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    Microfluidic device
    31.
    发明授权
    Microfluidic device 有权

    公开(公告)号：US10449541B2

    公开(公告)日：2019-10-22

    申请号：US15025858

    申请日：2013-09-30

    Applicant: Agency for Science, Technology and Research

    Inventor： Jackie Y. Ying ,  Saravana Kumar Kumarasamy ,  Rensheng Deng

    IPC: B01L3/00 ,  C12Q1/689 ,  C12Q1/686

    Abstract: There is provided a microfluidic device comprising: a plurality of wells, each well having an inlet and an outlet, wherein the inlets are in fluid communication with one or more entry channels and the outlets are in fluid communication with one or more exit channels, wherein said outlet is connected to the exit channel via an outlet connecting channel and said inlet is connected to the entry channel via an inlet connecting channel wherein the dimension of the outlet connecting channel is configured such that the surface tension of a liquid comprised in the well prevents the release of the liquid through the outlet connecting channel. There is also provided a system, method and use of the device.

    ANTIFUNGAL COMPOUND
    32.
    发明申请
    ANTIFUNGAL COMPOUND 有权
    抗菌化合物

    公开(公告)号：US20170037013A1

    公开(公告)日：2017-02-09

    申请号：US15297906

    申请日：2016-10-19

    Applicant: Agency for Science, Technology and Research

    Inventor： Yugen Zhang ,  Jackie Y. Ying ,  Lihong Liu ,  Hong Wu

    IPC: C07D233/61

    CPC classification number: C07D233/61 ,  A01N43/50 ,  A61K31/787

    Abstract: There is provided compound for use in therapy, the compound comprising repeating units of hydrophilic heterocyclic amine monomers that are coupled by hydrophobic linkers selected to confer a therapeutic effect. There is also provided the use of the above compound in the manufacture of a medicament for the treatment of a fungal infection and a method of treating a fungal infection using the above compound.

    Abstract translation: 提供用于治疗的化合物，所述化合物包含亲水性杂环胺单体的重复单元，所述亲水性杂环胺单体通过被选择赋予治疗效果的疏水性接头偶联。 还提供了上述化合物在制备用于治疗真菌感染的药物中的用途以及使用上述化合物治疗真菌感染的方法。

    APPARATUS FOR A DIAPER, A SYSTEM, A DIAPER AND A METHOD OF MANUFACTURING AN ELECTRODE
    33.
    发明申请
    APPARATUS FOR A DIAPER, A SYSTEM, A DIAPER AND A METHOD OF MANUFACTURING AN ELECTRODE 审中-公开
    一种DIAPER，一种系统，一种DIAPER和一种制造电极的方法的装置

    公开(公告)号：US20150209193A1

    公开(公告)日：2015-07-30

    申请号：US14424379

    申请日：2013-08-26

    Applicant: Agency for Science, Technology and Research

    Inventor： Jackie Y. Ying ,  Guolin Xu ,  Rensheng Deng ,  Xiaojun Chen

    IPC: A61F13/42 ,  A61F13/15

    CPC classification number: A61F13/42 ,  A61F13/15707 ,  A61F13/49 ,  A61F2013/424

    Abstract: Various embodiments provide an apparatus for a diaper. The apparatus has two electrodes and an electronic device. The electronic device is coupled to the two electrodes. The two electrodes are operable to generate a potential difference when they are electrically connected together by ionized liquid. The electronic device is operable to generate an alarm signal when the potential difference is generated. Various other embodiments relate to a corresponding system, diaper and method of manufacturing an electrode.

    Abstract translation: 各种实施例提供了一种用于尿布的装置。 该装置具有两个电极和一个电子装置。 电子设备耦合到两个电极。 当两个电极通过电离液体电连接在一起时，可以产生电位差。 当产生电位差时，电子设备可操作以产生报警信号。 各种其它实施例涉及相应的系统，尿布和制造电极的方法。

    Device and method for detecting target molecules
    39.
    发明授权
    Device and method for detecting target molecules 有权

    公开(公告)号：US10544458B2

    公开(公告)日：2020-01-28

    申请号：US15552021

    申请日：2016-02-24

    Applicant: Agency for Science, Technology and Research

    Inventor： Jackie Y. Ying ,  Somenath Roy ,  Jun Hui Soh

    IPC: C12Q1/6876

    Abstract: The present invention relates to a microarray device for detecting a target molecule such as miRNA in a sample. The device comprises a carrier substrate such as glass, an anti-fouling polymer layer which is functionalised with N-Hydroxysuccinimide (NHS) or carboxyl-groups and a capture probe. In an embodiment, the capture probe is an oligonucleotide with a stem-loop structure. The invention further defines a method for fabricating the device, a kit for detecting the target nucleic acid molecule comprising the device and a detection probe.

    Nanoprobe-based genetic testing
    40.
    发明授权
    Nanoprobe-based genetic testing 有权

    公开(公告)号：US10214776B2

    公开(公告)日：2019-02-26

    申请号：US14783392

    申请日：2014-04-04

    Applicant: Agency for Science, Technology and Research

    Inventor： Yanbing Zu ,  Jackie Y. Ying

    IPC: C12Q1/6827 ,  C12Q1/6883 ,  B82Y15/00

    Abstract: The present application relates to methods of detecting a mutation in a target nucleic acid molecule. Two phosphorodiamidate morpholino oligomer probes that differ by at least one base are each covalently coupled to a nano article and hybridized to a target sequence. The melting temperature of the complexes between each of the two probes and the target nucleic acid are measured and compared to determine whether the sample contains a nucleic acid with the mutation. Further, the present invention relates to kits comprising a first and second conjugate as described herein and to the use of such kits for the detection of mutations in a target nucleic acid molecule or for assigning a genotype to a target nucleic acid molecule.

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