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    Engine delay compensation
    31.
    发明授权
    Engine delay compensation 失效
    发动机延时补偿

    公开(公告)号：US07006909B1

    公开(公告)日：2006-02-28

    申请号：US10969143

    申请日：2004-10-20

    Applicant: Andrew May

    Inventor： Andrew May

    IPC: F02D41/14

    CPC classification number: G05B11/42 ,  F02D41/1401 ,  F02D41/1403 ,  F02D2041/141 ,  F02D2041/1431 ,  F02D2041/1433 ,  G05B13/048

    Abstract: An engine with inertial integration and delay is controlled through the use of a disturbance estimator. Control logic includes a feed-forward control path driving a control input with a control signal. The feed-forward control path is designed to provide closed-loop control of the controlled parameter without the presence of transport delay. The disturbance estimator generates an estimate of the engine disturbance. A Smith predictor generates a compensation signal for the feed-forward control path based on the control signal and the engine disturbance estimate.

    Abstract translation: 通过使用干扰估计器来控制具有惯性积分和延迟的发动机。 控制逻辑包括用控制信号驱动控制输入的前馈控制路径。 前馈控制路径被设计为提供受控参数的闭环控制，而不存在传输延迟。 干扰估计器产生发动机扰动的估计。 史密斯预测器根据控制信号和发动机扰动估计值产生前馈控制路径的补偿信号。

    Methods and apparatus for inspection utilizing pulsed eddy current
    32.
    发明申请
    Methods and apparatus for inspection utilizing pulsed eddy current 失效
    使用脉冲涡流检查的方法和装置

    公开(公告)号：US20050068026A1

    公开(公告)日：2005-03-31

    申请号：US10675822

    申请日：2003-09-30

    Applicant: Andrew May ,  Changting Wang ,  Yuri Plotnikov

    Inventor： Andrew May ,  Changting Wang ,  Yuri Plotnikov

    IPC: G01D5/20 ,  G01N27/72 ,  G01N27/90 ,  G01B7/06 ,  G01R33/12

    CPC classification number: G01N27/9046

    Abstract: In some aspects, the present invention provides a method for estimating at least one measurement/object property of a metal object. The method includes generating a time-varying eddy current in a wall of the metal object utilizing a pulsed-signal transmitter. The method further includes measuring the time-varying eddy current, fitting the time-varying measured eddy current to a parameterized polynomial, and interpreting the parameterized polynomial to determine one or more measurement/object properties of the metal object.

    Abstract translation: 在一些方面，本发明提供了一种用于估计金属物体的至少一个测量/物体特性的方法。 该方法包括利用脉冲信号发射器在金属物体的壁上产生时变涡流。 该方法还包括测量时变涡流，将随时间变化的测量的涡流拟合到参数化多项式，以及解释参数化多项式以确定金属物体的一个或多个测量/物体特性。

    System and method for lowering mortgage payments associated with a mortgage loan
    33.
    发明申请
    System and method for lowering mortgage payments associated with a mortgage loan 有权

    公开(公告)号：US20220398658A1

    公开(公告)日：2022-12-15

    申请号：US17346340

    申请日：2021-06-14

    Applicant: Eric Iseley ,  Andrew May

    Inventor： Eric Iseley ,  Andrew May

    IPC: G06Q40/02 ,  G06Q40/04

    Abstract: In the present invention, a system and method is described for lowering costs associated with taxes, insurance and HOA payments, during the initial five and/or ten year periods of owning a home, by financing these costs and other ongoing charges related to the consummation of a mortgage loan. In addition to the cost savings, the consumer may set up an asset that helps generate additional income to the consumer. Cost savings are achieved and secondary market ownership of the mortgage results in a lower overall risk to the investor through the creation of an asset that may be accessed to offset costs of homeownership or mitigate risk to the investor in the mortgage.

    Nucleic acid encoding reactions
    34.
    发明授权
    Nucleic acid encoding reactions 有权
    核酸编码反应

    公开(公告)号：US09074204B2

    公开(公告)日：2015-07-07

    申请号：US13476911

    申请日：2012-05-21

    Applicant: Megan Anderson ,  Peilin Chen ,  Brian Fowler ,  Robert C. Jones ,  Fiona Kaper ,  Ronald Lebofsky ,  Andrew May

    Inventor： Megan Anderson ,  Peilin Chen ,  Brian Fowler ,  Robert C. Jones ,  Fiona Kaper ,  Ronald Lebofsky ,  Andrew May

    IPC: C12Q1/68 ,  C12N15/10 ,  C12N15/65 ,  C12N15/66

    CPC classification number: C12Q1/6855 ,  C12N15/10 ,  C12N15/1065 ,  C12N15/65 ,  C12N15/66 ,  C12Q1/686 ,  C12Q1/6874

    Abstract: Described herein are methods useful for incorporating one or more adaptors and/or nucleotide tag(s) and/or barcode nucleotide sequence(s) one, or typically more, target nucleotide sequences. In particular embodiments, nucleic acid fragments having adaptors, e.g., suitable for use in high-throughput DNA sequencing are generated. In other embodiments, information about a reaction mixture is encoded into a reaction product. Also described herein are methods and kits useful for amplifying one or more target nucleic acids in preparation for applications such as bidirectional nucleic acid sequencing. In particular embodiments, methods of the invention entail additionally carrying out bidirectional DNA sequencing. Also described herein are methods for encoding and detecting and/or quantifying alleles by primer extension.

    Abstract translation: 本文所描述的方法可用于掺入一个或多个衔接子和/或核苷酸标签和/或条形码核苷酸序列，一个或多个靶核苷酸序列。 在具体实施方案中，产生具有适配器（例如适合用于高通量DNA测序）的核酸片段。 在其它实施方案中，关于反应混合物的信息被编码成反应产物。 本文还描述了可用于扩增一种或多种靶核酸以准备应用如双向核酸测序的方法和试剂盒。 在具体实施方案中，本发明的方法还需要进行双向DNA测序。 本文还描述了通过引物延伸来编码和检测和/或定量等位基因的方法。

    Microfluidic devices with removable cover and methods of fabrication and application
    35.
    发明授权
    Microfluidic devices with removable cover and methods of fabrication and application 有权
    具有可拆卸盖的微流体装置和制造和应用的方法

    公开(公告)号：US09039997B2

    公开(公告)日：2015-05-26

    申请号：US13499879

    申请日：2010-09-29

    Applicant: David Cohen ,  Andrew May ,  Martin Pieprzyk ,  Brian Fowler ,  Kim Huat Lee ,  Jun Yan ,  Ming Fang Zhou ,  Seng Beng Ng

    Inventor： David Cohen ,  Andrew May ,  Martin Pieprzyk ,  Brian Fowler ,  Kim Huat Lee ,  Jun Yan ,  Ming Fang Zhou ,  Seng Beng Ng

    IPC: B01L99/00 ,  B01L3/00 ,  B01L9/00 ,  B01L7/00 ,  G01N1/40

    CPC classification number: B01L3/5027 ,  B01L3/502738 ,  B01L7/52 ,  B01L9/527 ,  B01L2200/12 ,  B01L2300/045 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/0655 ,  G01N1/405

    Abstract: The present invention includes microfluidic systems having a microfabricated cavity that may be covered with a removable cover, where the removable cover allows at least part of the opening of the microfabricated cavity to be exposed or directly accessed by an operator. The microfluidic systems comprise chambers, flow and control channels formed in elastomeric layers that may comprise PDMS. The removable cover comprises a thermoplastic base film bonded to an elastomer layer by an adhesive layer. When the removable cover is peeled off, the chamber is at least partially open to allow sample extraction from the chamber. The chamber may have macromolecular crystals formed inside or resulting contents from a PCR reaction. The invention also includes a method for making vias in elastomeric layers by using the removable cover. The invention further includes methods and devices for peeling the peelable cover or a removable component such as Integrated Heater Spreader.

    Abstract translation: 本发明包括具有微型空腔的​​微流体系统，其可以被可移除的盖覆盖，其中可移除的盖允许微加工腔的至少一部分开口被操作者暴露或直接访问。 微流体系统包括在可包括PDMS的弹性体层中形成的腔室，流动和控制通道。 可移除的盖包括通过粘合剂层结合到弹性体层的热塑性基底膜。 当可移除的盖被剥离时，室至少部分地打开以允许从室中取样。 该室可能在PCR反应内部形成大分子晶体或产生内含物。 本发明还包括通过使用可移除盖制造弹性体层中的通孔的方法。 本发明还包括用于剥离可剥离盖或诸如集成式加热器撒布机的可移除部件的方法和装置。

    MICROFLUIDIC DEVICES WITH REMOVABLE COVER AND METHODS OF FABRICATION AND APPLICATION
    37.
    发明申请
    MICROFLUIDIC DEVICES WITH REMOVABLE COVER AND METHODS OF FABRICATION AND APPLICATION 失效
    具有可拆卸盖的微流体装置以及制造和应用方法

    公开(公告)号：US20120195810A1

    公开(公告)日：2012-08-02

    申请号：US13499879

    申请日：2010-09-09

    Applicant: David Cohen ,  Andrew May ,  Martin Pieprzyk ,  Brian Fowler ,  Kim Huat Lee ,  Jun Yan ,  Ming Fang Zhou ,  Seng Beng Ng

    Inventor： David Cohen ,  Andrew May ,  Martin Pieprzyk ,  Brian Fowler ,  Kim Huat Lee ,  Jun Yan ,  Ming Fang Zhou ,  Seng Beng Ng

    IPC: B01L3/00 ,  B32B38/00

    CPC classification number: B01L3/5027 ,  B01L3/502738 ,  B01L7/52 ,  B01L9/527 ,  B01L2200/12 ,  B01L2300/045 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/0655 ,  G01N1/405

    Abstract: The present invention includes microfluidic systems having a microfabricated cavity that may be covered with a removable cover, where the removable cover allows at least part of the opening of the microfabricated cavity to be exposed or directly accessed by an operator. The microfluidic systems comprise chambers, flow and control channels formed in elastomeric layers that may comprise PDMS. The removable cover comprises a thermoplastic base film bonded to an elastomer layer by an adhesive layer. When the removable cover is peeled off, the chamber is at least partially open to allow sample extraction from the chamber. The chamber may have macromolecular crystals formed inside or resulting contents from a PCR reaction. The invention also includes a method for making vias in elastomeric layers by using the removable cover. The invention further includes methods and devices for peeling the peelable cover or a removable component such as Integrated Heater Spreader.

    Abstract translation: 本发明包括具有微型空腔的​​微流体系统，其可以被可移除的盖覆盖，其中可移除的盖允许微加工腔的至少一部分开口被操作者暴露或直接访问。 微流体系统包括在可包括PDMS的弹性体层中形成的腔室，流动和控制通道。 可移除的盖包括通过粘合剂层结合到弹性体层的热塑性基底膜。 当可移除的盖被剥离时，室至少部分地打开以允许从室中取样。 该室可能在PCR反应内部形成大分子晶体或产生内含物。 本发明还包括通过使用可移除盖制造弹性体层中的通孔的方法。 本发明还包括用于剥离可剥离盖或诸如集成式加热器撒布机的可移除部件的方法和装置。

    Method and system for crystallization and X-ray diffraction screening
    38.
    发明授权
    Method and system for crystallization and X-ray diffraction screening 有权
    用于结晶和X射线衍射筛选的方法和系统

    公开(公告)号：US07974380B2

    公开(公告)日：2011-07-05

    申请号：US12118185

    申请日：2008-05-09

    Applicant: Brian Fowler ,  Andrew May

    Inventor： Brian Fowler ,  Andrew May

    IPC: G01N23/20

    CPC classification number: G01N23/20025

    Abstract: An integrated fluidic circuit includes a substrate layer and a first structure coupled to the substrate layer and including a plurality of channels. The first structure is configured to provide for flow of one or more materials through the plurality of channels. The integrated fluidic circuit also includes a second structure coupled to the substrate layer. The second structure includes a plurality of control channels configured to receive an actuation pressure. The integrated fluidic circuit is characterized by a thickness of less than 1.5 mm.

    Abstract translation: 集成流体回路包括衬底层和耦合到衬底层并且包括多个通道的第一结构。 第一结构被配置为提供通过多个通道的一种或多种材料的流动。 集成流体回路还包括耦合到衬底层的第二结构。 第二结构包括被配置为接收致动压力的多个控制通道。 集成流体回路的特征在于厚度小于1.5mm。

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