公开(公告)号：US20230323397A1

公开(公告)日：2023-10-12

申请号：US18100028

申请日：2023-01-23

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： SUJIT PUJHARI ,  ROBERT ANDERSON SMITHWICK

IPC: C12N15/113 ,  C12N9/22 ,  C12N15/86

CPC classification number: C12N15/86 ,  C12N9/22 ,  C12N15/1131 ,  C12N2310/122 ,  C12N2750/14143

Abstract: Disclosed is a method of purifying recombinant adeno-associated virus (rAAV) particles. For instance, the rAAV particles may be derived from an AAV-producing cell culture. According to the present disclosure, the method can include a) producing a crude cell lysate comprising rAAV particles by hypotonic lysing of the cell culture; b) clarifying the crude cell lysate using filtration producing a supernatant comprising rAAV particles; c) isolating the supernatant to obtain a virus pellet comprising rAAV particles; and d) resuspending the virus pellet with a buffer to obtain purified rAAV particles.

公开(公告)号：US11781921B2

公开(公告)日：2023-10-10

申请号：US17083606

申请日：2020-10-29

Applicant: University of South Carolina

Inventor： Amitav Tikadar ,  Sowmya Raghu ,  Jamil A. Khan

IPC: G01K7/04 ,  H10N10/00 ,  H10N10/01 ,  H10N10/10 ,  H10N10/17

CPC classification number: G01K7/04 ,  H10N10/00 ,  H10N10/01 ,  H10N10/10 ,  H10N10/17

Abstract: An in-contact temperature measurement probe, which can measure temperature accurately on the surface of a current carrying wire, rod, heater, or other device, while maintaining the safety of the user via employing non-electrically conductive but thermally conductive materials.

公开(公告)号：US11772089B2

公开(公告)日：2023-10-03

申请号：US17830692

申请日：2022-06-02

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： Abolfazl Shakouri ,  Horie Adabi Firouzjaie ,  John R. Regalbuto ,  Christopher T. Williams ,  William E. Mustain

IPC: B01J37/02 ,  B01J21/18 ,  B01J35/02 ,  B01J23/42

CPC classification number: B01J37/0209 ,  B01J21/18 ,  B01J23/42 ,  B01J35/023 ,  B01J35/026

Abstract: Disclosed are methods for forming a supported catalyst and catalysts formed according to disclosed methods. Methods include contacting a catalyst support with a precursor solution and displacing the solvent of the precursor solution (e.g., water) with a second solvent that has a lower surface tension than the first solvent. The second solvent displaces the first solution according to the Marangoni effect. Methods also include activation of the precursor to form a catalyst, e.g., a supported platinum group metal catalyst or the like.

公开(公告)号：US20230285331A1

公开(公告)日：2023-09-14

申请号：US17993027

申请日：2022-11-23

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： SAJISH MATHEW

IPC: A61K31/164 ,  A61K31/198 ,  A61K31/405 ,  A61K31/4164 ,  A61P25/28

CPC classification number: A61K31/164 ,  A61K31/198 ,  A61K31/405 ,  A61K31/4164 ,  A61P25/28

Abstract: Methods and compositions are described herein for modulating protein synthesis, especially monosome translation and DNA damage response, especially short-patch base excision repair (SP-BER), NHEJ and HR for treating a disorder. Compositions include a therapeutically effective amount of a tyrosine or a resveratrol derivative.

公开(公告)号：US11738311B2

公开(公告)日：2023-08-29

申请号：US17158394

申请日：2021-01-26

Applicant: University of South Carolina

Inventor： Chuanbing Tang ,  Tianyu Zhu

IPC: C07F17/02 ,  C08F30/04 ,  B01J45/00 ,  H01M8/1072 ,  B01D67/00 ,  B01D71/82 ,  H01M8/1048 ,  H01M8/1023 ,  H01M8/1067 ,  B01J47/12 ,  C08J5/22 ,  B01D69/02 ,  B01D69/14 ,  C08G61/08

CPC classification number: B01D67/0079 ,  B01D67/0006 ,  B01D67/0093 ,  B01D71/82 ,  B01J45/00 ,  B01J47/12 ,  C08J5/2231 ,  H01M8/1023 ,  H01M8/1048 ,  H01M8/1067 ,  H01M8/1072 ,  B01D69/02 ,  B01D69/148 ,  B01D2323/30 ,  B01D2323/36 ,  B01D2325/16 ,  B01D2325/26 ,  B01D2325/42 ,  C08G61/08 ,  C08G2261/122 ,  C08G2261/135 ,  C08G2261/149 ,  C08G2261/1424 ,  C08G2261/1529 ,  C08G2261/3322 ,  C08G2261/418 ,  C08G2261/516 ,  C08G2261/62 ,  C08G2261/72 ,  C08G2261/724 ,  C08G2261/76 ,  C08J2345/00 ,  C08J2365/00

Abstract: Chemically inert, mechanically tough, cationic metallo-polyelectrolytes designed as durable anion-exchange membranes (AEMs) via ring-opening metathesis polymerization (ROMP) of cobaltocenium-containing cyclooctene with triazole as the only linker group, followed by backbone hydrogenation to provide a new class of AEMs with a polyethylene-like framework and alkaline-stable cobaltocenium cation for ion transport, which exhibit excellent thermal, chemical and mechanical stability, as well as high ion conductivity.

公开(公告)号：US20230204462A1

公开(公告)日：2023-06-29

申请号：US18171425

申请日：2023-02-20

Applicant: University of South Carolina

Inventor： Paul Ziehl

IPC: G01M17/02 ,  G01L1/22 ,  B60C19/00 ,  G01L1/14 ,  G01L1/24 ,  B33Y80/00

CPC classification number: G01M17/02 ,  G01L1/22 ,  B60C19/00 ,  G01L1/146 ,  G01L1/242 ,  B33Y80/00 ,  B60C2019/004

Abstract: Described herein are systems and methods for determination of rolling resistance from a sensor or sensors in a tire or tires for application in smart cars to provide feedback to interested parties, such as Departments of Transportation or tire manufacturers.

公开(公告)号：US20230139938A1

公开(公告)日：2023-05-04

申请号：US17870593

申请日：2022-07-21

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： HIPPOKRATIS KIARIS ,  Ioulia Chatzistamou ,  Asieh Naderi ,  Bernardo Chavez

IPC: C07K16/24 ,  A61P11/00 ,  A61P29/00 ,  G01N33/50

Abstract: Methods for treating lung injury by administration of an anti-CCL8 antibody are disclosed. Also disclosed are methods for evaluating lung therapies by use of an animal model of the genus Peromyscus.

公开(公告)号：US11639915B2

公开(公告)日：2023-05-02

申请号：US17018327

申请日：2020-09-11

Applicant: University of South Carolina

Inventor： Victor Giurgiutiu ,  Jingjing Bao ,  Banibrata Poddar ,  Md Yeasin Bhuiyan

IPC: G01N29/14 ,  G01N29/44 ,  G01N29/24 ,  G01N29/46

Abstract: The current disclosure determines if structural faults exist and extracts geometric features of the structural faults from acoustic emission waveforms, such as crack length and orientation, and can evaluate the structural faults online, during normal operation conditions.

公开(公告)号：US20230111601A1

公开(公告)日：2023-04-13

申请号：US17963305

申请日：2022-10-11

Applicant: University of South Carolina

Inventor： Richard Hoppmann ,  Floyd Bell ,  Robert Haddad ,  Keith Barron

IPC: G16H40/20 ,  G06N3/08 ,  G16H50/30 ,  G16H10/60

Abstract: Described herein are systems and methods for using artificial intelligence (AI) in real-time to assess the difficulty level of a patient being scanned and assigning an objective scanning difficulty level (SDL) to the patient to help inform medical personnel and educators of the difficulty of scanning said patient.

公开(公告)号：US11614410B2

公开(公告)日：2023-03-28

申请号：US17205672

申请日：2021-03-18

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： Paul Ziehl

IPC: G01N21/88 ,  G06V20/17 ,  G01N7/14 ,  G10L25/51 ,  H04N7/18 ,  G01N29/14 ,  G06V20/10

Abstract: Structural health monitoring (SHM)/nondestructive evaluation (NDE) exists as a tool in conjunction with manufactured pieces. Presently disclosed subject matter integrates automated video with a structural health monitoring system. In conjunction with bridge monitoring, integration of such two systems automates determination of the effect or correlation of vehicular loading on SHM data from a subject bridge. Such correlations help to understand the sources of structural health monitoring data, particularly acoustic emission data, in bridges and other structures, such as dams and nuclear plants. Automation of the evaluation of bridges and other structures increases accuracy and minimizes risk to workers and the public. Assessing the structural condition of bridges and other structures as presently disclosed also facilitates automated asset management of transportation systems, such as by state departments of transportation and other bridge/structural owners.