公开(公告)号：US5531685A

公开(公告)日：1996-07-02

申请号：US284076

申请日：1994-08-01

Applicant: Chad G. Hemmer ,  John A. Steen ,  Michael R. Forman ,  Jonathan R. McGrath

Inventor： Chad G. Hemmer ,  John A. Steen ,  Michael R. Forman ,  Jonathan R. McGrath

IPC: A61M25/01 ,  A61M37/00 ,  A61M25/00

CPC classification number: A61M25/0158

Abstract: An apparatus includes a flexible tubular member containing a shape-memory tube formed to include a lumen extending along the central axis of the tubular member. A liner sleeve extends through the lumen of the shape-memory tube and lies inside the tubular member. A control system selectively heats the shape-memory tube to its activated state causing the shape-memory tube to move toward a predetermined shape if it is different than its present configuration. Whether the shape-memory tube moves or not, it will increase significantly in stiffness, both axial and bending to help retain, hold, or wedge the apparatus in place in a selected body cavity while catheters or other objects are passed through a lumen in the liner sleeve.

Abstract translation: 一种装置包括柔性管状构件，其包含形状记忆管，该形状记忆管形成为包括沿管状构件的中心轴延伸的内腔。 衬套套筒延伸穿过形状记忆管的内腔并位于管状构件的内部。 控制系统选择性地将形状记忆管加热至其激活状态，导致形状记忆管如果不同于其当前配置则朝预定形状移动。 无论形状记忆管是否移动，它将在刚度（轴向和弯曲）方面显着增加，以帮助将装置保持，保持或楔入所选体腔内的适当位置，同时导管或其它物体通过内窥镜 衬套。

公开(公告)号：US5505699A

公开(公告)日：1996-04-09

申请号：US217306

申请日：1994-03-24

Applicant: Michael R. Forman ,  Michael N. Helmus ,  Joseph E. Laptewicz, Jr.

Inventor： Michael R. Forman ,  Michael N. Helmus ,  Joseph E. Laptewicz, Jr.

IPC: A61M25/00 ,  A61F2/82 ,  A61M29/02 ,  A61M29/00

CPC classification number: A61M25/104 ,  A61M2025/0186 ,  A61M2025/09141 ,  A61M2025/1015 ,  A61M2025/1093

Abstract: This invention relates to an angioplasty device that is formed from a hollow metallic tube, a balloon affixed adjacent the distal end of the tube and being in fluid communication with the lumen of the tube, a flexible distal segment connected to the distal end of the tube and a removable hub connected adjacent to the proximal end of the tube. The tube is preferably formed from a superelastic material such as nickel-titanium alloy. This invention also relates to various methods of using this angioplasty device.

Abstract translation: 本发明涉及一种由中空金属管形成的血管成形术装置，邻近管的远端固定并与管的内腔流体连通的球囊，连接到管的远端的柔性远端段 以及与管的近端相邻连接的可移除的轮毂。 该管优选由诸如镍 - 钛合金的超弹性材料形成。 本发明还涉及使用该血管成形术装置的各种方法。

公开(公告)号：US5501759A

公开(公告)日：1996-03-26

申请号：US304413

申请日：1994-09-12

Applicant: Michael R. Forman

Inventor： Michael R. Forman

IPC: A61M25/00 ,  A61M25/16 ,  B29C35/08 ,  B29C65/00 ,  B29C65/14 ,  B29C65/16 ,  B32B31/00

CPC classification number: A61M25/1034 ,  B29C65/1622 ,  B29C65/1635 ,  B29C65/1654 ,  B29C65/1664 ,  B29C65/1667 ,  B29C65/1683 ,  B29C65/1687 ,  B29C65/68 ,  B29C66/1122 ,  B29C66/3452 ,  B29C66/53241 ,  B29C66/5344 ,  B29C66/63 ,  B29C66/65 ,  B29C66/652 ,  B29C66/73921 ,  B29C66/80 ,  A61M2025/1031 ,  A61M25/0009 ,  B29C2035/0822 ,  B29C65/1616 ,  B29C65/1619 ,  B29C65/1661 ,  B29C66/71 ,  B29K2995/0049 ,  B29K2995/0069 ,  B29L2022/022 ,  B29L2031/7542 ,  B29L2031/7543

Abstract: A process for assembling a balloon catheter involves selectively concentrating laser energy along an annular fusion bond site at contiguous surface portions of a length of catheter tubing and a shaft or neck portion of a dilatation balloon. The laser energy wavelength, and the polymeric materials of the balloon and catheter, are matched for high absorption of the laser energy to minimize conductive heat transfer in axial directions away from the bond site. This minimizes crystallization and stiffening in regions near the bond site, permitting fusion bonds to be located close to the proximal and distal cones of the dilatation balloon while preserving the soft, pliant quality of the cones. The disclosure further is directed to an embodiment of a balloon catheter assembled according to the process.

Abstract translation: 一种用于组装气囊导管的方法包括选择性地将激光能量沿着一定长度的导管管线和扩张球囊的轴或颈部部分的连续表面部分处的环形熔合部位集中。 激光能量波长以及球囊和导管的聚合物材料匹配，以激光能量的高吸收，以最小化离开粘结部位的轴向方向的传导热传递。 这使得结合位置附近的区域的结晶化和硬化最小化，允许熔融粘合位置靠近扩张球囊的近端和远端锥体，同时保持锥体的柔软，质地良好的质量。 本发明进一步涉及根据该方法组装的球囊导管的实施例。

公开(公告)号：US07338487B2

公开(公告)日：2008-03-04

申请号：US10010911

申请日：2001-11-20

Applicant: Victor I. Chornenky ,  Michael R. Forman

Inventor： Victor I. Chornenky ,  Michael R. Forman

IPC: A61B18/18 ,  A61B5/10

CPC classification number: A61N5/1001 ,  A61N5/1002 ,  A61N2005/1003 ,  H01J35/32 ,  H01J2201/304 ,  H01J2201/306

Abstract: Generally, the present invention provides a device for insertion into a body of a subject being treated to deliver localized x-ray radiation, and a method for fabricating such a device. The device includes a cathode structure that has a thin, diamond film as a cathode. The device further comprises a vacuum housing and an anode. A method for fabricating a device for localized x-ray radiation is described which includes the formation of a thin diamond film on a getter at temperatures below an activation temperature of the getter.

Abstract translation: 通常，本发明提供一种用于插入被处理以递送局部x射线辐射的对象的身体的装置，以及用于制造这种装置的方法。 该器件包括具有薄的金刚石膜作为阴极的阴极结构。 该装置还包括真空壳体和阳极。 描述了一种用于制造用于局部x射线辐射的装置的方法，其包括在低于吸气剂的活化温度的温度下在吸气剂上形成薄金刚石膜。

公开(公告)号：US06503224B1

公开(公告)日：2003-01-07

申请号：US09631750

申请日：2000-08-04

Applicant: Michael R. Forman ,  Jonathan S. Stinson ,  Michael N. Helmus

Inventor： Michael R. Forman ,  Jonathan S. Stinson ,  Michael N. Helmus

IPC: A61M2900

CPC classification number: A61M25/104 ,  A61B2017/00685 ,  A61M1/101 ,  A61M1/1018 ,  A61M1/1036 ,  A61M1/122 ,  A61M1/125 ,  A61M1/127 ,  A61M25/00 ,  A61M29/02 ,  A61M2025/1095

Abstract: A balloon catheter having a perfusion lumen communicating with a blood vessel, and a magnetically driven impeller disposed in the perfusion lumen to increase blood flow through the catheter and the arteries.

Abstract translation: 具有与血管连通的灌注腔的气囊导管和设置在灌注腔内的磁驱动叶轮以增加通过导管和动脉的血流。

公开(公告)号：US06265016B1

公开(公告)日：2001-07-24

申请号：US09531925

申请日：2000-03-21

Applicant: Fritz Hostettler ,  David Rhum ,  Michael R. Forman ,  Michael N. Helmus ,  Ni Ding

Inventor： Fritz Hostettler ,  David Rhum ,  Michael R. Forman ,  Michael N. Helmus ,  Ni Ding

IPC: B05D302

CPC classification number: C08J7/047 ,  A61L29/085 ,  A61L31/10 ,  C08G18/10 ,  C08G18/283 ,  C08G2230/00 ,  C08J7/04 ,  C08J2475/00 ,  Y10T428/31554 ,  Y10T428/31562 ,  Y10T428/31565 ,  Y10T428/31569 ,  Y10T428/31587 ,  Y10T428/31678 ,  A61L31/145 ,  A61L29/145 ,  C08L75/04 ,  C08G18/307 ,  C08G18/3225

Abstract: A process for the preparation of slippery, hydrophilic polyurethane hydrogel coating compositions, and materials composed of a polymeric plastic or rubber substrate or a metal substrate with a coating of a slippery, hydrophilic polyurethane hydrogel thereon, such that the coating composition tenaciously adheres to the substrate, are disclosed. The coating compositions and coated materials are non-toxic and biocompatible, and are ideally suited for use on medical devices, particularly, catheters, catheter balloons and stents. The coating compositions, coated materials and coated devices demonstrate low coefficients of friction in contact with body fluids, especially blood, as well as a high degree of wear permanence over prolonged use of the device. The hydrogel coating compositions are capable of being dried to facilitate storage of the devices to which they have been applied, and can be instantly reactivated for later use by exposure to water.

Abstract translation: 用于制备光滑的亲水性聚氨酯水凝胶涂料组合物的方法，以及由聚合物塑料或橡胶基材或金属基材组成的材料，其上具有光滑的亲水性聚氨酯水凝胶涂层，使得涂料组合物顽固地粘附于基材 ，被披露。 涂料组合物和涂层材料是无毒的和生物相容的，并且理想地适用于医疗装置，特别是导管，导管气囊和支架。 涂层组合物，涂覆材料和涂覆的装置表现出与体液，特别是血液接触的低摩擦系数，以及在长时间使用该装置时高度的磨损持久性。 水凝胶涂料组合物能够被干燥以促进其已被施加到其上的装置的储存，并且可以立即重新活化以便随后通过暴露于水中使用。

公开(公告)号：US6030656A

公开(公告)日：2000-02-29

申请号：US126375

申请日：1998-03-24

Applicant: Fritz Hostettler ,  David Rhum ,  Michael R. Forman ,  Michael N. Helmus ,  Ni Ding

Inventor： Fritz Hostettler ,  David Rhum ,  Michael R. Forman ,  Michael N. Helmus ,  Ni Ding

IPC: A61L29/08 ,  A61L31/10 ,  C08G18/10 ,  C08G18/28 ,  C08J7/04 ,  B05D7/14

CPC classification number: C08J7/047 ,  A61L29/085 ,  A61L31/10 ,  C08G18/10 ,  C08G18/283 ,  C08J7/04 ,  C08G2230/00 ,  C08J2475/00 ,  Y10T428/31554 ,  Y10T428/31562 ,  Y10T428/31565 ,  Y10T428/31569 ,  Y10T428/31587 ,  Y10T428/31678

Abstract: A process for the preparation of slippery, hydrophilic polyurethane hydrogel coating compositions, and materials composed of a polymeric plastic or rubber substrate or a metal substrate with a coating of a slippery, hydrophilic polyurethane hydrogel thereon, such that the coating composition tenaciously adheres to the substrate, are disclosed. The coating compositions and coated materials are non-toxic and biocompatible, and are ideally suited for use on medical devices, particularly, catheters, catheter balloons and stents. The coating compositions, coated materials and coated devices demonstrate low coefficients of friction in contact with body fluids, especially blood, as well as a high degree of wear permanence over prolonged use of the device. The hydrogel coating compositions are capable of being dried to facilitate storage of the devices to which they have been applied, and can be instantly reactivated for later use by exposure to water.

Abstract translation: 用于制备光滑的亲水性聚氨酯水凝胶涂料组合物的方法，以及由聚合物塑料或橡胶基材或金属基材组成的材料，其上具有光滑的亲水性聚氨酯水凝胶涂层，使得涂料组合物顽固地粘附于基材 ，被披露。 涂料组合物和涂层材料是无毒的和生物相容的，并且理想地适用于医疗装置，特别是导管，导管气囊和支架。 涂层组合物，涂覆材料和涂覆的装置表现出与体液，特别是血液接触的低摩擦系数，以及在长时间使用该装置时高度的磨损持久性。 水凝胶涂料组合物能够被干燥以促进其已被施加到其上的装置的储存，并且可以立即重新活化以便随后通过暴露于水中使用。

公开(公告)号：US06799075B1

公开(公告)日：2004-09-28

申请号：US08701764

申请日：1996-08-22

Applicant: Victor I. Chornenky ,  Michael R. Forman

Inventor： Victor I. Chornenky ,  Michael R. Forman

IPC: A61B1818

CPC classification number: A61N5/1001 ,  A61N5/1002 ,  A61N2005/1003 ,  H01J35/32 ,  H01J2201/304 ,  H01J2201/306

Abstract: A catheter for emitting radiation is disclosed, comprising a catheter shaft and an x-ray unit attached to the distal end of the catheter shaft. The x-ray unit comprises an anode and a cathode coupled to an insulator to define a vacuum chamber. The cathode is preferably a field emission cathode of graphite or graphite coated with titanium carbide, for example. The anode is preferably tungsten and the insulator is preferably pyrolytic boron nitride. The x-ray unit is preferably coupled to a voltage source through a coaxial cable. The anode is preferably a heavy metal such as tungsten. The cathode may also be a ferroelectric material. The x-ray unit can have a diameter less than about 4 mm and a length less than about 15 mm. Methods of use of the catheter are also disclosed. The catheter of the present invention can be used to irradiate the site of an angioplasty procedure to prevent restenosis. It can also be used to treat other conditions in any vessel, lumen or cavity of the body.

Abstract translation: 公开了一种用于发射辐射的导管，包括导管轴和附接到导管轴的远端的x射线单元。 x射线单元包括阳极和阴极，其耦合到绝缘体以限定真空室。 阴极优选为例如涂覆有碳化钛的石墨或石墨的场致发射阴极。 阳极优选为钨，绝缘体优选为热解氮化硼。 X射线单元优选地通过同轴电缆耦合到电压源。 阳极优选为重金属，例如钨。 阴极也可以是铁电材料。 x射线单元的直径可以小于约4毫米，长度小于约15毫米。 还公开了导管的使用方法。 本发明的导管可用于照射血管成形术程序的部位以防止再狭窄。 它也可以用于治疗身体的任何血管，腔或腔中的其他病症。