公开(公告)号：US20200315168A1

公开(公告)日：2020-10-08

申请号：US16496574

申请日：2018-03-26

申请人： The American University in Cairo ,  Universidade do Porto ,  Instituto Politécnino de Braganca

发明人： Asma Mohamad Abdallah Sharkawy ,  tamer Shoeib ,  Alirio Egidio Rodrigues ,  Maria Filomena Filipe Barreiro ,  Isabel Patrícia Martins Fernandes

IPC分类号： A01N25/28 ,  A01N25/08 ,  A01N27/00 ,  A01N31/16 ,  B01J13/10 ,  B01J13/20 ,  C11B9/00 ,  C11D3/50 ,  C11D3/48 ,  D06M13/00 ,  D06M13/07 ,  D06M13/13 ,  D06M13/192 ,  D06M15/03 ,  D06M16/00 ,  D06M23/12

摘要： Fragrant and antimicrobial properties were conferred to cotton fabrics following microencapsulation using green materials. Limonene and vanillin microcapsules were produced by complex coacervation using chitosan/gum Arabic as shell materials and tannic acid as hardening agent. The effect of two emulsifiers; Span 85 and polyglycerol polyricinoleate (PGPR), on the encapsulation efficiency (EE %), microcapsule's size and morphology, and cumulative release profiles was studied. The use of Span 85 resulted in mononuclear morphology while PGPR gave rise to polynuclear structures, regardless of the core material (vanillin or limonene). The obtained microcapsules demonstrated a sustained release patter. Grafting of the produced microcapsules onto cotton fabrics through an esterification reaction using citric acid as anon-toxic cross-linker followed by thermofixation and curing, was confirmed by SEM and FTIR spectroscopy. Standard antibacterial assays conducted on both microcapsules alone and impregnated onto the fabrics indicated a sustained antibacterial activity.

公开(公告)号：US10653139B2

公开(公告)日：2020-05-19

申请号：US15772176

申请日：2015-10-30

申请人： UNIVERSIDADE DO PORTO ,  INSTITUTO SUPERIOR DE AGRONOMIA ,  INSTITUTO NACIONAL DE INVESTIGAÇÃO AGRÁRIA E VETERINÁRIA

发明人： Margarida Maria Da Silva Monteiro Bastos ,  Fernão Domingos De Montenegro Baptista Malheiro De Magalhaes ,  José Manuel Ribeiro De Sousa ,  Carlos Filipe Gonçalves Pires Da Silva ,  Joana Vieira De Freitas Barbosa ,  António Maria Marques Mexia ,  Ana Maria Da Costa Aldir Magro ,  Maria Da Graça Fraga Freire De Barros Barbosa Maia ,  Cláudia Verónica Sánchez Lara ,  José Manuel Ferreira Nobre Semedo ,  Maria Manuela Roldão De Oliveira ,  Olivia Cruz De Matos

IPC分类号： A01N31/00 ,  A01N35/06 ,  A01N31/16 ,  A01N25/18 ,  A23L3/3409 ,  A01N65/22 ,  A01N65/28 ,  A23B7/144 ,  A23B9/18

摘要： The present disclosure relates to a method for protecting stored agricultural dry products during storage, consisting of a controlled release system of essential oils and a shell for allowing oil diffusion in vapour phase towards the outer atmosphere without direct contact of the support material with stored products. This system is characterized by being suitable for use within containers for protecting stored dried agricultural plant products for a long period of time, in particular more than 4 weeks, more preferably more than 8 or 12 weeks.

公开(公告)号：US10443678B2

公开(公告)日：2019-10-15

申请号：US15514991

申请日：2015-09-25

申请人： UNIVERSIDADE DO PORTO

发明人： Francisco José Galindo Rosales ,  Laura Campo Deaño

IPC分类号： F16F15/023 ,  A42B3/12 ,  F16F9/00 ,  F16F9/30

摘要： The present disclosure relates to the customization of a composite layer material for absorbing or dissipating mechanical energy under impacts or vibrations. The composite layer material comprises at least a support layer of a resilient material, said support layer having recessed fluid-tight microchannels comprising a fluid, wherein the channel section and fluid viscosity is such to dampen the external load by the constricted fluid flow through said microchannels. Therefore, the present disclosure relates to a maximization of safety and/or comfort.

公开(公告)号：US10300870B2

公开(公告)日：2019-05-28

申请号：US15529598

申请日：2015-11-25

申请人： UNIVERSIDADE DO PORTO ,  ADDVOLT, S.A.

发明人： Adriano Da Silva Carvalho ,  Bruno Filipe Azevedo Costa ,  José Manuel Ferreira Duarte ,  José Ricardo Sousa Soares ,  Justino Miguel Neto De Sousa ,  Rodrigo Manuel Marinho Pires

IPC分类号： B60R16/033 ,  H02J3/38 ,  H02S40/38 ,  B60K17/28 ,  B60L8/00

摘要： An energy harvesting device for a transport vehicle comprising an electric converter circuit and a power take-off unit is disclosed. The electric converter circuit comprises: an electric energy storage; a first DC bus; an electric generator connected to the first DC bus through an electronic brake controller; a second DC bus connected to the first DC bus through a DC/DC converter, and an inverter connected to the second DC bus and having an output connected to the electrical load of the energy harvesting device. The power take-off unit comprises: a rotatable pivot plate for coupling to the vehicle chassis and supporting the electric generator; an electric generator pulley coupled to the electric generator; a shaft pulley; a shaft attachment for attaching the shaft pulley to the vehicle driveline shaft; and a belt connecting the electric generator pulley and the shaft pulley.

公开(公告)号：US20190148763A1

公开(公告)日：2019-05-16

申请号：US16243792

申请日：2019-01-09

申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  UNIVERSIDADE DO PORTO ,  LNEG-LABORATORIO NACIONAL DE ENERGIA E GEOLOGIA

发明人： John B. Goodenough ,  Maria Helena Sousa Soares De Oliveira Braga ,  Jose Jorge Do Amaral Ferreira ,  Joana Cassilda Rodrigues Espain De Oliveira ,  Andrew Murchison

IPC分类号： H01M10/054 ,  H01M10/052 ,  H01M4/38 ,  H01M10/0562 ,  H01M4/62

摘要： The present disclosure provides an electrochemical cell including a solid glass electrolyte including an alkali metal working ion that is conducted by the electrolyte, and a dipole, an anode having an effective anode chemical potential μA, and a cathode having an effective cathode chemical potential μC. One or both of the cathode and anode substantially lack the working ion prior to an initial charge or discharge of the electrochemical cell. At open-circuit prior to an initial charge or discharge, an electric double-layer capacitor is formed at one or both of an interface between the solid glass electrolyte and the anode and an interface between the solid glass electrolyte and the cathode due to a difference between μA and μC.

公开(公告)号：US20180264074A1

公开(公告)日：2018-09-20

申请号：US15571213

申请日：2016-05-18

申请人： UNIVERSIDADE DO PORTO

发明人： Felix CARVALHO ,  Juliana GARCIA ,  Maria DE LOURDES BASTOS ,  Vera Marisa FREITAS COSTA ,  Alexandra CARVALHO ,  Ricardo SILVESTRE ,  Jose Alberto RAMOS DUARTE ,  Ricardo Jorge DINIS OLIVEIRA

IPC分类号： A61K38/12 ,  A61P39/02

CPC分类号： A61K38/12 ,  A61P39/02

摘要： The present application refers to the development of a new effective antidote for the poisonous Amanita mushroom species, after exploring an innovative in silico and in vivo approach based on the binding site of amatoxin to RNA polymerase II (RNAPII) and the screening of clinical drugs with bioisosterism with amatoxins in the same models. Proof of concept was attained in vivo, using CD-1 mice, and clinical application is immediately proposed, in addition to the already prescribed therapeutic measures, taking advantage of well-established clinical use of the drug found to be an effective antidote, polymyxin B. Thus, Polymyxin and/or its derivatives/precursors consist in a therapeutic strategy on Amanita Phalloides as demonstrated by data gathered and showed in the present application.

公开(公告)号：US20180185370A1

公开(公告)日：2018-07-05

申请号：US15739353

申请日：2016-06-23

申请人： UNIVERSIDADE DO PORTO

发明人： Vítor Manuel DE OLIVEIRA E VASCONCELOS ,  Lucinda Janete DA SILVA BESSA ,  Anake KIJJOA ,  Suradet BUTTACHON ,  Tida DETHOUP ,  Paulo Manuel RODRIGUES MARTINS DA COSTA

IPC分类号： A61K31/519 ,  A61K31/43 ,  C07D519/00 ,  A61P31/04 ,  A61K31/431 ,  A61K45/06

CPC分类号： A61K31/519 ,  A61K31/43 ,  A61K31/431 ,  A61K31/527 ,  A61K45/06 ,  A61P31/04 ,  C07D519/00 ,  A61K2300/00

摘要： The present disclosure relates to compounds and compositions displaying antibacterial activity, particularly against Gram-positive bacteria. The compounds comprise a class of pyrazinoquinazolinone derivatives, including neofiscalin A and fiscalin C, or pharmaceutically acceptable salts, esters, solvates or prodrugs thereof. The present disclosure further relates to methods for treating a patient with a bacterial infection with the disclosed compounds and compositions.

公开(公告)号：US09491684B2

公开(公告)日：2016-11-08

申请号：US14404737

申请日：2013-09-30

申请人： UNIVERSIDADE DO PORTO ,  CARNEGIE MELLON UNIVERSITY

发明人： João Francisco Cordeiro De Oliveira Barros ,  Rui Manuel Pacheco Meireles ,  Peter Alfons Roland Steenkiste

IPC分类号： H04W40/20 ,  G08G1/09 ,  G08G1/16 ,  H04L12/823 ,  H04L29/08 ,  H04W72/04 ,  H04W72/06 ,  H04L12/733 ,  H04W40/24

CPC分类号： H04W40/20 ,  G08G1/093 ,  G08G1/163 ,  H04L45/126 ,  H04L47/32 ,  H04L67/12 ,  H04W40/244 ,  H04W40/246 ,  H04W72/0446 ,  H04W72/06

摘要： A method for multi-hop forwarding of data packets in vehicular ad-hoc networks is disclosed. Each node knows both its own and the destination's geographical coordinates. The coordinates of the one-hop neighbors are obtained from periodically broadcast Cooperative-Awareness Messages (CAMs). The method comprises the following distributed coordination scheme, executed by each node upon receiving a packet: i) computing the set of candidate forwarders; ii) ranking the candidate forwarders according to an utility metric; iii) forwarding the packet after a period of time proportional to its rank if top-ranked, dropping the packet otherwise. The base utility metric used for ranking forwarders is the inverse of the distance to the destination. Moreover, an extension is disclosed where this metric is replaced by the inverse of the expected number of packet transmissions to reach the destination. The latter metric is calculated based on spatial connectivity information cooperatively collected by nodes in the network.

摘要翻译： 公开了一种用于车载自组织网络中数据包的多跳转发的方法。 每个节点都知道自己和目的地的地理坐标。 从周期性广播合作意识消息（CAM）获得一跳邻居的坐标。 该方法包括以下分布式协调方案，在接收到分组时由每个节点执行：i）计算候选转发器集合; ii）根据效用度量对候选转发器进行排名; iii）如果数据包在与其排名成比例的时间段之后转发数据包，否则丢弃数据包。 用于对转发器进行排名的基本效用度量是到目的地的距离的倒数。 此外，公开了一种扩展，其中该度量被到达目的地的分组传输的预期数量的倒数替换。 后一个度量是基于由网络中的节点协同收集的空间连通性信息来计算的。

公开(公告)号：US20160137693A1

公开(公告)日：2016-05-19

申请号：US14902375

申请日：2014-06-20

申请人： UNIVERSIDADE DO MINHO ,  UNIVERSIDADE DO PORTO ,  BIOMODE - BIOMOLECULAR DETERMINATION, S.A.

发明人： Laura Isabel Macieira CERQUEIRA ,  Carina Manuela Femandes ALMEIDA ,  Nuno Filipe Ribeiro Pinto DE OLIVEIRA AZEVEDO ,  Maria Joao Lopes DA COSTA VIEIRA

IPC分类号： C07K7/02 ,  C12Q1/68

CPC分类号： C07K7/02 ,  C12Q1/6895 ,  C12Q2525/107

摘要： The present invention refers to the development of a Peptide Nucleic Acid (PNA) probe for the detection and discrimination of Aspergillus fumigatus in different types of samples.PNA is a synthetic molecule analogue to DNA that, due to its physicochemical properties, allows a faster analysis with higher sensitivity than the DNA probes.These probes are combined with Fluorescence in situ hybridization (FISH), a molecular biology technique that allows the detection of Aspergillus fumigatus in diverse clinical samples, such as blood, serum, sputum, bronchoalveolar lavage fluid and biopsies.The combination of these two technologies rendered the FISH procedure faster, simpler and more efficient.The present invention also includes the development of the kit of detection and respective procedure for the Aspergillus fumigatus identification in clinical samples.

摘要翻译： 本发明涉及用于在不同类型样品中检测和鉴别烟曲霉的肽核酸（PNA）探针的开发。 PNA是与DNA类似的合成分子，由于其物理化学性质，可以比DNA探针更快的分析灵敏度。 这些探针与荧光原位杂交（FISH）组合，这是一种分子生物学技术，允许在不同临床样品如血液，血清，痰，支气管肺泡灌洗液和活组织检查中检测烟曲霉。 这两种技术的组合使得FISH程序更快，更简单和更有效率。 本发明还包括临床样品中烟曲霉鉴定试剂盒的开发和相应的程序。

公开(公告)号：US09276743B2

公开(公告)日：2016-03-01

申请号：US14402536

申请日：2013-11-07

申请人： UNIVERSIDADE DO PORTO

发明人： Joäo Francisco Cordeiro De Oliveira Barros ,  Joäo Paulo Patriarca De Almeida ,  Mate Boban ,  Saurabh Shintre

IPC分类号： H04L29/06 ,  H04L9/14 ,  H04L9/08 ,  H04L9/32 ,  H04W12/04 ,  H04L9/30 ,  H04L29/08 ,  H04L9/00 ,  H04W4/04 ,  H04W84/18

CPC分类号： H04L9/3263 ,  H04L9/006 ,  H04L9/083 ,  H04L9/0838 ,  H04L9/0844 ,  H04L9/14 ,  H04L9/30 ,  H04L9/3265 ,  H04L63/06 ,  H04L63/061 ,  H04L63/062 ,  H04L63/065 ,  H04L63/068 ,  H04L63/0869 ,  H04L67/12 ,  H04L2209/24 ,  H04L2209/80 ,  H04L2209/84 ,  H04W4/046 ,  H04W12/04 ,  H04W12/06 ,  H04W84/18

摘要： Method and system of key distribution by trusted nodes for a vehicular ad hoc network, the nodes of said network having at least one pair of public-private keys and the corresponding certificates, issued by a CA, said method comprising each vehicle node, on entering said network region, requesting a set of keys from an RSU node that is within range and within that region, said RSU node sending said vehicle node a set of private keys, selected from a pool of private keys, and a list with the key identifiers of the private keys shared by said vehicle node and the other vehicle nodes that have most recently contacted said RSU for a predetermined period of time; such that two nodes are able to establish a secure connection without further interaction by deriving a shared secret which is a cryptographic hash function of the keys shared by said two nodes.

摘要翻译： 用于车辆自组织网络的信任节点的密钥分发方法和系统，所述网络的节点具有由CA发布的至少一对公共 - 私人密钥和相应的证书，所述方法包括每个车辆节点，在进入时 所述网络区域从所述区域内的所述RSU节点请求一组密钥，所述RSU节点向所述车辆节点发送从私钥池中选择的一组私钥，以及具有所述密钥标识符的列表 由所述车辆节点和最近接触所述RSU的其他车辆节点共享的私钥预定时间段; 使得两个节点能够通过导出作为所述两个节点共享的密钥的加密散列函数的共享秘密来建立安全连接而无需进一步的交互。