-
31.发明申请公开(公告)号：US20190038808A1
公开(公告)日：2019-02-07
申请号：US16153139
申请日：2018-10-05
发明人： Robert S. Langer , Rajiv Saigal , Yang Teng
IPC分类号： A61L27/50 , A61L27/26 , A61K9/00 , A61L31/06 , A61L27/56 , A61L27/58 , A61L31/04 , A61L27/38 , A61L27/18 , A61L31/14 , A61L31/00 , A61F2/02 , A61F2/44 , A61L27/54 , A61L31/16 , C08L67/04
摘要： Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. More particularly, certain embodiments of the present invention are directed to polymeric mini-tubes that may be used for the treatment of spinal cord injuries. In addition, other embodiments are directed to polymeric “fill-in” bandages that may be used for the treatment of spinal cord injuries. For example, an erodible, or biodegradable, form of biocompatible polymer of the present invention is fabricated for surgical implantation into the site of the spinal cord injury.
-
公开(公告)号：US20180360765A1
公开(公告)日：2018-12-20
申请号：US16108465
申请日：2018-08-22
发明人： Arturo J. Vegas , Joshua C. Doloff , Omid Veiseh , Minglin Ma , Robert S. Langer , Daniel G. Anderson
IPC分类号： A61K9/50 , C08B37/00 , A61K35/39 , C12N5/00 , A61L29/08 , C12N5/071 , A61L33/08 , A61K9/00 , A61L31/10 , C08L5/04
摘要： Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for coating of any material where reduced fibrosis is desired, such as encapsulated cells for transplantation and medical devices implanted or used in the body.
-
公开(公告)号：US09867869B2
公开(公告)日：2018-01-16
申请号：US14652011
申请日：2013-12-12
发明人： Daniel G. Anderson , Hung-Chieh Chou , Michael J. Webber , Benjamin C. Tang , Yair Levi , Yunlong Zhang , Rosemary Lynn Kanasty , Arturo Jose Vegas , Robert S. Langer
CPC分类号： A61K38/28 , A61K47/54 , A61K47/542 , A61K47/543 , A61K47/549 , A61K47/554 , G01N33/66 , G01N33/74 , G01N2333/62
摘要： Compounds, compositions, and methods for “smart” delivery of a therapeutic, prophylactic or diagnostic agent, such as glucose-mediated delivery of insulin through glucose-sensing insulin derivatives, are provided. The insulin derivatives bind serum albumin or agglomerate in vivo. The insulin derivatives effectively dissociate to release insulin in a hyperglycemic condition, where the complexation of glucose to a glucose-sensing element alters properties of the insulin derivative leading to the dissociation. The compounds, compositions, and methods provide a delivery strategy for both self-regulated and long-term diabetes management.
-
34.发明授权公开(公告)号：US09440008B2
公开(公告)日：2016-09-13
申请号：US14694466
申请日：2015-04-23
发明人： Robert S. Langer , Rajiv Saigal , Yang Teng
IPC分类号： A61F13/00 , A61L31/06 , A61K9/00 , A61F2/02 , A61L31/14 , A61L27/26 , A61L27/58 , A61L31/16 , A61F2/44 , A61L31/00 , A61L31/04
CPC分类号： A61L27/50 , A61F2/02 , A61F2/442 , A61F2210/0004 , A61K9/0085 , A61L27/18 , A61L27/26 , A61L27/383 , A61L27/3834 , A61L27/3878 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/005 , A61L31/048 , A61L31/06 , A61L31/14 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/41 , A61L2300/412 , A61L2300/414 , A61L2300/60 , A61L2300/606 , A61L2300/64 , A61L2300/802 , A61L2400/00 , A61L2430/38 , C08L67/04
摘要： Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. More particularly, certain embodiments of the present invention are directed to polymeric mini-tubes that may be used for the treatment of spinal cord injuries. In addition, other embodiments are directed to polymeric “fill-in” bandages that may be used for the treatment of spinal cord injuries. For example, an erodible, or biodegradable, form of biocompatible polymer of the present invention is fabricated for surgical implantation into the site of the spinal cord injury.
-
35.发明授权Methods and compositions for the treatment of open and closed wound spinal cord injuries 有权用于治疗开放性和闭合性伤口脊髓损伤的方法和组合物公开(公告)号：US09101695B2
公开(公告)日：2015-08-11
申请号：US14496742
申请日：2014-09-25
发明人： Robert S. Langer , Rajiv Saigal , Yang Teng
CPC分类号： A61L27/50 , A61F2/02 , A61F2/442 , A61F2210/0004 , A61K9/0085 , A61L27/18 , A61L27/26 , A61L27/383 , A61L27/3834 , A61L27/3878 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/005 , A61L31/048 , A61L31/06 , A61L31/14 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/41 , A61L2300/412 , A61L2300/414 , A61L2300/60 , A61L2300/606 , A61L2300/64 , A61L2300/802 , A61L2400/00 , A61L2430/38 , C08L67/04
摘要： Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. More particularly, certain embodiments of the present invention are directed to polymeric mini-tubes that may be used for the treatment of spinal cord injuries. In addition, other embodiments are directed to polymeric “fill-in” bandages that may be used for the treatment of spinal cord injuries. For example, an erodible, or biodegradable, form of biocompatible polymer of the present invention is fabricated for surgical implantation into the site of the spinal cord injury.
摘要翻译： 公开了用于治疗开放和闭合伤口脊髓损伤的装置和方法。 例如，本文描述了用于减轻脊髓原发性损伤的继发性损伤并促进恢复的装置和方法。 更具体地，本发明的某些实施方案涉及可用于治疗脊髓损伤的聚合物微型管。 此外，其它实施方案涉及可用于治疗脊髓损伤的聚合物“填充”绷带。 例如，制造本发明的可侵蚀或可生物降解的生物相容性聚合物形式用于外科植入到脊髓损伤部位。
-
36.发明申请公开(公告)号：US20140161861A1
公开(公告)日：2014-06-12
申请号：US14177888
申请日：2014-02-11
发明人： Robert S. Langer , Rajiv Saigal , Yang Teng
CPC分类号： A61L27/50 , A61F2/02 , A61F2/442 , A61F2210/0004 , A61K9/0085 , A61L27/18 , A61L27/26 , A61L27/383 , A61L27/3834 , A61L27/3878 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/005 , A61L31/048 , A61L31/06 , A61L31/14 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/41 , A61L2300/412 , A61L2300/414 , A61L2300/60 , A61L2300/606 , A61L2300/64 , A61L2300/802 , A61L2400/00 , A61L2430/38 , C08L67/04
摘要： Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. More particularly, certain embodiments of the present invention are directed to polymeric mini-tubes that may be used for the treatment of spinal cord injuries. In addition, other embodiments are directed to polymeric “fill-in” bandages that may be used for the treatment of spinal cord injuries. For example, an erodible, or biodegradable, form of biocompatible polymer of the present invention is fabricated for surgical implantation into the site of the spinal cord injury.
摘要翻译： 公开了用于治疗开放和闭合伤口脊髓损伤的装置和方法。 例如，本文描述了用于减轻脊髓原发性损伤的继发性损伤并促进恢复的装置和方法。 更具体地，本发明的某些实施方案涉及可用于治疗脊髓损伤的聚合物微型管。 此外，其它实施方案涉及可用于治疗脊髓损伤的聚合物“填充”绷带。 例如，制造本发明的可侵蚀或可生物降解的生物相容性聚合物形式用于外科植入到脊髓损伤部位。
-
公开(公告)号：US20210353781A1
公开(公告)日：2021-11-18
申请号：US17278383
申请日：2019-09-23
发明人： Omid Veiseh , Volkan Yesilyurt , Andrew Bader , Whitney Loo , Daniel G. Anderson , Robert S. Langer
摘要： Surface-modified cell containing a cell and a conformal coating on the extracellular surface of the cell are described. The conformal coating contains two or more layers containing particles (e.g. nanoparticles) or macromolecules. The cell is an islet cell, a B cell, or a T cell. The macromolecules or particles are formed from zwitterionic polymers. Covalent linkages are employed to link the particles or macromolecules to a cell surface molecule containing an abiotic functional group, or between macromolecules and/or particles in adjacent layers. Also described are methods of making and using a surface-modified cell.
-
公开(公告)号：US20210186886A1
公开(公告)日：2021-06-24
申请号：US17080355
申请日：2020-10-26
摘要： Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for the encapsulation and transplantation of cells. Also disclosed are high throughput methods for the characterizing the biocompatibility and physiochemical properties of modified alginate polymers.
-
公开(公告)号：US10898443B2
公开(公告)日：2021-01-26
申请号：US16108465
申请日：2018-08-22
发明人： Arturo J. Vegas , Joshua C. Doloff , Omid Veiseh , Minglin Ma , Robert S. Langer , Daniel G. Anderson
IPC分类号： A61K35/39 , A61K9/00 , A61K9/50 , A61L29/08 , A61L31/10 , C08B37/00 , C12N5/00 , C12N5/071 , A61L33/08
摘要： Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for coating of any material where reduced fibrosis is desired, such as encapsulated cells for transplantation and medical devices implanted or used in the body.
-
公开(公告)号：US20200054559A1
公开(公告)日：2020-02-20
申请号：US16544464
申请日：2019-08-19
申请人： Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc. , President and Fellows of Harvard College , The Children's Medical Center Corporation
发明人： Ulrich H. von Andrian , Omid C. Farokhzad , Robert S. Langer , Tobias Junt , Elliott Ashley Moseman , Liangfang Zhang , Pamela Basto , Matteo Iannacone , Frank Alexis
摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or in B cells, in some embodiments, comprising at least one immunomodulatory agent, and optionally comprising at least one targeting moiety and optionally at least one immunostimulatory agent. The invention provides pharmaceutical compositions comprising inventive vaccine nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive vaccine nanocarriers and pharmaceutical compositions thereof. The invention provides methods of prophylaxis and/or treatment of diseases, disorders, and conditions comprising administering at least one inventive vaccine nanocarrier to a subject in need thereof.
-
-
-
-
-
-
-
-
-
搜索结果
366 条记录 (耗时 0.036 秒)
