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公开(公告)号：US20180290136A1
公开(公告)日：2018-10-11
申请号：US15764731
申请日：2016-10-19
Applicant: Rohto Pharmaceutical Co., Ltd.
Inventor： Tetsuo Koike , Masahiro Takimoto , Yoshiki Yagi
Abstract: Provided is a cell treatment apparatus that includes: an isolator; a disposal box that includes a storage part; and a decontamination unit, wherein the disposal box includes: a first opening and closing device that is configured to allow the isolator and the storage part to be communicated with each other at the time of disposal of the waste product and allow them to be shut off from each other after the putting-in of the waste product and before the disposal of the same; and a second opening and closing device that is configured to allow the storage part and the outside to be communicated with each other at the time of disposal of the waste product, which has been put into the storage part, and allow them to be shut off from each other after the disposal of the waste product.
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公开(公告)号：US20180161262A1
公开(公告)日：2018-06-14
申请号：US15577552
申请日：2016-05-26
Applicant: ROHTO PHARMACEUTICAL CO., LTD.
Inventor： Tomohiro Tsuda , Masayo Yumoto
CPC classification number: A61K8/65 , A61K8/345 , A61K8/64 , A61K38/06 , A61K38/07 , A61K2800/592 , A61K2800/78 , A61Q19/00 , G01N33/502 , G01N33/5029 , G01N33/5073
Abstract: The present invention relates to a cosmetic method comprising applying a migration imparting agent for adipose-derived stem cells to the skin, thereby allowing adipose-derived stem cells to migrate to the dermal layer and improving a skin condition. The present invention also relates to an external skin preparation for use in the cosmetic method, the external skin preparation comprising a migration imparting agent allowing adipose-derived stem cells to migrate to the dermal layer by application to the skin. The present invention further relates to a migration imparting agent for adipose-derived stem cells, comprising at least one of a polyol compound and a hydrophilic biomaterial. The present invention further relates to a method of screening for a component for use in a cosmetic method for improving a skin condition, comprising evaluating migratory activity of adipose-derived stem cells by using a prepared medium containing a sample.
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33.发明申请公开(公告)号：US20180072980A1
公开(公告)日：2018-03-15
申请号：US15553872
申请日：2016-03-03
Applicant: Rohto Pharmaceutical Co., Ltd.
Inventor： Tetsuo Koike , Masahiro Takimoto , Yoshiki Yagi
CPC classification number: C12M41/36 , C12M1/00 , C12M1/34 , C12M1/36 , C12M3/02 , C12M41/46 , C12M41/48 , C12N5/06 , C12R1/91 , G06T1/0014
Abstract: Provided is an apparatus to produce cultured cell products including: an isolator configured to maintain its inside in aseptic conditions and process cell culture vessels therein; and at least one robot arm located within the isolator, wherein a taking-out step of taking out cells cultured in the cell culture vessels, a cell density-adjusting step of adjusting density of the cells in a cell-containing liquid containing the taken-out cells, and a subdividing step of subdividing and placing the cell-containing liquid with its density adjusted into a plurality of product containers are performed within the isolator by the at least one robot arm.
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公开(公告)号：US20170105934A1
公开(公告)日：2017-04-20
申请号：US15317851
申请日：2015-06-09
Applicant: ROHTO Pharmaceutical Co., Ltd.
Inventor： Yoko Mizutare , Yasuko Matsumura
CPC classification number: A61K9/08 , A61K9/0048 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/18 , A61K47/26
Abstract: An aqueous ophthalmic composition is provided comprising at least one component which is selected from the group consisting of a polysaccharide, a monosaccharide, at least one vitamin component selected from the group consisting of vitamin B12, vitamin B2, vitamin A and panthenol, at least one oil component selected from the group consisting of a plant oil, an animal oil and a mineral oil, at least one surfactant selected from the group consisting of polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, polyoxyethylene polyoxypropylene glycol and polyoxyl stearate, an anti-allergic component, a preservative, a thickening component, a polyhydric alcohol, an anti-inflammatory component, an anti-bacterial agent and a cooling and/or refreshing agent; and (B) a buffering agent. When the composition is brought into contact with a polybutylene terephthalate-containing resin container, the container can be prevented from weight change, deterioration and wetting and can be improved in a liquid cutting property.
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35.发明申请公开(公告)号：US20170027880A1
公开(公告)日：2017-02-02
申请号：US15038897
申请日：2014-11-28
Applicant: ROHTO PHARMACEUTICAL CO., LTD.
Inventor： Satoshi Yamaguchi , Kazuhiro Tsuji
IPC: A61K31/01 , A61K47/44 , A61K47/02 , A61K9/08 , A61K9/00 , A61K36/18 , A61K31/355 , A61K47/18 , A61K47/26 , A61K47/10
CPC classification number: A61K31/01 , A61K9/0043 , A61K9/0048 , A61K9/08 , A61K9/107 , A61K9/12 , A61K31/355 , A61K36/18 , A61K47/02 , A61K47/10 , A61K47/183 , A61K47/26 , A61K47/44
Abstract: The present invention relates to an aqueous composition for ophthalmological use or otolaryngological use, the aqueous composition containing: (A) a petrolatum; and two or more (B) nonionic surfactants.
Abstract translation: 本发明涉及用于眼科用途或耳鼻喉科用途的水性组合物，所述水性组合物含有：（A）凡士林; 和两种或更多种（B）非离子表面活性剂。
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Patent Agency Ranking
公开(公告)号：US20150209437A1
公开(公告)日：2015-07-30
申请号：US14683579
申请日：2015-04-10
Applicant: ROHTO PHARMACEUTICAL CO., LTD.
Inventor： Chinatsu FURUMIYA , Takayuki MIYANO , Atsuko NAKATA , Eri MATSUMOTO
CPC classification number: A61K47/44 , A61K9/0048 , A61K9/08 , A61K47/02 , A61K47/10 , A61K47/24 , A61K47/26
Abstract: This invention relates to an aqueous ophthalmic composition comprising (A) polyoxyethylene castor oil in which the average number of moles of added ethylene oxide is 2 to 12 and (B) terpenoid. According to the present invention, an aqueous ophthalmic composition having an improved foam disappearance speed can be obtained.
Abstract translation: 本发明涉及一种水性眼用组合物，其包含（A）聚氧乙烯蓖麻油，其中加入的环氧乙烷的平均摩尔数为2至12，（B）萜类化合物。 根据本发明，可以获得具有改善的泡沫消失速度的眼用组合物。
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公开(公告)号：US20150018416A1
公开(公告)日：2015-01-15
申请号：US14384810
申请日：2013-11-29
Applicant: ROHTO PHARMACEUTICAL CO., LTD.
Inventor： Ryo Komurasaki , Yoko Mizutare , Atsuko Nakata
CPC classification number: A61K47/44 , A01N25/22 , A01N37/36 , A61K9/0048 , A61K31/07 , A61K31/23 , A61K47/10 , A61K47/14 , A61K47/34
Abstract: The present invention relates to an aqueous ophthalmic composition comprising (A) polyoxyethylene castor oil, (B) polyethylene glycol monostearate, and (C) at least one member selected from the group consisting of sesame oil, castor oil, vitamin A, and chlorobutanol.
Abstract translation: 本发明涉及包含（A）聚氧乙烯蓖麻油，（B）聚乙二醇单硬脂酸酯和（C）至少一种选自由芝麻油，蓖麻油，维生素A和氯丁醇组成的组的组合物的水性眼用组合物。
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公开(公告)号：US20140296348A1
公开(公告)日：2014-10-02
申请号：US14355383
申请日：2012-10-31
Applicant: ROHTO PHARMACEUTICAL CO., LTD.
Inventor： Yasuko Matsumura , Chinatsu Furumiya , Masashi Itoh
IPC: A61K47/02 , A61K31/045
CPC classification number: A61K47/02 , A61K9/0048 , A61K9/08 , A61K31/045 , A61K31/122 , A61K31/125 , A61K33/30 , A61K2300/00
Abstract: The present invention provides an aqueous ophthalmic composition having a pH of 7 or more, containing a terpenoid and zinc chloride. According to the present invention, an aqueous ophthalmic composition is provided in which adsorption of the terpenoid to a container can be inhibited, thereby making it possible to inhibit the reduction in the terpenoid content for a long period of time, the aqueous ophthalmic composition having some excellent actions such as an inhibitory action for histamine release, and an inhibitory action for discharges from the eyes.
Abstract translation: 本发明提供了含有萜类化合物和氯化锌的pH为7以上的水性眼用组合物。 根据本发明，提供一种眼科组合物，其中可以抑制萜类化合物对容器的吸附，从而可以长时间抑制萜类化合物含量的降低，眼用组合物具有一些 优良的作用如对组胺释放的抑制作用，以及从眼睛排出的抑制作用。
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公开(公告)号：US08754029B2
公开(公告)日：2014-06-17
申请号：US13678064
申请日：2012-11-15
Applicant: Rohto Pharmaceutical Co., Ltd.
Inventor： Yasuko Matsumura , Kazuhiro Fukushima
IPC: A61K31/00
CPC classification number: A61K31/045 , A61F9/0061 , A61K9/0046 , A61K31/125 , A61K31/717 , A61K31/721 , A61K31/74
Abstract: The present invention provides an ophthalmic composition which stabilizes the tear film during wearing contact lens, prevents eye dryness, imparts a favorable sensation in using, is highly convenient with no risk of misuse and shows a high efficiency in the course from manufacturing to sales. More specifically, the present invention provides a wetting solution—eye drops for contact lenses comprising (A) one or more member(s) selected from the group consisting of a cellulose-based polymer, a vinyl-based polymer, polyethylene glycol and dextran; and (B) a terpenoid.
Abstract translation: 本发明提供了一种眼用组合物，其在佩戴隐形眼镜期间稳定了泪膜，防止眼睛干涩，赋予使用感觉，非常方便，没有被误用的风险，并且在制造过程中显示出高效率。 更具体地说，本发明提供一种用于隐形眼镜的润湿溶液 - 滴眼剂，其包括（A）一种或多种选自纤维素基聚合物，乙烯基类聚合物，聚乙二醇和葡聚糖的成员; 和（B）萜类化合物。
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公开(公告)号：US20140045948A1
公开(公告)日：2014-02-13
申请号：US14056264
申请日：2013-10-17
Applicant: ROHTO PHARMACEUTICAL CO., LTD.
Inventor： Takayuki MIYANO , Takahiro KUROSE
IPC: A61K31/121 , A61K9/00
CPC classification number: A61K31/121 , A01N1/0226 , A61K9/0048 , A61K47/02 , A61K47/24 , A61K47/26 , A61K47/44 , A61L12/12 , B65D65/38 , Y10T428/1397
Abstract: An ophthalmic composition kit comprising an ophthalmic container holding an ophthalmic composition comprising geranylgeranylacetone, the ophthalmic container having a surface in contact with the ophthalmic composition, the surface being at least partially or wholly made of a container material selected from the group consisting of a polyolefin, an acrylic acid resin, a terephthalic acid ester, a polycarbonate, a polymethylterpene, a fluorine resin and a glass, the ophthalmic composition kit having an advantage that the loss of the geranylgeranylacetone content or decrease in the geranylgeranylacetone concentration in the ophthalmic composition is very little.
Abstract translation: 一种眼用组合物试剂盒，其包含容纳含有香叶基香叶基丙酮的眼用组合物的眼用容器，所述眼用容器具有与所述眼用组合物接触的表面，所述表面至少部分或全部由选自以下的容器材料制成：聚烯烃， 丙烯酸树脂，对苯二甲酸酯，聚碳酸酯，聚甲基萜烯，氟树脂和玻璃，眼用组合物试剂盒具有以下优点，即眼用组合物中er牛ger牛儿基丙酮含量的损失或香叶基香叶基丙酮浓度的降低非常小 。
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