公开(公告)号：US20240189485A1

公开(公告)日：2024-06-13

申请号：US18516271

申请日：2023-11-21

Applicant: Boston Scientific Scimed, Inc.

Inventor： Cristian Parisi ,  Yen-Hao Hsu, JR. ,  Joseph Thomas Delaney, JR.

IPC: A61L27/50 ,  A61L27/16

CPC classification number: A61L27/50 ,  A61L27/16 ,  A61L2300/202

Abstract: The disclosure pertains to radiopaque, unsaturated multi-arm polymers that comprise a plurality of hydrophilic polymer arms having end moieties comprising one or more radiopaque halogen groups and one or more unsaturated groups, the end moieties linked to the hydrophilic polymer arms though an ester or an amide linkage. In some embodiments, the disclosure pertains to systems for forming hydrogels, which systems comprise (a) a polyamino compound and (b) a radiopaque, unsaturated multi-arm polymer that comprises a plurality of hydrophilic polymer arms having end moieties comprising one or more radiopaque halogen groups and one or more unsaturated groups, the end moieties linked to the hydrophilic polymer arms though an ester or an amide linkage, wherein the one or more unsaturated groups are reactive with the amino groups of the polyamino compound. Other embodiments pertain to methods of treatment using such systems and to hydrogels formed from such systems.

公开(公告)号：US20220243009A1

公开(公告)日：2022-08-04

申请号：US17724892

申请日：2022-04-20

Applicant: Boston Scientific Scimed Inc.

Inventor： Joseph Thomas Delaney, JR. ,  Carey Rehder ,  Tatyana Dyndikova ,  John Kummailil

IPC: C08G63/91 ,  C08G73/02 ,  C08K5/00

Abstract: In some aspects, the present disclosure pertains to multi-arm polymers that comprise a core, a plurality of polymer segments having a first end that is covalently attached to the core and a second end comprising a moiety that comprises a reactive group, wherein the polymer segments comprise one or more free-radical-polymerizable monomers. In some aspects, systems are provided that comprise a first composition comprising such a multi-arm polymer and a second composition comprising a multifunctional compound that comprises functional groups that are reactive with the reactive groups of the multi-arm polymer. In some aspects, systems are provided that comprise crosslinked reaction products of such a multi-arm polymer and such a multifunctional compound.

公开(公告)号：US20190247523A1

公开(公告)日：2019-08-15

申请号：US16276169

申请日：2019-02-14

Applicant: Boston Scientific Scimed, Inc.

Inventor： Joseph Thomas Delaney, JR. ,  Douglas Dean Pagoria ,  Douglas Pennington ,  Paul Sorajja

IPC: A61K49/10

CPC classification number: A61K49/10 ,  A61F2/01 ,  A61K47/555 ,  A61K49/103

Abstract: A functional gadolinium contrast agent comprising a gadolinium cation and a ligand secured to the gadolinium cation is disclosed, the ligand comprising a reactive group capable of bonding to a capture substrate. A method of removing gadolinium contrast agents from a patient is disclosed, the method comprising providing a gadolinium contrast agent containing a reactive group; providing a capture substrate for insertion into a patient's bloodstream; administering the gadolinium contrast agent to the patient; conducting a magnetic resonance imaging procedure; and sequestering the gadolinium contrast agent on the capture substrate. A system for removing gadolinium contrast agents is also disclosed.

公开(公告)号：US20170014227A1

公开(公告)日：2017-01-19

申请号：US15205098

申请日：2016-07-08

Applicant: Boston Scientific SciMed, Inc.

Inventor： Mark W. Boden ,  Peter G. Edelman ,  Joseph Thomas Delaney, JR.

IPC: A61F2/24

CPC classification number: A61F2/2412 ,  A61F2/2415 ,  A61F2210/0076 ,  A61F2220/0016 ,  A61F2250/0028 ,  A61F2250/0029 ,  A61F2310/00011 ,  A61F2310/00179 ,  A61L27/20

Abstract: A prosthetic heart valve leaflet is composed of a self-reinforced composite (SRC) structure that includes a first layer. The first layer can include a first plurality of fused fibers composed of a first polymeric material in which each fiber is fused to at least one adjacent fiber by a reflowed fiber domain region.

Abstract translation: 假体心脏瓣膜小叶由包括第一层的自增强复合材料（SRC）结构组成。 第一层可以包括由第一聚合物材料组成的第一多个熔融纤维，其中每个纤维通过回流纤维畴区域与至少一个相邻纤维熔合。

公开(公告)号：US20160296322A1

公开(公告)日：2016-10-13

申请号：US15082293

申请日：2016-03-28

Applicant: Boston Scientific SciMed, Inc.

Inventor： Peter G. Edelman ,  Mark W. Boden ,  Joseph Thomas Delaney, JR.

IPC: A61F2/24

CPC classification number: A61F2/2412 ,  A61F2002/009 ,  A61F2310/00389 ,  A61L27/14 ,  C08L101/02

Abstract: A prosthetic heart valve includes a plurality of synthetic polymeric leaflets. Each leaflet has a base polymer and a polymer coating at least partially disposed over the base polymer, wherein the polymer coating includes polymerized units of a monomer comprising a zwitterionic group when the polymer coating is exposed to an aqueous environment at a pH of about 7.4

Abstract translation: 假体心脏瓣膜包括多个合成的聚合单张。 每个小叶具有至少部分地设置在基础聚合物上的基础聚合物和聚合物涂层，其中当聚合物涂层暴露于约7.4的pH的水性环境时，聚合物涂层包括包含两性离子基团的单体的聚合单元

公开(公告)号：US20160213228A1

公开(公告)日：2016-07-28

申请号：US15003924

申请日：2016-01-22

Applicant: Boston Scientific Scimed, Inc. ,  Mayo Foundation for Medical Education and Research

Inventor： James P. Rohl ,  David R. Wulfman ,  Brian T. Berg ,  Joseph Thomas Delaney, JR. ,  Brian J. Tischler ,  Peter M. Pollak ,  Harold M. Burkhart ,  Joseph A. Dearani ,  Sorin V. Pislaru

IPC: A61B1/00 ,  A61B1/018 ,  A61B17/128 ,  A61B1/05 ,  A61B17/122 ,  A61B17/04 ,  A61B1/313

CPC classification number: A61B1/00082 ,  A61B1/00087 ,  A61B1/00147 ,  A61B1/018 ,  A61B1/05 ,  A61B1/0676 ,  A61B1/3137 ,  A61B8/12 ,  A61B17/0401 ,  A61B17/0469 ,  A61B17/0644 ,  A61B17/068 ,  A61B17/122 ,  A61B17/1227 ,  A61B17/1285 ,  A61B2017/00526 ,  A61B2017/00783 ,  A61B2017/00902 ,  A61B2017/00907 ,  A61B2017/0406 ,  A61B2017/0409 ,  A61B2017/0472 ,  A61B2017/048 ,  A61B2017/06042 ,  A61B2017/0649 ,  A61B2090/306 ,  A61B2090/309 ,  A61B2090/3612 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61M25/1002 ,  A61M25/1029 ,  A61M2025/105 ,  A61M2025/1075 ,  A61M2025/1088

Abstract: A direct visualization catheter includes an elongate shaft defining a lumen and having a distal end portion and a proximal end portion and a transparent balloon attached to the distal end portion of the shaft. The balloon includes a first layer comprising a thermoset polymer and a plurality of polymeric fibers at least partially embedded in the thermoset polymer and a second layer disposed on the first layer and comprising a hydrogel.

Abstract translation: 直接可视导管包括限定内腔的细长轴，并且具有远端部分和近端部分以及附接到轴的远端部分的透明囊。 气囊包括包含热固性聚合物和至少部分地嵌入热固性聚合物中的多个聚合物纤维的第一层和设置在第一层上并包含水凝胶的第二层。

公开(公告)号：US20150182673A1

公开(公告)日：2015-07-02

申请号：US14581404

申请日：2014-12-23

Applicant: Boston Scientific Scimed, Inc.

Inventor： Joseph Thomas Delaney, JR. ,  Kasyap Seethamraju ,  John Kummailil ,  Paul Vincent Grosso

IPC: A61L31/14 ,  A61L27/50 ,  A61L29/14 ,  A61L27/34 ,  A61L31/10 ,  A61L29/08

CPC classification number: A61L31/14 ,  A61L27/34 ,  A61L27/50 ,  A61L27/54 ,  A61L29/085 ,  A61L29/14 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2400/10

Abstract: In some aspects of the present invention, coatings are provided which provide lubricity as well as additional functionality. Further aspects of the invention pertain to medical devices having such coatings and methods of forming such coatings.

Abstract translation: 在本发明的一些方面，提供了提供润滑性以及附加功能的涂层。 本发明的其它方面涉及具有这种涂层的医疗装置和形成这种涂层的方法。