公开(公告)号：US20170095595A1

公开(公告)日：2017-04-06

申请号：US15380350

申请日：2016-12-15

Applicant: FUJIFILM Corporation

Inventor： Kentaro NAKAMURA

IPC: A61L27/38 ,  A61L27/56 ,  A61L27/22

CPC classification number: A61L27/3878 ,  A61K35/28 ,  A61L27/00 ,  A61L27/222 ,  A61L27/3808 ,  A61L27/3834 ,  A61L27/56 ,  A61L2430/32 ,  C07K14/78

Abstract: An object of the present invention is to provide a cell structure for brain damage treatment which does not contain glutaraldehyde and in which it is possible to exhibit a sufficient effect of treating brain damage, a production method thereof, and a brain damage treatment agent. According to the present invention, there is provided a cell structure for brain damage treatment which contains biocompatible macromolecular blocks and at least one kind of cell and in which a plurality of the biocompatible macromolecular blocks are disposed in gaps between a plurality of the cells, in which the tap density of the biocompatible macromolecular block is 10 mg/cm3 to 500 mg/cm3 or a value obtained by dividing a square root of a cross-sectional area in a two-dimensional cross-sectional image of the biocompatible macromolecular block by a peripheral length is 0.01 to 0.13.

公开(公告)号：US20230414669A1

公开(公告)日：2023-12-28

申请号：US18463631

申请日：2023-09-08

Applicant: FUJIFILM Corporation ,  NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY

Inventor： Kentaro NAKAMURA ,  Shunsuke TOMINAGA ,  Ichiro SEKIYA ,  Mitsuru MIZUNO ,  Hisako KATANO ,  Nobutake OZEKI

IPC: A61K35/28 ,  C12N5/0775 ,  G01N1/40 ,  A61P19/02 ,  G06T7/60 ,  G06T7/00

CPC classification number: A61K35/28 ,  C12N5/0668 ,  G01N1/4044 ,  A61P19/02 ,  G06T7/60 ,  G06T7/0012 ,  G06T2207/30024

Abstract: There are provided a production method for a therapeutic agent for arthrosis, in which a population including a plurality of mesenchymal stem cells being cultured is imaged to acquire a cell image, the cell image is analyzed to derive density information on the mesenchymal stem cells in the cell image, colonies, which are formed by the mesenchymal stem cells in the population, are detected based on the density information, and the population is sorted based on at least one of an average colony size or a colony forming unit, which is derived from the detected colonies, and provided a therapeutic agent for arthrosis, which is produced by the production method for a therapeutic agent for arthrosis.

公开(公告)号：US20200148747A1

公开(公告)日：2020-05-14

申请号：US16747948

申请日：2020-01-21

Applicant: FUJIFILM Corporation ,  TERUMO KABUSHIKI KAISHA

Inventor： Kentaro NAKAMURA ,  Shinya SANO ,  Yosuke KURUMA ,  Tadashi SAMESHIMA

IPC: C07K14/78 ,  C12M1/00 ,  A61L27/00 ,  C12N15/09 ,  A61L27/22 ,  A61L27/38 ,  A61L27/58

Abstract: An object of the present invention is to provide a cell sheet embedding agent, which makes it possible to stably transport a cell sheet at the time of transport at a low temperature and to collect the cell sheet from the cell sheet embedding agent in a simple manner after being transported, a cell sheet-containing composition, and a kit. According to the present invention, there is provided a cell sheet embedding agent containing a polypeptide represented by the following Formula 1, in which in a case where a molecular weight distribution of the polypeptide is measured, a peak area of a maximum molecular weight is equal to or greater than 80% of the total peak area of all molecular weights. A-[(Gly-X—Y)n]m—B  Formula 1: In the formula, X and Y each independently represent an amino acid, m is an integer of 2 to 10, n is an integer of 3 to 100, and A and B each represent any amino acid or any amino acid sequence.

公开(公告)号：US20190262122A1

公开(公告)日：2019-08-29

申请号：US16409241

申请日：2019-05-10

Applicant: FUJIFILM Corporation

Inventor： Yusuke MOCHIZUKI ,  Kentaro NAKAMURA ,  Shigeaki OHTANI ,  Naohiro MATSUNAGA ,  Ryuta TAKEGAMI

IPC: A61F2/02 ,  A61L27/16 ,  A61L27/18 ,  A61L27/38 ,  A61L31/04 ,  A61L31/14 ,  A61K35/12 ,  A61K38/28

Abstract: According to the present invention, there are provided a membrane for immunoisolation, including: a porous membrane that contains a polymer, in which the porous membrane includes a layered compact portion where a pore diameter is the smallest within the membrane, and a pore diameter continuously increases in a thickness direction from the compact portion toward at least one surface of the porous membrane; a chamber for transplantation for enclosing a biological constituent therein, including the above-described membrane for immunoisolation on at least a part of a surface forming an inside and an outside of the chamber for transplantation; and a device for transplantation, including the above-described chamber for transplantation enclosing the biological constituent therein. In the membrane for immunoisolation of the present invention which can be manufactured at low costs, a deterioration in substance permeability is unlikely to occur.

公开(公告)号：US20190010214A1

公开(公告)日：2019-01-10

申请号：US16139620

申请日：2018-09-24

Applicant: FUJIFILM Corporation ,  TERUMO KABUSHIKI KAISHA

Inventor： Kentaro NAKAMURA ,  Shinya SANO ,  Yosuke KURUMA ,  Tadashi SAMESHIMA

IPC: C07K14/78 ,  A61L27/38 ,  A61L27/58 ,  A61L27/22

Abstract: An object of the present invention is to provide a cell sheet embedding agent, which makes it possible to stably transport a cell sheet at the time of transport at a low temperature and to collect the cell sheet from the cell sheet embedding agent in a simple manner after being transported, a cell sheet-containing composition, and a kit. According to the present invention, there is provided a cell sheet embedding agent containing a polypeptide represented by the following Formula 1, in which in a case where a molecular weight distribution of the polypeptide is measured, a peak area of a maximum molecular weight is equal to or greater than 80% of the total peak area of all molecular weights. A-[(Gly-X—Y)n]m—B  Formula 1: In the formula, X and Y each independently represent an amino acid, m is an integer of 2 to 10, n is an integer of 3 to 100, and A and B each represent any amino acid or any amino acid sequence.

公开(公告)号：US20160069909A1

公开(公告)日：2016-03-10

申请号：US14840710

申请日：2015-08-31

Applicant: FUJIFILM Corporation

Inventor： Kazuhiro NAKAMURA ,  Noriyuki KASAGI ,  Hiroyuki CHIKU ,  Kentaro NAKAMURA

IPC: G01N33/74 ,  G01N33/58 ,  G01N33/553

CPC classification number: G01N33/74 ,  G01N33/54313 ,  G01N33/54346 ,  G01N33/553 ,  G01N33/582 ,  G01N33/587 ,  G01N2333/695

Abstract: The present invention provides a reagent kit which is used for measuring a test substance in a biological sample and can improve measurement sensitivity of the test substance; measurement kit; and a method of measuring the test substance. Provided is a reagent kit which is used for measuring the above-described test substance in the biological sample and contains first particles which are modified by a first binding substance having specific binding properties with respect to the test substance and have a label, and a compound which has at least one amino group having a positive charge.

Abstract translation: 本发明提供了一种用于测量生物样品中测试物质并可提高测试物质的测量灵敏度的试剂盒; 测量套件; 以及测定被检物质的方法。 提供一种试剂盒，其用于测量生物样品中的上述测试物质，并含有由相对于被检物质具有特异性结合特性的第一结合物修饰并具有标记的第一颗粒和化合物 其具有至少一个具有正电荷的氨基。