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公开(公告)号：US07196189B2
公开(公告)日：2007-03-27
申请号：US10402056
申请日：2003-03-28
CPC分类号： C07K14/38
摘要： The invention provides variant regulator proteins of secondary metabolite production and nucleic acids encoding said variant regulator proteins. In particular, the invention provides variant regulator molecules of the lovE protein.
摘要翻译： 本发明提供次级代谢产物的变体调节蛋白和编码所述变体调节蛋白的核酸。 特别地，本发明提供了lovE蛋白的变体调节剂分子。
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公开(公告)号：US07022513B2
公开(公告)日：2006-04-04
申请号：US10200013
申请日：2002-07-18
申请人： Jun Xu , Joshua Trueheart
发明人： Jun Xu , Joshua Trueheart
IPC分类号： C12N1/16
CPC分类号： C07K14/39 , C07K2319/00
摘要： The present invention makes available a rapid, reproducible, robust assay system for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular protein, e.g., a receptor or ion channel. The subject assay enables rapid screening of large numbers of compounds to identify those which act as an agonist or antagonist to the bioactivity of the cellular protein. In particular, the assay of the invention makes use of a cell that harbors a protein that is responsive to a cellular signal transduction pathway. The protein is operatively linked to a polypeptide which causes a detectable signal to be generated upon stimulation of the pathway, e.g., when a compound interacts with and modulates the activity of a cellular receptor or ion channel of the cell. Thus, the cell provides a signal generation means comprising a novel fusion protein the expression of which is independent of stimulation/activation of the signal transduction pathway, but the activity of which is responsive to the signal transduction pathway.
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公开(公告)号：US20050118690A1
公开(公告)日：2005-06-02
申请号：US10492051
申请日：2002-10-09
申请人： Shannon Roberts , Amir Sherman , Joshua Trueheart , G. Milne
发明人： Shannon Roberts , Amir Sherman , Joshua Trueheart , G. Milne
CPC分类号： C07K14/38
摘要： The invention provides variant regulator proteins of secondary metabolite production and nucleic acids encoding said variant regulator proteins. In particular, the invention provides variant regulator molecules of the lovE protein.
摘要翻译： 本发明提供次级代谢产物的变体调节蛋白和编码所述变体调节蛋白的核酸。 特别地，本发明提供了lovE蛋白的变体调节剂分子。
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公开(公告)号：US20050095633A1
公开(公告)日：2005-05-05
申请号：US10952045
申请日：2004-09-28
申请人： Brian Cali , Douglas Holtzman , Jeffrey Silva , Joshua Trueheart , Lixin Zhang , Kevin Madden , G. Milne , Amir Sherman
发明人： Brian Cali , Douglas Holtzman , Jeffrey Silva , Joshua Trueheart , Lixin Zhang , Kevin Madden , G. Milne , Amir Sherman
IPC分类号： C12N15/09 , C07K14/37 , C07K14/38 , C07K14/385 , C12N15/31 , C12Q1/68 , C07H21/04 , C12N1/18 , C12N9/22 , C12N15/74
CPC分类号： C07K14/385 , C07K14/38
摘要： The invention relates to regulators of fungal gene expression and their use in commercial and medical applications. More particularly, the invention relates to regulators of fungal genes involved in production of enzymes, secondary metabolites and other useful products, as well as to regulators of genes involved in fungal invasion. The invention provides novel regulators of fungal gene expression, and methods for using regulator genes in commercial and medical applications.
摘要翻译： 本发明涉及真菌基因表达的调节剂及其在商业和医学应用中的应用。 更具体地，本发明涉及涉及酶，次生代谢物和其它有用产物的生产的真菌基因调节剂，以及参与真菌侵袭的基因的调节剂。 本发明提供了真菌基因表达的新型调节剂，以及在商业和医学应用中使用调节基因的方法。
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35.发明授权Isolated nucleic acid molecule encoding a regulator of fungal gene expression 有权分离的核酸分子编码真菌基因表达的调节剂公开(公告)号：US06806082B2
公开(公告)日：2004-10-19
申请号：US10029180
申请日：2001-12-22
申请人： Brian M. Cali , Douglas Holtzman , Kevin T. Madden , G. Todd Milne , Amir Sherman , Jeffrey C. Silva , Joshua Trueheart , Lixin Zhang
发明人： Brian M. Cali , Douglas Holtzman , Kevin T. Madden , G. Todd Milne , Amir Sherman , Jeffrey C. Silva , Joshua Trueheart , Lixin Zhang
IPC分类号： C12N510
CPC分类号： C07K14/385 , C07K14/38
摘要： The invention relates to regulators of fungal gene expression and their use in commercial and medical applications. More particularly, the invention relates to regulators of fungal genes involved in production of enzymes, secondary metabolites and other useful products, as well as to regulators of genes involved in fungal invasion. The invention provides novel regulators of fungal gene expression, and methods for using regulator genes in commercial and medical applications.
摘要翻译： 本发明涉及真菌基因表达的调节剂及其在商业和医学应用中的应用。 更具体地，本发明涉及涉及酶，次生代谢物和其它有用产物的生产的真菌基因调节剂，以及参与真菌侵袭的基因的调节剂。 本发明提供了真菌基因表达的新型调节剂，以及在商业和医学应用中使用调节基因的方法。
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公开(公告)号：US08691555B2
公开(公告)日：2014-04-08
申请号：US12443362
申请日：2007-09-28
申请人： Richard B. Bailey , Kevin T. Madden , Joshua Trueheart , Reed Doten , Maria Mayorga , Joshua Griffin Dunn , Dan Dueppen
发明人： Richard B. Bailey , Kevin T. Madden , Joshua Trueheart , Reed Doten , Maria Mayorga , Joshua Griffin Dunn , Dan Dueppen
摘要： The present invention provides systems for producing engineered oleaginous yeast or fungi that express carotenoids.
摘要翻译： 本发明提供用于生产表达类胡萝卜素的工程化含油酵母或真菌的系统。
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公开(公告)号：US20130045504A1
公开(公告)日：2013-02-21
申请号：US13586611
申请日：2012-08-15
摘要： The present invention provides systems for producing engineered oleaginous yeast or fungi that express carotenoids
摘要翻译： 本发明提供用于生产表达类胡萝卜素的工程化含油酵母或真菌的系统
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公开(公告)号：US08367395B2
公开(公告)日：2013-02-05
申请号：US12443350
申请日：2007-09-28
CPC分类号： C12P7/6481 , A23K20/111 , A23K50/40 , A23K50/80 , C11B1/10 , C12N15/52 , C12P7/6463 , C12P33/00 , Y02A40/818
摘要： The present invention provides methods for production of one or more sterol compounds. Further provided are methods and systems for producing engineered oleaginous yeast or fungi that are capable of production of one or more sterol compounds, and compositions which utilize the produced sterol compound(s).
摘要翻译： 本发明提供一种或多种甾醇化合物的制备方法。 还提供了用于生产能够生产一种或多种甾醇化合物的工程化含油酵母或真菌的方法和系统，以及利用所产生的固醇化合物的组合物。
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公开(公告)号：US20110045559A1
公开(公告)日：2011-02-24
申请号：US12600537
申请日：2008-05-19
申请人： Aaron Adriaan Winkler , Abraham Frederik De Hulster , Johannes Pieter Van Dijken , Jacobus Thomas Pronk , Joshua Trueheart , Kevin T. Madden , Jacob C. Harrison , Carlos Gancedo Rodriguez , Carmen-Lisset Flores Mauriz
发明人： Aaron Adriaan Winkler , Abraham Frederik De Hulster , Johannes Pieter Van Dijken , Jacobus Thomas Pronk , Joshua Trueheart , Kevin T. Madden , Jacob C. Harrison , Carlos Gancedo Rodriguez , Carmen-Lisset Flores Mauriz
CPC分类号： C12P7/46
摘要： The present disclosure relates to modified yeast, wherein the yeast has reduced pyruvate decarboxylase polypeptide (PDC) activity and methods of using such yeast to produce malic and/or succinic acid.
摘要翻译： 本公开涉及修饰的酵母，其中酵母具有还原的丙酮酸脱羧酶多肽（PDC）活性和使用这种酵母产生苹果酸和/或琥珀酸的方法。
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公开(公告)号：US20110039299A1
公开(公告)日：2011-02-17
申请号：US12443362
申请日：2007-09-28
申请人： Richard B. Bailey , Kevin T. Madden , Joshua Trueheart , Reed Doten , Maria Mayorga , Joshua Griffin Dunn , Dan Dueppen
发明人： Richard B. Bailey , Kevin T. Madden , Joshua Trueheart , Reed Doten , Maria Mayorga , Joshua Griffin Dunn , Dan Dueppen
摘要： The present invention provides systems for producing engineered oleaginous yeast or fungi that express carotenoids.
摘要翻译： 本发明提供用于生产表达类胡萝卜素的工程化含油酵母或真菌的系统。
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