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公开(公告)号:US10443045B2
公开(公告)日:2019-10-15
申请号:US16374482
申请日:2019-04-03
Applicant: Factor Bioscience Inc.
Inventor: Matthew Angel , Christopher Rohde
Abstract: The present invention relates in part to methods for producing tissue-specific cells from patient samples, and to tissue-specific cells produced using these methods. Methods for reprogramming cells using RNA are disclosed. Therapeutics comprising cells produced using these methods are also disclosed.
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公开(公告)号:US10415060B2
公开(公告)日:2019-09-17
申请号:US15670639
申请日:2017-08-07
Applicant: Factor Bioscience Inc.
Inventor: Matthew Angel , Christopher Rohde
IPC: C07H21/04 , C12N15/00 , C12N15/90 , A61K31/7115 , C12N9/22 , C07K14/195 , C12N15/10 , A61K35/14 , A61K38/46 , A61K48/00 , C12N15/86 , G01N33/50 , A01K67/00 , A61K35/12
Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.
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公开(公告)号:US20170362612A1
公开(公告)日:2017-12-21
申请号:US15670639
申请日:2017-08-07
Applicant: Factor Bioscience Inc.
Inventor: Matthew Angel , Christopher Rohde
CPC classification number: C12N15/907 , A61K31/7115 , A61K35/14 , A61K38/465 , A61K48/005 , A61K2035/124 , C07K14/195 , C07K2319/80 , C12N9/22 , C12N15/1024 , C12N15/86 , C12N2800/80 , C12Y301/00 , C12Y301/21004 , G01N33/5014
Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.
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公开(公告)号:US20170152483A1
公开(公告)日:2017-06-01
申请号:US15429795
申请日:2017-02-10
Applicant: Factor Bioscience Inc.
Inventor: Matthew Angel , Christopher Rohde
IPC: C12N5/0789 , C12N15/90 , C12N9/22
CPC classification number: C12N5/0647 , A61K35/28 , A61K2035/124 , C08G77/08 , C08K5/5399 , C12N5/0657 , C12N9/16 , C12N9/22 , C12N15/87 , C12N15/907 , C12N2500/25 , C12N2500/44 , C12N2501/115 , C12N2501/155 , C12N2501/165 , C12N2501/2303 , C12N2501/26 , C12N2501/91 , C12N2501/998 , C12N2506/09 , C12N2800/80 , C12P21/00 , C12Y301/21 , H01L31/048 , Y02E10/50 , C08L83/04
Abstract: The present invention relates in part to nucleic acids encoding proteins, nucleic acids containing non-canonical nucleotides, therapeutics comprising nucleic acids, methods, kits, and devices for inducing cells to express proteins, methods, kits, and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods for inducing cells to express proteins and for reprogramming and gene-editing cells using RNA are disclosed. Methods for producing cells from patient samples, cells produced using these methods, and therapeutics comprising cells produced using these methods are also disclosed.
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公开(公告)号:US09487768B2
公开(公告)日:2016-11-08
申请号:US15156829
申请日:2016-05-17
Applicant: Factor Bioscience Inc.
Inventor: Matthew Angel , Christopher Rohde
CPC classification number: C12N15/907 , A61K31/7115 , A61K35/14 , A61K38/465 , A61K48/005 , A61K2035/124 , C07K14/195 , C07K2319/80 , C12N9/22 , C12N15/1024 , C12N15/86 , C12N2800/80 , C12Y301/00 , C12Y301/21004 , G01N33/5014
Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.
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公开(公告)号:US12227768B2
公开(公告)日:2025-02-18
申请号:US17958816
申请日:2022-10-03
Applicant: Factor Bioscience Inc.
Inventor: Matthew Angel , Christopher Rohde
Abstract: The present invention relates in part to methods for producing tissue-specific cells from patient samples, and to tissue-specific cells produced using these methods. Methods for reprogramming cells using RNA are disclosed. Therapeutics comprising cells produced using these methods are also disclosed.
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公开(公告)号:US12227757B2
公开(公告)日:2025-02-18
申请号:US17817966
申请日:2022-08-05
Applicant: Factor Bioscience Inc.
Inventor: Matthew Angel , Christopher Rohde
IPC: C12N15/85 , A61K35/28 , C08K5/5399 , C12N5/074 , C12N5/077 , C12N5/0789 , C12N9/16 , C12N9/22 , C12N15/87 , C12N15/90 , C12P21/00 , H01L31/048 , A61K35/12 , C08G77/08
Abstract: The present invention relates in part to nucleic acids encoding proteins, nucleic acids containing non-canonical nucleotides, therapeutics comprising nucleic acids, methods, kits, and devices for inducing cells to express proteins, methods, kits, and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods for inducing cells to express proteins and for reprogramming and gene-editing cells using RNA are disclosed. Methods for producing cells from patient samples, cells produced using these methods, and therapeutics comprising cells produced using these methods are also disclosed.
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公开(公告)号:US11904023B2
公开(公告)日:2024-02-20
申请号:US17018728
申请日:2020-09-11
Applicant: Factor Bioscience Inc.
Inventor: Matthew Angel , Christopher Rohde
IPC: A61P3/10 , A61K48/00 , A61K31/7115 , A61P1/16 , A61P3/06 , A61P11/00 , A61P3/00 , A61P9/00 , A61P29/00 , A61P35/00 , C07K14/00 , C12N9/22 , A61K9/00
CPC classification number: A61K48/005 , A61K9/0019 , A61K31/7115 , A61K48/0058 , A61K48/0066 , A61P1/16 , A61P3/00 , A61P3/06 , A61P3/10 , A61P9/00 , A61P11/00 , A61P29/00 , A61P35/00 , C07K14/001 , C12N9/22 , C07K14/003 , C12N2310/20 , C12Y301/21
Abstract: The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices.
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公开(公告)号:US11708586B2
公开(公告)日:2023-07-25
申请号:US16913315
申请日:2020-06-26
Applicant: Factor Bioscience Inc.
Inventor: Matthew Angel , Christopher Rohde
IPC: C12N15/85 , C12N15/87 , C08K5/5399 , C12N5/074 , H01L31/048 , C12P21/00 , C12N9/16 , C12N5/0789 , C12N5/077 , C12N15/90 , C12N9/22 , A61K35/28 , C08G77/08 , A61K35/12
CPC classification number: C12N15/87 , A61K35/28 , C08K5/5399 , C12N5/0647 , C12N5/0657 , C12N5/0696 , C12N9/16 , C12N9/22 , C12N15/907 , C12P21/00 , C12Y301/21 , H01L31/048 , A61K2035/124 , C08G77/08 , C12N2500/25 , C12N2500/44 , C12N2501/115 , C12N2501/155 , C12N2501/165 , C12N2501/2303 , C12N2501/26 , C12N2501/91 , C12N2501/998 , C12N2506/09 , C12N2800/80 , Y02E10/50 , C08L83/04 , C08L83/04 , C08K5/5399
Abstract: The present invention relates in part to nucleic acids encoding proteins, nucleic acids containing non-canonical nucleotides, therapeutics comprising nucleic acids, methods, kits, and devices for inducing cells to express proteins, methods, kits, and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods for inducing cells to express proteins and for reprogramming and gene-editing cells using RNA are disclosed. Methods for producing cells from patient samples, cells produced using these methods, and therapeutics comprising cells produced using these methods are also disclosed.
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公开(公告)号:US11332759B2
公开(公告)日:2022-05-17
申请号:US16657318
申请日:2019-10-18
Applicant: Factor Bioscience Inc.
Inventor: Matthew Angel , Christopher Rohde
IPC: C07H21/04 , C12N15/63 , C12N15/90 , A61K31/7115 , C12N9/22 , C07K14/195 , C12N15/10 , A61K35/14 , A61K38/46 , A61K48/00 , C12N15/86 , G01N33/50 , A01K67/00 , A61K35/12
Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.
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