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公开(公告)号：US20150224133A1
公开(公告)日：2015-08-13
申请号：US14694112
申请日：2015-04-23
Applicant: Covidien LP
Inventor： Rachit Ohri , Phillip D. Blaskovich
IPC: A61K31/717 , A61K31/445 , A61K49/00 , A61K33/24 , A61K31/295 , A61K47/22 , A61K31/714
CPC classification number: A61K31/717 , A61K31/282 , A61K31/295 , A61K31/445 , A61K31/714 , A61K33/24 , A61K49/048 , A61L24/06 , A61L2430/36 , C08L1/04
Abstract: A method for forming an embolism within a blood vessel is disclosed. The method includes including: implanting an oxidized cellulose embolization solution into a lumen of a blood vessel to form an embolism within the lumen. The oxidized cellulose is present in an amount from about 10% by weight to 20% by weight of the oxidized cellulose embolization solution. The method also includes adjusting recanalization time of the embolism, which may be adjusted by tailoring a degradation rate of the oxidized cellulose.
Abstract translation: 公开了一种在血管内形成栓塞的方法。 该方法包括：将氧化的纤维素栓塞溶液植入血管的内腔，以在内腔内形成栓塞。 氧化纤维素以氧化纤维素栓塞溶液的约10重量％至20重量％的量存在。 该方法还包括调节栓塞的再通时间，其可以通过调节氧化纤维素的降解速率来调节。
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32.发明授权Crosslinked polymers with the crosslinker as therapeutic for sustained release 有权具有交联剂的交联聚合物作为持续释放的治疗剂公开(公告)号：US08889889B2
公开(公告)日：2014-11-18
申请号：US13862500
申请日：2013-04-15
Applicant: Confluent Surgical, Inc. , Covidien LP
Inventor： Rachit Ohri , Phillip Blaskovich , Joshua Kennedy , Steven L. Bennett , Arthur Driscoll
IPC: C07D207/46 , A61K47/30 , C07C231/02 , A61K47/48 , C08G65/00
CPC classification number: C07C231/02 , A61K47/30 , A61K47/60 , A61K47/6903 , C07D207/46 , C08G65/00 , Y10T428/31551
Abstract: Crosslinked polymers, methods for their preparation and use, are described in which the crosslinked polymers are formed from at least two polymer precursors, one of which is designed, upon degradation of the crosslinked polymer, to release the second polymer precursor in its original, unmodified chemical form.
Abstract translation: 描述了交联聚合物，其制备和使用方法，其中交联聚合物由至少两种聚合物前体形成，其中一种聚合物前体在交联聚合物降解时被设计为以其原始的未改性的方式释放第二聚合物前体 化学形式。
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33.发明申请Dissolution of Oxidized Cellulose and Particle Preparation by Dispersion and Neutralization 有权氧化纤维素的溶解和通过分散和中和制备颗粒公开(公告)号：US20140005377A1
公开(公告)日：2014-01-02
申请号：US13927315
申请日：2013-06-26
Applicant: Covidien LP , Confluent Surgical, Inc.
Inventor： Valentino Tramontano , Phillip Blaskovich , Rachit Ohri , Daniel S. Costa , Joshua Kennedy , Sajida Farooqi
Abstract: A process for dissolving modified cellulose includes contacting modified cellulose solution with at least one neutralizing agent to form a plurality of modified cellulose particles.
Abstract translation: 溶解改性纤维素的方法包括使改性纤维素溶液与至少一种中和剂接触以形成多个改性纤维素颗粒。
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公开(公告)号：US20210238314A1
公开(公告)日：2021-08-05
申请号：US17233694
申请日：2021-04-19
Applicant: Covidien LP
Inventor： Valentino J. Tramontano , Joshua Kennedy , Philip D. Blaskovich , Rachit Ohri , Daniel S. Costa , Sajida Farooqi
Abstract: A process for dissolving modified cellulose is disclosed. The process includes contacting modified cellulose with a solvent in a mixture to form swelled modified cellulose and then contacting the mixture with a salt to dissolve the swelled modified cellulose.
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公开(公告)号：US11065204B2
公开(公告)日：2021-07-20
申请号：US16540426
申请日：2019-08-14
Applicant: Covidien LP
Inventor： Phillip Blaskovich , Rachit Ohri , Lan Pham
IPC: A61K9/16 , A61K31/714 , A61K31/445 , A61K33/24 , B01J13/12 , A61L15/28 , A61L27/20
Abstract: A process for forming microspheres is disclosed. The process includes contacting a solvent with a modified cellulose to form a solution; contacting the modified cellulose solution with at least one bioactive agent to form a discontinuous phase liquid; contacting the discontinuous phase liquid with a continuous phase liquid to form an emulsion; and contacting the emulsion with a third phase liquid to extract the solvent from the emulsion, thereby forming a plurality of modified cellulose microspheres.
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Patent Agency Ranking
公开(公告)号：US20200000727A1
公开(公告)日：2020-01-02
申请号：US16540426
申请日：2019-08-14
Applicant: Covidien LP
Inventor： Phillip Blaskovich , Rachit Ohri , Lan Pham
IPC: A61K9/16 , A61K31/714 , A61K31/445 , A61K33/24 , B01J13/12 , A61L15/28 , A61L27/20
Abstract: A process for forming microspheres is disclosed. The process includes contacting a solvent with a modified cellulose to form a solution; contacting the modified cellulose solution with at least one bioactive agent to form a discontinuous phase liquid; contacting the discontinuous phase liquid with a continuous phase liquid to form an emulsion; and contacting the emulsion with a third phase liquid to extract the solvent from the emulsion, thereby forming a plurality of modified cellulose microspheres.
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公开(公告)号：US10426730B2
公开(公告)日：2019-10-01
申请号：US16225169
申请日：2018-12-19
Applicant: Covidien LP
Inventor： Phillip Blaskovich , Rachit Ohri , Lan Pham
IPC: A61K9/16 , A61K31/714 , A61K31/445 , A61K33/24 , B01J13/12 , A61L15/28 , A61L27/20
Abstract: A process for forming microspheres is disclosed. The process includes contacting a solvent with a modified cellulose to form a solution; contacting the modified cellulose solution with at least one bioactive agent to form a discontinuous phase liquid; contacting the discontinuous phase liquid with a continuous phase liquid to form an emulsion; and contacting the emulsion with a third phase liquid to extract the solvent from the emulsion, thereby forming a plurality of modified cellulose microspheres.
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公开(公告)号：US20180221511A1
公开(公告)日：2018-08-09
申请号：US15899505
申请日：2018-02-20
Applicant: Covidien LP
Inventor： Rachit Ohri , Phillip D. Blaskovich
IPC: A61K49/00 , A61K9/50 , A61L31/18 , A61L31/04 , A61K51/12 , A61K49/22 , A61K49/18 , A61K49/04 , A61K31/714 , A61K31/445 , A61K31/282 , B82Y5/00 , B82Y30/00
CPC classification number: A61K49/00 , A61K9/5031 , A61K9/5042 , A61K9/5073 , A61K9/5084 , A61K31/282 , A61K31/445 , A61K31/714 , A61K49/0017 , A61K49/0091 , A61K49/04 , A61K49/1818 , A61K49/225 , A61K51/1251 , A61L31/042 , A61L31/18 , B82Y5/00 , B82Y30/00 , C01P2004/04
Abstract: A microsphere and method for forming the same are disclosed. The microsphere includes modified cellulose and at least one of a visualization agent, a magnetic material, or a radioactive material.
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公开(公告)号：US09782430B2
公开(公告)日：2017-10-10
申请号：US14694112
申请日：2015-04-23
Applicant: Covidien LP
Inventor： Rachit Ohri , Phillip D. Blaskovich
IPC: A61L24/04 , A61M5/178 , A61K31/717 , A61K31/445 , A61K31/714 , A61K33/24 , A61K31/295 , A61L24/06 , A61K49/04 , A61K31/282
CPC classification number: A61K31/717 , A61K31/282 , A61K31/295 , A61K31/445 , A61K31/714 , A61K33/24 , A61K49/048 , A61L24/06 , A61L2430/36 , C08L1/04
Abstract: A method for forming an embolism within a blood vessel is disclosed. The method includes including: implanting an oxidized cellulose embolization solution into a lumen of a blood vessel to form an embolism within the lumen. The oxidized cellulose is present in an amount from about 10 % by weight to 20 % by weight of the oxidized cellulose embolization solution. The method also includes adjusting recanalization time of the embolism, which may be adjusted by tailoring a degradation rate of the oxidized cellulose.
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公开(公告)号：US20170246113A1
公开(公告)日：2017-08-31
申请号：US15593871
申请日：2017-05-12
Applicant: Covidien LP
Inventor： Phillip Blaskovich , Rachit Ohri , Lan Pham
IPC: A61K9/16 , A61K31/445 , A61K31/714
CPC classification number: A61K9/1682 , A61K9/1652 , A61K9/1694 , A61K31/445 , A61K31/714 , A61K33/24 , A61L15/28 , A61L27/20 , B01J13/12 , B01J13/125
Abstract: A process for forming microspheres is disclosed. The process includes contacting a solvent with a modified cellulose to form a solution; contacting the modified cellulose solution with at least one bioactive agent to form a discontinuous phase liquid; contacting the discontinuous phase liquid with a continuous phase liquid to form an emulsion; and contacting the emulsion with a third phase liquid to extract the solvent from the emulsion, thereby forming a plurality of modified cellulose microspheres.
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