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    Vanilloid receptor ligands and their use in treatments
    33.
    发明授权
    Vanilloid receptor ligands and their use in treatments 失效
    香草素受体配体及其在治疗中的应用

    公开(公告)号：US07582761B2

    公开(公告)日：2009-09-01

    申请号：US10688246

    申请日：2003-10-16

    Applicant: Chenera Balan ,  Yunxin Bo ,  Celia Dominguez ,  Christopher H. Fotsch ,  Vijay K. Gore ,  Vu Van Ma ,  Mark H. Norman ,  Vassil I. Ognyanov ,  Yi-xin Qian ,  Xianghong Wang ,  Ning Xi ,  Shimin Xu

    Inventor： Chenera Balan ,  Yunxin Bo ,  Celia Dominguez ,  Christopher H. Fotsch ,  Vijay K. Gore ,  Vu Van Ma ,  Mark H. Norman ,  Vassil I. Ognyanov ,  Yi-xin Qian ,  Xianghong Wang ,  Ning Xi ,  Shimin Xu

    IPC: C07D401/04 ,  C07D401/06 ,  C07D403/04

    CPC classification number: C07D401/04 ,  C07D235/30 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

    Abstract: Therapeutic benzimidazoles having the general structure: and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

    Abstract translation: 具有一般结构的治疗性苯并咪唑和含有它们的组合物，用于治疗急性，炎性和神经性疼痛，牙痛，一般头痛，偏头痛，丛集性头痛，混合血管和非血管综合征，紧张性头痛，一般炎症，关节炎 ，风湿性疾病，骨关节炎，炎症性肠病，炎症性眼病，炎性或不稳定性膀胱疾病，牛皮癣，皮肤炎症成分炎症，慢性炎性病症，炎症性疼痛及相关的痛觉过敏和异常性疼痛，神经性疼痛和相关的痛觉过敏和异常性疼痛，糖尿病性神经病变 疼痛，咳嗽，交感神经保持疼痛，交感综合征，哮喘，上皮组织损伤或功能障碍，单纯疱疹，呼吸道内脏运动紊乱，泌尿生殖道，胃肠道或血管区，伤口，烧伤，过敏性皮肤反应，瘙痒，白癜风， 胃肠疾病，胃溃疡，十二指肠溃疡，腹泻，坏死因子诱导的胃损伤，毛发生长，血管舒缩或过敏性鼻炎，支气管疾病或膀胱疾病。

    Vanilloid receptor ligands and their use in treatments
    35.
    发明申请
    Vanilloid receptor ligands and their use in treatments 失效
    香草素受体配体及其在治疗中的应用

    公开(公告)号：US20060160872A1

    公开(公告)日：2006-07-20

    申请号：US11337188

    申请日：2006-01-20

    Applicant: Mark Norman ,  Vassil Ognyanov ,  Xianghong Wang

    Inventor： Mark Norman ,  Vassil Ognyanov ,  Xianghong Wang

    IPC: A61K31/4184 ,  C07D235/30

    CPC classification number: C07D235/26 ,  C07D235/30 ,  C07D401/12

    Abstract: Substituted benzimidazoles and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

    Abstract translation: 取代的苯并咪唑和含有它们的组合物，用于治疗急性，炎性和神经性疼痛，牙痛，一般头痛，偏头痛，丛集性头痛，混合血管和非血管性综合征，紧张性头痛，一般炎症，关节炎，风湿性疾病，骨关节炎 ，炎症性肠病，炎症性眼病，炎症性或不稳定性膀胱病，银屑病，皮肤炎症成分炎症，慢性炎性病症，炎性疼痛及相关的痛觉过敏和异常性疼痛，神经性疼痛及相关的痛觉过敏和异常性疼痛，糖尿病性神经病疼痛，灼痛，交感神经痛 维持疼痛，输血综合征，哮喘，上皮组织损伤或功能障碍，单纯疱疹，呼吸道，泌尿生殖道，胃肠道或血管区内脏运动紊乱，伤口，烧伤，过敏性皮肤反应，瘙痒，白癜风，一般胃肠道疾病，胃溃疡 十二指肠溃疡，腹泻，坏死因子诱导的胃损伤，毛发生长，血管舒缩或过敏性鼻炎，支气管疾病或膀胱疾病。

    Vanilloid receptor ligands and their use in treatments
    36.
    发明申请
    Vanilloid receptor ligands and their use in treatments 失效
    香草素受体配体及其在治疗中的应用

    公开(公告)号：US20050165049A1

    公开(公告)日：2005-07-28

    申请号：US11041173

    申请日：2005-01-21

    Applicant: Christopher Hulme ,  Mghele Ncube ,  Mark Norman ,  Vassil Ognyanov ,  Liping Pettus ,  Xianghong Wang ,  Jiawang Zhu

    Inventor： Christopher Hulme ,  Mghele Ncube ,  Mark Norman ,  Vassil Ognyanov ,  Liping Pettus ,  Xianghong Wang ,  Jiawang Zhu

    IPC: C07D215/38 ,  C07D215/48 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D471/04 ,  C07D495/04 ,  C07D43/02 ,  A61K31/4709

    CPC classification number: C07D471/04 ,  C07D215/38 ,  C07D215/48 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D495/04

    Abstract: Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

    Abstract translation: 具有一般结构和含有它们的组合物的化合物，用于治疗急性，炎性和神经性疼痛，牙痛，一般头痛，偏头痛，丛集性头痛，混合血管和非血管综合征，紧张性头痛，一般炎症，关节炎，风湿性 疾病，骨关节炎，炎症性肠病，炎症性眼病，炎症性或不稳定性膀胱病，银屑病，皮肤炎症成分炎症，慢性炎性病症，炎性疼痛及相关的痛觉过敏和异常性疼痛，神经性疼痛及相关的痛觉过敏和异常性疼痛，糖尿病性神经病疼痛， 咳嗽痛，交感神经痛，交感综合征，哮喘，上皮组织损伤或功能障碍，单纯疱疹，呼吸系统内脏运动紊乱，泌尿生殖道，胃肠道或血管区，伤口，烧伤，过敏性皮肤反应，瘙痒，白癜风，一般胃肠道疾病， G 腹部溃疡，十二指肠溃疡，腹泻，坏死因子诱发的胃损伤，毛发生长，血管舒缩或过敏性鼻炎，支气管疾病或膀胱疾病。

    Vanilloid receptor ligands and their use in treatments
    37.
    发明申请
    Vanilloid receptor ligands and their use in treatments 失效
    香草素受体配体及其在治疗中的应用

    公开(公告)号：US20050165046A1

    公开(公告)日：2005-07-28

    申请号：US11041169

    申请日：2005-01-21

    Applicant: Christopher Hulme ,  Mghele Ncube ,  Mark Norman ,  Vassil Ognyanov ,  Liping Pettus ,  Xianghong Wang ,  Jiawang Zhu

    Inventor： Christopher Hulme ,  Mghele Ncube ,  Mark Norman ,  Vassil Ognyanov ,  Liping Pettus ,  Xianghong Wang ,  Jiawang Zhu

    IPC: A61K31/405 ,  A61K31/4184 ,  A61K31/428 ,  A61K31/4709 ,  A61K31/4743 ,  C07D209/08 ,  C07D215/38 ,  C07D235/06 ,  C07D277/82 ,  C07D319/18 ,  C07D319/20 ,  C07D405/12 ,  C07D407/12 ,  C07D417/02 ,  C07D417/12 ,  C07D495/04 ,  C07D498/02 ,  C07D47/02

    CPC classification number: C07D495/04 ,  C07D209/08 ,  C07D215/38 ,  C07D235/06 ,  C07D277/82 ,  C07D319/18 ,  C07D319/20 ,  C07D405/12 ,  C07D407/12 ,  C07D417/12

    Abstract: bis-Bicyclic amides and derivatives thereof and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

    Abstract translation: 双环酰胺及其衍生物和含有它们的组合物，用于治疗急性，炎症和神经性疼痛，牙痛，一般头痛，偏头痛，丛集性头痛，混合血管和非血管综合征，紧张性头痛，一般炎症，关节炎 ，风湿性疾病，骨关节炎，炎症性肠病，炎症性眼病，炎性或不稳定性膀胱疾病，牛皮癣，皮肤炎症成分炎症，慢性炎性病症，炎症性疼痛及相关的痛觉过敏和异常性疼痛，神经性疼痛和相关的痛觉过敏和异常性疼痛，糖尿病性神经病变 疼痛，咳嗽症状，交感神经保持疼痛，输血综合征，哮喘，上皮组织损伤或功能障碍，单纯疱疹，呼吸道内脏运动性紊乱，泌尿生殖道，胃肠道或血管区域，伤口，烧伤，过敏性皮肤反应，瘙痒，白癜风， 混乱 rs，胃溃疡，十二指肠溃疡，腹泻，坏死因子诱发的胃损伤，毛发生长，血管舒缩或过敏性鼻炎，支气管疾病或膀胱疾病。

    Press-fit bearing housing with non-cylindrical diameter
    38.
    发明授权
    Press-fit bearing housing with non-cylindrical diameter 有权
    非圆柱形直径的压配轴承座

    公开(公告)号：US09458850B2

    公开(公告)日：2016-10-04

    申请号：US13428337

    申请日：2012-03-23

    Applicant: Ronald J. Duppert ,  Xianghong Wang

    Inventor： Ronald J. Duppert ,  Xianghong Wang

    IPC: F04C23/00 ,  F04C18/02 ,  F01C21/00

    CPC classification number: F04C29/005 ,  F01C21/007 ,  F04C18/0215 ,  F04C18/023 ,  F04C23/008 ,  F04C29/0085 ,  F04C2230/60 ,  F04C2230/603 ,  F04C2240/30 ,  F04C2240/40 ,  F04C2240/50 ,  F04C2240/56 ,  F04C2240/60 ,  F04C2240/805

    Abstract: A scroll compressor that includes a housing and scroll compressor bodies disposed in the housing. A motor is disposed within the housing and operably connected to a drive shaft for driving one of the scroll compressor bodies. The drive shaft is rotationally supported at one end by a crankcase which includes a bearing housing and a bearing. The crankcase includes a plurality of openings or gas passages passing through the crankcase, as well as a plurality of generally cylindrical sections positioned respectively between adjacent openings. The cylindrical sections define contact regions which can engage an inner periphery of the housing when the crankcase is mounted therein.

    Abstract translation: 一种涡旋压缩机，其包括设置在壳体中的壳体和涡旋压缩机体。 电动机设置在壳体内并且可操作地连接到用于驱动涡旋压缩机主体之一的驱动轴。 驱动轴在一端通过包括轴承壳体和轴承的曲轴箱旋转地支撑。 曲轴箱包括通过曲轴箱的多个开口或气体通道，以及分别位于相邻开口之间的多个大致圆柱形部分。 圆柱形部分限定了当曲轴箱安装在其中时可与壳体的内周接合的接触区域。

    Vanilloid receptor ligands and their use in treatments
    40.
    发明授权
    Vanilloid receptor ligands and their use in treatments 失效
    香草素受体配体及其在治疗中的应用

    公开(公告)号：US08026241B2

    公开(公告)日：2011-09-27

    申请号：US12367352

    申请日：2009-02-06

    Applicant: Chenera Balan ,  Yunxin Bo ,  Celia Dominguez ,  Christopher H. Fotsch ,  Vijay K. Gore ,  Vu Van Ma ,  Mark H. Norman ,  Vassil I. Ognyanov ,  Yi-xin Qian ,  Xianghong Wang ,  Ning Xi ,  Shimin Xu

    Inventor： Chenera Balan ,  Yunxin Bo ,  Celia Dominguez ,  Christopher H. Fotsch ,  Vijay K. Gore ,  Vu Van Ma ,  Mark H. Norman ,  Vassil I. Ognyanov ,  Yi-xin Qian ,  Xianghong Wang ,  Ning Xi ,  Shimin Xu

    IPC: A61K31/497 ,  C07D403/04 ,  C07D401/04

    CPC classification number: C07D401/04 ,  C07D235/30 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

    Abstract: Therapeutic benzimidazoles and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotizing agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

    Abstract translation: 治疗性苯并咪唑和含有它们的组合物，用于治疗急性，炎性和神经性疼痛，牙痛，一般头痛，偏头痛，丛集性头痛，混合血管和非血管综合征，紧张性头痛，一般炎症，关节炎，风湿性疾病，骨关节炎 ，炎症性肠病，炎症性眼病，炎症性或不稳定性膀胱病，银屑病，皮肤炎症成分炎症，慢性炎性病症，炎性疼痛及相关的痛觉过敏和异常性疼痛，神经性疼痛及相关的痛觉过敏和异常性疼痛，糖尿病性神经病疼痛，灼痛，交感神经痛 维持疼痛，输血综合征，哮喘，上皮组织损伤或功能障碍，单纯疱疹，呼吸道，泌尿生殖道，胃肠道或血管区内脏运动紊乱，伤口，烧伤，过敏性皮肤反应，瘙痒，白癜风，一般胃肠道疾病，胃溃疡 十二指肠溃疡，腹泻，坏死因子诱发的胃损伤，毛发生长，血管舒缩或过敏性鼻炎，支气管疾病或膀胱疾病。

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