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    Patch and method for producing the same
    31.
    发明授权
    Patch and method for producing the same 有权
    补片及其制作方法

    公开(公告)号：US09511051B2

    公开(公告)日：2016-12-06

    申请号：US14417205

    申请日：2013-07-25

    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

    Inventor： Masayuki Suzuki ,  Hiroaki Okutsu ,  Takashi Yasukochi ,  Yasunori Takada

    IPC: A61K31/407 ,  A61K47/06 ,  A61K9/70 ,  A61K47/14 ,  A61K47/12

    CPC classification number: A61K47/12 ,  A61K9/7038 ,  A61K9/7046 ,  A61K9/7053 ,  A61K9/7061 ,  A61K9/7069 ,  A61K31/407 ,  A61K31/55 ,  A61K47/06 ,  A61K47/10 ,  A61K47/14 ,  A61M37/00

    Abstract: A method for producing a patch comprising a support layer and an adhesive agent layer comprises: a mixture preparation step of mixing asenapine or a pharmaceutically acceptable salt thereof with sodium acetate whose particle diameter D50 at a cumulative volume of 50% in a particle diameter distribution is 40 to 1000 μm, in such a manner that the sodium acetate and sodium diacetate generated from the sodium acetate have a particle diameter D50 of 10 μm or smaller, thereby obtaining a mixture containing the sodium diacetate and the asenapine or pharmaceutically acceptable salt; and an adhesive-agent-layer formation step of forming the adhesive agent layer comprising the sodium diacetate, the asenapine or pharmaceutically acceptable salt, and a pressure-sensitive adhesive base agent, by using an adhesive agent layer composition obtained by mixing the mixture with the pressure-sensitive adhesive base agent.

    Abstract translation: 在包含支撑层和粘合剂层的贴剂中，粘合剂层包含游离的阿替那非，马来酸碱金属盐和橡胶基粘合剂。

    Applicator
    32.
    发明授权
    Applicator 有权
    申请人

    公开(公告)号：US09498611B2

    公开(公告)日：2016-11-22

    申请号：US14349523

    申请日：2012-10-02

    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

    Inventor： Seiji Tokumoto ,  Makoto Ogura

    IPC: A61M37/00 ,  A61B5/151 ,  A61B5/15

    CPC classification number: A61M37/0015 ,  A61B5/150984 ,  A61B5/15117 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0061

    Abstract: An active agent is effectively administered without giving fear to the user when the microneedles are applied. An applicator 10 includes a transmission member that transmits biasing force of a biasing member to a microneedle array including micro projections (microneedles) with a needle density of 500 needles/cm2 or more. The transmission member has a mass of 1.5 g or less, and the transmission member activated by the biasing force of the biasing member has a momentum of from 0.0083 (N·s) to 0.015 (N·s).

    Abstract translation: 当施用微针时，有效地施用活性剂，而不会对使用者产生恐惧。 涂抹器10包括透射构件，其以500针/ cm 2以上的针密度将偏压构件的偏置力传递到包括微突起（微针）的微针阵列。 传递部件的质量为1.5g以下，由偏置部件的作用力而被驱动的传动部件的动量为0.0083（N·s）〜0.015（N·s）。

    Gel Patch
    33.
    发明申请
    Gel Patch 审中-公开
    凝胶补丁

    公开(公告)号：US20160175262A1

    公开(公告)日：2016-06-23

    申请号：US14974288

    申请日：2015-12-18

    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

    Inventor： Keiichiro TSURUSHIMA ,  Yasuhisa KOSE ,  Takaaki YOSHINAGA

    IPC: A61K9/70 ,  A61K47/14

    CPC classification number: A61K9/7061 ,  A61K31/618 ,  A61K47/14 ,  A61K47/26

    Abstract: A gel patch includes a base fabric, an adhesive layer, and a release liner in this order, wherein the adhesive layer contains a physiologically active substance, a water-soluble (meth)acrylic polymer, water, a surfactant, and poly(methyl acrylate/2-ethylhexyl acrylate), and the surfactant comprises a polyethylene glycol fatty acid ester or a polyoxyethylene sorbitan fatty acid ester.

    Abstract translation: 凝胶贴剂依次包括基底织物，粘合剂层和剥离衬垫，其中粘合剂层含有生理活性物质，水溶性（甲基）丙烯酸聚合物，水，表面活性剂和聚（丙烯酸甲酯 丙烯酸-2-乙基己酯），表面活性剂包括聚乙二醇脂肪酸酯或聚氧乙烯脱水山梨糖醇脂肪酸酯。

    APPLICATOR
    34.
    发明申请
    APPLICATOR 有权
    申请人

    公开(公告)号：US20150314117A1

    公开(公告)日：2015-11-05

    申请号：US14654029

    申请日：2013-11-27

    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

    Inventor： Shunsuke ARAMI ,  Makoto OGURA ,  Seiji TOKUMOTO

    IPC: A61M37/00

    CPC classification number: A61M37/0015 ,  A61K9/0021 ,  A61M5/1454 ,  A61M2005/14506 ,  A61M2005/1585 ,  A61M2037/0023 ,  A61M2037/0046

    Abstract: An applicator includes a piston plate, a non-linear coil spring, a casing, a lock means and a release means. The casing includes a tubular main body part that houses therein the piston plate and the non-linear coil spring, and a cover part that is arranged on one end side of the main body part. The cover part and the piston plate sandwich the non-linear coil spring there between. The lock means locks the piston plate with the casing such that the piston plate is held at a retraction position thereof on the cover part side in a state where the cover part and the piston plate compress the non-linear coil spring. The release means releases a locked state where the piston plate is locked with the casing by the lock means and where the cover part and the piston plate compress the non-linear coil spring.

    Abstract translation: 施加器包括活塞板，非线性螺旋弹簧，壳体，锁定装置和释放装置。 壳体包括容纳活塞板和非线性螺旋弹簧的管状主体部分和布置在主体部分的一端侧的盖部分。 盖部分和活塞板夹在其间的非线性螺旋弹簧。 锁定装置将活塞板与壳体锁定，使得活塞板在盖部分和活塞板压缩非线性螺旋弹簧的状态下在盖部分侧保持在其缩回位置。 释放装置释放锁定状态，其中活塞板通过锁定装置与壳体锁定，并且盖部分和活塞板压缩非线性螺旋弹簧。

    Patch having easily detachable release sheet
    36.
    再颁专利
    Patch having easily detachable release sheet 有权
    贴片具有易拆卸的脱模片

    公开(公告)号：USRE45510E1

    公开(公告)日：2015-05-05

    申请号：US13687376

    申请日：2012-11-28

    Applicant: Hisamitsu Pharmaceutical Co., Inc.

    Inventor： Hideaki Iwahashi ,  Shigeo Ota ,  Nobuo Tsutsumi ,  Takafumi Miyachika

    IPC: A61F13/00

    CPC classification number: A61F13/00029 ,  A61F13/0259 ,  A61F2013/00289 ,  A61F2013/00812

    Abstract: A patch permitting division of only its release sheet by simply pulling right and left, wherein detachment of the release sheet is easy. There is provided a patch comprising a stretchable support, a plaster applied substantially all over one major surface of the support and a release sheet attached to the whole surface of the plaster wherein only the release sheet is divided at a division zone by simply pulling right and left, and wherein one or two or more precut parts that open when the patch is pulled right and left are disposed in the neighborhood on the division zone.

    Abstract translation: 一个补丁只允许通过简单地向左和向右拉动分离其释放片，其中剥离片的脱离容易。 提供了一种贴片，其包括可拉伸支撑件，基本上涂覆在支撑体的整个主表面上的石膏和附着到石膏整个表面的剥离片，其中只有剥离片在分隔区域被简单地向右拉和 左，并且其中当所述贴片被左右拉动时打开的一个或两个或更多个预切割部分设置在所述分割区域附近。

    Puncture Device and Method for Manufacturing Same
    38.
    发明申请
    Puncture Device and Method for Manufacturing Same 审中-公开
    穿刺装置及其制造方法

    公开(公告)号：US20150057604A1

    公开(公告)日：2015-02-26

    申请号：US14390260

    申请日：2013-04-02

    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

    Inventor： Shunsuke Arami ,  Makoto Ogura ,  Seiji Tokumoto

    IPC: A61M37/00

    CPC classification number: A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053 ,  A61M2207/00 ,  Y10T29/49826

    Abstract: A puncture device is a device for transferring an active ingredient into a body through a skin by piercing the skin with a microneedle. The puncture device comprises a tubular housing, a piston slidably arranged within the housing and having a main surface intersecting a sliding direction, and a nonlinear coil spring arranged within the housing and providing the piston with a biasing force. A plurality of microneedles are arranged on the main surface side.

    Abstract translation: 穿刺装置是通过用微针刺穿皮肤通过皮肤将活性成分转移到身体中的装置。 穿刺装置包括管状壳体，可滑动地布置在壳体内并且具有与滑动方向相交的主表面的活塞和布置在壳体内的非线性螺旋弹簧，并为活塞提供偏置力。 多个微针布置在主表面侧。

    METHOD FOR PRODUCING PRESSURE-SENSITIVE ADHESIVE TAPE PACKAGE
    40.
    发明申请
    METHOD FOR PRODUCING PRESSURE-SENSITIVE ADHESIVE TAPE PACKAGE 有权
    用于生产压敏粘合胶带包装的方法

    公开(公告)号：US20140246144A1

    公开(公告)日：2014-09-04

    申请号：US14353107

    申请日：2012-10-23

    Applicant: HISAMITSU PHARMACEUTICAL CO.,INC.

    Inventor： Takafumi Miyachika ,  Kiyotaka Takada

    IPC: B32B37/26 ,  B32B38/00

    CPC classification number: B32B37/26 ,  A61F13/0008 ,  A61F13/0276 ,  A61F13/0279 ,  B32B38/0004 ,  B32B2037/268 ,  C09J7/38 ,  Y10T156/1015 ,  Y10T156/1036

    Abstract: An object of the present invention is to provide a method for producing a pressure-sensitive adhesive tape package suitable for mass production. The production method according to the present invention aims at producing a pressure-sensitive adhesive tape package which is a pressure-sensitive adhesive tape package 10 accommodating a pressure-sensitive adhesive tape 14 having a support 18 and an adhesive agent layer 12 provided on one surface of the support 18, the pressure-sensitive adhesive tape package comprising a release sheet 16 to which the adhesive agent layer of the adhesive tape is releasably attached. In this method, the adhesive tape 14 is bonded to the release sheet base material 116, and folded in two. Subsequently, a plurality of adhesive tapes 14 is heat sealed and temporarily attached to one release sheet base material 116, and the release sheet base material 116 is cut.

    Abstract translation: 本发明的目的是提供一种适用于批量生产的压敏胶带包装的制造方法。 根据本发明的制造方法的目的在于制造压敏粘合带包装，其是容纳具有支撑体18和设置在一个表面上的粘合剂层12的压敏粘合带14的压敏粘合带包装10 支撑件18的压敏胶带包装，其包括剥离片16，粘合剂胶带的粘合剂层可释放地附着到剥离片16上。 在该方法中，粘合带14与剥离片基材116接合，折叠成两层。 随后，多个粘合带14被热密封并临时附接到一个剥离片基材116上，并且剥离片基材116被切割。

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