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公开(公告)号:US5725777A
公开(公告)日:1998-03-10
申请号:US149319
申请日:1993-11-09
申请人: Michael A. Taylor
发明人: Michael A. Taylor
IPC分类号: A61L2/02 , B01D61/04 , B01D61/08 , B01D61/10 , B01F1/00 , B01J4/00 , B01J8/02 , C02F1/44 , B01D61/00
CPC分类号: C02F1/441 , A61L2/022 , B01D61/025 , B01D61/04 , B01D61/08 , B01D61/10 , B01D61/147 , B01F1/00 , B01F1/0033 , B01D2311/04 , B01F2001/0077 , C02F1/444
摘要: A reagent cartridge for reacting a soluble reagent with a fluid diluent is disclosed having a fluid inlet for accepting a diluent and fluid outlet for expelling a solution. The cartridge casing also has fluid manifolds adjacent to the inlet and the outlet for directing fluid in a radial direction from the inlet to the outlet. The casing further defines a receptacle for a soluble reagent. A volumetric compensation means for volumetrically compensating for dissolution of the reagent upon introduction of the diluent into the fluid inlet is provided. The volumetric compensation means can take the form of a resilient sponge material having a compressed volume and an expanded volume, wherein the expanded volume is up to at least 500% of the compressed volume. The volumetric compensation means can also take the form of resilient coil springs. In other embodiments, a fluid permeable pressure plate is positioned adjacent to a free end of the coil spring and the reagent is positioned against the pressure plate. A method for obtaining injectable quality intravenous solutions in the field using the reagent cartridge is also disclosed.
摘要翻译: 公开了一种用于使可溶性试剂与流体稀释剂反应的试剂盒,其具有用于接受用于排出溶液的稀释剂和流体出口的流体入口。 筒壳体还具有邻近入口和出口的流体歧管,用于将流体沿径向从入口引导到出口。 壳体还限定了可溶性试剂的容器。 提供了体积补偿装置,用于体积补偿试剂在将稀释剂引入流体入口时的溶解。 体积补偿装置可以采取具有压缩体积和膨胀体积的弹性海绵材料的形式,其中膨胀体积至多为压缩体积的至少500%。 体积补偿装置也可以采取弹性螺旋弹簧的形式。 在其它实施例中,流体可渗透的压力板被定位成与螺旋弹簧的自由端相邻,并且试剂抵靠压力板定位。 还公开了使用试剂盒在现场获得可注射质量静脉内溶液的方法。
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公开(公告)号:US5624678A
公开(公告)日:1997-04-29
申请号:US435946
申请日:1995-05-10
CPC分类号: C12Y302/01006 , A23K20/189 , A61K38/47 , A61K38/48 , C12Y302/01001 , C12Y302/01004 , C12Y302/01015 , C12Y302/01032 , C12Y304/21014 , Y10S426/807
摘要: The present invention provides a method of use, and a composition, of a carbohydrase and/or a protease for the manufacture of an agent for the treatment and/or prophylaxis of coccidiosis. The agent can be in the form of a cereal-based animal feed. The carbohydrase may be a polysaccharidase such as a xylanase or a cellulase e.g., .beta.-glucanase. The agent may include conventional non-enzymic anticoccidial agents.
摘要翻译: 本发明提供了用于制备用于治疗和/或预防球虫病的药剂的糖酶和/或蛋白酶的使用和组合物的方法。 药剂可以是谷物动物饲料的形式。 碳水解酶可以是多糖酶,例如木聚糖酶或纤维素酶,例如β-葡聚糖酶。 该试剂可以包括常规的非酶抗球虫剂。
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公开(公告)号:US20090008318A1
公开(公告)日:2009-01-08
申请号:US12173636
申请日:2008-07-15
CPC分类号: C02F9/00 , B01D61/18 , B01D63/02 , C02F1/283 , C02F1/42 , C02F1/44 , C02F2201/006 , C02F2301/08
摘要: A modular filter system is provided with one or more modules that can be interchangeable, depending upon the specific application or specific health or environmental issue presented. Disclosed combinations can include one or more of any of the following modules in any relative position to one another: (a) a microbiological contaminant mitigation module, preferably in the form of an inverted u-shaped hollow fiber filter module wherein the fibers have ends potted on the downstream side and that consists essentially of hydrophilic fibers for water filtration with a small amount of hydrophobic fibers for venting of entrapped air; (b) a first chemical mitigation module, preferably in the form of an adsorption module comprising carbon or the combination of carbon and a deionization resin; and (c) a second chemical mitigation module, preferably in the form of a deionization resin module. Modules including a carbon bed or a resin bed may be equipped with a pair of hydrophobic foam bed restraints that apply opposing axial pressure to the bed in all operating conditions.
摘要翻译: 模块化过滤器系统具有可以互换的一个或多个模块,这取决于具体应用或所呈现的特定健康或环境问题。 公开的组合可以包括彼此相对位置的任何以下模块中的一个或多个:(a)微生物污染物减轻模块,优选为倒U形中空纤维过滤器模块的形式,其中纤维具有端部盆 在下游侧,并且基本上由亲水纤维组成,用于用少量疏水纤维进行水过滤以排出被截留的空气; (b)第一化学缓解模块,优选为包含碳或碳与去离子树脂的组合的吸附模块的形式; 和(c)第二化学缓解模块,优选以去离子树脂模块的形式。 包括碳床或树脂床的模块可以配备一对疏水泡沫床限制器,其在所有操作条件下对床施加相反的轴向压力。
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公开(公告)号:US06986872B2
公开(公告)日:2006-01-17
申请号:US10664215
申请日:2003-09-16
申请人: Michael A. Taylor
发明人: Michael A. Taylor
IPC分类号: B01D11/02
CPC分类号: B01D67/0093 , A61M1/1656 , A61M1/1666 , A61M1/1668 , A61M1/28 , B01D61/00 , B01D61/002 , B01D61/18 , B01F1/0022 , B01F1/0033 , B01F15/0254 , B01F2215/0034 , C02F1/283 , C02F1/42 , C02F1/444 , C02F1/688 , C02F9/005 , C02F2001/422 , C02F2001/425 , C02F2103/026 , C02F2103/04 , Y02A20/214 , Y10S210/90 , Y10S210/908
摘要: The invention provides an apparatus and method for storing and transporting peritoneal dialysate in dry or lyophilized form, and for forming a deliverable peritoneal dialysis solution therefrom. In one embodiment, a dry reagent bed, including reagents sufficient to produce a dialysis solution, is suspended in a diluent flow path through the apparatus housing. Continuous pressure on the reagent bed causes the bed to compact as it erodes when purified water is passed through the housing. The pressure ensures complete and even dissolution of the reagents. Through dry storage and simple dissolution, even in a home, the invention enables a wider variety of solution constituents, including reduced acid content and the use of bicarbonate as a stable buffer component. The latter is illustrated in a double-bed embodiment, where bicarbonate is stored separately from calcium or magnesium salts within a single housing.
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公开(公告)号:US06932791B2
公开(公告)日:2005-08-23
申请号:US10437412
申请日:2003-05-12
申请人: Michael A. Taylor
发明人: Michael A. Taylor
CPC分类号: A61M5/282 , A61M5/284 , A61M5/288 , A61M5/31531 , A61M5/3294 , A61M2005/3142
摘要: A microinjection system comprises a device for housing dried forms of medical reagents, such as vaccines, hormones, etc. in single doses. Within a single chamber, a dry reagent bed is provided adjacent a compression component that keeps the bed compacted. In operation, diluent flows through the chamber to carry the reagent out of the chamber in fluid form. In the illustrated embodiments, the fluid carrying reagent is directly delivered from the chamber via a needle. Integral or connectable diluent delivery devices are disclosed for providing an appropriate volume of diluent to the reagent chamber. Unstable formulations of drugs, for example, can be safely stored in dry form. When injection is needed, the drug can be delivered almost instantly in fluid form simply by releasing diluent through the chamber, where the reagent bed is dissolved or suspended while the remaining reagent is continually compacted. The resultant fluid contains a single dose of the reagent and is delivered directly to a patient, desirably without measurement of the fluid form.
摘要翻译: 显微注射系统包括用于以单次剂量容纳干燥形式的药物试剂例如疫苗,激素等的装置。 在单个室内,在压缩部件附近设置干燥的试剂床,其保持床层压实。 在操作中,稀释剂流过室以将流体形式的试剂输送出室。 在所示实施例中,流体携带试剂通过针直接从腔室输送。 公开了用于向试剂室提供适当体积的稀释剂的整体或可连接的稀释剂输送装置。 不稳定的药物制剂,例如,可以安全地以干燥的形式储存。 当需要注射时,药物几乎可以以流体形式立即输送,简单地通过释放稀释剂通过室,其中试剂床溶解或悬浮,同时剩余的试剂持续压实。 所得流体含有单剂量的试剂,并且直接递送至患者,理想地不测量流体形式。
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公开(公告)号:US06916305B2
公开(公告)日:2005-07-12
申请号:US10339715
申请日:2003-01-08
申请人: Eugene C. Jones , Michael A. Taylor
发明人: Eugene C. Jones , Michael A. Taylor
CPC分类号: A61M5/1409 , A61M2202/064
摘要: Several improvements are disclosed for a drug delivery pack with dry reagent in a housing, each of which can be employed independently or in conjunction with others of the improvements. A novel spring is provided with two spring columns extending in parallel between a spring top and a spring bottom. The spring is particularly designed for fitting within the housing and compacting a dry reagent bed. A plunger mechanism to ratchet housing portions between two positions. In one position, a compression component adjacent the reagent bed is relatively uncompressed, such that it does not “set” over time. When the user is about to use the drug delivery device, the plunger is slid to compress the compression component so that it exerts pressure on the reagent bed. A similar sliding mechanism can also divert a stream of diluent through the housing from a priming path, where diluent bypasses the reagent bed, to a functional path passing through and eroding the reagent bed. Additionally, a method is provided for lyophilizing a liquid form of reagent within the housing from which it is to be delivered, thereby avoiding separate lyophilization and separate loading of dry form of the reagent.
摘要翻译: 在壳体中公开了具有干试剂的药物递送包的各种改进,每个可以独立地或与其他改进一起使用。 一个新的弹簧设有两个在弹簧顶部和弹簧底部之间平行延伸的弹簧柱。 弹簧特别设计用于安装在外壳内并压实干试剂床。 一种用于在两个位置之间棘轮收纳部分的柱塞机构。 在一个位置,邻近试剂床的压缩部件相对未压缩,使得其随着时间不“设定”。 当使用者即将使用药物输送装置时,柱塞被滑动以压缩压缩部件,从而对试剂床施加压力。 类似的滑动机构还可以将稀释剂流通过壳体从灌注路径转移到通过并侵蚀试剂床的功能路径上。 此外,提供了一种用于将液体形式的试剂冻结在壳体内以从其被输送的方法,从而避免单独的冻干和干燥形式的试剂的分离加载。
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公开(公告)号:US06858139B2
公开(公告)日:2005-02-22
申请号:US10639840
申请日:2003-08-12
申请人: Michael A. Taylor
发明人: Michael A. Taylor
IPC分类号: A61M1/16 , A61M1/28 , B01D61/00 , B01D61/18 , B01D67/00 , B01F1/00 , C02F1/28 , C02F1/42 , C02F1/44 , C02F1/68 , C02F9/00
CPC分类号: B01D67/0093 , A61M1/1656 , A61M1/1666 , A61M1/1668 , A61M1/167 , A61M1/28 , B01D61/00 , B01D61/18 , B01F1/0022 , B01F15/0254 , B01F2215/0034 , C02F1/283 , C02F1/42 , C02F1/444 , C02F1/688 , C02F9/005 , C02F2001/422 , C02F2001/425 , C02F2103/026 , C02F2103/04
摘要: A single housing comprising a diluent inlet, a solution outlet, and a plurality of discrete reagent beds comprising at least one reagent in dry form, wherein said reagent is present in the discrete reagent bed in a proportion sufficient for production of a complete hemodialysate solution.
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公开(公告)号:US06719745B1
公开(公告)日:2004-04-13
申请号:US09364631
申请日:1999-07-30
申请人: Michael A. Taylor
发明人: Michael A. Taylor
IPC分类号: A61B1900
CPC分类号: B01D67/0093 , A61M1/1656 , A61M1/1666 , A61M1/1668 , A61M1/28 , B01D61/00 , B01D61/002 , B01D61/18 , B01F1/0022 , B01F1/0033 , B01F15/0254 , B01F2215/0034 , C02F1/283 , C02F1/42 , C02F1/444 , C02F1/688 , C02F9/005 , C02F2001/422 , C02F2001/425 , C02F2103/026 , C02F2103/04 , Y02A20/214 , Y10S210/90 , Y10S210/908
摘要: An apparatus and methods are disclosed for purifying fluid, such as potable water, to quality levels suitable for medical application, particularly to applications involving injection of the fluid into a human body. The apparatus comprises a portable purification pack constructed for a single use. The pack houses depth filtration, activated carbon, mixed bed ion exchange resins and terminal filtration stages in series. The terminal filter comprises a fine (microfiltration or ultrafiltration), permeable membrane, treated with an endotoxin-binding chemistry. In contrast with semi-permeable osmotic membranes, the permeable membrane produces high flow rates at relatively low pressures, while still safely purifying fluid to injection quality.
摘要翻译: 公开了用于将诸如饮用水的流体净化到适合于医疗应用的质量水平的装置和方法,特别是涉及将流体注入人体内的应用。 该装置包括用于单次使用的便携式净化包。 包装深度过滤,活性炭,混合床离子交换树脂和终端过滤阶段。 终端过滤器包括用内毒素结合化学物质处理的细微(微滤或超滤),可渗透的膜。 与半渗渗透膜相反,渗透膜在相对低的压力下产生高流量,同时仍然可靠地将流体净化到注射质量。
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公开(公告)号:US06657019B2
公开(公告)日:2003-12-02
申请号:US09988459
申请日:2001-11-20
IPC分类号: C08F200
CPC分类号: C08F2/22 , B01J19/0006 , B01J19/24 , B01J19/2445 , B01J2219/00006 , B01J2219/00063 , B01J2219/00069 , B01J2219/00081 , B01J2219/00164 , B01J2219/00198 , B01J2219/00213 , B01J2219/00231 , C08F2400/02 , G01N33/442 , G05B13/048 , G05B17/02
摘要: The present invention is a method for predicting polymer latex properties for an emulsion polymer latex based on statistical relationships between the polymer latex properties and process parameters for the emulsion polymerization process. The method for predicting one or more polymer latex properties for an emulsion polymer latex according to the invention includes conducting an emulsion polymerization process in a reactor including one or more reactor inputs to produce an emulsion polymer latex, measuring a set of process parameters for the emulsion polymerization process, performing a heat balance and a mass balance across the reactor based on the set of measured process parameters to determine a set of calculated polymer latex properties for the emulsion polymerization process, and determining one or more predicted polymer latex properties for the emulsion polymer being prepared in the emulsion polymerization process using the measured process parameters, the calculated polymer latex properties, and a set of predetermined statistical relationships between the process parameters and the polymer latex properties to be predicted. The present invention also includes an apparatus and a computer program product for predicting the polymer latex properties of an emulsion polymer latex.
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公开(公告)号:US06478102B1
公开(公告)日:2002-11-12
申请号:US09838990
申请日:2001-04-21
IPC分类号: B62D33063
CPC分类号: B60G99/004 , B60G2204/162 , B62D27/04 , B62D33/0604 , F16F1/445
摘要: A vehicle includes a body structure that is suspended from a chassis of the vehicle by a vehicle body suspension system. The vehicle body suspension system is constructed in a manner to allow relative movement to occur between the suspended body structure and the chassis in such a manner to at least partially isolate the suspended body structure from the vibrations and accelerations of the chassis. The vehicle body suspension system includes one or more spring/damper components that comprise an elastomer body that is surrounded and, therefore, reinforced by a reinforcing wall constructed of a relatively rigid material. The vehicle body suspension system may utilize one or more of the reinforced elastomer block spring/damper components as bump stops and/or primary spring/damper components.
摘要翻译: 车辆包括通过车身悬挂系统从车辆的底盘悬挂的车体结构。 车身悬挂系统构造成允许在悬挂体结构和底盘之间发生相对运动,使得悬挂的主体结构至少部分地与底盘的振动和加速度隔离。 车身悬挂系统包括一个或多个弹簧/阻尼器部件,其包括被包围的弹性体,并且因此由由相对刚性的材料构成的加强壁增强。 车身悬挂系统可以利用一个或多个增强的弹性体弹簧/弹簧/阻尼器部件作为凸块止动件和/或初级弹簧/阻尼器部件。
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