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    NEUROSTIMULATOR SYSTEM, APPARATUS, AND METHOD
    35.
    发明申请
    NEUROSTIMULATOR SYSTEM, APPARATUS, AND METHOD 审中-公开
    神经细胞系统，装置和方法

    公开(公告)号：US20130116745A1

    公开(公告)日：2013-05-09

    申请号：US13722260

    申请日：2012-12-20

    申请人： Kellie Fletcher ,  Patrick Hard ,  Anthony V. Caparso ,  Karen Tsuei

    发明人： Kellie Fletcher ,  Patrick Hard ,  Anthony V. Caparso ,  Karen Tsuei

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36075 ,  A61N1/37241 ,  A61N1/37247 ,  A61N1/37282 ,  A61N1/3787

    摘要： The invention relates to a method (200) for conducting a clinical trial with a medical device. The method (200) includes the step (202) of providing a medical device to a trial subject, the medical device being capable of providing an adjustable level of therapy. The method also comprises the step (204) of using the medical device to apply therapy to the trial subject. The method further comprises the step (206) of controlling the application of therapy applied to the trial subject according to a clinical trial design.

    摘要翻译： 本发明涉及一种用医疗设备进行临床试验的方法（200）。 方法（200）包括向试验对象提供医疗装置的步骤（202），该医疗装置能够提供可调节的治疗水平。 该方法还包括使用医疗装置对试验对象施加治疗的步骤（204）。 该方法还包括根据临床试验设计控制应用于试验对象的治疗应用的步骤（206）。

    SYSTEMS AND METHODS FOR PROVIDING NEURAL STIMULATION TRANSITIONS
    37.
    发明申请
    SYSTEMS AND METHODS FOR PROVIDING NEURAL STIMULATION TRANSITIONS 有权
    用于提供神经刺激转换的系统和方法

    公开(公告)号：US20120310304A1

    公开(公告)日：2012-12-06

    申请号：US13587654

    申请日：2012-08-16

    申请人： Marina V. Brockway ,  Paul A. Haefner ,  Anthony V. Caparso ,  Wondimeneh Tesfayesus

    发明人： Marina V. Brockway ,  Paul A. Haefner ,  Anthony V. Caparso ,  Wondimeneh Tesfayesus

    IPC分类号： A61N1/08

    CPC分类号： A61N1/36114 ,  A61N1/36117

    摘要： A method embodiment comprises generating a neural stimulation signal for a neural stimulation therapy. The signal is generated during a duty cycle of a stimulation period to provide the neural stimulation therapy with an intensity at a therapy level for a portion of the duty cycle. In various embodiments, a ramp up protocol is implemented to begin the duty cycle, a ramp down protocol is implemented to end the duty cycle, or both the ramp up protocol and the ramp down protocol are implemented. The ramp up protocol includes ramping up the intensity from a non-zero first subthreshold level for the neural stimulation therapy at the beginning of the duty cycle to the therapy level. The ramp down protocol includes ramping down the intensity from the therapy intensity level to a non-zero second subthreshold level for the neural stimulation therapy at the end of the duty cycle.

    摘要翻译： 方法实施例包括产生用于神经刺激治疗的神经刺激信号。 在刺激期的占空比期间产生信号，以在占空比的一部分的治疗水平上提供具有强度的神经刺激治疗。 在各种实施例中，实现斜坡上升协议以开始占空比，实现斜降协议以结束占空比，或者实现升温协议和斜降协议两者。 加速协议包括在占空比开始时到神经刺激治疗的非零第一亚阈值水平上升到治疗水平。 斜坡协议包括在占空比结束时将神经刺激治疗的强度从治疗强度水平向下降至非零秒次阈值水平。

    Implantable and rechargeable neural stimulator
    38.
    发明授权
    Implantable and rechargeable neural stimulator 有权

    公开(公告)号：US08315702B2

    公开(公告)日：2012-11-20

    申请号：US13402196

    申请日：2012-02-22

    申请人： Abhi V. Chavan ,  Anthony V. Caparso ,  Avram Scheiner

    发明人： Abhi V. Chavan ,  Anthony V. Caparso ,  Avram Scheiner

    IPC分类号： A61N1/00

    摘要： One aspect of the present subject matter relates to an implantable medical device. An embodiment of the device comprises a rechargeable power supply adapted to be recharged through an ultrasound signal, a neural stimulator connected to the rechargeable power supply, and a controller connected to the rechargeable power supply. The neural stimulator is adapted to generate a neural stimulation signal for delivery to a neural stimulation target through an electrode. The controller is further connected to the neural stimulator to control the neural stimulator according to a neural stimulation protocol. Other aspects are provided herein.

    METHOD AND APPARATUS FOR NEURAL STIMULATION WITH RESPIRATORY FEEDBACK
    39.
    发明申请
    METHOD AND APPARATUS FOR NEURAL STIMULATION WITH RESPIRATORY FEEDBACK 有权
    用呼吸反馈神经刺激的方法和装置

    公开(公告)号：US20120130446A1

    公开(公告)日：2012-05-24

    申请号：US13363198

    申请日：2012-01-31

    申请人： Paul A. Haefner ,  Kristofer J. James ,  Kent Lee ,  Imad Libbus ,  Anthony V. Caparso ,  Jonathan Kwok ,  Yachuan Pu

    发明人： Paul A. Haefner ,  Kristofer J. James ,  Kent Lee ,  Imad Libbus ,  Anthony V. Caparso ,  Jonathan Kwok ,  Yachuan Pu

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36053 ,  A61B5/08 ,  A61B5/4035 ,  A61B5/4818 ,  A61N1/3601 ,  A61N1/36114

    摘要： A neural stimulation system controls the delivery of neural stimulation using a respiratory signal as a therapy feedback input. The respiratory signal is used to increase the effectiveness of the neural stimulation, such as vagal nerve stimulation, while decreasing potentially adverse side effects in respiratory functions. In one embodiment, the neural stimulation system synchronizes the delivery of the neural stimulation pulses to the respiratory cycles using a respiratory fiducial point in the respiratory signal and a delay interval. In another embodiment, the neural stimulation system detects a respiratory disorder and, in response, adjusts the delivery of the neural stimulation pulses and/or delivers a respiratory therapy treating the detected respiratory disorder.

    摘要翻译： 神经刺激系统使用呼吸信号作为治疗反馈输入来控制神经刺激的传递。 呼吸信号用于增加神经刺激的有效性，例如迷走神经刺激，同时减少呼吸功能的潜在不利副作用。 在一个实施例中，神经刺激系统使用呼吸信号中的呼吸基准点和延迟间隔将神经刺激脉冲的传送同步到呼吸周期。 在另一个实施例中，神经刺激系统检测呼吸障碍，并且作为响应调整神经刺激脉冲的递送和/或递送治疗所检测的呼吸障碍的呼吸治疗。

    Method and apparatus for neural stimulation with respiratory feedback
    40.
    发明授权
    Method and apparatus for neural stimulation with respiratory feedback 有权
    呼吸反馈神经刺激的方法和装置

    公开(公告)号：US08121692B2

    公开(公告)日：2012-02-21

    申请号：US11468595

    申请日：2006-08-30

    申请人： Paul A. Haefner ,  Kristofer J. James ,  Kent Lee ,  Imad Libbus ,  Anthony V. Caparso ,  Jonathan Kwok ,  Yachuan Pu

    发明人： Paul A. Haefner ,  Kristofer J. James ,  Kent Lee ,  Imad Libbus ,  Anthony V. Caparso ,  Jonathan Kwok ,  Yachuan Pu

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36053 ,  A61B5/08 ,  A61B5/4035 ,  A61B5/4818 ,  A61N1/3601 ,  A61N1/36114

    摘要： A neural stimulation system controls the delivery of neural stimulation using a respiratory signal as a therapy feedback input. The respiratory signal is used to increase the effectiveness of the neural stimulation, such as vagal nerve stimulation, while decreasing potentially adverse side effects in respiratory functions. In one embodiment, the neural stimulation system synchronizes the delivery of the neural stimulation pulses to the respiratory cycles using a respiratory fiducial point in the respiratory signal and a delay interval. In another embodiment, the neural stimulation system detects a respiratory disorder and, in response, adjusts the delivery of the neural stimulation pulses and/or delivers a respiratory therapy treating the detected respiratory disorder.

    摘要翻译： 神经刺激系统使用呼吸信号作为治疗反馈输入来控制神经刺激的传递。 呼吸信号用于增加神经刺激的有效性，例如迷走神经刺激，同时减少呼吸功能的潜在不利副作用。 在一个实施例中，神经刺激系统使用呼吸信号中的呼吸基准点和延迟间隔将神经刺激脉冲的传送同步到呼吸周期。 在另一个实施例中，神经刺激系统检测呼吸障碍，并且作为响应调整神经刺激脉冲的递送和/或递送治疗所检测的呼吸障碍的呼吸治疗。