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公开(公告)号：US20120071516A1
公开(公告)日：2012-03-22
申请号：US13240548
申请日：2011-09-22
申请人： Jianguo Cao , Jeffrey P. Whitten , Yazhong Pei , Zhijun Wang , Evan Rogers , Jonathan Grey
发明人： Jianguo Cao , Jeffrey P. Whitten , Yazhong Pei , Zhijun Wang , Evan Rogers , Jonathan Grey
IPC分类号： A61K31/4439 , C07D401/14 , C07D417/14 , C07D277/64 , A61P3/14 , C07D293/06 , A61K31/4155 , A61K31/428 , A61K31/343 , A61K31/41 , C07D231/12 , C07D307/36
CPC分类号： C07D421/04 , C07D293/06 , C07D421/12 , C07D421/14
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
摘要翻译： 本文描述了含有这种化合物的化合物和药物组合物，其调节储存操作的钙（SOC）通道的活性。 本文还描述了使用这种SOC通道调节剂单独和与其它化合物组合用于治疗将受益于SOC通道活性抑制的疾病或病症的方法。
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公开(公告)号：US20110263612A1
公开(公告)日：2011-10-27
申请号：US13085324
申请日：2011-04-12
申请人： Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
发明人： Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
IPC分类号： A61K31/497 , A61K31/44 , C07D405/10 , A61K31/4433 , C07D417/10 , A61K31/4439 , C07D401/10 , C07D413/10 , C07D413/14 , A61K31/444 , C07D471/04 , A61K31/437 , A61P29/00 , A61P13/12 , A61P11/00 , A61P1/00 , A61P19/02 , A61P19/10 , A61P37/06 , A61P25/00 , A61P17/06 , C07D213/75
CPC分类号： C07D213/74 , C07D213/75 , C07D241/20 , C07D401/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D493/10 , C07D495/04
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
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公开(公告)号：US20110230536A1
公开(公告)日：2011-09-22
申请号：US13124888
申请日：2009-10-23
IPC分类号： A61K31/415 , C07D231/12 , A61P19/02 , A61P37/06 , A61P17/06 , A61P1/04
CPC分类号： A61K31/415 , C07D231/12 , C07D231/14 , C07D409/12 , C07D417/12
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases, disorders or conditions that would benefit from inhibition of SOC channel activity.
摘要翻译： 本文描述了含有这种化合物的化合物和药物组合物，其调节储存操作的钙（SOC）通道的活性。 本文还描述了使用这种SOC通道调节剂单独和与其它化合物组合用于治疗将受益于SOC通道活性抑制的疾病，病症或病症的方法。
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公开(公告)号：US20110166159A1
公开(公告)日：2011-07-07
申请号：US13050356
申请日：2011-03-17
申请人： Gonul Velicelebi , Kenneth A. Stauderman , Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
发明人： Gonul Velicelebi , Kenneth A. Stauderman , Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
IPC分类号： A61K31/497 , C07D409/04 , A61K31/381 , C07D401/04 , A61K31/4436 , C07D403/04 , A61K31/506 , A61K31/405 , A61K31/4184 , C07D417/14 , A61K31/428 , C07D401/14 , A61K31/4709 , A61K31/4155 , A61K31/4535 , A61P1/00 , A61P19/02 , A61P3/10 , A61P25/28 , A61P17/06 , A61P37/06 , A61P7/06
CPC分类号： C07D409/04 , C07D333/38 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
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公开(公告)号：US07906553B2
公开(公告)日：2011-03-15
申请号：US12548189
申请日：2009-08-26
申请人： Gonul Velicelebi , Kenneth A. Stauderman , Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
发明人： Gonul Velicelebi , Kenneth A. Stauderman , Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
IPC分类号： A61K31/38
CPC分类号： C07D409/04 , C07D333/38 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Described herein are compounds of Formula (I) having the structure: where A, J, R1, R4, Z and X are described herein; and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
摘要翻译： 本文描述了具有以下结构的式（I）的化合物：其中A，J，R 1，R 4，Z和X在本文中描述; 和含有这种化合物的药物组合物，其调节储存操作的钙（SOC）通道的活性。 本文还描述了使用这种SOC通道调节剂单独和与其它化合物组合用于治疗将受益于SOC通道活性抑制的疾病或病症的方法。
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36.发明申请公开(公告)号：US20050064530A1
公开(公告)日：2005-03-24
申请号：US09811132
申请日：2001-03-14
申请人： Christen Anderson , Robert Davis , Tomas Szabo , Soumitra Ghosh , Walter Moos , Yazhong Pei
发明人： Christen Anderson , Robert Davis , Tomas Szabo , Soumitra Ghosh , Walter Moos , Yazhong Pei
IPC分类号： G01N33/50 , A61K31/704 , A61K31/7048 , A61K31/7056 , A61K31/7064 , A61K45/00 , A61P3/00 , A61P3/10 , A61P17/06 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/28 , A61P27/16 , A61P35/00 , A61P43/00 , C07H15/256 , C07H15/26 , C07K1/22 , C07K14/47 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/62 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , C12Q1/48 , C07J17/00
CPC分类号： C07K14/47 , C07K2319/00 , C07K2319/07 , C07K2319/21 , C07K2319/23 , C12N15/62 , C12N2799/021
摘要： Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.
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公开(公告)号：US5840500A
公开(公告)日：1998-11-24
申请号：US678136
申请日：1996-07-11
申请人： Yazhong Pei , John S. Kiely
发明人： Yazhong Pei , John S. Kiely
IPC分类号： C07B61/00 , C07D215/42 , C07D215/44 , G01N33/94 , G01N33/53 , G01N33/531 , G01N33/536 , G01N33/566
CPC分类号： C07D215/42 , C07D215/44 , G01N33/9486
摘要： The present invention relates to novel tetrahydro-quinoline compounds of the following formula, libraries containing such compounds, and to the generation of such combinatorial libraries composed of such compounds: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8 and Y have the meanings provided.
摘要翻译： 本发明涉及下式的新的四氢 - 喹啉化合物，含有这些化合物的文库，以及由这些化合物组成的组合文库的产生：其中R1，R2，R3，R4，R5，R6 ，R7，R8和Y具有所提供的含义。
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公开(公告)号：US5330994A
公开(公告)日：1994-07-19
申请号：US856603
申请日：1992-03-24
申请人： Yazhong Pei , Haile Tecle
发明人： Yazhong Pei , Haile Tecle
IPC分类号： C07D413/04 , C07D413/14 , C07D401/04 , A61K31/44
CPC分类号： C07D413/04 , C07D413/14
摘要： A novel compound of the following formulas useful in treating immune-related diseases, inflammation, stoke, epilepsy, dystonias, psychoses, anxiety, and depression: ##STR1##
摘要翻译： 用于治疗免疫相关疾病，炎症，发作，癫痫，肌张力障碍，精神病，焦虑和抑郁症的下列化学式的新化合物：
I II -
公开(公告)号：US20130345193A1
公开(公告)日：2013-12-26
申请号：US13975238
申请日：2013-08-23
申请人： Jeffrey P. WHITTEN , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
发明人： Jeffrey P. WHITTEN , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
IPC分类号： C07D405/04 , C07D413/14 , C07D471/04 , C07D413/04 , C07D213/75 , C07D417/04
CPC分类号： C07D213/74 , C07D213/75 , C07D241/20 , C07D401/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D493/10 , C07D495/04
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
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公开(公告)号：US20130123265A1
公开(公告)日：2013-05-16
申请号：US13734827
申请日：2013-01-04
IPC分类号： C07D403/04 , A61K31/506 , A61K31/444 , A61K31/4436 , A61K31/4439 , A61K31/415 , A61K31/381 , C07D495/04 , C07D401/14 , C07D401/04 , C07D409/12 , C07D231/38 , C07D333/68 , C07D333/38 , A61K45/06 , A61K31/5025
CPC分类号： C07D403/04 , A61K31/381 , A61K31/415 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/5025 , A61K31/506 , A61K45/06 , C07D207/456 , C07D213/55 , C07D213/80 , C07D231/38 , C07D231/40 , C07D261/18 , C07D333/38 , C07D333/68 , C07D333/74 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/12 , C07D413/04 , C07D413/14 , C07D495/04
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases, disorders or conditions that would benefit from inhibition of SOC channel activity.
摘要翻译： 本文描述了含有这种化合物的化合物和药物组合物，其调节储存操作的钙（SOC）通道的活性。 本文还描述了使用这种SOC通道调节剂单独和与其它化合物组合用于治疗将受益于SOC通道活性抑制的疾病，病症或病症的方法。
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