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公开(公告)号:US20210077520A1
公开(公告)日:2021-03-18
申请号:US17042441
申请日:2019-03-27
Inventor: Shulamit LEVENBERG , Shaowei GUO , Daniel OFFEN , Nisim PERETS
IPC: A61K31/713 , A61K35/28 , A61K38/51 , C12N15/113
Abstract: The present invention provides pharmaceutical compositions comprising membrane vesicles, including extracellular vesicles including those referred to as exosomes, loaded with an exogenous Phosphatase and tensin homolog (PTEN) inhibitor. Methods of treating neurological diseases, disorders or conditions using the extracellular vesicles are provided. Isolated extracellular vesicles loaded with an exogenous Phosphatase and tensin homolog (PTEN) inhibitor are provided as well.
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公开(公告)号:US10603315B2
公开(公告)日:2020-03-31
申请号:US15037412
申请日:2014-11-26
Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LIMITED , HEALTH CORPORATION—RAMBAM , THE RAPPAPORT INSTITUTE
Inventor: Asya Rolls , Tamar Ben Shannan , Hilla Azulay-Debbie , Fahed Hakim , Maya Schiller , Shai Shen-Orr , Elina Starosvetsky
IPC: A61N2/00 , A61N2/02 , A61K31/48 , A61K31/428 , A61K31/473 , A61K31/506 , A61K31/404 , A61K31/4045
Abstract: A method for modulating an immune response by activating or inhibiting dopaminergic neurons in the Ventral Tegmental Area (VTA) is provided. Modulation is achieved by modulating the activity, the abundance or both of: a natural killer cell, a CD8 T-cell, a CD4 T-cell, a B-cell, a dendritic cell, a macrophage, a granulocyte, or their combination.
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公开(公告)号:US20190329911A1
公开(公告)日:2019-10-31
申请号:US16310175
申请日:2017-06-15
Inventor: Igal KRONHAUS
Abstract: A vacuum arc thruster device having a cathode rod disposed within a concentric insulator tube, and an anode electrode located at the distal edge of the insulator tube, separated from the cathode rod by the insulator tube. A controlled feeding mechanism moves the cathode towards the distal exit plane in a helical motion, the cathode rotating as it moves forward. The cathode rod is fixed in the center of a headless screw segment, which is rotated within a screw thread on the internal surface of a cylindrical wall of the device. As the erosion rate is concentrated at the exit plane, the screw action path enables uniform erosion around the cathode circumference, and cathode linear motion that can be matched to the radial erosion rate. The feeding rate and hence the thrust are proportional to the input power, which can be regulated by the pulse frequency.
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公开(公告)号:US20180067077A1
公开(公告)日:2018-03-08
申请号:US15818837
申请日:2017-11-21
Inventor: Moran Bercovici , Ortal Schwartz
IPC: G01N27/447
Abstract: A system comprising a protein and a channel. The channel has a domain that binds a membranal component. The channel is configured to carry a liquid sample to an isotachophoresis (ITP) apparatus. The liquid sample comprising or suspected of comprising a cell, a cell membrane or a fraction of a cell membrane. The ITP apparatus comprises a first zone and a second zone. The first zone is configured to contain a solution of high effective mobility leading electrolyte (LE) ion. The second zone is configured to contain a solution of low effective mobility trailing electrolyte (TE) ion. The first zone and the second zone are configured to be operably connected to at least one anode and at least one cathode.
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公开(公告)号:US20170219739A1
公开(公告)日:2017-08-03
申请号:US15418743
申请日:2017-01-29
Applicant: The Board of Trustees of the Leland Stanford Junior University , TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LIMITED , Florida Research Foundation, Inc.
Inventor: Dianmin Lin , Mark L. Brongersma , Erez Hasman , Pieter G. Kik , Aaron L. Holsteen
Abstract: A multifunctional dielectric gradient metasurface optical device has a layer of nanoscale dielectric gradient metasurface optical antenna elements deposited on a substrate layer, arranged with spatially varying orientations, shapes, or sizes in the plane of the device such that the optical device has a spatially varying optical phase response capable of optical wavefront shaping. The spatially varying optical phase response is a spatial interleaving of multiple distinct phase profiles corresponding to multiple optical sub-elements, thereby providing multifunctional wavefront shaping in the single optical element.
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公开(公告)号:US09655848B2
公开(公告)日:2017-05-23
申请号:US14440834
申请日:2013-11-19
Inventor: Nahum Allon , Moshe Gavish
CPC classification number: A61K9/1272 , A61K9/1277 , A61K31/365 , A61K47/42 , C07K1/1077 , C07K7/00 , C12N15/88 , C12N2320/32 , C12N2320/53 , C12N2500/36 , C12Q2563/161
Abstract: The present invention provides a liposome based composition wherein the liposome includes a peptide conjugated thereto via a peptide bond, wherein the peptide includes a spacer amino acid and a short Apolipoprotein E recognition sequence or a short Amyloid beta recognition sequence. This invention further provides a process for making the liposome and methods of utilizing the liposome based composition for therapeutic and diagnostic purposes.
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公开(公告)号:US12171545B2
公开(公告)日:2024-12-24
申请号:US16889173
申请日:2020-06-01
Inventor: Alon Wolf , Hadar Shaulian
Abstract: A robotic shoe which provides real-time feedback regarding forces acting on the foot of the user, in order to modify these forces in a corrective or diagnostic manner. The shoe comprises an insole equipped with embedded pressure sensors enabling it to continuously monitor the ground reaction forces (GRF) and the foot center of pressure (COP) while the user is standing, walking, and running. The insole COP and GRF readings are input to a programmable system that shifts the COP trajectory dynamically in a patient-specific manner via the robotic platform of the shoe. The robotic platform contains motors that control elements whose movement manipulates the forces acting on the foot and lower limb, resulting in modification of the GRF. Closed loop feedback enables a dynamic fit of an optimal COP. The COP and GRF information can be stored for analysis and diagnosis of gait and instability events accruing during locomotion.
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公开(公告)号:US20240391802A1
公开(公告)日:2024-11-28
申请号:US18695811
申请日:2022-09-28
Inventor: Matthew E. Suss , Arunchander Asokan , Shada Abu Khalla
IPC: C02F1/46 , C02F1/461 , C02F103/08
Abstract: The present invention provides a non-biological deionization fuel cell (DFC) comprising, inter alia, a cathode comprising a non-platinum group metal and a nitrogen doped carbon matrix. Further provided is a method of preparing the catalyst through a zeolitic imidazolate framework precursor.
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公开(公告)号:US20230330130A1
公开(公告)日:2023-10-19
申请号:US18194163
申请日:2023-03-31
Inventor: Shulamit Levenberg , Shaowei Guo , Daniel Offen , Nisim Perets
IPC: A61K31/713 , A61K35/28 , A61K38/51 , C12N15/113 , A61K9/50 , C12N15/11
CPC classification number: A61K31/713 , A61K35/28 , A61K38/51 , C12N15/1137 , A61K9/5068 , C12N15/111 , C12N15/113 , A61K9/127
Abstract: The present invention provides pharmaceutical compositions comprising membrane vesicles, including extracellular vesicles including those referred to as exosomes, loaded with an exogenous Phosphatase and tensin homolog (PTEN) inhibitor. Methods of treating neurological diseases, disorders or conditions using the extracellular vesicles are provided. Isolated extracellular vesicles loaded with an exogenous Phosphatase and tensin homolog (PTEN) inhibitor are provided as well.
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公开(公告)号:US20230272742A1
公开(公告)日:2023-08-31
申请号:US17792151
申请日:2021-01-12
Inventor: BENI CUKUREL
CPC classification number: F02C3/045 , F01D5/085 , F01D15/10 , F01D25/12 , F02K1/002 , F05D2220/76 , F05D2230/30 , F05D2260/20
Abstract: A novel structural arrangement for the various components of an Ultra-Micro Gas Turbine Generator, based on a single part impeller element which comprises the compressor, the turbine and the electrical generator core in a single annular structure, produced as a single piece by an additive manufacturing process. The single annular structure has a hollow shell structure, with a supporting structure within in. The internal hollow space of the shell structure provides for a flow of cooling air from the outside through the internal space, for cooling the turbine region of the impeller. This air flow could be assisted by the use of internal blades, which can also serve as the supporting structure to increase the strength of the shell structure. The air flow can either be ejected at the center of the turbine, or can provide a high pressure supply for air bearings of the impeller element.
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