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    Stair-climbing wheelchair
    32.
    发明授权
    Stair-climbing wheelchair 失效
    楼梯轮椅

    公开(公告)号：US06857490B2

    公开(公告)日：2005-02-22

    申请号：US10316717

    申请日：2002-12-11

    Applicant: Robert T. Quigg

    Inventor： Robert T. Quigg

    IPC: A61G5/06 ,  A61G5/10 ,  A61G5/12 ,  B62D55/075 ,  B62D55/04

    CPC classification number: A61G5/061 ,  A61G5/045 ,  A61G5/066 ,  A61G5/10 ,  A61G5/1075 ,  A61G5/1089 ,  A61G5/125 ,  A61G2203/14 ,  B62D55/075

    Abstract: A stair-climbing wheelchair has a pair of track assemblies that can be placed in an operative drive mode to propel the wheelchair along ascending and descending paths of travel relative to an obstacle such as a stairway, curb, or the like. Each track assembly includes a guide member with rollers at opposite ends thereof carrying an endless cleated belt. The guide member is arched between its end sections thereby permitting the endless belt to deflect upwardly between the rollers when the endless belt engages an obstacle such as a step, curb or the like. This permits a smooth gradual transition of the wheelchair onto and/or off the top step of a staircase. Preferably, each track assembly also includes an inclined tail section having a separate endless cleated belt. The track assemblies can also be utilized in connection with remote control and/or unmanned motorized vehicles.

    Abstract translation: 楼梯轮椅具有一对轨道组件，其可以被放置在操作驱动模式中，以相对于诸如楼梯，路边等的障碍物的上行和下行路径推动轮椅。 每个轨道组件包括引导构件，其具有在其相对端部处的滚子，其具有无端橡胶带。 引导构件在其端部部分之间拱起，从而当环形带接合诸如台阶，路缘等的障碍物时允许环形带在辊之间向上偏转。 这允许轮椅平稳地过渡到楼梯的顶部步骤和/或离开楼梯的顶部步骤。 优选地，每个轨道组件还包括具有单独的环形橡胶带的倾斜尾部。 轨道组件也可以与遥控器和/或无人驾驶的机动车辆一起使用。

    Sliding contact guide for transmitting medium
    33.
    发明授权
    Sliding contact guide for transmitting medium 有权
    用于传输介质的滑动接触导轨

    公开(公告)号：US06843742B2

    公开(公告)日：2005-01-18

    申请号：US10341022

    申请日：2003-01-13

    Applicant: Masahiko Konno

    Inventor： Masahiko Konno

    IPC: F16H7/08 ,  F16H7/18

    CPC classification number: F16H7/18 ,  F16H2007/0872 ,  Y10T403/1616

    Abstract: A sliding contact guide for a chain, or other flexible transmission medium comprises a synthetic resin guide body having a shoe on which the transmission medium slides, and a slotted, plate-receiving portion on the back side of the shoe for receiving a reinforcing plate. The plate-receiving portion is composed of a pair of opposed, longitudinally extending, slot-defining walls. Raised ribs, for sandwiching the reinforcing plate, are disposed on opposed inner surfaces of the walls, and are oriented in the direction of insertion of the reinforcing plate into the slot. The guide suppresses shock noises due to wobbling of the guide during operation, and molding and assembly of the guide are enhanced.

    Abstract translation: 用于链条或其它柔性传动介质的滑动接触引导件包括合成树脂引导体，该合成树脂引导体具有传动介质在其上滑动的滑块，并且在鞋的后侧上具有开槽的板接收部分，用于接收加强板。 板接收部分由一对相对的纵向延伸的槽限定壁组成。 用于夹持加强板的凸肋设置在壁的相对的内表面上，并且沿着将加强板插入槽的方向定向。 引导件可以抑制由于操作过程中引导件的摆动引起的冲击噪音，导向件的成型和组装也得到提高。

    Pharmaceutical composition comprising GHB gastro-retentive raft forming systems having trigger pulse drug release
    34.
    发明授权
    Pharmaceutical composition comprising GHB gastro-retentive raft forming systems having trigger pulse drug release 有权

    公开(公告)号：US11337920B2

    公开(公告)日：2022-05-24

    申请号：US16955392

    申请日：2018-12-18

    Applicant: Tris Pharma, Inc.

    Inventor： Paras Rameshlal Jain ,  Sachin Vasant Chaudhari

    IPC: A61K9/00 ,  A61K31/19 ,  A61K47/58 ,  A61K9/16 ,  A61K9/50

    Abstract: An orally administrable drug powder composition which forms a gastro-retentive RAFT having at least two trigger pulses is provided. The composition contains, at a minimum, (a) at least one GHB drug in a first pulse release which releases in less than about 3 hours; (b) at least one GHB drug in a delayed trigger release form; (c) at least one non-toxic gas generating agent; and (d) a RAFT system, wherein following oral ingestion, the composition provides a self-assembling gastro-retentive RAFT having entrapped therein, the at least one drug of (a) and (b) and the gas generated in situ by the non-toxic gas generating agent, thereby providing a floating gastro-retentive RAFT having a dual pulse system wherein at least the second pulse is a trigger pulse and which retains the at least one GHB drug in the stomach for at least about 3 hours.

    Compositions, methods and microfluidics device for telomerase based in vitro diagnostic assays for detecting circulating tumor cells (CTC)
    38.
    发明授权
    Compositions, methods and microfluidics device for telomerase based in vitro diagnostic assays for detecting circulating tumor cells (CTC) 有权

    公开(公告)号：US10338071B2

    公开(公告)日：2019-07-02

    申请号：US15812105

    申请日：2017-11-14

    Applicant: The Trustees of the University of Pennsylvania

    Inventor： Stephen M. Hahn ,  Jay F. Dorsey ,  Gary D. Kao ,  Emigdio Reyes

    IPC: G01N33/574 ,  C12Q1/6897 ,  C12Q1/68 ,  G01N33/543 ,  B01L3/00 ,  G01N30/52

    Abstract: A repeatable method for detecting circulating tumor cells in vitro is provided. The method involves combining a test sample from a patient suspected of having circulating tumor cells, and a non-lytic adenoviral system, and culture media for the cells. The adenoviral system utilizes (i) a first replication-defective adenoviral particle in which an expression cassette is packaged, said expression cassette comprising an adenoviral 5′ and 3′ ITRs and a tumor-specific promoter; and (ii) a coding sequence for a reporter protein which is expressed in the presence of circulating tumor cells, and an adenoviral 3′ ITR. The test sample and the non-lytic adenoviral system are incubated for a sufficient time to permit expression of the reporter protein, and measuring reporter protein expression in the test samples, whereby presence of reporter expression indicates the presence of circulating tumor cells in the sample. Because the system is non-lytic, the testing can be repeated on the cells which remain viable in culture. Also provided is a method for enriching test samples having circulating tumor cells and a microfluidics device suitable for CTC-specification identification and enumeration.

    Spectral light therapy for autism spectral disorders
    40.
    发明授权
    Spectral light therapy for autism spectral disorders 有权
    光谱光疗法用于自闭症光谱障碍

    公开(公告)号：US09352170B1

    公开(公告)日：2016-05-31

    申请号：US13754277

    申请日：2013-01-30

    Applicant: Christina Davis

    Inventor： Christina Davis

    IPC: A61N5/06

    CPC classification number: A61N5/0618 ,  A61H2201/10 ,  A61N2005/0663

    Abstract: A spectral color and light therapy system is described which is useful in treating mood, anxiety, attention, substance, and/or behavioral disorders. The system utilizes one or more light source which emits visible colored light at a brilliance factor of at least about 2500 and at least one of four colors which are different from each other, said system providing (a) (i) a light source emitting blue light in the range of about 450 to about 475 nm; and (ii) a source emitting green visible light in the range of about 495 nm to about 570 nm; and (b) a light source emitting rose pink light in the range of about 635 nm to about 650 nm; and a light source of peach light in the range of about 590 nm to about 630 nm. Also provided are methods of treating mood, anxiety, attention, substance, and/or behavioral disorders. Methods of treating and/or ameliorating the symptoms of autism spectrum disorders are described.

    Abstract translation: 描述了可用于治疗情绪，焦虑，注意力，物质和/或行为障碍的光谱颜色和光疗系统。 该系统利用一种或多种光源，其以至少约2500的亮度因数和彼此不同的四种颜色中的至少一种发出可见的有色光，所述系统提供（a）（i）发射蓝色的光源 在约450至约475nm的范围内的光; 和（ii）发射在约495nm至约570nm范围内的绿色可见光的源; 和（b）在约635nm至约650nm的范围内发射玫瑰红色光的光源; 以及在约590nm至约630nm的范围内的桃光源。 还提供了治疗情绪，焦虑，注意力，物质和/或行为障碍的方法。 描述了治疗和/或改善自闭症谱系障碍症状的方法。

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