公开(公告)号：US20060270674A1

公开(公告)日：2006-11-30

申请号：US11500903

申请日：2006-08-09

申请人： Masahiro Yasuda ,  Hitoshi Harada ,  Shuhei Miyazawa ,  Seiichi Kobayashi ,  Kokichi Harada ,  Takayuki Hida ,  Hisashi Shibata ,  Nobuyuki Yasuda ,  Osamu Asano ,  Yoshihiko Kotake

发明人： Masahiro Yasuda ,  Hitoshi Harada ,  Shuhei Miyazawa ,  Seiichi Kobayashi ,  Kokichi Harada ,  Takayuki Hida ,  Hisashi Shibata ,  Nobuyuki Yasuda ,  Osamu Asano ,  Yoshihiko Kotake

IPC分类号： A61K31/5377 ,  A61K31/506 ,  C07D413/14 ,  C07D403/14

CPC分类号： A61K31/506 ,  A61K31/519 ,  A61K31/522 ,  A61K31/5377 ,  A61K31/7076 ,  H04B10/112

摘要： The present invention provides a medicament having a gentle but strong defecation-promoting action without causing diarrhea. That is, it provides a defecation-promoting agent comprising a compound having an adenosine A2receptor antagonism, preferably an adenosine A2b receptor antagonism, or a salt thereof.

摘要翻译： 本发明提供一种具有温和但强烈的排便促进作用而不引起腹泻的药物。 也就是说，它提供了包含具有腺苷A 2受体拮抗作用的化合物，优选腺苷A 2b受体拮抗剂或其盐的排便促进剂。

公开(公告)号：US07083349B2

公开(公告)日：2006-08-01

申请号：US10487545

申请日：2002-08-23

申请人： Hisashi Iida ,  Shigeru Okumura ,  Kazuaki Matsumoto ,  Seiichi Kobayashi ,  Yusuke Kobayashi

发明人： Hisashi Iida ,  Shigeru Okumura ,  Kazuaki Matsumoto ,  Seiichi Kobayashi ,  Yusuke Kobayashi

IPC分类号： B43K5/02 ,  B43K7/00 ,  A46B11/06

CPC分类号： B43K7/10 ,  B43K5/005 ,  B43K5/18 ,  B43K8/04

摘要： A writing implement includes a cylindrical shaft member, a pen tip member which is fixed to one end of the shaft member and from which colored ink seeps out, liquid for ink which is stored in the shaft member and which comprises a part of the colored ink seeping out from the end of the pen tip member, and colorant to be added to the above described liquid for ink to be the colored ink. Moreover, at least a part of a cylindrical side surface of the shaft member corresponding to the storing part of the liquid for ink is formed to be transparent. Between the liquid for ink and the colorant-storing part storing the colorant is provided a colorant-adsorbing core which introduces the liquid for ink into the colorant-storing part while capturing the colorant diffusing toward the storing part of the liquid for ink.

摘要翻译： 一种书写工具，包括圆柱形轴构件，笔尖构件，其固定到轴构件的一端，彩色墨水从其中渗出，存储在轴构件中的用于存储的墨的液体包括彩色墨水的一部分 从笔尖构件的端部渗出，并将着色剂加入到上述用于油墨的液体中作为着色油墨。 此外，与油墨用液体的储存部相对应的轴构件的筒状侧面的至少一部分形成为透明的。 在用于墨水的液体和存储着色剂的着色剂储存部分之间提供着色剂吸附芯，其将用于油墨的液体引入着色剂储存部分中，同时捕捉着着色剂朝向用于墨水的液体的储存部分扩散。

公开(公告)号：US07070352B2

公开(公告)日：2006-07-04

申请号：US10488049

申请日：2002-08-30

申请人： Hisashi Iida ,  Shigeru Okumura ,  Kazuaki Matsumoto ,  Seiichi Kobayashi ,  Takeshi Kobayashi ,  Yusuke Kobayashi ,  Yosuke Mito

发明人： Hisashi Iida ,  Shigeru Okumura ,  Kazuaki Matsumoto ,  Seiichi Kobayashi ,  Takeshi Kobayashi ,  Yusuke Kobayashi ,  Yosuke Mito

IPC分类号： B43K5/02 ,  B43K5/12 ,  B43K5/00

CPC分类号： C09D11/16 ,  B43K5/005 ,  B43K5/03 ,  B43K5/12 ,  B43K5/18 ,  B43K7/005 ,  B43K7/06 ,  B43K7/08 ,  B43K7/10 ,  B43K8/003 ,  B43K8/022 ,  B43K8/024 ,  B43K8/04 ,  B43K23/128 ,  B43K27/08

摘要： A writing implement includes a cylindrical shaft member, a pen tip member which is fixed to one end of the shaft member and from which colored ink seeps out, liquid for ink which is stored in the shaft member and which comprises a major component of the colored ink seeping out from an end of the pen tip member, colorant to be added to the liquid for ink, and a valve member for isolating the colorant from the liquid for ink. In the writing implement, at least a part of a cylindrical side surface of the shaft member corresponding to a part where the liquid for ink is stored is formed to be transparent, the valve member is positioned between the storing part of the liquid for ink and the colorant, and the storing part of the liquid for ink is provided with a pressure-regulating part.

摘要翻译： 书写工具包括圆柱形轴构件，笔尖构件，其固定到轴构件的一端并​​且彩色墨水从其中渗出，存储在轴构件中的用于墨的液体包括着色的主要部件 油墨从笔尖部件的端部渗出，要添加到用于油墨的液体中的着色剂，以及用于将着色剂与用于油墨的液体分离的阀构件。 在书写工具中，形成有与油墨用液体一部分相对应的轴部件的圆筒形侧面的至少一部分是透明的，阀部件位于油墨用液体的收纳部和 着色剂和用于油墨的液体的储存部分设置有压力调节部分。

公开(公告)号：US20050215757A1

公开(公告)日：2005-09-29

申请号：US10504190

申请日：2003-02-27

申请人： Seiichi Kobayashi ,  Hiroyuki Morijiri

发明人： Seiichi Kobayashi ,  Hiroyuki Morijiri

IPC分类号： C07D331/04 ,  C08G75/06 ,  C08G69/14

CPC分类号： C07D331/04 ,  C08G75/06

摘要： A sulfur-containing compound has a structure represented by formula (1): (wherein R1 represents a hydrogen atom, a reactive terminal group, a straight, branched or cyclic alkyl group having 1 to 10 carbon atoms and a reactive terminal group or its thia derivative thereof, an aryl group, or an aralkyl group; Y represents an oxygen atom, a sulfur atom, a selenium atom, or a tellurium atom; R represents a substituted or unsubstituted bivalent hydrocarbon group having 1 to 10 carbon atoms, which may be thianated; n represents an integer of 0 to 3; X1 is substituted for any one of groups R2 to R7 of a partial structure represented by formula (2) in which the groups R2 to R7 other than the group substituted by X1 are independently a hydrogen atom or a substituted or unsubstituted monovalent hydrocarbon group having 1 to 10 carbon atoms; and R1 is not a group having a (meth)acryl group when Y is an oxygen atom.) The compound has a high refractive index and high Abbe's number, and produces a resin having excellent impact resistance.

摘要翻译： 含硫化合物具有由式（1）表示的结构：其中，R 1表示氢原子，反应性末端基，碳原子数1〜10的直链，支链或环状烷基，反应性末端基或其硫原子 衍生物，芳基或芳烷基; Y表示氧原子，硫原子，硒原子或碲原子; R表示取代或未取代的碳原子数1〜10的二价烃基，可以是 噻吩化; n表示0〜3的整数，X 1代表由式（2）表示的部分结构的基团R 2〜R 7中的任何一个，其中基团R 2〜R 7除 被X 1 X取代的基团独立地为氢原子或取代或未取代的碳原子数为1〜10的一价烃基;当Y为氧时，R 1为不具有（甲基）丙烯酰基的基团 原子。）该化合物具有高折射率和高的阿贝氏 并且产生具有优异抗冲击性的树脂。

公开(公告)号：US06692609B2

公开(公告)日：2004-02-17

申请号：US09985379

申请日：2001-11-02

申请人： Seiichi Kobayashi ,  Tadayoshi Nagasawa ,  Yutaka Noguchi ,  Hiroyasu Mori ,  Mitsuo Sakakura

发明人： Seiichi Kobayashi ,  Tadayoshi Nagasawa ,  Yutaka Noguchi ,  Hiroyasu Mori ,  Mitsuo Sakakura

IPC分类号： H01F1700

CPC分类号： H01F17/0013 ,  H01F41/046 ,  Y10T29/4902 ,  Y10T29/49073

摘要： A method for manufacturing a laminated electronic component, in which magnetic layers and conductive patterns for coil are sequentially provided, a coil pattern is enclosed between the magnetic layers inside a laminated body, and a nonmagnetic section is provided between adjacent conductive patterns for coil, the coil pattern being provided by repeatedly performing: a first step of providing a second magnetic layer over the entire top face of a first magnetic layer, which a first conductive pattern for coil is provided on; a second step of providing a loop-shaped groove in the second magnetic layer by using laser processing; a third step of providing a nonmagnetic section in one portion of the loop-shaped groove; and a fourth step of printing a second conductive pattern for coil so that one end section thereof overlaps the end section of the first conductive pattern for coil and the other end section extends to the surface of the nonmagnetic section.

摘要翻译： 一种层叠电子部件的制造方法，其中依次设有用于线圈的磁性层和导电图案，在层叠体内的磁性层之间包围线圈图案，并且在相邻的线圈用导电图案之间设置非磁性部分， 通过重复执行提供线圈图案：第一步骤，在第一磁性层的整个顶面上提供第二磁性层，第一磁性层设置有用于线圈的第一导电图案; 通过使用激光加工在第二磁性层中设置环形槽的第二步骤; 在所述环形槽的一部分中设置非磁性部分的第三步骤; 以及第四步骤，打印用于线圈的第二导电图案，使得其一个端部与第一导电图案的端部重叠，并且另一端部延伸到非磁性部分的表面。

公开(公告)号：US06333322B1

公开(公告)日：2001-12-25

申请号：US09125451

申请日：1998-09-21

申请人： Mitsuaki Miyamoto ,  Tatsuya Yoshiuchi ,  Keizo Sato ,  Makoto Kaino ,  Masayuki Tanaka ,  Motohiro Soejima ,  Katsuhiro Moriya ,  Yoshinori Sakuma ,  Koji Yamada ,  Kokichi Harada ,  Yukio Nishizawa ,  Seiichi Kobayashi ,  Makoto Okita ,  Koichi Katayama

发明人： Mitsuaki Miyamoto ,  Tatsuya Yoshiuchi ,  Keizo Sato ,  Makoto Kaino ,  Masayuki Tanaka ,  Motohiro Soejima ,  Katsuhiro Moriya ,  Yoshinori Sakuma ,  Koji Yamada ,  Kokichi Harada ,  Yukio Nishizawa ,  Seiichi Kobayashi ,  Makoto Okita ,  Koichi Katayama

IPC分类号： A61K315415

CPC分类号： C07D417/06 ,  C07D279/22 ,  C07D279/24 ,  C07D417/12 ,  C09B21/00 ,  C09B57/08

摘要： A phenothiazine, acridan, acridone oxime, acridone hydrazone and dibenzodiazepine derivative represented by formula (I) effective against diseases in which histamine, leukotrienes, etc. participate and effective in preventing or treating diseases in which chemical mediators such as histamine and leukotrienes participate, for example, asthma, allergic rhinitis, atopic dermatitis, urticaria, hay fever, gastrointestinal allergy and food allergy.

摘要翻译： 苯并噻嗪，吖啶酮肟，吖啶酮肟，腙酮腙和二苯并二氮杂衍生物，其对组胺，白细胞三烯等参与并有效预防或治疗化学介质如组胺和白三烯参与的疾病有效， 例如哮喘，过敏性鼻炎，特应性皮炎，荨麻疹，花粉症，胃肠道过敏和食物过敏。

公开(公告)号：US6121309A

公开(公告)日：2000-09-19

申请号：US125522

申请日：1998-08-20

申请人： Katsuya Tagami ,  Hiroyuki Yoshimura ,  Mitsuo Nagai ,  Shigeki Hibi ,  Kouichi Kikuchi ,  Takashi Sato ,  Makoto Okita ,  Yasushi Okamoto ,  Yumiko Nagasaka ,  Naoki Kobayashi ,  Takayuki Hida ,  Kenji Tai ,  Naoki Tokuhara ,  Seiichi Kobayashi

发明人： Katsuya Tagami ,  Hiroyuki Yoshimura ,  Mitsuo Nagai ,  Shigeki Hibi ,  Kouichi Kikuchi ,  Takashi Sato ,  Makoto Okita ,  Yasushi Okamoto ,  Yumiko Nagasaka ,  Naoki Kobayashi ,  Takayuki Hida ,  Kenji Tai ,  Naoki Tokuhara ,  Seiichi Kobayashi

IPC分类号： C07C69/76 ,  C07C69/94 ,  C07D207/32 ,  C07D207/337 ,  C07D307/54 ,  C07D333/24 ,  C07D405/04 ,  C07D405/10 ,  C07D405/14 ,  C07D407/04 ,  C07D409/04 ,  C07D409/10 ,  C07D409/14 ,  A61K31/40 ,  C07D405/00

CPC分类号： C07D207/337 ,  C07C69/76 ,  C07C69/94 ,  C07D307/54 ,  C07D333/24 ,  C07D405/04 ,  C07D405/10 ,  C07D405/14 ,  C07D407/04 ,  C07D409/04 ,  C07D409/10 ,  C07D409/14

摘要： The present invention provides a medicament exhibiting excellent retinoic acid receptor agonism.A Carboxylic acid derivative having a fused ring which is represented by the following formula or a pharmacologically acceptable salt thereof: ##STR1## {wherein the symbol ----- represents a single bond or a double bond; X, Y, Z, P, Q, U, V and W are each a group represented by the formula: --O-- or --S--, or a group represented by the formula: ##STR2## [wherein R.sup.k (k:1 to 8) is hydrogen, halogeno, optionally substituted lower alkyl or the like, with either of R.sup.7 and R.sup.8 being a group represented by the formula: ##STR3## (wherein A and B are each independently an optionally substituted aromatic hydrocarbon ring or an optionally substituted unsaturated heterocycle; and D is optionally protected carboxyl)]}.

摘要翻译： PCT No.PCT / JP97 / 00852 Sec。 371日期：1998年8月20日 102（e）1998年8月20日PCT PCT 1997年3月18日PCT公布。 公开号WO97 / 34869 日期：1997年9月25日本发明提供了显示出优异的视黄酸受体激动作用的药物。 具有由下式表示的稠环的羧酸衍生物或其药理学上可接受的盐：{其中符号+ E，uns ----- + EE表示单键或双键; X，Y，Z，P，Q，U，V和W分别是由下式表示的基团：-O-或-S-，或由下式表示的基团：[其中R k（k：1至8） 是氢，卤素，任选取代的低级烷基等，其中R 7和R 8中的任一个是由下式表示的基团：（其中A和B各自独立地是任选取代的芳族烃环或任选取代的不饱和杂环; D 任选保护羧基）]}。

公开(公告)号：US5935938A

公开(公告)日：1999-08-10

申请号：US658656

申请日：1996-06-05

申请人： William J. Christ ,  Daniel P. Rossignol ,  Seiichi Kobayashi ,  Tsutomu Kawata

发明人： William J. Christ ,  Daniel P. Rossignol ,  Seiichi Kobayashi ,  Tsutomu Kawata

IPC分类号： C07H15/12 ,  A61K31/70 ,  A61K31/7028 ,  A61P31/00 ,  A61P31/04 ,  C07H3/04 ,  C07H11/00 ,  C07H11/04 ,  C07H13/06 ,  C07H15/04 ,  C13K5/00

CPC分类号： C07H15/04 ,  A61K9/0073 ,  C07H11/00 ,  C07H15/12 ,  C07H3/04

摘要： Novel substituted liposaccharides useful as in the prophylactic and affirmative treatment of endotoxemia including sepsis, septicemia and various forms of septic shock and methods of using these agents are provided. Also provided are methods of preparing these agents and intermediates useful therein.

公开(公告)号：US5909975A

公开(公告)日：1999-06-08

申请号：US943074

申请日：1997-10-01

申请人： Seiichi Kobayashi

发明人： Seiichi Kobayashi

IPC分类号： B43K25/02 ,  B43K24/10 ,  B43K24/14 ,  B43K27/00 ,  B43K7/01

CPC分类号： B43K24/14

摘要： The multiplex writing implement includes: a cylindrical portion formed in the rear of the elliptical cylinder portion of the middle barrel; a rotary shaft which is disposed in the bore of the cylindrical portion so as to rotate in a range of about 180.degree. relative to the middle barrel and has a pair of cam grooves in the peripheral surface thereof; and a rear barrel which fits on the outer periphery of the cylindrical portion and is integrally attached to the rear end of the rotary shaft which is projected out from the rear end of the cylindrical portion, and is constructed such that the rear barrel is rotatable relative to the middle barrel; the pair of sliding pieces which respectively have projections on inner sides facing each other, engaging the cam grooves of the rotary shaft are guided inside the bore of the middle barrel so as to only move forwards and backwards; and the sliding pieces can alternately move forwards and backwards following the rotation of the rotary shaft as the rear barrel is rotated.

摘要翻译： 多重书写工具包括：形成在中间筒的椭圆筒部分的后部的圆柱形部分; 旋转轴，其设置在所述圆筒部的孔中，以相对于所述中筒在约180度的范围内旋转，并且在其外周面具有一对凸轮槽; 以及后筒，其配合在所述圆筒部的外周，并且一体地安装在从所述圆筒部的后端突出的所述旋转轴的后端，并且构造成使得所述后筒能够相对旋转 到中桶; 一对滑动件在内侧面彼此面对，与旋转轴的凸轮槽接合，在中间筒的孔内被引导以仅向前后移动; 并且当后筒旋转时，滑动件可随着旋转轴的旋转而交替地向前和向后移动。

公开(公告)号：US5655847A

公开(公告)日：1997-08-12

申请号：US334182

申请日：1994-11-03

申请人： Seiichi Kobayashi ,  Kazuhiko Furukawa

发明人： Seiichi Kobayashi ,  Kazuhiko Furukawa

IPC分类号： B43K5/18 ,  B43K7/01 ,  B43K7/10 ,  B43K7/00

CPC分类号： B43K7/10 ,  B43K5/1881 ,  B43K7/01

摘要： A ball-point pen of the present invention is provided which includes: a ball-point pen refill being accommodated in the barrel cylinder and having: a tip with a tip ball held at the front end thereof; an ink reservoir which stores low-viscosity oily ink and has an ink follower provided in the rear end of the ink; and a joint disposed between the tip and the ink reservoir. The joint further includes: a valve chamber holding a ball valve in its inside and communicating with the rear end of the tip; and a ball valve seat disposed on the rear side of the valve chamber for the ball valve in order to prevent backward flow of ink. With this configuration, it is possible to provide a ball-point pen which, without need of any cap, can create dense writing traces free from blotting and unevenness even when a low viscosity oily ink is used.

摘要翻译： 提供本发明的圆珠笔，其包括：圆珠笔笔芯，其容纳在所述圆柱滚筒中，并具有：尖端，其顶端保持在其前端; 存储低粘度油性墨水并具有设置在墨水后端的墨汁随动物的墨水储存器; 以及设置在尖端和墨水容器之间的接头。 接头还包括：阀室，其内部保持有球阀，并与尖端的后端连通; 以及球阀座，其设置在球阀的阀室的后侧，以防止墨的反向流动。 利用这种结构，即使使用低粘度的油性油墨，也可以提供一种不需要任何盖子的圆珠笔即可产生无印迹和不均匀的致密书写痕迹。