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公开(公告)号：US20110003388A1
公开(公告)日：2011-01-06
申请号：US12886353
申请日：2010-09-20
申请人： John K. Fraser , Marc H. Hedrick
发明人： John K. Fraser , Marc H. Hedrick
IPC分类号： C12N5/071
CPC分类号： A61K35/28 , A61B10/0283 , A61K9/0019 , A61K35/35 , A61M1/0039 , A61M2202/08 , C12M47/04 , C12N5/0667 , C12N5/069 , C12N2506/1384 , G06F19/00
摘要： Cells present in processed lipoaspirate tissue are used to treat patients. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of stem cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the stem cells are not exposed to an external environment prior to being administered to a patient. Compositions that are administered to a patient include a mixture of adipose tissue and stem cells so that the composition has a higher concentration of stem cells than when the adipose tissue was removed from the patient.
摘要翻译： 存在于加工的lipoaspirate组织中的细胞用于治疗患者。 治疗患者的方法包括加工脂肪组织以将从脂肪组织获得的浓缩量的干细胞输送给患者。 所述方法可以在封闭系统中实施，使得干细胞在施用于患者之前不暴露于外部环境。 施用于患者的组合物包括脂肪组织和干细胞的混合物，使得组合物具有比从患者中除去脂肪组织时更高浓度的干细胞。
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32.发明申请SYSTEMS AND METHODS FOR ISOLATING AND USING CLINICALLY SAFE ADIPOSE DERIVED REGENERATIVE CELLS 有权用于分离和使用临床安全性ADIPOSE衍生的再生细胞的系统和方法公开(公告)号：US20100136668A1
公开(公告)日：2010-06-03
申请号：US12554755
申请日：2009-09-04
申请人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Ronda Elizabeth Schreiber , Isabella Wulur
发明人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Ronda Elizabeth Schreiber , Isabella Wulur
IPC分类号： C12M1/00
摘要： Systems and methods are described that are used to separate cells from a wide variety of tissues. In particular, automated systems and methods are described that separate regenerative cells, e.g., stem and/or progenitor cells, from adipose tissue. The systems and methods described herein provide rapid and reliable methods of separating and concentrating regenerative cells suitable for re-infusion into a subject.
摘要翻译： 描述了用于从多种组织分离细胞的系统和方法。 特别地，描述了从脂肪组织分离再生细胞例如干细胞和/或祖细胞的自动化系统和方法。 本文所述的系统和方法提供了快速且可靠的分离和浓缩适于再次输注到受试者中的再生细胞的方法。
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33.发明授权Systems and methods for separating and concentrating adipose derived stem cells from tissue 有权从组织中分离和浓缩脂肪来源的干细胞的系统和方法公开(公告)号：US07514075B2
公开(公告)日：2009-04-07
申请号：US10877822
申请日：2004-06-25
申请人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Robert K. Shanahan
发明人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Robert K. Shanahan
IPC分类号： A01N63/00
CPC分类号： A61K35/28
摘要： Systems and methods are described that are used to separate cells from a wide variety of tissues. In particular, automated systems and methods are described that separate regenerative cells, e.g., stem and/or progenitor cells, from adipose tissue. The systems and methods described herein provide rapid and reliable methods of separating and concentrating regenerative cells suitable for re-infusion into a subject.
摘要翻译： 描述了用于从多种组织分离细胞的系统和方法。 特别地，描述了从脂肪组织分离再生细胞例如干细胞和/或祖细胞的自动化系统和方法。 本文所述的系统和方法提供了快速且可靠的分离和浓缩适于再次输注到受试者中的再生细胞的方法。
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34.发明申请Devices and Methods for Monitoring, Managing, and Servicing Medical Devices 审中-公开医疗设备的监控，管理和维修的设备和方法公开(公告)号：US20080140451A1
公开(公告)日：2008-06-12
申请号：US11813579
申请日：2005-01-12
摘要： A method and apparatus for billing entities for use of a medical device, which relates to the processing of regenerative cells to facilitate at least one of hard and soft tissue formation, are described. When an operator uses the medical device, a corresponding charge is determined. Billing for usage of the medical device is performed on a periodic or per-use basis. Communication over a network facilitates remote management and servicing of the medical device. Support is provided for automatic ordering of supplies consumed by the medical device.
摘要翻译： 描述了用于使用医疗装置的计费实体的方法和装置，其涉及用于促进硬组织和软组织形成中的至少一个的再生细胞的处理。 当操作者使用医疗设备时，确定相应的费用。 按照定期或每次使用的方式对医疗器械的使用计费。 通过网络进行通信有助于医疗设备的远程管理和维护。 提供支持，用于自动排序由医疗设备消耗的耗材。
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35.发明授权Methods of using regenerative cells in the treatment of stroke and related diseases and disorders 有权使用再生细胞治疗中风及相关疾病和病症的方法公开(公告)号：US09511094B2
公开(公告)日：2016-12-06
申请号：US13586735
申请日：2012-08-15
申请人： John K. Fraser , Marc H. Hedrick , Brian M. Strem
发明人： John K. Fraser , Marc H. Hedrick , Brian M. Strem
IPC分类号： A61K35/12 , A61K35/28 , C12N5/0775 , C12N5/071 , A61K35/36 , A61K35/44 , A61K38/18 , A61K45/06
CPC分类号： A61K35/28 , A61K9/0014 , A61K35/12 , A61K35/35 , A61K35/36 , A61K35/44 , A61K38/1866 , A61K45/06 , A61L15/40 , A61L15/44 , A61L27/3604 , A61L27/3834 , A61L27/54 , A61L27/56 , A61L2300/412 , A61L2300/64 , C12N5/0667 , C12N5/069 , C12N2506/1384 , A61K2300/00
摘要： Cells present in adipose tissue are used to stroke and stroke related diseases and disorders in a patient. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of regenerative cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the regenerative cells are not exposed to an external environment prior to being administered to a patient. Accordingly, in a preferred method, cells present in adipose tissue are placed directly into a recipient along with such additives necessary to promote, engender or support a therapeutic benefit.
摘要翻译： 存在于脂肪组织中的细胞用于卒中和中风患者的疾病和病症。 治疗患者的方法包括加工脂肪组织以将从脂肪组织获得的浓缩量的再生细胞输送给患者。 所述方法可以在封闭系统中实施，使得再生细胞在施用于患者之前不暴露于外部环境。 因此，在优选的方法中，存在于脂肪组织中的细胞与促进，产生或支持治疗益处所必需的这种添加剂一起直接放置在受体中。
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36.发明授权Methods of using adipose tissue-derived cells in augmenting autologous fat transfer 有权使用脂肪组织来源的细胞增强自体脂肪转移的方法公开(公告)号：US08771678B2
公开(公告)日：2014-07-08
申请号：US13588989
申请日：2012-08-17
申请人： Marc H. Hedrick , John K. Fraser
发明人： Marc H. Hedrick , John K. Fraser
IPC分类号： C12N5/00
CPC分类号： A61K35/44 , A61K35/28 , A61L27/3604 , A61L27/3834 , A61L27/3886 , A61L27/54 , A61L2300/414 , A61L2300/416 , A61L2300/426 , A61L2430/34 , C12N5/0667 , C12N5/069 , C12N2506/1384
摘要： Methods of treating patients for conditions such as breast augmentation, soft tissue defects, and urinary incontinence, are described. The methods include removing adipose tissue from a patient, processing a portion of the adipose tissue to obtain a substantially isolated population of cells comprising disaggregated adipose-derived stem cells, mixing the concentrated population of adipose-derived cells comprising disaggregated adipose-derived cells with a portion of unprocessed, intact, non-disaggregated adipose tissue to form a composition, and administering the composition to the patient from which the adipose tissue was removed.
摘要翻译： 描述了治疗患者的症状如隆胸，软组织缺损和尿失禁的方法。 所述方法包括从患者中去除脂肪组织，加工脂肪组织的一部分以获得包含解聚的脂肪来源的干细胞的基本上分离的细胞群，将包含解聚的脂肪来源的细胞的浓缩的脂肪来源的细胞与 未处理的，未分解的脂肪组织的部分以形成组合物，并将组合物施用于除去脂肪组织的患者。
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37.发明授权公开(公告)号：US08404229B2
公开(公告)日：2013-03-26
申请号：US10884639
申请日：2004-07-01
申请人： John K. Fraser , Marc H. Hedrick , Eric Daniels
发明人： John K. Fraser , Marc H. Hedrick , Eric Daniels
IPC分类号： C12N5/00
CPC分类号： A61K35/28 , A61K35/22 , A61K35/35 , A61K35/44 , A61L27/3834 , A61L27/3886 , A61L27/54 , A61L2300/414 , A61L2300/416 , A61L2430/26 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M2202/0437 , A61M2202/08 , C12N5/0667
摘要： Cells present in processed lipoaspirate tissue are used to treat patients, including patients with renal conditions, diseases or disorders. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of stem cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the stem cells are not exposed to an external environment prior to being administered to a patient. Accordingly, in a preferred method, cells present in processed lipoaspirate are placed directly into a recipient along with such additives necessary to promote, engender or support a therapeutic renal benefit.
摘要翻译： 存在于加工的脂肪抽吸组织中的细胞用于治疗患者，包括患有肾脏疾病或疾病的患者。 治疗患者的方法包括加工脂肪组织以将从脂肪组织获得的浓缩量的干细胞输送给患者。 所述方法可以在封闭系统中实施，使得干细胞在施用于患者之前不暴露于外部环境。 因此，在优选的方法中，存在于加工的lipoaspirate中的细胞与用于促进，产生或支持治疗性肾功能所必需的这些添加剂一起直接放置在受体中。
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38.发明申请METHODS OF USING REGENERATIVE CELLS IN THE TREATMENT OF STROKE AND RELATED DISEASES AND DISORDERS 有权再生细胞在治疗和相关疾病和病症中的应用方法公开(公告)号：US20120308518A1
公开(公告)日：2012-12-06
申请号：US13586735
申请日：2012-08-15
申请人： John K. Fraser , Marc H. Hedrick , Brian M. Strem
发明人： John K. Fraser , Marc H. Hedrick , Brian M. Strem
CPC分类号： A61K35/28 , A61K9/0014 , A61K35/12 , A61K35/35 , A61K35/36 , A61K35/44 , A61K38/1866 , A61K45/06 , A61L15/40 , A61L15/44 , A61L27/3604 , A61L27/3834 , A61L27/54 , A61L27/56 , A61L2300/412 , A61L2300/64 , C12N5/0667 , C12N5/069 , C12N2506/1384 , A61K2300/00
摘要： Cells present in adipose tissue are used to stroke and stroke related diseases and disorders in a patient. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of regenerative cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the regenerative cells are not exposed to an external environment prior to being administered to a patient. Accordingly, in a preferred method, cells present in adipose tissue are placed directly into a recipient along with such additives necessary to promote, engender or support a therapeutic benefit.
摘要翻译： 存在于脂肪组织中的细胞用于卒中和中风患者的疾病和病症。 治疗患者的方法包括加工脂肪组织以将从脂肪组织获得的浓缩量的再生细胞输送给患者。 所述方法可以在封闭系统中实施，使得再生细胞在施用于患者之前不暴露于外部环境。 因此，在优选的方法中，存在于脂肪组织中的细胞与促进，产生或支持治疗益处所必需的这种添加剂一起直接放置在受体中。
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公开(公告)号：US08119121B2
公开(公告)日：2012-02-21
申请号：US10614648
申请日：2003-07-07
申请人： John K. Fraser , Marc H. Hedrick
发明人： John K. Fraser , Marc H. Hedrick
IPC分类号： C12N5/00
CPC分类号： A61K35/28 , A61B10/0283 , A61K9/0019 , A61K35/35 , A61M1/0039 , A61M2202/08 , C12M47/04 , C12N5/0667 , C12N5/069 , C12N2506/1384 , G06F19/00
摘要： Cells present in processed lipoaspirate tissue are used to treat patients. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of stem cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the stem cells are not exposed to an external environment prior to being administered to a patient. Compositions that are administered to a patient include a mixture of adipose tissue and stem cells so that the composition has a higher concentration of stem cells than when the adipose tissue was removed from the patient.
摘要翻译： 存在于加工的lipoaspirate组织中的细胞用于治疗患者。 治疗患者的方法包括加工脂肪组织以将从脂肪组织获得的浓缩量的干细胞输送给患者。 所述方法可以在封闭系统中实施，使得干细胞在施用于患者之前不暴露于外部环境。 施用于患者的组合物包括脂肪组织和干细胞的混合物，使得组合物具有比从患者中除去脂肪组织时更高浓度的干细胞。
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40.发明申请METHODS OF USING ADIPOSE TISSUE-DERIVED CELLS IN AUGMENTING AUTOLOGOUS FAT TRANSFER 有权使用ADIPOSE TISSUE衍生细胞进行自动脂肪转移的方法公开(公告)号：US20100233139A1
公开(公告)日：2010-09-16
申请号：US12694103
申请日：2010-01-26
申请人： Marc H. Hedrick , John K. Fraser
发明人： Marc H. Hedrick , John K. Fraser
CPC分类号： A61K35/44 , A61K35/28 , A61L27/3604 , A61L27/3834 , A61L27/3886 , A61L27/54 , A61L2300/414 , A61L2300/416 , A61L2300/426 , A61L2430/34 , C12N5/0667 , C12N5/069 , C12N2506/1384
摘要： Methods of treating patients for conditions such as breast augmentation, soft tissue defects, and urinary incontinence, are described. The methods include removing adipose tissue from a patient, processing a portion of the adipose tissue to obtain a substantially isolated population of cells comprising disaggregated adipose-derived stem cells, mixing the concentrated population of adipose-derived cells comprising disaggregated adipose-derived cells with a portion of unprocessed, intact, non-disaggregated adipose tissue to form a composition, and administering the composition to the patient from which the adipose tissue was removed.
摘要翻译： 描述了治疗患者的症状如隆胸，软组织缺损和尿失禁的方法。 所述方法包括从患者中去除脂肪组织，加工脂肪组织的一部分以获得包含解聚的脂肪来源的干细胞的基本上分离的细胞群，将包含解聚的脂肪来源的细胞的浓缩的脂肪来源的细胞与 未处理的，未分解的脂肪组织的部分以形成组合物，并将组合物施用于除去脂肪组织的患者。
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