Coatings based on hyaluronic acid and the derivatives thereof for the protection of electronic parts from external agents
    31.
    发明授权
    Coatings based on hyaluronic acid and the derivatives thereof for the protection of electronic parts from external agents 失效
    基于透明质酸的涂料及其衍生物,用于保护电子部件免受外部试剂的影响

    公开(公告)号:US06428903B1

    公开(公告)日:2002-08-06

    申请号:US09403144

    申请日:1999-12-20

    IPC分类号: B32B900

    摘要: There are disclosed electronic or microelectronic components having on at least a portion of a surface thereof a coating containing hyaluronic acid or a derivative thereof wherein said coating has the ability to inhibit adhesion of microorganisms and formation of biofilms. Also disclosed are methods of inhibiting corrosion and changes in electrical conductivity by inhibiting biofilm formation on electronic or microelectronic components by applying a coating containing hyaluronic acid or a derivative thereof directly onto the surface of said components.

    摘要翻译: 公开了在其表面的至少一部分上具有含有透明质酸或其衍生物的涂层的电子或微电子部件,其中所述涂层具有抑制微生物粘附和生物膜形成的能力。 还公开了通过将含有透明质酸或其衍生物的涂层直接施加到所述部件的表面上来抑制电子或微电子部件上的生物膜形成来抑制腐蚀和导电性变化的方法。

    Biomaterial comprising hyaluronic acid and derivatives thereof in
interpenetrating polymer networks (IPN)
    33.
    发明授权
    Biomaterial comprising hyaluronic acid and derivatives thereof in interpenetrating polymer networks (IPN) 失效
    包含透明质酸及其衍生物在互穿聚合物网络(IPN)中的生物材料

    公开(公告)号:US5644049A

    公开(公告)日:1997-07-01

    申请号:US367137

    申请日:1995-02-23

    摘要: Provided is a biomaterial comprising an interpenetrating polymer network (IPN), wherein one of the polymer components is an acidic polysaccharide or a semi-synthetic derivative thereof. The polysaccharide can be hyaluronic acid, and the second polymer component can be a non-toxic, non-carcinogenic synthetic chemical polymer. The derivative can be a total or partial hyaluronic acid ester or a hyaluronic acid salt. The ester or salt can be formed with a pharmacologically active molecule. Methods for preparing the IPN are also disclosed. The acidic polysaccharide or derivative thereof and the synthetic chemical polymer comprising the IPN can be cross-linked, or the synthetic chemical polymer can be grafted onto the acidic polysaccharide. The cross-linking or grafting can be achieved using compounds capable of generating radicals, or via functional groups on the acidic polysaccharide and the synthetic chemical polymer. The IPN can be formed prior to cross-linking or grafting. The IPN biomaterial can be in the form of a film, a membrane, a sponge, a hydrogel, a guide channel, a thread, a gauze, or a non-woven tissue. Such IPN biomaterials can be used in the biomedical and sanitary fields, including dermatology, urology, orthopedics, otologic microsurgery, otoneurology, functional, post-traumatic and rhinosinusal endoscopic microsurgery, plastic surgery, and in the cardiovascular system.

    摘要翻译: PCT No.PCT / EP93 / 01727 Sec。 371日期1995年2月23日 102(e)日期1995年2月23日PCT提交1993年7月5日PCT公布。 公开号WO94 / 01468 PCT 日期1994年1月20日提供了包含互穿聚合物网络(IPN)的生物材料,其中聚合物组分之一是酸性多糖或其半合成衍生物。 多糖可以是透明质酸,第二聚合物组分可以是无毒的,非致癌的合成化学聚合物。 该衍生物可以是全部或部分透明质酸酯或透明质酸盐。 酯或盐可以用药理活性分子形成。 还公开了制备IPN的方法。 酸性多糖或其衍生物和包含IPN的合成化学聚合物可以是交联的,或者合成化学聚合物可以接枝到酸性多糖上。 可以使用能够产生自由基的化合物或通过酸性多糖和合成化学聚合物上的官能团来实现交联或接枝。 IPN可以在交联或接枝之前形成。 IPN生物材料可以是膜,膜,海绵,水凝胶,引导通道,线,纱布或无纺布组织的形式。 这种IPN生物材料可用于生物医学和卫生领域,包括皮肤病学,泌尿学,骨科,耳科学显微外科,耳鼻喉科,功能性,创伤后和鼻内窥镜显微外科手术,整形手术和心血管系统。

    Biological material suitable for the therapy of osteoarthrosis, ligament damage and for the treatment of joint disorders
    36.
    发明授权
    Biological material suitable for the therapy of osteoarthrosis, ligament damage and for the treatment of joint disorders 有权
    生物材料适用于治疗骨关节炎,韧带损伤和治疗关节疾病

    公开(公告)号:US08771672B2

    公开(公告)日:2014-07-08

    申请号:US13380971

    申请日:2010-06-29

    摘要: The present invention regards a biological material comprising: a) a liquid carrier comprising a viscous solution containing at least one natural and/or semisynthetic polysaccharide, and having a Dynamic viscosity measured at 20° C. and at shear rate of D=350 s−1, comprised between 100 and 250 c Poise and/or a Kinematic viscosity comprised between 99 and 248 cSt (measured at the same conditions); b) a culture of mesenchymal stem cells, and/or c) a platelet-rich hemo-derivative. This type of material in form of viscous liquid is particularly suitable for the therapy of osteoarthrosis, ligament damage, in particular tendon and cartilage damage) and may be administered intra-articularly, intradermally or directly applied in situ without altering the properties of the mesenchymal stem cells and/or platelets contained therein.

    摘要翻译: 本发明涉及一种生物材料,其包括:a)液体载体,其包含含有至少一种天然和/或半合成多糖的粘稠溶液,并且具有在20℃下测得的动态粘度和D = 350s- 1,在100和250c之间Poise和/或运动粘度在99和248cSt之间(在相同条件下测量); b)间充质干细胞的培养,和/或c)富含血小板的血红素衍生物。 这种粘稠液体形式的材料特别适用于治疗骨关节炎,韧带损伤,特别是肌腱和软骨损伤),并且可以在原位进行关节内,皮内或直接施用,而不改变间充质干细胞的性质 细胞和/或血小板。

    BIOLOGICAL MATERIAL SUITABLE FOR THE THERAPY OF OSTEOARTHROSIS, LIGAMENT DAMAGE AND FOR THE TREATMENT OF JOINT DISORDERS
    37.
    发明申请
    BIOLOGICAL MATERIAL SUITABLE FOR THE THERAPY OF OSTEOARTHROSIS, LIGAMENT DAMAGE AND FOR THE TREATMENT OF JOINT DISORDERS 有权
    生物材料适用于骨质疏松症,大便性损伤和治疗关节病的治疗

    公开(公告)号:US20120114609A1

    公开(公告)日:2012-05-10

    申请号:US13380971

    申请日:2010-06-29

    摘要: The present invention regards a biological material comprising: a) a liquid carrier comprising a viscous solution containing at least one natural and/or semisynthetic polysaccharide, and having a Dynamic viscosity measured at 20° C. and at shear rate of D=350 s−1, comprised between 100 and 250 c Poise and/or a Kinematic viscosity comprised between 99 and 248cSt (measured at the same conditions); b) a culture of mesenchymal stem cells, and/or c) a platelet-rich hemo-derivative. This type of material in form of viscous liquid is particularly suitable for the therapy of osteoarthrosis, ligament damage, in particular tendon and cartilage damage) and may be administered intra-articularly, intradermally or directly applied in situ without altering the properties of the mesenchymal stem cells and/or platelets contained therein.

    摘要翻译: 本发明涉及一种生物材料,其包括:a)液体载体,其包含含有至少一种天然和/或半合成多糖的粘稠溶液,并且具有在20℃下测得的动态粘度和D = 350s- 1,在100和250c之间Poise和/或运动粘度在99和248cSt之间(在相同条件下测量); b)间充质干细胞的培养,和/或c)富含血小板的血红素衍生物。 这种粘稠液体形式的材料特别适用于治疗骨关节炎,韧带损伤,特别是肌腱和软骨损伤),并且可以在原位进行关节内,皮内或直接施用,而不改变间充质干细胞的性质 细胞和/或血小板。