利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

70 条记录 (耗时 0.033 秒)

    Tissue-engineering scaffolds containing self-assembled-peptide hydrogels
    33.
    发明申请
    Tissue-engineering scaffolds containing self-assembled-peptide hydrogels 有权
    含有自组装肽水凝胶的组织工程支架

    公开(公告)号：US20080145934A1

    公开(公告)日：2008-06-19

    申请号：US10951357

    申请日：2004-09-28

    申请人： Ian Ross Harris ,  Alexander M. Harmon ,  Laura J. Brown ,  Anna Gosiewska

    发明人： Ian Ross Harris ,  Alexander M. Harmon ,  Laura J. Brown ,  Anna Gosiewska

    IPC分类号： C12N5/06

    CPC分类号： C12N5/06 ,  A61L27/227 ,  A61L27/52 ,  A61L27/56 ,  C12N2533/40 ,  C12N2533/50

    摘要： The present invention is directed to tissue-engineering scaffolds containing both a microporous scaffold made from a biocompatible material suitable for use in tissue-engineering scaffolds and a nanofiberous, nanoporous hydrogel formed from a self-assembling peptide, where at least a portion of the hydrogel is disposed within the pores of the microporous scaffold, thus providing tissue-engineering scaffolds having average pore diameters in the nanometer range and that provide both mechanical properties suitable for implantation into a body of a mammal and excellent tissue response once implanted in the body.

    摘要翻译： 本发明涉及包含由适合用于组织工程支架的生物相容性材料制成的微孔支架和由自组装肽形成的纳米纤维，纳米多孔水凝胶的组织工程支架，其中至少一部分水凝胶 设置在微孔支架的孔内，从而提供具有纳米范围内的平均孔径的组织工程支架，并且提供适合于植入哺乳动物身体的机械性能并且一旦植入体内就具有优异的组织反应。

    Bioabsorbable bag containing bioabsorbable materials of different bioabsorption rates for tissue engineering
    37.
    发明授权
    Bioabsorbable bag containing bioabsorbable materials of different bioabsorption rates for tissue engineering 有权
    生物可吸收袋，含有组织工程不同生物吸收率的生物可吸收材料

    公开(公告)号：US06656488B2

    公开(公告)日：2003-12-02

    申请号：US09832700

    申请日：2001-04-11

    申请人： Chin-Feng Yi ,  Anna Gosiewska ,  Susan Roweton

    发明人： Chin-Feng Yi ,  Anna Gosiewska ,  Susan Roweton

    IPC分类号： A61F200

    CPC分类号： A61L27/52 ,  A61L27/58

    摘要： A device for tissue engineering is formed of a porous bioabsorbable bag containing at least two bioabsorbable materials having different rates of bioabsorption such as beads of different degrading rates and a bioabsorbable binding gel such as fibrin that binds the bioabsorbable materials in relation to each other. Slow degrading beads and the bag may be made of a copolymer of poly(L-lactide) and poly(glycolide), and fast degrading beads may be made of gelatin. The bag may contain cells and/or wound healing stimulants such as growth factors. Hydrolyzing enzymes may be used to enhance biodegradation of polymers. The device can be used to promote in-growth of host tissue into a void by inserting the bag with its contents into the void and conforming the bag to a desired shape. The binding gel may be injected into the bag after being placed in the void .

    摘要翻译： 用于组织工程的装置由含有至少两种具有不同生物吸收速率的生物可吸收材料（例如不同降解率的珠子）和生物可吸收结合凝胶（例如纤维蛋白）的多孔生物可吸收袋形成，其结合生物可吸收材料相互之间。 缓慢降解的珠和袋可以由聚（L-丙交酯）和聚（乙交酯）的共聚物制成，并且快速降解的珠可以由明胶制成。 袋子可以含有细胞和/或伤口愈合兴奋剂如生长因子。 水解酶可用于增强聚合物的生物降解。 该装置可用于通过将其内含物插入到空隙中并将袋符合到期望的形状来促进宿主组织的生长成为空隙。 结合凝胶在放入空隙后可以注入袋中。

    Repair and regeneration of renal tissue using human umbilical cord tissue-derived cells
    38.
    发明授权
    Repair and regeneration of renal tissue using human umbilical cord tissue-derived cells 有权
    使用人脐带组织来源的细胞修复和再生肾组织

    公开(公告)号：US08034329B2

    公开(公告)日：2011-10-11

    申请号：US12245571

    申请日：2008-10-03

    申请人： David C. Colter ,  Anna Gosiewska

    发明人： David C. Colter ,  Anna Gosiewska

    IPC分类号： A01N65/00

    CPC分类号： A61K35/44 ,  A61K35/12 ,  C12N5/0605

    摘要： Methods for treating a patient having a disease or damage to at least one kidney are provided. The methods comprise administering cells obtained from human umbilical cord tissue, or administering pharmaceutical compositions comprising such cells or prepared from such cells. When administered, the cells promote and support the repair and regeneration of the diseased or damaged kidney tissue in the patient. Pharmaceutical compositions for use in the inventive methods, as well as kits for practicing the methods are also provided.

    摘要翻译： 提供了治疗患有至少一种肾脏疾病或损伤的患者的方法。 所述方法包括施用从人脐带组织获得的细胞，或施用包含此类细胞的药物组合物或由此类细胞制备。 当施用时，细胞促进并支持患者中患病或损坏的肾组织的修复和再生。 还提供了用于本发明方法的药物组合物，以及用于实施该方法的试剂盒。

    Device and method for tissue engineering
    40.
    发明申请
    Device and method for tissue engineering 有权
    组织工程的装置和方法

    公开(公告)号：US20080131477A1

    公开(公告)日：2008-06-05

    申请号：US10654145

    申请日：2003-09-03

    申请人： Chin-Feng Yi ,  Anna Gosiewska ,  Susan Roweton

    发明人： Chin-Feng Yi ,  Anna Gosiewska ,  Susan Roweton

    IPC分类号： A61F2/00 ,  C12M1/00 ,  A61K38/48

    CPC分类号： A61L27/52 ,  A61L27/58

    摘要： A device and method for tissue engineering is disclosed. More particularly this invention relates to a bioabsorbable device and a method of its use which promotes controlled new tissue in-growth into voids or cavities occupied by the device as portions of the device are selectively absorbed within a host thereby minimizing collapse of surrounding, pre-existing host tissue into the engineered site.

    摘要翻译： 公开了一种用于组织工程的装置和方法。 更具体地说，本发明涉及一种生物可吸收装置及其使用方法，其促进受控的新组织生长成由装置占据的空隙或空腔，因为装置的部分选择性地吸收在主体内，从而最小化周围， 现有宿主组织进入工程现场。