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公开(公告)号：USRE39197E1
公开(公告)日：2006-07-18
申请号：US10356794
申请日：2002-08-29
申请人： James T. Link , Gang Liu , Zhonghua Pei , Tom von Geldern , Martin Winn , Zhili Xin
发明人： James T. Link , Gang Liu , Zhonghua Pei , Tom von Geldern , Martin Winn , Zhili Xin
IPC分类号： A61K31/505 , A61K31/405 , C07D239/70 , C07D319/14 , C07D319/00
CPC分类号： C07D207/27 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D207/09 , C07D207/14 , C07D207/20 , C07D207/22 , C07D207/26 , C07D209/08 , C07D209/18 , C07D211/22 , C07D211/26 , C07D211/42 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D211/74 , C07D213/74 , C07D213/75 , C07D213/81 , C07D215/36 , C07D217/06 , C07D235/26 , C07D239/42 , C07D241/04 , C07D241/24 , C07D243/08 , C07D265/30 , C07D295/13 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D295/32 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/62 , C07D319/18 , C07D319/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D471/10 , C07D487/08 , C07D491/10
摘要： The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
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2.发明授权公开(公告)号：US06878700B1
公开(公告)日：2005-04-12
申请号：US09541795
申请日：2000-03-31
申请人： James Link , Gang Liu , ZhongHua Pei , Tom von Geldern , Martin Winn , Zhili Xin , Steven A. Boyd , Gui-Dong Zhu , Jennifer C. Freeman , Indrani W. Gunawardana , Michael A. Staeger , Hwan-Soo Jae , John K. Lynch , Sheldon Wang
发明人： James Link , Gang Liu , ZhongHua Pei , Tom von Geldern , Martin Winn , Zhili Xin , Steven A. Boyd , Gui-Dong Zhu , Jennifer C. Freeman , Indrani W. Gunawardana , Michael A. Staeger , Hwan-Soo Jae , John K. Lynch , Sheldon Wang
IPC分类号： A61K31/454 , A61K31/495 , A61K31/496 , A61K31/537 , A61K31/54 , C07C323/62 , C07D205/04 , C07D207/09 , C07D207/14 , C07D207/26 , C07D207/27 , C07D209/08 , C07D211/20 , C07D211/46 , C07D211/60 , C07D213/40 , C07D213/81 , C07D217/06 , C07D241/04 , C07D295/185 , C07D295/26 , C07D401/04 , C07D521/00 , A61K31/33 , A61K31/415 , C07D221/02 , C07D265/30 , C07D319/00
CPC分类号： C07D207/27 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/537 , A61K31/54 , C07C323/62 , C07C2601/02 , C07D205/04 , C07D207/09 , C07D207/14 , C07D209/08 , C07D211/20 , C07D211/46 , C07D211/60 , C07D213/40 , C07D213/81 , C07D217/06 , C07D231/12 , C07D233/56 , C07D241/04 , C07D249/08 , C07D295/185 , C07D295/26 , C07D401/04
摘要： The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immunune diseases, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
摘要翻译： 本发明涉及可用于治疗炎性和免疫疾病的新型肉桂酰胺化合物，含有这些化合物的药物组合物，以及抑制哺乳动物炎症或抑制免疫应答的方法。
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3.发明授权
公开(公告)号：US6110922A
公开(公告)日：2000-08-29
申请号：US222491
申请日：1998-12-29
申请人： James Link , Gang Liu , Zhonghua Pei , Tom von Geldern , Martin Winn , Zhili Xin
发明人： James Link , Gang Liu , Zhonghua Pei , Tom von Geldern , Martin Winn , Zhili Xin
IPC分类号： C07D295/12 , A61K31/16 , A61K31/164 , A61K31/165 , A61K31/167 , A61K31/40 , A61K31/4015 , A61K31/404 , A61K31/407 , A61K31/417 , A61K31/438 , A61K31/44 , A61K31/443 , A61K31/445 , A61K31/4465 , A61K31/4468 , A61K31/45 , A61K31/453 , A61K31/454 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/541 , A61P29/00 , A61P37/02 , C07C323/00 , C07C323/62 , C07C323/63 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/20 , C07D207/22 , C07D207/26 , C07D207/263 , C07D207/27 , C07D207/273 , C07D207/34 , C07D207/36 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D211/22 , C07D211/26 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D211/66 , C07D211/74 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/04 , C07D215/36 , C07D217/06 , C07D233/61 , C07D235/26 , C07D239/42 , C07D241/04 , C07D241/18 , C07D241/24 , C07D243/08 , C07D265/30 , C07D295/13 , C07D295/16 , C07D295/18 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D295/32 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/62 , C07D319/18 , C07D319/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D411/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/10 , C07D487/08 , C07D491/10 , A61K31/505 , A61K31/405 , C07C319/00 , C07D239/70 , C07D319/14
CPC分类号： C07D207/27 , C07C323/62 , C07D207/09 , C07D207/14 , C07D207/20 , C07D207/22 , C07D207/26 , C07D209/08 , C07D209/18 , C07D211/22 , C07D211/26 , C07D211/42 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D211/74 , C07D213/74 , C07D213/75 , C07D213/81 , C07D215/36 , C07D217/06 , C07D235/26 , C07D239/42 , C07D241/04 , C07D241/24 , C07D243/08 , C07D265/30 , C07D295/13 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D295/32 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/62 , C07D319/18 , C07D319/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D471/10 , C07D487/08 , C07D491/10 , C07C2101/02 , C07C2101/04 , C07C2101/08
摘要： The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
摘要翻译： 本发明涉及可用于治疗炎性和免疫疾病的新颖的肉桂酰胺化合物，包含这些化合物的药物组合物，以及抑制哺乳动物炎症或抑制免疫应答的方法。
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4.发明申请公开(公告)号：US20050250768A1
公开(公告)日：2005-11-10
申请号：US10921965
申请日：2004-08-20
申请人： James Link , Gang Liu , ZhongHua Pei , Tom Geldern , Martin Winn , Zhili Xin , Steven Boyd , Gui-Dong Zhu , Jennifer Freeman , Indrani Gunawardana , Michael Staeger , Hwan-Soo Jae , John Lynch , Sheldon Wang
发明人： James Link , Gang Liu , ZhongHua Pei , Tom Geldern , Martin Winn , Zhili Xin , Steven Boyd , Gui-Dong Zhu , Jennifer Freeman , Indrani Gunawardana , Michael Staeger , Hwan-Soo Jae , John Lynch , Sheldon Wang
IPC分类号： A61K31/454 , A61K31/495 , A61K31/496 , A61K31/537 , A61K31/54 , C07C323/62 , C07D205/04 , C07D207/09 , C07D207/14 , C07D207/26 , C07D207/27 , C07D209/08 , C07D211/20 , C07D211/46 , C07D211/60 , C07D213/40 , C07D213/81 , C07D217/06 , C07D241/04 , C07D295/185 , C07D295/26 , C07D401/04 , C07D521/00
CPC分类号： C07D207/27 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/537 , A61K31/54 , C07C323/62 , C07C2601/02 , C07D205/04 , C07D207/09 , C07D207/14 , C07D209/08 , C07D211/20 , C07D211/46 , C07D211/60 , C07D213/40 , C07D213/81 , C07D217/06 , C07D231/12 , C07D233/56 , C07D241/04 , C07D249/08 , C07D295/185 , C07D295/26 , C07D401/04
摘要： The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
摘要翻译： 本发明涉及可用于治疗炎症和免疫疾病的新颖的肉桂酰胺化合物，含有这些化合物的药物组合物，以及抑制哺乳动物炎症或抑制免疫反应的方法。
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公开(公告)号：US07169797B2
公开(公告)日：2007-01-30
申请号：US10771926
申请日：2004-02-04
申请人： Zhili Xin , Gang Liu , Zhonghua Pei , Bruce G. Szczepankiewicz , Michael D. Serby , Hongyu Zhao
发明人： Zhili Xin , Gang Liu , Zhonghua Pei , Bruce G. Szczepankiewicz , Michael D. Serby , Hongyu Zhao
IPC分类号： A61K31/445 , A61K31/41 , C07D211/32 , C07D285/12 , C07D271/06
CPC分类号： C07D413/04 , C07D261/18 , C07D413/12
摘要： The present invention is directed to compounds of formula (I), or a pharmaceutically suitable salt or prodrug thereof, which are useful for the selective inhibition of protein tyrosine phosphatase-1B (PTP1B), and are useful for the treatment of disorders caused by overexpressed or altered protein tyrosine phosphatase 1B.
摘要翻译： 本发明涉及可用于选择性抑制蛋白酪氨酸磷酸酶1B（PTP1B）的式（I）化合物或其药学上合适的盐或前药，并且可用于治疗由过表达 或改变的蛋白酪氨酸磷酸酶1B。
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公开(公告)号：US06972340B2
公开(公告)日：2005-12-06
申请号：US09941471
申请日：2001-08-29
IPC分类号： A61P3/00 , A61P3/10 , C07C209/68 , C07C233/56 , C07C235/74 , C07C237/22 , C07C237/24 , C07C237/42 , C07C271/20 , C07C271/22 , C07C275/24 , C07C311/06 , C07C311/47 , C07C317/40 , C07C323/59 , C07D209/08 , C07D211/20 , C07D241/18 , C07D265/06 , C07D295/135 , C07D295/155 , C07D295/185 , C07D319/18 , C07C321/00 , C07C69/76 , C07C229/00 , C07C271/00
CPC分类号： C07C209/68 , C07C233/56 , C07C235/74 , C07C237/22 , C07C237/24 , C07C237/42 , C07C271/20 , C07C271/22 , C07C275/24 , C07C311/06 , C07C311/47 , C07C317/40 , C07C323/59 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07D209/08 , C07D211/20 , C07D241/18 , C07D265/06 , C07D295/135 , C07D295/155 , C07D295/185 , C07D319/18
摘要： Compounds of formula (I) or therapeutically acceptable salts thereof, are selective protein tyrosine kinase-B (PTP1B) inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of disorders using the compounds are disclosed.
摘要翻译： 式（I）化合物或其治疗上可接受的盐是选择性蛋白酪氨酸激酶-B（PTP1B）抑制剂。 公开了化合物的制备，含有该化合物的组合物和使用该化合物治疗病症。
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公开(公告)号：US07115767B2
公开(公告)日：2006-10-03
申请号：US10893484
申请日：2004-07-16
申请人： Bo Liu , Gang Liu , Lissa T. J. Nelson , Jyoti R. Patel , Hing L. Sham , Zhili Xin , Hongyu Zhao
发明人： Bo Liu , Gang Liu , Lissa T. J. Nelson , Jyoti R. Patel , Hing L. Sham , Zhili Xin , Hongyu Zhao
IPC分类号： C07C271/06 , A61K31/27 , C07D211/06 , A61K31/401
CPC分类号： C07C235/40 , C07C233/58 , C07C271/24 , C07C2602/10
摘要： The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by ghrelin including anorexia, cancer cachexia, eating disorders, age-related decline in body composition, weight gain, obesity, and diabetes mellitus.
摘要翻译： 本发明涉及式（I）化合物或其治疗上合适的盐或前药，该化合物的制备，含该化合物的组合物以及该化合物在预防或治疗由生长素释放肽（包括厌食症）调节的疾病中的用途 ，癌症恶病质，进食障碍，身体组成，体重增加，肥胖和糖尿病年龄相关的下降。
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公开(公告)号：US20050070712A1
公开(公告)日：2005-03-31
申请号：US10671723
申请日：2003-09-26
申请人： Christi Kosogof , Bo Liu , Gang Liu , Mei Liu , Lissa Nelson , Michael Serby , Hing Sham , Bruce Szczepankiewicz , Zhili Xin , Hongyu Zhao
发明人： Christi Kosogof , Bo Liu , Gang Liu , Mei Liu , Lissa Nelson , Michael Serby , Hing Sham , Bruce Szczepankiewicz , Zhili Xin , Hongyu Zhao
IPC分类号： A61K31/505 , A61K31/506 , A61K31/513 , A61P3/00 , C07D239/48 , C07D405/12 , C07D409/12 , C07D43/04
CPC分类号： C07D239/48 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/12
摘要： The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by ghrelin including anorexia, cancer cachexia, eating disorders, age-related decline in body composition, weight gain, obesity, and diabetes mellitus.
摘要翻译： 本发明涉及式（I）化合物或其治疗上合适的盐或前药，该化合物的制备，含该化合物的组合物以及该化合物在预防或治疗由生长素释放肽（包括厌食症）调节的疾病中的用途 ，癌症恶病质，进食障碍，身体组成，体重增加，肥胖和糖尿病年龄相关的下降。
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9.发明申请Novel acetyl-CoA carboxylase (ACC) inhibitors and their use in diabetes, obesity and metabolic syndrome 审中-公开新型乙酰辅酶A羧化酶（ACC）抑制剂及其在糖尿病，肥胖症和代谢综合征中的应用公开(公告)号：US20060178400A1
公开(公告)日：2006-08-10
申请号：US11268698
申请日：2005-11-07
申请人： Bruce Beutel , Heidi Camp , Richard Clark , Yu-Gui Gu , Todd Hansen , Robert Keyes , Qun Li , Gang Liu , Hing Sham , Xiaojun Wang , Moshe Weitzberg , Zhili Xin , Xiangdong Xu , Tianyuan Zhang
发明人： Bruce Beutel , Heidi Camp , Richard Clark , Yu-Gui Gu , Todd Hansen , Robert Keyes , Qun Li , Gang Liu , Hing Sham , Xiaojun Wang , Moshe Weitzberg , Zhili Xin , Xiangdong Xu , Tianyuan Zhang
IPC分类号： C07D211/68 , A61K31/445
CPC分类号： C07D211/68
摘要： The present invention relates to compounds of formula (I), which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.
摘要翻译： 本发明涉及抑制乙酰辅酶A羧化酶（ACC）并可用于预防或治疗人类代谢综合征，II型糖尿病，肥胖症，动脉粥样硬化和心血管疾病的式（I）化合物。
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公开(公告)号：US20060173050A1
公开(公告)日：2006-08-03
申请号：US11337862
申请日：2006-01-23
申请人： Gang Liu , Hing Sham , Bruce Szczepankiewicz , Zhili Xin , Hongyu Zhao , Michael Serby , Bo Liu , Mei Liu
发明人： Gang Liu , Hing Sham , Bruce Szczepankiewicz , Zhili Xin , Hongyu Zhao , Michael Serby , Bo Liu , Mei Liu
IPC分类号： C07D213/84 , A61K31/44
CPC分类号： C07D417/12 , C07D213/73 , C07D213/81 , C07D213/84 , C07D213/85 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/06 , C07D413/10 , C07D417/06 , C07D417/10
摘要： The present invention relates to compounds that are inhibitors of c-jun N-terminal kinase 1, 2, or 3 (JNK1, JNK2, or JNK3), compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by the activation of JNK1, JNK2 and JNK3.
摘要翻译： 本发明涉及作为c-jun N-末端激酶1,2或3（JNK1，JNK2或JNK3）的抑制剂的化合物，含有这些化合物的组合物和该化合物在预防或治疗调节疾病中的用途 通过激活JNK1，JNK2和JNK3。
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