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    Method and system for detecting a target within a population of molecules
    343.
    发明授权
    Method and system for detecting a target within a population of molecules 有权
    用于检测分子群体内靶标的方法和系统

    公开(公告)号：US09575068B2

    公开(公告)日：2017-02-21

    申请号：US13909109

    申请日：2013-06-04

    Applicant: Ramot at Tel-Aviv University Ltd.

    Inventor： Ady Arie ,  Amos Danielli

    IPC: G01N33/543 ,  G01N33/58 ,  G01N21/64 ,  G01N21/17

    CPC classification number: G01N33/582 ,  C12Q1/6818 ,  G01N21/1717 ,  G01N21/64 ,  G01N21/6428 ,  G01N33/54333 ,  G01N2021/6439

    Abstract: A method of detecting a target within a population of molecules comprising: contacting a plurality of labeled probe molecules with the population of molecules potentially containing a target of the probe molecules; acquiring a probe specific signal emitted by said labeled probe molecules that bound to said target together with a background signal; preferentially modulating said probe specific signal by at least one of modulating said acquisition and modulating an emission of said probe specific signal; and detecting said probe specific signal over said background signal using said preferential modulation.

    Abstract translation: 一种检测分子群体内的靶的方法，包括：使多个标记的探针分子与潜在地含有探针分子靶标的分子群接触; 获得与所述靶标结合的所述标记的探针分子发射的探针特异性信号与背景信号; 通过调制所述获取和调制所述探针特定信号的发射中的至少一个来优先调制所述探针特定信号; 以及使用所述优先调制在所述背景信号上检测所述探针特定信号。

    Portable interferometric device
    344.
    发明授权
    Portable interferometric device 有权
    便携式干涉仪

    公开(公告)号：US09574868B2

    公开(公告)日：2017-02-21

    申请号：US14386031

    申请日：2013-03-14

    Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

    Inventor： Natan Tzvi Shaked ,  Pinhas Girshovitz

    IPC: G01B11/02 ,  G01B9/02 ,  G02B21/00 ,  G01B11/06 ,  G01B9/04

    CPC classification number: G02B21/0056 ,  G01B9/02024 ,  G01B9/02032 ,  G01B9/02042 ,  G01B9/02049 ,  G01B9/02054 ,  G01B9/02057 ,  G01B9/02075 ,  G01B9/02097 ,  G01B9/04 ,  G01B11/06 ,  G01B2290/50 ,  G02B21/0008 ,  G02B21/0016 ,  G02B21/008 ,  G02B21/0088

    Abstract: The present invention provides a novel simple, portable, compact and inexpensive approach for interferometric optical thickness measurements that can be easily incorporated into an existing microscope (or other imaging systems) with existing cameras. According to the invention, the interferometric device provides a substantially stable, easy to align common path interferometric geometry, while eliminating a need for controllably changing the optical path of the beam. To this end, the inexpensive and easy to align interferometric device of the invention is configured such that it applies the principles of the interferometric measurements to a sample beam only, being a single input into the interferometric device.

    Abstract translation: 本发明提供了一种用于干涉光学厚度测量的新型简单，便携，紧凑和便宜的方法，其可以容易地结合到具有现有照相机的现有显微镜（或其他成像系统）中。 根据本发明，干涉测量装置提供了基本上稳定的，容易对准的共同路径干涉几何，同时消除了对可控地改变光束的光路的需要。 为此，本发明的便宜且易于对准的干涉测量装置被配置为使得其仅将干涉测量的原理应用于仅用于干涉测量装置的单个输入的采样光束。

    DELIVERY SYSTEM IN MICELLAR FORM HAVING MODULAR SPECTRAL RESPONSE BASED ON ENZYME-RESPONSIVE AMPHIPHILIC PEG-DENDRON HYBRID POLYMERS
    346.
    发明申请
    DELIVERY SYSTEM IN MICELLAR FORM HAVING MODULAR SPECTRAL RESPONSE BASED ON ENZYME-RESPONSIVE AMPHIPHILIC PEG-DENDRON HYBRID POLYMERS 审中-公开
    基于酶的反应性PEG-DENDRON混合聚合物的具有模块化光谱响应的MICELLAR形式的递送系统

    公开(公告)号：US20170035916A1

    公开(公告)日：2017-02-09

    申请号：US15227305

    申请日：2016-08-03

    Applicant: Ramot at Tel-Aviv University Ltd.

    Inventor： Roey Jacob AMIR ,  Marina BUZHOR ,  Assaf Josef HARNOY

    IPC: A61K49/18 ,  A61K45/00 ,  C08G65/00 ,  A61K9/107 ,  C08G83/00 ,  A61K49/12 ,  A61K47/34

    Abstract: The present invention relates to new molecular design that allows micelles to report their activation and disassembly by an enzymatic trigger. The molecular design is based on introduction of a labeling moiety selected from a fluorescent dye, a dark quencher, combinations of dyes or dyes/quenchers, and a fluorinated moiety (a 19F-magenetic resonance (MR) probe for turn ON/OFF of a 19F-MR signal) through covalent binding to the focal point of amphiphilic polymer-dendron hybrids with the labeling moiety. At the assembled micellar state, the dyes are closely packed and hence the probability for intermolecular interactions increases significantly, leading to alteration of the fluorescent properties (signal quench or shift) or the 19F-MR signal (OFF state) of the micelles. Upon enzymatic cleavage of the hydrophobic end-groups from enzyme-responsive dendron, the polymers become hydrophilic and disassemble. This structural change is then translated into a spectral change as dye-dye interactions are halted and the dyes regain their intrinsic fluorescent properties, or alternatively by turn ON the 19F-MR signal. The high modularity of the design allows the introduction of various types of dyes and thus enables rational adjustment of the spectral response. Two major types of responses are described: Turn-On/Off and spectral shift, depending on the type of labeling dye. The present invention further provides methods of use of the hybrid delivery system and to a kit comprising the same.

    Abstract translation: 本发明涉及允许胶束通过酶触发来报告其活化和拆解的新分子设计。 分子设计基于引入选自荧光染料，暗猝灭剂，染料或染料/猝灭剂的组合的标记部分和氟化部分（用于ON / OFF的19F-杂交共振（MR）探针） 19F-MR信号）通过与标记部分的两亲性聚合物 - 树突状杂交体的聚焦点共价结合。 在组装的胶束状态下，染料紧密堆积，因此分子间相互作用的可能性显着增加，导致胶束的荧光性质（信号淬灭或移位）或19F-MR信号（OFF状态）的改变。 在从酶反应性树突中将疏水性端基酶切割后，聚合物变得亲水并分解。 随着染料 - 染料相互作用的停止，染料重新获得其本身的荧光特性，或者通过接通19F-MR信号，此结构变化被转化为光谱变化。 设计的高模块性允许引入各种类型的染料，因此能够合理调整光谱响应。 描述两种主要类型的响应：开启/关闭和光谱偏移，这取决于标签染料的类型。 本发明还提供了混合递送系统的使用方法和包含该混合递送系统的试剂盒。

    SELF-ASSEMBLED PEPTIDE NANOSTRUCTURES
    347.
    发明申请
    SELF-ASSEMBLED PEPTIDE NANOSTRUCTURES 有权
    自组装肽的纳米结构

    公开(公告)号：US20160326215A1

    公开(公告)日：2016-11-10

    申请号：US15150622

    申请日：2016-05-10

    Applicant: Ramot at Tel-Aviv University Ltd.

    Inventor： Pini MARCU ,  Lihi ADLER-ABRAMOVICH ,  Ehud GAZIT

    IPC: C07K5/065 ,  C08J5/04 ,  C09D7/12

    CPC classification number: C07K5/06078 ,  B82Y5/00 ,  B82Y40/00 ,  C09D7/70

    Abstract: Nanostructures made up from two or more types of short peptides (e.g., aromatic dipeptides), which differ from one another by the presence (or absence) of an end-capping moiety, are disclosed. The disclosed nanostructures exhibit a closed tubular structure, short average length and narrow length distribution. Also disclosed are processes of preparing the nanostructures, articles comprising the nanostructures, and use of the nanostructures in, for example, reinforcement of materials.

    Abstract translation: 公开了由两个或多个类型的短肽（例如芳族二肽）组成的纳米结构，其通过封端部分的存在（或不存在）而彼此不同。 所公开的纳米结构显示封闭的管状结构，平均长度短和长度分布窄。 还公开了制备纳米结构，包含纳米结构的制品以及在例如增强材料中使用纳米结构的方法。

    Low-level energy laser therapy
    349.
    发明申请
    Low-level energy laser therapy 有权
    低能量激光治疗

    公开(公告)号：US20160228725A1

    公开(公告)日：2016-08-11

    申请号：US15130979

    申请日：2016-04-17

    Applicant: Ramot at Tel Aviv University Ltd.

    Inventor： Uri Oron ,  Hana Tuby

    IPC: A61N5/06

    CPC classification number: A61N5/0613 ,  A61N5/0601 ,  A61N5/0618 ,  A61N2005/0612 ,  A61N2005/0643 ,  A61N2005/0651 ,  A61N2005/0659 ,  A61N2005/0662 ,  A61N2005/067

    Abstract: Methods and systems (10, 54, 72) are provided for administering phototherapy to an injured tissue in a living subject by delivering visible or infrared biostimulatory energy to bone marrow at a dose sufficient to cause mesenchymal stem cells to appear in the injured tissue. The energy may be coherent light and can be administered transcutaneously, subcutaneously, or via an intramedullary probe (74). The technique is useful for treating many types of tissue injury, including ischemic cardiac and renal conditions.

    Abstract translation: 提供方法和系统（10,54,72），用于通过以足以使间充质干细胞出现在损伤组织中的剂量递送可见或红外生物刺激能量给骨髓，向活体受试者的受损组织施用光疗。 能量可以是相干光，并且可以经皮，皮下或经髓内探针施用（74）。 该技术可用于治疗许多类型的组织损伤，包括缺血性心脏和肾脏疾病。

    GLYCOGEN SYNTHASE KINASE-3 INHIBITORS
    350.
    发明申请
    GLYCOGEN SYNTHASE KINASE-3 INHIBITORS 有权

    公开(公告)号：US20160200763A1

    公开(公告)日：2016-07-14

    申请号：US14392205

    申请日：2014-06-24

    Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD. ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD.

    Inventor： Hagit ELDAR-FINKELMAN ,  Miriam EISENSTEIN ,  Avital LICHT-MURAVA

    IPC: C07K7/06 ,  C40B30/02 ,  G06F19/16 ,  C07K7/08 ,  A61K47/48

    CPC classification number: C07K7/06 ,  A61K38/00 ,  A61K38/08 ,  A61K38/10 ,  C07K7/08 ,  C40B30/02 ,  G06F19/16 ,  Y02A50/401 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/414 ,  Y02A50/415 ,  Y02A50/419 ,  Y02A50/422 ,  Y02A50/423 ,  Y02A50/491

    Abstract: Novel peptide inhibitors of GSK-3, compositions containing same and uses thereof are disclosed. The novel peptide inhibitors are converted to inhibitors of GSK-3 upon interacting with the enzyme's catalytic site and hence act as disease-selective inhibitors for treating conditions associated with increased activity and/or expression of GSK-3. Each of the disclosed peptides is independently of no more than 15 amino acid residues, and has an amino acid sequence which comprises a ZX1X2X3Z(p) recognition motif of GSK-3, wherein Z(p) is a phosphorylated serine or threonine residue; Z is a phosphorylatable serine or threonine residue, and each of X1, X2 and X3 is independently any amino acid, as defined in the specification. Further disclosed are methods of identifying a putative substrate-competitive peptide inhibitor of GSK-3 which are effected by computational modeling and screening.

    Abstract translation: 公开了GSK-3的新型肽抑制剂，含有其的组合物及其用途。 当与酶的催化位点相互作用时，新型肽抑制剂被转化为GSK-3的抑制剂，因此作为用于治疗与增加的GSK-3的活性和/或表达相关的病症的疾病选择性抑制剂。 所公开的肽各自独立地不超过15个氨基酸残基，并且具有包含GSK-3的ZX1X2X3Z（p）识别基序的氨基酸序列，其中Z（p）是磷酸化丝氨酸或苏氨酸残基; Z是可磷酸化的丝氨酸或苏氨酸残基，X1，X2和X3各自独立地是任何氨基酸，如说明书中所定义的。 进一步公开的是鉴定GSK-3的推定的底物竞争性肽抑制剂的方法，其通过计算建模和筛选来实现。

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