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公开(公告)号：US08852876B2
公开(公告)日：2014-10-07
申请号：US13675396
申请日：2012-11-13
Applicant: Corning Incorporated
Inventor： Ye Fang , Ann MeeJin Ferrie , Norman Henry Fontaine , Joydeep Lahiri , Po Ki Yuen
IPC: G01N33/567 , C12Q1/02
CPC classification number: G01N33/5008 , G01N33/54373 , G01N33/554
Abstract: Disclosed are compositions and methods for using label free optical biosensors for performing cell assays. In certain embodiments the assays can be performed in high throughput methods and can be multiplexed.
Abstract translation: 公开了使用无标签光学生物传感器进行细胞测定的组合物和方法。 在某些实施方案中，测定可以以高通量方法进行并且可以被复用。
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公开(公告)号：US20240360397A1
公开(公告)日：2024-10-31
申请号：US18647679
申请日：2024-04-26
Applicant: CORNING INCORPORATED
Inventor： Ye Fang , Anthony Glenn Frutos , Vasiliy Nikolaevich Goral , Joel Andrew Schultes , Elena Ravilievna Streltsova , Todd Michael Upton , Jennifer Lynn Weber
Abstract: A cell culture bioreactor is disclosed that has a cell culture vessel with an interior reservoir to contain a cell substrate, an inlet fluidly connected to the reservoir, and an outlet fluidly connect to the reservoir. The bioreactor also has a sensor system for measuring impedance within the reservoir. The sensor system includes a pair of electrodes that are spaced apart from each other with at least a portion of the cell substrate disposed between the pair of electrodes. Each electrode of the pair of electrodes includes a plurality of pores to allow at least one of cells and culture media to flow through the electrode.
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公开(公告)号：US20240026287A1
公开(公告)日：2024-01-25
申请号：US18226559
申请日：2023-07-26
Applicant: CORNING INCORPORATED
Inventor： Ye Fang , Ann MeeJin Ferrie , Vasiliy Nikolaevich Goral , David Henry , Martial Hervy , Corinne Walerack , Yue Zhou
IPC: C12N5/00 , C08J3/24 , C09D167/00
CPC classification number: C12N5/0075 , C12N5/0068 , C08J3/24 , C09D167/00 , C12N2533/40 , C12N2533/50 , C12N2537/10 , C12N2533/32 , C12N2533/74
Abstract: A cell culture article includes a substrate having a polymer coating that is conducive to colony passaging of cells cultured on the coating. Example polymer coatings are formed from polygalacturonic acid (PGA), alginate, or combinations thereof. Cells cultured on the polymer coating can be separated from the substrate as a colony or layer of cells by exposing the polymer coating to (i) a chelating agent, (ii) a proteinase-free enzyme, or (iii) a chelating agent and a proteinase-free enzyme.
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公开(公告)号：US20230364606A1
公开(公告)日：2023-11-16
申请号：US18226855
申请日：2023-07-27
Applicant: CORNING INCORPORATED
Inventor： Ye Fang , Jin Su Kim , Aize Li
IPC: B01L3/00
CPC classification number: B01L3/502715 , B01L3/502707 , B01L2300/12 , B01L2300/161 , B01L2300/168 , B01L2200/12 , B01L2200/027
Abstract: A method for manufacturing a microfluidic device includes depositing a bonding layer on a surface of a second glass layer of a glass substrate having a first glass layer and the second glass layer fused to the first glass layer, such that a masked region of the surface is covered by the bonding layer, and an exposed region of the surface is uncovered by the bonding layer; removing a portion of the second glass layer corresponding to the exposed region of the surface to form a flow channel in the glass substrate; and bonding a cover to the glass substrate with the bonding layer.
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公开(公告)号：US11274059B2
公开(公告)日：2022-03-15
申请号：US16203002
申请日：2018-11-28
Applicant: CORNING INCORPORATED
Inventor： Huayun Deng , Ye Fang , Qiang Fu , John Christopher Mauro , Michael S Pambianchi
IPC: A61K6/00 , A61K33/06 , A61K8/25 , A61K31/69 , C03C3/19 , C03C3/064 , C03C3/087 , C03C3/091 , C03C3/097 , A61Q11/00 , C03C4/00 , A61K8/21 , A61K8/19 , A61K8/26 , A61K6/20 , A61K6/77 , A61K6/836
Abstract: A dental formulation including: a bioactive glass composition as defined herein, in an effective amount; and a suitable carrier as defined herein, in an effective amount. Also disclosed is a method of making and using the dental formulation to treat, for example, dentin sensitivities.
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Patent Agency Ranking
公开(公告)号：US20210252505A1
公开(公告)日：2021-08-19
申请号：US17251010
申请日：2019-06-10
Applicant: CORNING INCORPORATED
Inventor： Donald Erwin Allen , Ye Fang , Jeffrey Glenn Lynn , Barry James Paddock
IPC: B01L3/00
Abstract: A process of manufacturing a microfluidic device (200, 201, 202, 300, 301, 302, 400, 401, 402) includes the steps of attaching a monolayer of polymer beads onto a first substrate (210, 410) depositing a metal oxide film onto the first substrate (210, 410) over the monolayer of polymer beads, and removing the polymer beads to form an array of metal oxide nano-wells (240, 440) wherein the first substrate (210, 410) is exposed at the bottom of the nano-wells (240, 440). The process also includes depositing an organophosphate layer onto the metal oxide film. The process also calls for depositing a silane coating layer or an acrylate polymer onto the exposed first substrate (210, 410). The method further includes bonding a second substrate (220, 420) to the first substrate (210, 410) to enclose the array of metal oxide nano-wells (240, 440) in a cavity within the first and second substrates (210, 220, 410, 420).
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公开(公告)号：US10808221B2
公开(公告)日：2020-10-20
申请号：US15537111
申请日：2015-12-16
Applicant: Corning Incorporated
Inventor： Ye Fang , Ann MeeJin Ferrie , Vasiliy Nikolaevich Goral , David Henry , Martial Hervy , Corinne Walerack , Yue Zhou
IPC: C12N5/00 , C08J3/24 , C09D167/00
Abstract: A cell culture article includes a substrate having a polymer coating that is conducive to colony passaging of cells cultured on the coating. Example polymer coatings are formed from polygalacturonic acid (PGA), alginate, or combinations thereof. Cells cultured on the polymer coating can be separated from the substrate as a colony or layer of cells by exposing the polymer coating to (i) a chelating agent, (ii) a proteinase-free enzyme, or (iii) a chelating agent and a proteinase-free enzyme.
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公开(公告)号：US20190161393A1
公开(公告)日：2019-05-30
申请号：US16203002
申请日：2018-11-28
Applicant: CORNING INCORPORATED
Inventor： Huayun Deng , Ye Fang , Qiang Fu , John Christopher Mauro , Michael S. Pambianchi
Abstract: A dental formulation including: a bioactive glass composition as defined herein, in an effective amount; and a suitable carrier as defined herein, in an effective amount. Also disclosed is a method of making and using the dental formulation to treat, for example, dentin sensitivities.
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公开(公告)号：US20170340666A1
公开(公告)日：2017-11-30
申请号：US15603208
申请日：2017-05-23
Applicant: Corning Incorporated
Inventor： Huayun Deng , Ye Fang , Qiang Fu , Lina Ma , John Christopher Mauro , Michael Joshua Snyder , Dana Lynne Widmer-Quiel
CPC classification number: A61K33/42 , A61L15/18 , A61L15/44 , A61L26/0004 , A61L26/0066 , C03B19/102 , C03C3/064 , C03C3/19 , C03C4/0007 , C03C4/0014 , C03C11/002 , C03C12/00
Abstract: An aluminoborate composition, an alumino-borosilicate glass composition, or a mixture thereof, and solid or hollow microspheres thereof, as defined herein. Also disclosed are methods of making and using the disclosed compositions, for example, forming microspheres for use in bioactive applications, and composition extracts for use in treating or healing wounds.
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公开(公告)号：US20170340527A1
公开(公告)日：2017-11-30
申请号：US15603098
申请日：2017-05-23
Applicant: Corning Incorporated
Inventor： Theresa Chang , Ye Fang , David Henry , Wendell Porter Weeks , Ying Wei
CPC classification number: A61K8/11 , A61K8/0241 , A61K8/19 , A61K8/25 , A61K8/26 , A61K8/73 , A61K8/733 , A61K2800/28 , A61K2800/412 , A61K2800/413 , A61K2800/624 , A61K2800/651 , A61Q19/10
Abstract: An exfoliant composition including: a microbead comprising a core and a shell: the core comprising an abrasive particle having an average particle size of from 50 to 1,000 microns; and the shell comprising a hydrogel. Also disclosed is a method of making the exfoliant composition and a method of using the exfoliant composition.
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