摘要:
The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
摘要:
A procedure for designing WDM optical networks provides both working circuits and protection circuits for carrying traffic demands between node pairs. The protection circuits are activated for the purpose of network recovery in case of a fault on a working circuit. Each protection circuit is link-disjoint, and preferably node-disjoint, from its corresponding working circuit. The network is subdivided into logically defined rings, such that each working and protection circuit lies on one or more of the rings. In particular embodiments of the invention, the joint routing of circuits is carried out so as to minimize the total length of the working and protection circuits according to a length that includes a weight for each link. The weight is selected to promote the efficient packing of optical fibers with wavelength channels.
摘要:
A system for controlling a media player with a media controller includes a host computer (1), a media controller (11), and a Liquid Crystal Display (LCD) panel (12). The media controller is used for users to input commands of controlling the media player, and generating media control signals according to the commands. The LCD panel is used for displaying media information from a media player (6) installed in an operation system of the host computer. A motherboard (10) of the host computer includes: an audio DJ data processing module (103) for receiving media control signals, transforming the media control signals to audio DJ data, and sending the audio DJ data through a south bridge (102) to the media player to play media; and an LCD controlling module (104) for receiving and processing media information, controlling the media information to be displayed on the LCD panel. A related method is also disclosed.
摘要:
The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by the action of ghrelin receptor, including Prader-Willi syndrome, eating disorder, weight gain, weight-loss maintainance following diet and exercise, obesity and disorders associated with obesity such as non-insulin dependent diabetes mellitus.
摘要:
A pulse width modulation (PWM) circuit has a PWM output signal that features accurate timing even in the face of interference imposed upon the control signal representative of the desired PWM duty cycle. The PWM circuit includes or has a first or switching section and a second or analog section. The second section has an operational amplifier with a summing circuit that sums two input signals, namely a triangular wave signal and the control input signal, and then amplifies the summed signal to produce a trapezoidal waveform output delivered to the second section. The first section features a two-input comparator that produces a PWM signal output with a fast transition in response to trapezoidal output fed as an input and compared to a stable reference signal. Due to the speed of the op amp, timing errors on the PWM output signal due to interference on the control signal are minimized.
摘要:
The present invention encompasses structures of the Formula or the pharmaceutically acceptable non-toxic salts thereof wherein: X is hydrogen, halogen, (un)substituted alkyl, (un)substituted alkoxy or amino; and Y is (un)substituted alkyl, aryl, or heteroaryl, which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors. These compounds are useful in the diagnosis and treatment of anxiety, Down Syndrome, sleep, cognitive and seizure disorders, and overdose with benzodiazepine drugs and for enhancement of alertness.
摘要:
Disclosed are compounds of the formula or the pharmaceutically acceptable non-toxic salts thereof wherein: R is hydrogen, alkyl, or(un)substituted alkoxy or amino; and W is (un)substituted alkyl, aryl, or heteroaryl, which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors. The compounds of the invention are useful in the diagnosis and treatment of anxiety, Down Syndrome, sleep, cognitive and seizure disorders, and overdose with benzodiazepine drugs and for enhancement of alertness.
摘要:
Compounds having Formula I are useful for treating cancer. Also disclosed are pharmaceutical compositions comprising compounds of Formula I, and methods of treating cancer in a mammal.
摘要:
Disclosed are compounds of the formula: or the pharmaceutically acceptable non-toxic salts thereof wherein: G, X, T, n, and R3-R6 are as defined herein, which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors. These compounds are useful in the diagnosis and treatment of anxiety, sleep and seizure disorders, overdose with benzodiazepine drugs and for enhancement of memory.
摘要:
The present invention encompasses structures of the Formula ##STR1## or the pharmaceutically acceptable non-toxic salts thereof wherein: x is hydrogen, halogen, (un)substituted alkyl, (un)substituted alkoxy or amino; andY is (un)substituted alkyl, aryl, or heteroaryl,which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors. These compounds are useful in the diagnosis and treatment of anxiety, Down Syndrome, sleep, cognitive and seizure disorders, and overdose with benzodiazepine drugs and for enhancement of alertness.