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公开(公告)号：US06528509B1
公开(公告)日：2003-03-04
申请号：US09972437
申请日：2001-10-05
申请人： Michael Hale , Xiaoling Xie , Jeremy Green , Jingrong Cao , Christopher Baker , Francois Maltais , James Janetka , Guy Bemis , Michael Mullican , Judith Straub , Qing Tang , Robert Mashal
发明人： Michael Hale , Xiaoling Xie , Jeremy Green , Jingrong Cao , Christopher Baker , Francois Maltais , James Janetka , Guy Bemis , Michael Mullican , Judith Straub , Qing Tang , Robert Mashal
IPC分类号： A61K315377
CPC分类号： C07D401/14 , C07D231/38 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/14 , C07D471/04
摘要： Described herein are compounds that are useful as protein kinase inhibitors having the formula: where R1-4, Q, and T are described in the specification. The compounds are useful for treating disease states in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.
摘要翻译： 本文描述了可用作具有下式的蛋白激酶抑制剂的化合物：其中R1-4，Q和T在说明书中描述。 该化合物可用于治疗由蛋白激酶抑制剂，特别是诸如癌症，炎症性疾病，再狭窄和心血管疾病等疾病减轻的哺乳动物的疾病状态。
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公开(公告)号：US20210040092A1
公开(公告)日：2021-02-11
申请号：US17083569
申请日：2020-10-29
申请人： Paul S. Charifson , Michael P. Clark , Upal K. Bandarage , Randy S. Bethiel , Michael J. Boyd , Ioana Davies , Hongbo Deng , John P. Duffy , Luc J. Farmer , Huai Gao , Wenxin Gu , Joseph M. Kennedy , Brain Ledford , Mark W. Ledeboer , Francois Maltais , Emanuele Perola , Tiansheng Wang
发明人： Paul S. Charifson , Michael P. Clark , Upal K. Bandarage , Randy S. Bethiel , Michael J. Boyd , Ioana Davies , Hongbo Deng , John P. Duffy , Luc J. Farmer , Huai Gao , Wenxin Gu , Joseph M. Kennedy , Brain Ledford , Mark W. Ledeboer , Francois Maltais , Emanuele Perola , Tiansheng Wang
IPC分类号： C07D471/04 , A61K31/506 , A61K45/06 , C07F9/6561 , A61K31/215 , A61K31/351 , A61K31/444 , A61K31/497
摘要： Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.
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公开(公告)号：US20160355512A1
公开(公告)日：2016-12-08
申请号：US15177546
申请日：2016-06-09
申请人： Paul S. Charifson , Michael P. Clark , Upul K. Bandarage , Randy S. Bethiel , Michael J. Boyd , loana Davies , Hongbo Deng , John P. Duffy , Luc J. Farmer , Huai Gao , Wenxin Gu , Joseph M. Kennedy , Brian Ledford , Mark W. Ledeboer , Francois Maltais , Emanuele Perola , Tiansheng Wang
发明人： Paul S. Charifson , Michael P. Clark , Upul K. Bandarage , Randy S. Bethiel , Michael J. Boyd , loana Davies , Hongbo Deng , John P. Duffy , Luc J. Farmer , Huai Gao , Wenxin Gu , Joseph M. Kennedy , Brian Ledford , Mark W. Ledeboer , Francois Maltais , Emanuele Perola , Tiansheng Wang
IPC分类号： C07D471/04 , A61K31/351 , A61K31/215 , A61K31/497 , A61K31/506 , A61K31/444
CPC分类号： C07D471/04 , A61K31/215 , A61K31/351 , A61K31/444 , A61K31/497 , A61K31/506 , A61K45/06 , C07F9/6561
摘要： Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.
摘要翻译： 或其药学上可接受的盐，其中结构式（I）的值如本文所述。 化合物由结构式（I）表示或其药学上可接受的盐，其中结构式（I）的值如本文所述。 药物组合物包含有效量的这种化合物或其药学上可接受的盐，以及药学上可接受的载体，佐剂或媒介物。
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公开(公告)号：US20120270318A1
公开(公告)日：2012-10-25
申请号：US13538667
申请日：2012-06-29
申请人： ESTHER MARTINBOROUGH , Nicole Zimmermann , Robert B. Perni , Michael Arnost , Upul K. Bandarage , Francois Maltais , Guy Bemis
发明人： ESTHER MARTINBOROUGH , Nicole Zimmermann , Robert B. Perni , Michael Arnost , Upul K. Bandarage , Francois Maltais , Guy Bemis
IPC分类号： C12N5/071
CPC分类号： C07D409/14 , A61K31/506 , C07D239/28 , C07D239/30 , C07D239/42 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/06
摘要： In general, the invention relates to compounds useful as ion channel modulators. It has now been found that compounds of this invention, and pharmaceutically acceptable compositions thereof, are useful as inhibitors of voltage-gated sodium channels and/or calcium channels.
摘要翻译： 通常，本发明涉及可用作离子通道调节剂的化合物。 现已发现，本发明的化合物及其药学上可接受的组合物可用作电压门控钠通道和/或钙通道的抑制剂。
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公开(公告)号：US08236815B2
公开(公告)日：2012-08-07
申请号：US12724077
申请日：2010-03-15
申请人： Esther Martinborough , Nicole Zimmermann , Robert B. Perni , Michael Arnost , Upul Bandarage , Francois Maltais , Guy Bemis
发明人： Esther Martinborough , Nicole Zimmermann , Robert B. Perni , Michael Arnost , Upul Bandarage , Francois Maltais , Guy Bemis
IPC分类号： A01N43/54 , A61K31/505 , C07D239/02
CPC分类号： C07D409/14 , A61K31/506 , C07D239/28 , C07D239/30 , C07D239/42 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/06
摘要： The invention relates to ion channel modulators of formula Ia, pharmaceutical compositions thereof, and to methods of treating diseases using such compounds where activation or hyperactivity of calcium and/or sodium ion channels is implicated in the disease state.
摘要翻译： 本发明涉及式Ia的离子通道调节剂，其药物组合物，以及使用这样的化合物治疗疾病的方法，其中钙和/或钠离子通道的活化或多动症涉及疾病状态。
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公开(公告)号：US20110077237A1
公开(公告)日：2011-03-31
申请号：US12752283
申请日：2010-04-01
申请人： Juan-Miguel Jimenez , Guy W. Bemis , Francois Maltais , Tiansheng Wang , Ronald Knegtel , Chris Davis , Damien Fraysse , Dean Boyall , Luca Settimo , Stephen Young , Michael Mortimore
发明人： Juan-Miguel Jimenez , Guy W. Bemis , Francois Maltais , Tiansheng Wang , Ronald Knegtel , Chris Davis , Damien Fraysse , Dean Boyall , Luca Settimo , Stephen Young , Michael Mortimore
IPC分类号： A61K31/5513 , C07D401/06 , C07D401/14 , C07D417/14 , C07D409/06 , A61K31/444 , A61K31/496 , A61K31/4436 , A61K31/4439 , A61P25/28 , A61P25/16 , A61P25/18 , A61P25/00 , A61P29/00 , A61P35/00 , A61P35/02 , A61P1/00
CPC分类号： C07D213/73 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/06 , C07D409/14 , C07D417/06 , C07D417/14 , C07D487/04 , C07D487/08
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US07767680B2
公开(公告)日：2010-08-03
申请号：US11266142
申请日：2005-11-03
申请人： Esther Martinborough , Nicole Zimmermann , Robert B. Perni , Michael Arnost , Upul K. Bandarage , Francois Maltais , Guy Bemis
发明人： Esther Martinborough , Nicole Zimmermann , Robert B. Perni , Michael Arnost , Upul K. Bandarage , Francois Maltais , Guy Bemis
IPC分类号： A61K31/497 , A61K31/505 , C07D403/00 , C07D239/02
CPC分类号： C07D409/14 , A61K31/506 , C07D239/28 , C07D239/30 , C07D239/42 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/06
摘要： In general, the invention relates to novel 4-phenylpyrimidine compounds useful as ion channel modulators. It has now been found that compounds of this invention, and pharmaceutically acceptable compositions thereof, are useful as inhibitors of voltage-gated sodium channels and/or calcium channels.
摘要翻译： 通常，本发明涉及可用作离子通道调节剂的新型4-苯基嘧啶化合物。 现已发现，本发明的化合物及其药学上可接受的组合物可用作电压门控钠通道和/或钙通道的抑制剂。
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38.发明授权Pyrrole inhibitors of ERK protein kinase, synthesis thereof and intermediates thereto 有权ERK蛋白激酶的吡咯抑制剂，其合成及其中间体公开(公告)号：US07354939B2
公开(公告)日：2008-04-08
申请号：US11128870
申请日：2005-05-13
IPC分类号： A61K31/4439 , C07D401/04
CPC分类号： C07F9/65583 , C07D401/04
摘要： The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用于蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20060160807A1
公开(公告)日：2006-07-20
申请号：US11312618
申请日：2005-12-20
申请人： Alexander Aronov , Michael Hale , Francois Maltais , Gabriel Martinez-Botella , Judith Straub , Qing Tang
发明人： Alexander Aronov , Michael Hale , Francois Maltais , Gabriel Martinez-Botella , Judith Straub , Qing Tang
IPC分类号： A61K31/53 , A61K31/506 , C07D413/02 , C07D403/02
CPC分类号： C07D403/04
摘要： Described herein are compounds that are useful as ERK2 inhibitors. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including proliferative disorders such as cancer.
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公开(公告)号：US20060058318A1
公开(公告)日：2006-03-16
申请号：US11129114
申请日：2005-05-13
IPC分类号： A61K31/506 , C07D403/04
CPC分类号： C07D403/04
摘要： The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用于蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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