-
公开(公告)号：US12203059B2
公开(公告)日：2025-01-21
申请号：US17532196
申请日：2021-11-22
Applicant: CORNING INCORPORATED
Inventor： Ye Fang , Ann MeeJin Ferrie , Vasiliy Nikolaevich Goral , Allison Jean Tanner , Qi Wu
Abstract: A cell culture apparatus may include a substrate defining a well. The well may define an interior surface, an exterior surface, an upper aperture and a nadir. The substrate may define a thickness between the interior and exterior surfaces that has a thickness proximate the nadir that is greater than or equal to a thickness proximate the upper aperture.
-
公开(公告)号：US20240002778A1
公开(公告)日：2024-01-04
申请号：US18368281
申请日：2023-09-14
Applicant: CORNING INCORPORATED
Inventor： Gregory Roger Martin , Allison Jean Tanner
CPC classification number: C12M47/02 , C12M33/14 , C12N5/0075
Abstract: A cell separation device configured for separating cells from microcarriers or spheroids in a liquid is provided. The cell separation device includes a vessel comprising a first port, a second port, and a cavity; and a porous mesh disposed within the cavity to divide the cavity into a first compartment and a second compartment, wherein the first port is in communication with the first compartment of the cavity, the first port located to a first side of the porous mesh, wherein the second port is in communication with the second compartment of the cavity, the second port located to a second side of the porous mesh, and wherein the porous mesh is positioned within the cavity to have a substantially vertical orientation or an inclined orientation with respect to a flow of liquid through the porous mesh.
-
公开(公告)号：US20230383226A1
公开(公告)日：2023-11-30
申请号：US18031774
申请日：2021-10-27
Applicant: CORNING INCORPORATED
Inventor： Gregory Roger Martin , Allison Jean Tanner
CPC classification number: C12M23/16 , C12M23/12 , C12M23/20 , C12M41/46 , C12N5/0062 , C12M23/38 , C12N2513/00
Abstract: Microcavity plates (10) comprise a microcavity substrate and a base (303) comprising a bottom grid comprising a plurality of grid segments arranged in ordered rows and columns to form a plurality of openings, and an open well (307) comprising a plurality of sidewalls (309) extending vertically from a perimeter of the bottom grid. The microcavity substrate comprises a plurality of microcavities (315) arranged in ordered rows and columns that align with the plurality of openings in the bottom grid, each microcavity comprising a cavity disposed within an opening of the bottom grid. The microcavity plate may further comprise an upper grid (405) for placement on top of the bottom grid delineating the ordered rows and columns of the base.
-
公开(公告)号：US11788051B2
公开(公告)日：2023-10-17
申请号：US16061964
申请日：2016-12-13
Applicant: Corning Incorporated
Inventor： Gregory Roger Martin , Allison Jean Tanner
CPC classification number: C12M47/02 , C12M33/14 , C12N5/0075
Abstract: A cell separation device configured for separating cells from microcarriers or spheroids in a liquid is provided. The cell separation device includes a vessel comprising a first port, a second port, and a cavity; and a porous mesh disposed within the cavity to divide the cavity into a first compartment and a second compartment, wherein the first port is in communication with the first compartment of the cavity, the first port located to a first side of the porous mesh, wherein the second port is in communication with the second compartment of the cavity, the second port located to a second side of the porous mesh, and wherein the porous mesh is positioned within the cavity to have a substantially vertical orientation or an inclined orientation with respect to a flow of liquid through the porous mesh.
-
公开(公告)号：US11767499B2
公开(公告)日：2023-09-26
申请号：US16628810
申请日：2018-07-13
Applicant: CORNING INCORPORATED
Inventor： Gregory Roger Martin , Ana Maria Del Pilar Pardo , Michael Kurt Schaefer , Allison Jean Tanner
CPC classification number: C12M23/16 , B01L3/502715 , C12M23/08 , C12M23/24 , C12M29/04 , B01L2300/0681 , B01L2300/12
Abstract: A cell culture vessel (100) includes a wall including an inner surface defining a cell culture chamber of the vessel. A substrate (215) of non-porous material is positioned in the cell culture chamber between a first region of the cell culture chamber and a second region of the cell culture chamber. The substrate includes a plurality of microcavities (220), each microcavity of the plurality of microcavities includes a concave surface defining a well and an opening, the concave surface of each microcavity includes at least one aperture including a dimension less than or equal to about 15 microns defining a path from the well to the second region. A cell culture vessel including a substrate including a plurality of microcavities and a layer of porous material is also provided. Methods of culturing cells in the cell culture vessel are also provided.
-
Patent Agency Ranking
公开(公告)号：US20230257690A1
公开(公告)日：2023-08-17
申请号：US18018418
申请日：2021-07-28
Applicant: CORNING INCORPORATED
Inventor： Scott Matthew Bennett , Thomas Albert Cloutier , William Joseph Lacey , Gregory Roger Martin , Allison Jean Tanner
Abstract: A cell culture system for culturing cells is provided. The cell culture system including a cell culture vessel with a cell culture chamber for culturing cells, an inlet through which liquid can flow for filling the cell culture vessel, and an outlet through which fluid can exit the cell culture vessel. The system also includes at least one fill sensor arranged to detect liquid within the cell culture vessel reaching a fill level at a predetermined position of the cell culture vessel during filling of the cell culture vessel, where the at least one fill sensor can generate a detection signal when liquid within the cell culture vessel reaches the fill level. Also included is an actuator to change an orientation of the cell culture vessel in response to the detection signal.
-
公开(公告)号：US20230012125A1
公开(公告)日：2023-01-12
申请号：US17780448
申请日：2020-11-09
Applicant: CORNING INCORPORATED
Inventor： John Wilfred Coddaire , Maryanne De Chambeau , James Thomas Eickmann , Paula Mary Flaherty , Anthony Glenn Frutos , Vasiliy Nikolaevich Goral , Angela Langer Julien , Marshall Jay Kosovsky , Brent Ravaughn Lanterman , Gregory Roger Martin , Christie Leigh McCarthy , John Shyu , Tora Ann-Beatrice Eline Sirkka , Allison Jean Tanner , Kimberly Ann Titus , Timothy James Wood
Abstract: A sensing cell culture vessel having one or more sensors on or in the vessel is configured to collect readings of various parameters or characteristics of a cell culture located within the sensing cell culture vessel and transmit the readings. The sensing cell culture vessels may be accompanied by a sensing plate having means for reading the one or more sensors and transmitting the one or more sensors to a server hosting electronic lab notebook for analyzing and storage of the readings. Sensing plates may further be equipped with cameras for imaging cell cultures located in the sensing cell culture vessels and transmitting the images to the server hosting the electronic lab notebook for analyzing and storage of the images. Embodiments of the invention allow for the continuous and automatic monitoring of cell cultures.
-
公开(公告)号：US20210246407A1
公开(公告)日：2021-08-12
申请号：US17273462
申请日：2019-09-03
Applicant: CORNING INCORPORATED
Inventor： Gregory Roger Martin , Ana Maria del Pilar Pardo , Allison Jean Tanner
Abstract: A pipette structure (160B) includes first and second body sections (164, 166) connected at a junction and including first and second fluid passages, respectively, with the pipette structure including (i) a bellows joint (165) permitting pivotal movement between the first and second body sections (164, 165), and/or (ii) the second fluid passage of the second body section includes greater width dimension at a sample introduction end than a width dimension at the junction. Such a pipette structure may be embodied in a unitary measuring pipette or an extension tip device for a measuring pipette. A method is provided for transferring material between an interior of a cell culture housing that includes a structured surface defining an array of microwells suitable for three-dimensional culture of multi-cell aggregates and an external environment. A method for fabricating a pipette structures is further provided.
-
公开(公告)号：US20210230528A1
公开(公告)日：2021-07-29
申请号：US16629656
申请日：2018-07-13
Applicant: CORNING INCORPORATED
Inventor： William Joseph Lacey , Gregory Roger Martin , Allison Jean Tanner
Abstract: A cell culture vessel includes a vessel body, support columns, and a stabilizer device. The vessel body defines a cell culture chamber enclosed between a bottom wall and a top wall. The support column is within the cell culture chamber and extends between the top wall and the bottom wall. The stabilizer device covers a width and length of the cell culture chamber and has a column engaging structure that is sized to slidingly engage the support column such that the stabilizer device is movable along the support column as a liquid culture medium is received in the cell culture chamber. The support column guides the stabilizer device along a length of the support column as the stabilizer device rises with rising liquid level in the cell culture chamber during a liquid culture medium filling operation.
-
公开(公告)号：US10316281B2
公开(公告)日：2019-06-11
申请号：US15691102
申请日：2017-08-30
Applicant: CORNING INCORPORATED
Abstract: A cell culture apparatus includes cell culture units having cell culture chambers, each with at least one manifold. The manifold connects the cell culture unit to a fluid flow channel. The manifold has a dam which allows liquid to pool in the manifold and allows for the creation of an airspace in the manifold, which reduces hydrostatic pressure inside the apparatus and enables the stacking of multiple cell culture units. Embodiments include cascading manifolds, manifolds having reservoirs, and manifolds having valves.
-
-
-
-
-
-
-
-
-
Search Results
88
records
(took 0.026 seconds)
