clutter and other constituents that typically interfere with the detection of one or more agents of interest. A detection system of the invention generally contains a collection subsystem for obtaining a bulk sample, an interrogation subsystem for generating one or more analytical signals representative of the composition of the bulk sample, and an analytical subsystem according to the teachings of the invention that implements the methods and algorithms of the invention for analyzing the sample analytical signals to determine whether one or more agents of interest are present, e.g., at quantities above a certain threshold, in the bulk sample.

Abstract translation: 本发明通常提供用于检测大量物质中感兴趣的试剂的系统和方法，其还含有通常干扰一种或多种感兴趣的试剂的检测的杂波和其它成分。 本发明的检测系统通常包含用于获得批量样品的收集子系统，用于产生表示大体积样品的组成的一个或多个分析信号的询问子系统，以及根据本发明教导的分析子系统， 本发明的方法和算法用于分析样本分析信号，以确定在批量样本中是否存在一种或多种感兴趣的试剂，例如高于某一阈值的量。

公开(公告)号：US07460895B2

公开(公告)日：2008-12-02

申请号：US11042817

申请日：2005-01-24

Applicant: Mark A. Arnold ,  Jonathon T. Olesberg

Inventor： Mark A. Arnold ,  Jonathon T. Olesberg

IPC: A61B5/1455 ,  G01J3/00 ,  G12B13/00

CPC classification number: G01N21/35 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1495 ,  A61B2560/0223 ,  G01N21/1702 ,  G01N21/274 ,  G01N21/4738 ,  G01N21/552 ,  G01N2021/3595 ,  G01N2201/129

Abstract: A method for generating a net analyte signal calibration model for use in detecting and/or quantifying the amount of an analyte in a test subject. The net analyte signal can be generated by providing a set of in vivo infrared spectra for a test subject during a period in which an analyte concentration is essentially constant; calculating an optimal subspace of spectra that at least substantially describes all non-analyte dependent spectral variance in the in vivo spectra; providing a pure component infrared spectrum for the analyte; and calculating a net analyte signal spectrum from a data set comprising the optimal subspace spectra and the pure analyte spectrum. The net analyte signal calibration model can be used, for example, in measuring the concentration of analyte in a test subject, and/or for evaluating the analytical significance of an in vivo multivariate calibration model.

Abstract translation: 一种用于产生用于检测和/或定量测试对象中的分析物的量的净分析物信号校准模型的方法。 净分析物信号可以通过在分析物浓度基本恒定的期间内为测试对象提供一组体内红外光谱来产生; 计算光谱的最佳子空间，其至少基本上描述体内光谱中的所有非分析物相关的光谱方差; 为分析物提供纯分量红外光谱; 以及从包括最佳子空间光谱和纯分析物光谱的数据集计算净分析物信号光谱。 净分析物信号校准模型可用于例如测量受试者中分析物的浓度，和/或用于评估体内多变量校准模型的分析意义。

公开(公告)号：US07423749B2

公开(公告)日：2008-09-09

申请号：US11833897

申请日：2007-08-03

Applicant: Thomas W. Hagler

Inventor： Thomas W. Hagler

IPC: G01J3/06 ,  G01J3/18 ,  G01J3/28

CPC classification number: G01N21/552 ,  G01J3/02 ,  G01J3/0202 ,  G01J3/0208 ,  G01J3/0229 ,  G01J3/0291 ,  G01J3/0294 ,  G01J3/18 ,  G01J3/28 ,  G01J3/42 ,  G01N21/274 ,  G01N21/31 ,  G01N2021/317 ,  G01N2201/129

Abstract: An encoder spectrograph is used to analyze radiation from one or more samples in various configurations. The radiation is analyzed by spatially modulating the radiation after it has been dispersed by wavelength or imaged along a line. Dual encoder spectrographs may be used to encode radiation using a single modulator. An encoded photometric infrared spectroscopy (“EPIR”) analyzer employs orthogonal encoded components having substantially identical modulation frequencies, which may allow for the multiplexing of up to twice as many encoded components.

Abstract translation: 编码器光谱仪用于分析来自一种或多种不同配置样品的辐射。 通过在辐射被波长分散或沿着一条线成像后，通过空间调制辐射来分析辐射。 双编码器光谱仪可用于使用单个调制器对辐射进行编码。 编码的光度红外光谱（“EPIR”）分析仪使用具有基本上相同的调制频率的正交编码分量，这可以允许多达两倍的编码分量的多路复用。

公开(公告)号：US20080212077A1

公开(公告)日：2008-09-04

申请号：US11917019

申请日：2006-06-27

Applicant: Colin Jeffress

Inventor： Colin Jeffress

IPC: G01N21/00 ,  G01J3/00

CPC classification number: G01J3/02 ,  G01J3/0291 ,  G01N21/55 ,  G01N21/8507 ,  G01N33/025 ,  G01N2201/129

Abstract: A lance assembly for spectroscopically sampling bulk product (8) is disclosed. The assembly comprises: an elongate lance body (11) having a longitudinal axis (15), a proximal end (12) for maneuvering and a head (19) defining a cavity (18). Housed within the cavity (18) is a spectroscopic receiver (20) having a field of view and a radiant energy source (40) providing a beam of energy to be reflected from the bulk product (8) to the receiver 20 through a window (30). The window (30) has an external surface (31) which, in use, is in contact with the bulk product (8). The beam of energy and the field of view of the receiver (20) are both directed towards the external surface (31) so as to allow sampling adjacent the external surface (31).

Abstract translation: 公开了用于光谱取样散装产品（8）的喷枪组件。 组件包括：具有纵向轴线（15），用于操纵的近端（12）和限定空腔（18）的头部（19）的细长喷枪体（11）。 设置在空腔（18）内的是具有视野的分光学接收器（20）和辐射能源（40），其通过窗口（40）提供能够从散装产品（8）反射到接收器20的能量束 30）。 窗口（30）具有在使用中与散装产品（8）接触的外表面（31）。 能量束和接收器（20）的视野均指向外表面（31），以允许邻近外表面（31）进行取样。